Exploring the relationship between cardiac biomarkers and mortality risk in extensive burned patients ≥ 70 % TBSA: A retrospective study.

Background: Extensively burned patients face a significant risk of mortality, with their condition often being closely associated with severe cardiac insufficiency. However, the correlation between cardiac biomarkers and mortality in patients with burns involving ≥ 70 % total body surface area (TBSA) remains underexplored.

Materials And Methods: The study included 159 patients from the Kunshan factory explosion.

Effect of stress hyperglycaemia on the occurrence of haemorrhagic transformation after thrombolysis in patients with acute ischaemic stroke.

Objective: This study aimed to investigate the relationship between the stress hyperglycaemia ratio and haemorrhagic transformation after intravenous thrombolysis in acute ischaemic stroke patients.

Methods: We analysed data in Shanghai General Hospital from 2019 to 2022 on 161 men and 68 women with valid data on fasting blood glucose, glycated haemoglobin, and cranial computed tomography using multivariable regression models to examine the relationship between hyperglycaemia ratio and haemorrhagic transformation.

Results: All 229 patients in this study were included, with 161 males (70.

MYB Confers Sorafenib Resistance in Human Leukemia Cells via Inhibiting Ferroptosis Through FTH1 Upregulation.

Background: MYB is a key transcription factor that plays an essential role in regulating hematopoiesis, particularly influencing cell proliferation, differentiation, and apoptosis. It has been extensively implicated in the pathogenesis and progression of leukemia, as well as in determining patient prognosis and responsiveness to chemotherapy. Despite these well-documented roles, the precise molecular mechanisms by which MYB contributes to chemotherapy resistance in leukemia remain largely undefined.

Microglia replacement halts the progression of microgliopathy in mice and humans.

Colony-stimulating factor 1 receptor () is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and a fatal neurological disease without clinical cure. We developed mouse models harboring human hotspot mutations of CAMP and replaced CSF1R-deficient microglia with CSF1R-normal cells through microglia replacement by bone marrow transplantation (Mr BMT), which attenuated pathology in mice.

Preparation, characterization, and functional properties of zein/gallic acid/sodium alginate ternary composite nanoparticles for enhancing stability and bioaccessibility of phytosterols.

Phytosterols, a class of phytochemicals exhibiting limited aqueous solubility and low oil solubility, possess diverse physiological functions that have attracted considerable research interest. However, their poor aqueous solubility significantly restricts practical applications in functional food systems. To address these limitations, we developed a novel core-shell nanoparticle system.

Multi-omics profiling of Nanhaia speciosa and Nanhaia fordii: insights into lectin dynamics, nodulation, and triterpenoid saponin biosynthesis.

Background: Nanhaia speciosa (N. speciosa) has long been served as a traditional medicinal and edible plant. N.

Arterial, Venous, and Cerebrospinal Fluid Flow and Pulsatility in Stroke-Related Cerebral Small Vessel Disease: A Longitudinal Analysis.

Background: Cerebral small vessel disease (SVD) causes up to 45% of dementias and 25% of ischemic strokes, but the understanding of vascular pathophysiology is limited. We aimed to investigate the contribution of pulsatility of intracranial arteries, veins, and cerebrospinal fluid (CSF) and cerebral blood flow to long-term imaging and clinical outcomes in SVD.

Methods: We prospectively recruited participants in Edinburgh/Lothian, Scotland, with lacunar or nonlacunar ischemic stroke (modified Rankin Scale score ≤2, as controls) and assessed medical and brain magnetic resonance imaging characteristics at baseline and 1 year (2018-2022).

LPItabformer: Enhancing generalization in predicting lncRNA-protein interactions via a tabular Transformer.

Long-noncoding RNAs (LncRNAs) play important roles in physiological and pathological processes. Accurately predicting lncRNA-protein interactions (LPIs) is vital strategy for clarify functions and pathogenic mechanisms of lncRNAs. Current computational methods for evaluating LPIs with their utility and generalization have significant room for improvement.

Designing Physical Unclonable Functions From Optically Active Materials.

Physical unclonable functions (PUFs) are artificial "fingerprints" provided by physical devices to authenticate manufactured goods. Their inherent unclonable nature positions them as one of the most promising tools to tackle global counterfeiting challenges. Leveraging the large parameter space in solution chemistry, chemically generated PUFs can achieve excellent device performance.

Effect of calcium/sodium addition on rice starch-chickpea protein hydrolysate complexes: Microstructure, rheological properties and digestibility.

In the present study, we investigated for the first time the effects of different concentration ranges (0-2 %, w/w) of CaCl and NaCl on the microstructure, physicochemical properties and digestibility of rice starch-chickpea protein hydrolysate (RS-CPH) complexes. The results showed that CaCl (0-1.5 %, w/w) and NaCl (0-1 %, w/w) enhanced the hydrogen bonding interactions between RS and CPH.

Tritium dispersion analysis using HotSpot code: a comparative study across reactor types and environmental conditions.

Kenya is advancing plans to establish nuclear power plant in its coastal parts to boost its energy production. This study addresses the critical need for tritium monitoring and radiological dose assessment under a severe accident scenario. Tritium (H), due to its high mobility and biological relevance, presents a key concern in post-accident dispersion, particularly in developing nuclear states with limited baseline data.

Association of Self-Reported Sleep Metrics With Imaging Markers of Small Vessel Disease and Cognition in Patients With TIA or Mild Stroke.

Background And Objectives: Disturbed sleep is common after stroke, yet its relationship with cerebral small vessel disease (SVD) and cognitive performance in the stroke population, particularly patients with TIA/mild stroke who are on the milder end of the cerebrovascular spectrum, remains understudied. We aim to examine the associations of self-reported sleep metrics with neuroimaging markers of SVD and cognitive performance in patients with TIA/mild stroke from 2 prospective stroke cohorts.

Methods: We studied adult patients with TIA/mild stroke (NIH Stroke Scale [NIHSS] score <7) who were consecutively recruited from Mild Stroke Study 3 (MSS3, University of Edinburgh) and the stroke cohort (the University of Hong Kong, HKU) during 2018-2022.

Choroid plexus free-water correlates with glymphatic function in Alzheimer's disease.

Introduction: Free-water imaging of the choroid plexus (CP) may improve the evaluation of Alzheimer's disease (AD).

Methods: Our study investigated the role of free-water fraction (FWf) of CP in AD among 216 participants (133 Aβ+ participants and 83 Aβ- controls) enrolled in the NeuroBank-Dementia cohort at Ruijin Hospital (RJNB-D). The Alzheimer's Disease Neuroimaging Initiative dataset was used for external validation.

Deletion of a novel upstream promoter of p53 impairs cold tolerance capacity in zebrafish.

P53 is a tumor suppressor that plays a crucial role in stress responses. We previously identified a novel upstream p53 promoter in cold acclimated zebrafish cells, however the functional significance of this upstream promoter under cold stress in zebrafish remains unclear. We generated novel p53 promoter zebrafish using CRISPR/Cas9 and characterized their responses to cold stress.

Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study.

Introduction: This study explored the relationship between blood biomarkers of cerebrovascular function and small vessel disease (SVD) neuroimaging markers and cognitive outcomes in highly-phenotyped participants.

Methods: We conducted cross-sectional and 1-year longitudinal analyses on 181 patients with mild ischemic stroke, enriched for SVD features. We examined relationships between a panel of 13 blood biomarkers and magnetic resonance imaging (MRI) markers of SVD (structural lesions, diffusion-weighted imaging [DWI]-positive lesions, blood-brain barrier (BBB) permeability, and cerebrovascular reactivity (CVR), and cognition.

Alterations in Corneal Nerve Structure and Function in Prediabetes.

Although prediabetes increases the risk of developing diabetes, its role in neuropathy remains unclear. We aim to assess alterations in the corneal nerve structure and function in prediabetes and risk factors for corneal nerve loss. An examination of IVCM and corneal sensitivity was conducted on a cohort of 75 participants, comprising 23 controls, 32 prediabetes, and 20 Type 2 diabetes.

Tissue inhibitor of metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis.

Tissue inhibitor of metalloproteinase 1 (TIMP1) has been implicated in prostate cancer (PCa) metastasis. In this study, PC-3M-2B4 cells with TIMP1 knockdown (PC-3M-2B4-shTIMP1) or overexpression (PC-3M-2B4-TIMP1) were generated, and an inverse correlation was found between TIMP1 expression and cell migration and invasion, which was confirmed in vitro and in vivo. Differential TIMP1 expression was accompanied by variations in the expression of the ferroptosis-related proteins, glutathione peroxidase 4 (GPX4), transferrin receptor, transferrin, glutamine cysteine ligase catalytic subunit, and glutamine cysteine ligase modifier subunit.

RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells.

Background: RNA-binding proteins (RBPs) are essential in cardiac development. However, a large of them have not been characterized during the process.

Methods: We applied the human embryonic stem cells (hESCs) differentiated into cardiomyocytes model and constructed SAMD4A-knockdown/overexpression hESCs to investigate the role of SAMD4A in cardiomyocyte lineage specification.

A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion.

Hepatitis B virus (HBV) represents one of the major pathogenic factor that leads to chronic liver diseases and the development of hepatocellular carcinoma (HCC). The currently approved anti-HBV drugs cannot eradicate the virus or block the development of HCC. HBV nucleocapsid consists of the hepatitis B core antigen (HBcAg) and the HBV relaxed-circular partially double-stranded DNA (rcDNA), indispensable in virus replication.

Clinical Relevance of 'Cap' and 'Track' Development after Recent Small Subcortical Infarct.

Objective: After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities ('caps/tracks') to the index infarct on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigated the clinicoradiological correlates of 'caps/tracks', and their impact on long-term outcomes following RSSI.

Bright and stable anti-counterfeiting devices with independent stochastic processes covering multiple length scales.

Physical unclonable functions (PUFs) are considered the most promising approach to address the global issue of counterfeiting. Current PUF devices are often based on a single stochastic process, which can be broken, especially since their practical encoding capacities can be significantly lower than the theoretical value. Here we present stochastic PUF devices with features across multiple length scales, which incorporate semiconducting polymer nanoparticles (SPNs) as fluorescent taggants.

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy.

Background: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches.

Methods: We constructed a single-cell transcriptional atlas of DCM and normal patients.

Systemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study.

Introduction: We investigated the relationship between systematic regulators of inflammation and the risk of age-related macular degeneration (AMD), both wet and dry forms, by using bidirectional, two-sample Mendelian randomization (MR).

Methods: We performed bidirectional two-sample Mendelian randomization analysis using genome-wide study (GWAS) data for 91 plasma proteins from 14,824 individuals of European descent across 11 study groups. Next, we utilized data from the FinnGen consortium to study AMD using the inverse- variance-weighted approach for Mendelian randomization.