Relieving effect of an Maren-Zhizhu emulsion on loperamide hydrochloride-induced constipation in mice and its effects on the gut microbiota.

Introduction: Constipation, a common gastrointestinal disorder, is rapidly increasing in prevalence worldwide. An increasing number of individuals are choosing traditional Chinese medicine (TCM) as an adjunctive treatment for constipation. In this study, the effect of Maren-Zhizhu emulsion (MRZZ) prepared with L.

Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment via Anti-Inflammation, Antioxidation, and Microbiota Modulation.

Inflammatory bowel disease (IBD) management remains challenging due to the inadequate efficacy and systemic toxicity of conventional therapies. Herein, we developed an inulin hydrogel loaded with self-assembled nanoparticles of curcumin and glycyrrhizic acid (CURG@IN) for IBD treatment. CURG@IN exhibited remarkable gel characteristics and enzyme-responsive drug release behavior.

Open vocabulary detection for concealed object detection in AMMW image.

Currently, millimeter-wave imaging system plays a central role in security detection systems. Existing concealed object detectors for millimeter-wave images can only detect pre-trained categories and fail when encountering new, unseen categories. Accurately identifying the increasingly diverse types and shapes of concealed objects is a pressing challenge.

Association of a Healthy Lifestyle with Risk of Parkinson's Disease and Genetic Predisposition.

Background: Parkinson's disease (PD) is the second most common neurodegenerative disease with largely unknown etiology. Evaluating the association between a healthy lifestyle with PD and genetic risk is necessary.

Methods: The study included 438,241 participants from UK Biobank, with lifestyle information collected via baseline questionnaires.

Study on the Competitive Binding of Food Ingredients and Gambogic Acid to Plasma Proteins: Insights From Spectroscopy, Docking, and Cell Assay.

Human serum albumin (HSA) is the most abundant protein in plasma and an important transporter of exogenous small molecules. In this paper, the binary interaction of HSA with gambogic acid (GA), theophylline (TP), and quercetin (QC) and the ternary interaction of the HSA-QC system in the presence of food components were studied. Fluorescence emission and UV-Vis absorption spectra analysis showed that all three compounds bind HSA via a static quenching model.

Analysis of the prognostic and immune role of MCM6 in pan-cancer and experimental validation in lung adenocarcinoma cells.

Mini-chromosome maintenance protein 6 (MCM6), a member of the DNA replication initiation complex, is considered a potential prognostic marker for multiple tumors. However, the biological role of MCM6 has not been reported in pan-cancer. In present study, a pan-cancer analysis of MCM6 was performed using multiple databases and online websites.

Association of bilirubin with neurodegenerative disorders: A prospective cohort study from UK biobank.

Background: Emerging evidence suggests complex interaction between bilirubin, a heme catabolism byproduct, and neurodegenerative disorders (NDDs), though existing studies report inconsistent associations. We aimed to investigate longitudinal relationship between serum bilirubin levels and NDD risk in a large population-based cohort.

Methods: Utilizing data from the UK Biobank, we investigated the association between baseline direct bilirubin (DBIL) and total bilirubin (TBIL) and the risk of common NDDs using Cox proportional hazards regression analysis.

FN14 promotes ventilator-induced lung injury by regulating pyroptosis via the ANXA2/ERK1/2 axis.

Background: Uncontrollable inflammatory cascade is a key factor in the development of Ventilator-induced lung injury (VILI). Studies have shown that FN14 is involved in the pathophysiological processes of various acute inflammatory diseases. However, its mechanism of action in VILI has not been elucidated.

Lung function and the risk of Parkinson's disease: a population-based cohort study.

Objective: Some researchers have noted a faster decline in lung function among Parkinson's disease (PD) patients compared to healthy individuals. However, the relationship between lung function and the risk of developing PD remains unknown. This study aims to explore the association between lung function and the risk to develop PD.

Homocysteine and thyroid diseases.

Homocysteine (Hcy) is an important intermediate product in methionine metabolism which plays a key role in the methylation of DNA, RNA and proteins. High level of Hcy can induce endothelial cell damage, promote the release of inflammatory factors, stimulate oxidative stress and inhibit the fibrinolytic system. Numerous studies have confirmed the close relationship between hyperhomocysteinemia (HHcy) and the occurrence/development of various diseases such as cardiovascular diseases, neurological disorders, thrombotic diseases, and tumors.

Association of creatinine level with neurodegenerative disorders: a prospective cohort study and Mendelian randomization analysis.

Background: Multiple evidence has suggested interaction between neurodegenerative disorders (NDDs) and creatinine, a metabolite derived from the high-energy product creatine. However, findings across studies have shown inconsistency, and the effect direction remains controversial. Here, we aimed to explore the link between creatinine and the risk of NDDs.

Valorization of tea (Camellia sinensis) waste: Extraction of bioactive compounds using ionic liquids and evaluation of their stability, efficiency, and volatile profiles during the process.

This study explored 50 % 1-butyl-3-methylimidazolium chloride (BMIMCL) and 50 % 1-ethyl-3-methylimidazolium chloride (EMIMCL) as alternative solvents for extracting bioactives from tea waste (TW) of Camellia sinensis. As both release and degradation of catechins occur during extraction, the stability of the compounds was assessed under relevant time-temperature conditions to determine its influence on extraction. Ionic liquids (ILs) preserved catechins better than other solvents.

Metagenomic analysis reveals Bacillus cereus OTU8977 as a potential probiotic in promoting walnut growth.

Background: Rhizosphere microorganisms can improve soil quality, promote plant growth, and enhance plant health. Despite the isolation of numerous plant growth-promoting rhizobacteria (PGPR) strains, research on how PGPR enhances walnut growth remains limited.

Results: In this study, the metagenomic sequencing of the rhizosphere soil in 8 major walnut-producing areas in China was conducted to identify 150 shared core amplicon sequence variants.

MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway.

Ventilator induced lung injury (VILI) is caused by improper use of mechanical ventilation, and its pathogenesis remains unclear. The aim of this study was to establish animal and cell models of VILI, and to explore the mechanism of miR-125b-5p in alleviating VILI by inhibiting ferroptosis through targeted regulation of Keap1/Nrf2/GPX4 axis. Firstly, ferrostain-1(Fer-1), a ferroptosis inhibitor, was used to confirm that ferroptosis was involved in the progression of VILI.

Identification of Aspartate Aminotransferase FocAST2 as a Novel Target of Albendazole in f. sp. TR4.

Fusarium wilt, caused by f. sp. Tropical Race 4 ( TR4), poses a severe threat to global banana production.

Unraveling Charge Transport in Heterostructured Nanomotors for Efficient Photocatalytic Motion.

Photocatalytic micro/nanomotors have emerged as promising tools for environmental remediation, biosensing, and targeted delivery. To enhance their light-driven propulsion, significant efforts have focused on engineering semiconductor heterostructures, which promote charge separation. However, a clear understanding of how these architectures govern photocatalytic mechanisms and influence motion performance remains limited.

Minimizing and/or Avoiding Disease Progression Risk in Patients With the Three Highs: A Grounded Theory Study.

Hypertension, diabetes, and dyslipidemia, collectively referred to as the "three highs," pose a growing global health threat and have a significant impact on individuals' well-being. However, research addressing the primary concerns of patients managing all three diseases simultaneously is limited. In this study, we utilized classic grounded theory to identify the primary concerns of patients with hypertension, diabetes, and dyslipidemia, as well as to explore how these patients address their concerns.

Global trends in sitosterolemia research: A bibliometric and visualization analysis.

Background: Sitosterolemia is a rare autosomal recessive genetic lipid metabolism disorder characterized by high concentrations of plant sterols in plasma and tissues, which can cause a variety of clinical symptoms, such as xanthomatosis, atherosclerosis, and arthritis. In recent years, more and more scholars have begun to pay attention to the special disease of sitosterolemia. Bibliometric analysis, as a method of quantitative analysis of scientific literature, can help us systematically understand the research status and development trends in this field.

Retinoic Acid-Induced 1 Gene and Neuropsychiatric Diseases: A Systematic Review.

Background: Retinoic acid-induced 1 () is a dosage-sensitive gene implicated in a range of rare neuropsychiatric diseases.

Methods: This review provides a comprehensive overview of role, integrating both clinical and basic research on Smith-Magenis syndrome (SMS) and Potocki-Lupski syndrome (PTLS) while also summarising research progress on its involvement in spinocerebellar ataxia (SCA), autism spectrum disorder (ASD), schizophrenia, bipolar disorder and major depression. A systematic review of the literature was conducted using PubMed and EMBASE, following the PRISMA guidelines, with the protocol registered in PROSPERO (CRD42023474165).

Mechanism-Oriented Analysis of Core-Shell Structured CIP@SiO Magnetic Abrasives for Precision-Enhanced Magnetorheological Polishing.

This study addresses the critical challenge of precise control over active abrasive particles in magnetorheological polishing (MRP) through innovative core-shell particle engineering. A sol-gel synthesized CIP@SiO magnetic composite abrasive with controlled SiO encapsulation (20 nm shell thickness) was developed using tetraethyl orthosilicate (TEOS) as the silicon precursor, demonstrating significant advantages in optical-grade fused silica finishing. Systematic polishing experiments reveal that the core-shell architecture achieves a remarkable 20.

Comparative Analysis of Gut Bacteria of Four Waterbirds Species in Taolimiao-Alashan Nur (T-A Nur) in Erdos Relic Gull National Nature Reserve, Inner Mongolia, China.

Taolimiao-Alashan Nur (T-A Nur) is an important breeding site for the Relict Gulls () and many other waterbirds. To understand the gut health status of rare bird species living there and to protect these bird species, this study analyzed the gut microbiota of four waterbird species, including Relict Gull (), Black-necked Grebe (), Greylag Goose (), and Ruddy Shelduck (), using 16S rRNA high-throughput sequencing. Results showed that the gut microbiota of Ruddy Shelduck had the highest α-diversity, while Greylag Goose had the lowest.

Three-dimensional calculation methods on global stability safety factor of diaphragm wall slurry trench based on minimum potential energy principle.

Due to the unreasonable assumptions for the three-dimensional (3D) sliding surface, the calculated results of the global stability safety factor (GSF) of the diaphragm wall slurry trench are often excessively large. In order to improve this phenomenon, the 3D calculation model on the GSF of trench wall is established by assuming the sliding surface to be a quarter ellipsoidal surface and the sliding mass to be a quarter ellipsoid. Then the 3D energy method is proposed based on the minimum potential energy principle, and further the 3D equivalent energy method is also come up with adopting the equivalent trench length to replace the actual trench length.

Clinical and genetic characteristics of -related parkinsonism in Southwest China and a comprehensive literature review.

Background: Biallelic mutations are associated with early onset autosomal recessive parkinsonism, exhibiting a broad spectrum of clinical heterogeneity.

Objective: To comprehensively characterise the clinical, imaging and genetic features of -related parkinsonism.

Methods: We report 14 new cases of -related parkinsonism in Southwest China and conduct a systematic literature review.