Mechano-Electrochemical Synergy of Lignin Cross-Linked PVA Gel Polymer Electrolytes for Wide-Temperature Flexible Supercapacitors.

The rapid development of flexible electronics has intensified the demand for high-performance energy storage solutions. This research aims to enhance the performance of flexible supercapacitors under extreme temperatures through a lignin cross-linked poly(vinyl alcohol) (PVA) gel electrolyte. By incorporating lignin with PVA and using polyethylene glycol diglycidyl ether as a cross-linker, a hydrogel (PL, represents the mass ratio of lignin to PVA) with an enhanced three-dimensional network structure was constructed.

Biomarkers in body fluids and their detection techniques for human intestinal permeability assessment.

Introduction: Intestinal permeability (IP) is a crucial index for intestinal tract integrity, reflecting intestinal barrier function, injury, diseases, and related systemic conditions. However, current mainstream testing methods are invasive and qualitative. Biomarkers for IP in body fluids offer noninvasive and quantitative advantages for IP assessment while pose challenges for high-performance detection techniques.

Enhancing chemo-immunotherapy in triple-negative breast cancer: Co-delivery of doxorubicin and berberine using nanoparticles to downregulate PD-L1 and eliminate cancer stem cells.

Doxorubicin (DOX), a prominent chemotherapeutic agent for triple-negative breast cancer, can induce immunogenic cell death (ICD), while simultaneous enriching cancer stem cells (CSCs) and enhancing PD-L1 expression, leading to treatment resistance and tumor recurrence. Herein, we propose an innovative nanoparticle delivery system co-encapsulating DOX and berberine (BER), a natural alkaloid eliminating CSCs and downregulating PD-L1, to enhance chemo-immunotherapy effectiveness. In this study, a modified solvent-dialysis approach was used to encapsulate DOX and BER with hyaluronic acid (HA) and chitosan (CS).

Fast Synthesis of Biochar by Hydrolysis with an Acid Catalyst for Efficient Low-Temperature SCR of NO.

Biochar stands out as an excellent carrier for low-temperature SCR catalysts, but its synthesis is often time-consuming and requires high temperatures and fossil fuels. Therefore, sustainable and rapid synthesis methods are challenged. This paper proposes a sustainable method for the rapid synthesis of rice husk biochar by acid-catalyzed hydrolysis at ambient temperature and pressure.

Rosmarinic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Suppressing Ferroptosis and Oxidative Stress Through Nrf2/HO-1 Activation in Mice.

Liver injury caused by the irrational use of acetaminophen (APAP) represents a significant challenge in the field of public health. In clinical treatment, apart from N-acetylcysteine (NAC), the only approved antidote, there are extremely limited effective intervention measures for APAP-induced hepatotoxicity. Therefore, exploring novel liver-protecting drugs and elucidating their mechanisms of action is of great scientific significance and clinical value.

Idiopathic mesenteric phlebosclerosis associated with use of Chinese patent medicine: a case report and literature review.

Idiopathic Mesenteric Phlebosclerosis Colitis (IMP) is indeed a rare and potentially life-threatening condition characterized by chronic ischemic changes in the colon, primarily due to calcification of the mesenteric veins. This disease is often associated with long-term use of certain herbal medicines, particularly in Asian populations, where its prevalence is notably higher. This report describes a 55-year-old male patient who has been taking Chinese patent medicine orally for an extended period to treat prostatitis.

Knockdown SIRT6 Alleviates Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage through Inhibiting Ferroptosis by Promoting SMARCA2 Acetylation.

Ferroptosis has been identified as a mechanism underlying subarachnoid hemorrhage (SAH), attributed to blood-brain barrier (BBB) disruption. This study aimed to explore whether SIRT6 mediates ferroptosis affecting BBB disruption after SAH and the potential mechanism. Knockdown SIRT6 improved the neural function score in SAH rats, reduced the escape latency, increased the number of entering the target quadrant and the time of staying in the platform quadrant, and inhibited apoptosis while reducing brain water content and BBB disruption, leading to an improvement in neurological deficits after SAH.

Improve robustness to mismatched sampling rate: An alternating deep low-rank approach for exponential function reconstruction and its biomedical magnetic resonance applications.

Undersampling accelerates signal acquisition at the expense of introducing artifacts. Removing these artifacts is a fundamental problem in signal processing and this task is also called signal reconstruction. Through modeling signals as the superimposed exponential functions, deep learning has achieved fast and high-fidelity signal reconstruction by training a mapping from the undersampled exponentials to the fully sampled ones.

Ag/Cu2O nanoarray sensors for rapid detection of Bio-H2S in human blood.

The concentration of hydrogen sulfide (H2S) in human blood is closely associated with various chronic diseases. Therefore, it is imperative to design a sensor that can conveniently, rapidly, and accurately detect H2S in human blood at room temperature. In this work, we developed an Ag/Cu2O-based sensor using a two-dimensional electrodeposition in situ assembly method for detecting biological hydrogen sulfide (bio-H2S).

Clinical Characterization of Long COVID Among Chinese Healthcare Workers: A Multicenter, Cross-sectional Study.

Objectives: Since the outbreak of COVID-19, the pandemic has profoundly affected global health and socioeconomic systems. Many recovered patients continue to experience "long COVID" symptoms, affecting their daily life and work performance.

Methods: We utilized questionnaires to investigate long COVID symptoms among healthcare workers and their impact on daily life and work.

Comprehensive pan-cancer analysis identified SLC16A3 as a potential prognostic and diagnostic biomarker.

SLC16A3, belonging to the SLC16 gene family, is involved in the transportation of monocarboxylate. SLC16A family members play important roles in tumorigenesis, nonetheless, the specific involvement of SLC16A3 in tumor prognosis and diagnosis in human cancers remains unelucidated. This study dealt with the exploration of SLC16A3 expression in human pan-cancer and its significance regarding disease prognosis.

Complete closure utilizing titanium clips minimizes delayed postpolypectomy bleeding after colorectal endoscopic mucosal resection: a retrospective analysis.

Background: Delayed postpolypectomy bleeding (DPPB) constitutes one of the most prevalent complications following endoscopic mucosal resection (EMR) for colonic polyps and can be life-threatening. It has been affirmed that prophylactic clip closure can effectively diminish the risk of DPPB for colonic polyps exceeding 20 mm in the right half of the colon after EMR. Nevertheless, there remains controversy regarding whether prophylactic clip closure can prevent postoperative bleeding for polyps measuring less than 20 mm.

Effect of Solidification Direction on the Freckle Formation in Single-Crystal Superalloy Castings.

Solidification experiments in two opposite directions were conducted to investigate the buoyancy effect on freckle formation during directional solidification in single-crystal superalloy castings. During conventional upward solidification with the superalloy CMSX-4, severe freckles were observed in castings of various geometries. By reversing the solidification direction from upward to downward, freckle-free castings could be obtained.

Preparation of Highly Efficient All-pH Bifunctional Water Electrolysis Catalysts Through a Surface Modification Strategy.

Electrolytic hydrogen production from water is a very promising technology, and catalysts capable of efficient operation over a wide pH range are essential for energy storage and conversion. Herein, a trace Ru catalytic core restructures nickel foam (NF) under polymeric protection, with temperature gradient control forming HER-active metal monomers at low temperatures and OER-suitable oxides at high temperatures. It is demonstrated that the surface modification strategy can help NF to maintain its own backbone structure during the carbonation process and that the resulting catalysts possess excellent properties.

Protective effects of albiflorin on acetaminophen-induced hepatotoxicity: Regulation of blood-biliary barrier integrity by ATF3.

Background: Acetaminophen-induced hepatotoxicity remains a clinical challenge with limited targeted therapeutic options. While recent advances have identified blood‒biliary barrier disruption as a critical pathogenic mechanism, effective interventions preserving this barrier are notably lacking. Albiflorin, a key bioactive constituent of Paeonia lactiflora Pall.

Personalized Prophylactic Antiemetic Regimens for Control of Chemotherapy-Induced Nausea and Vomiting by Pharmacogenetic Analysis of Three Receptor Genes: , , .

Purpose: Contemporary prophylactic antiemetic regimens have improved the control of chemotherapy-induced nausea and vomiting (CINV). However, over 50% of patients still suffer from nausea. This study aimed to correlate the genetic determinants of individual patients with the efficacy of three prophylactic antiemetic regimens.

Ultrasensitive Room-Temperature NO Gas Sensor Based on MXene-CuO Composites.

The development of real-time trace-level NO quantification platforms that can be operated at room temperature constitutes a critical advancement for occupational safety and public health monitoring systems. This study demonstrates a room-temperature NO sensor using MXene-CuO composites prepared via a hydrothermal method. Systematic evaluation of MXene-introduced effects identified the 0.

High-Sensitivity Room-Temperature Detection of HS Using ZnO/TiCT Nanocomposite: Potential Applications in Exhaled Gas Monitoring.

The detection of hydrogen sulfide (HS) in exhaled breath at room temperature is essential for health monitoring and disease diagnosis. This study investigates a ZnO/TiCT nanocomposite synthesized by combining ZnO nanoparticles, prepared by a hydrothermal method, with TiCT MXene. Experimental results demonstrate that the ZnO/TiCT nanocomposite sensors exhibit excellent HS detection performance at room temperature with high sensitivity, rapid response time, and robust recovery capability.

Oral Exhalation HS Sensor Based on CuO/ZnO Heterostructures.

Developing a portable and compact sensor for room temperature detection of HS in exhaled breath for health assessment presents considerable technical challenges. This work successfully synthesized CuO/ZnO heterostructures with excellent gas sensitivity to HS at room and lower temperatures using a two-dimensional (2D) electrodeposition in situ assembly method with the application of a semisine wave voltage as well as CuZnO nanoarrays deposited under direct current voltage. The CuO/ZnO heterostructure sensors, with high response of 8.

Deciphering the tumor-suppressive role of RBMS3 in lung adenocarcinoma through genomic insights into prognosis and mechanisms.

Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, underscoring the urgent need for novel biomarkers and therapeutic targets. Through transcriptomic analysis of 4456 genes in TCGA-LUAD cohorts, we identified RBMS3 as a significantly downregulated tumor suppressor (log fold change = -1.82, adjusted P = 3.

Theaflavin Reduces Oxidative Stress and Apoptosis in Oxidized Protein-Induced Granulosa Cells and Improves Production Performance in Laying Hens.

This study aims to investigate the effects of theaflavins on production performance and egg quality in laying hens fed oxidized corn gluten meal while evaluating their antioxidant and anti-apoptotic effects on granulosa cells (GCs) from chicken follicles. In total, 600 Lohmann commercial laying hens, aged 64 weeks, were randomly assigned to four treatment groups: a control group, a theaflavin-supplemented group, an oxidized corn gluten meal group, and a combination group. After 8 weeks of feeding, production performance, egg quality, and antioxidant status, along with GC apoptosis and the antioxidant capacity of eggs, were measured.

A microfluidic DNA sensor array for real-time screening of early-stage lung cancer by simultaneous detection of multiple miRNAs.

We present a DNA sensor array for simultaneous detection of four targeted miRNAs in serum for early-stage lung cancer screening. Owing to effective microfluidic enrichment coupled with ultrasensitive solid-liquid capacitive sensing, the detection limit is as low as 12.84-24.

Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis.

Pyroptosis, a form of programmed cell death driven by the NLRP3 inflammasome, is a key contributor to inflammation in various diseases. This study aimed to investigate the anti-inflammatory mechanisms of cordycepin, focusing on its role in macrophage pyroptosis. Molecular docking analysis was performed to evaluate the binding affinity of cordycepin to key pyroptosis-related proteins, including NLRP3, Caspase-1, and GSDMD.

Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005-2018.

Background: Immunonutritional status is linked to the prognosis of cardiovascular disease (CVD) and diabetes, but the relationship between immunonutritional disorders and clinical outcomes in CVD patients with diabetes is unclear. This study aims to investigate the association of the novel immunonutritional indicator of prognostic nutritional index (PNI) with all-cause and CVD mortality in diabetic and prediabetic CVD patients.

Method: This is an open-cohort study involving 1,509 CVD patients with diabetes or prediabetes collected from The National Health and Nutrition Examination Survey (NHANES) and initially interviewed between 2005 and 2018.

Inhibition Effects and Mechanism Study of rAj-HRP30, a Recombinant Histidine-Rich Peptide from , on the Viability of Pancreatic Ductal Adenocarcinoma Cells Panc01 and Panc02.

rAj-HRP30 is a recombinant peptide derived from the wild-type rAj-HRP of through a gene-shortening mutation. It has a high histidine content (53.3% in its primary structure) and a molecular weight of 3.