Study on the Competitive Binding of Food Ingredients and Gambogic Acid to Plasma Proteins: Insights From Spectroscopy, Docking, and Cell Assay.

Human serum albumin (HSA) is the most abundant protein in plasma and an important transporter of exogenous small molecules. In this paper, the binary interaction of HSA with gambogic acid (GA), theophylline (TP), and quercetin (QC) and the ternary interaction of the HSA-QC system in the presence of food components were studied. Fluorescence emission and UV-Vis absorption spectra analysis showed that all three compounds bind HSA via a static quenching model.

Pore structure engineering in peat-derived hard carbon confined carbonization for boosted sodium storage.

The electrochemical Na storage properties of hard carbon prepared by direct annealing of peat are limited by its open pore structure. Here, we report a co-annealing strategy that repairs the structure within the confined mesopore space in peat, achieving a capacity of 242.5 mAh g at a current density of 30 mA g with an initial coulombic efficiency of 74.

Entropy-Production Type Prussian Blue Analogues: A Family of Promising Hosts for High-Performance Multivalent-Ion Batteries.

The advancement of high-performance, safe, and cost-effective multivalent-ion batteries is pivotal for sustainable energy storage. Prussian blue analogs (PBAs), with their open framework and tunable redox-active sites, hold significant promise but face challenges in structural instability and sluggish ion diffusion. This review focuses on entropy production PBAs (EP-PBAs) for non-monovalent ion (Zn, Al, Mg, and Ca) battery systems.

Effect of the presence of berberine/curcumin on the binding of limonin to human serum albumin and antitumor activity in vitro.

The competition among drugs for binding to plasma proteins is regarded as a pharmacokinetic drug interaction. Competition between antitumor agents and other drugs for plasma protein binding can alter the free concentration of the drug, potentially impacting its efficacy and increasing the risk of toxic side effects. Through a range of spectroscopic techniques, this study examined the interaction between limonin and human serum albumin (HSA) in the context of berberine (Ber) and curcumin (Cur) under physiological conditions to clarify the binding mechanisms of binary and ternary systems at the molecular level.