Bioinformatics analysis of COMMD family in pan-cancer reveals potential biomarkers and therapeutic targets.

The copper-metabolism Murr1 domain (COMMD) protein family plays an essential role in tumours and the immune system. However, the multi-omics characterisation of COMMD family genes and their role in tumour patients has yet to be explored. We collected data from 33 types of cancer and conducted a comprehensive analysis of the expression abnormalities, diagnostic and prognostic roles, subcellular localisation, pathway enrichment, immune microenvironment and immune checkpoint associations of COMMD family genes in these diseases.

Effect of Transition Layers on the Microstructure and Properties of CMT Additively Manufactured Steel/Copper Specimens.

During the cold metal transfer (CMT) arc additive manufacturing process of steel/copper bimetallic materials, interfacial penetration cracks have been observed due to the significant differences in thermal and physical properties between steel and copper. To mitigate the occurrence of these penetration cracks and enhance the interfacial elemental diffusion at the steel/copper junction, this study aims to fabricate high-performance steel/copper bimetallic materials with a uniform microstructure using CMT arc additive manufacturing techniques. A reciprocating additive sequence was adopted, with steel deposited first, followed by copper.

Immune-related biomarkers in the neuromyelitis optica spectrum disorder; pathogenesis and therapeutic approaches.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that mostly affects the optic nerves and spinal cord. About eighty percent of patients have antibodies that are directed against the water channel aquaporin-4 (AQP4)-IgG, which is expressed on astrocytes. This protein was shown to be both a biomarker and a pathogenic cause of NMOSD.

Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction.

Background: The inflammatory response is associated with cardiac repair and ventricular remodeling after myocardial infarction (MI). The key inflammation regulatory factor thymic stromal lymphopoietin (TSLP) plays a critical role in various diseases. However, its role in cardiac repair after MI remains uncertain.

Preparation and Adsorption Properties of a Three-Dimensional Superhydrophilic Mercury-Ion-Imprinted Polymer with Dual Recognition Site Based on MoS/SBA-15.

Water pollution resulting from Hg(II) ions has garnered significant global concern for public health. The flexibility and simplicity of design, cost savings, and ease of operation with adaptive designs provide adsorption with a considerable advantage over other processes. However, MoS is hydrophobic in nature, which limits its efficiency in the removal of Hg(II) ions from water.

Characterization of CD3+ T Lymphocytes in Human Coronary Thrombi with ST-segment Elevation Myocardial Infarction.

Background:  The occurrence and development of ST-segment elevation myocardial infarction (STEMI) are accompanied by coronary atherothrombosis and occlusion, and immune responses play prominent roles in their pathogeneses. However, the causes of atherothrombosis remain elusive, and a comprehensive study of T cell-mediated immune responses in coronary thrombi from STEMI patients is lacking.

Objectives:  The aim of this study was to determine the heterogeneity and clonality of CD3 T lymphocytes in STEMI patients at the single-cell level.

The Influence of Deep Cryogenic Treatment (DCT) on the Microstructure Evolution and Mechanical Properties of TC4 Titanium Alloy.

Deep cryogenic treatment (-196 °C, DCT) is an emerging application that can make significant changes to many materials. In this study, DCT was applied to Ti6Al4V (TC4) titanium alloy, and we delved into an examination of the impact on its microstructural morphologies and mechanical properties. It was observed that DCT has a significant effect on the grain refinement of the TC4 titanium alloy base material.

The deubiquitinating enzymes-related signature predicts the prognosis and immunotherapy response in breast cancer.

Background: Breast cancer is a prevalent disease that has a dismal prognosis for patients and a bad outlook for treatments. Ubiquitination is a reversible biological process that regulates protein production and degradation, as well as plays a vital role in protein transport, localization, and biological activity.

Methods: We obtained the breast cancer patient sample data and used a machine learning technique to create a novel index called Deubiquitinating enzyme related index (DUBRI) by gathering genes associated to deubiquitinating enzymes.

Unravelling CD4 T cell diversity and tissue adaptation of Tregs in abdominal aortic aneurysms through single-cell sequencing.

Immune cell infiltration is a significant pathological process in abdominal aortic aneurysms (AAA). T cells, particularly CD4 T cells, are essential immune cells responsible for substantial infiltration of the aorta. Regulatory T cells (Tregs) in AAA have been identified as tissue-specific; however, the time, location, and mechanism of acquiring the tissue-specific phenotype are still unknown.

Increased expression of protein tyrosine phosphatase nonreceptor type 22 alters early T-cell receptor signaling and differentiation of CD4 T cells in chronic heart failure.

CD4 T-cell counts are increased and activated in patients with chronic heart failure (CHF), whereas regulatory T-cell (Treg) expansion is inhibited, probably due to aberrant T-cell receptor (TCR) signaling. TCR signaling is affected by protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in autoimmune disorders, but whether PTPN22 influences TCR signaling in CHF remains unclear. This observational case-control study included 45 patients with CHF [18 patients with ischemic heart failure versus 27 patients with nonischemic heart failure (NIHF)] and 16 non-CHF controls.

Regulatory T cells and cardiovascular diseases.

Inflammation is a major underlying mechanism in the progression of numerous cardiovascular diseases (CVDs). Regulatory T cells (Tregs) are typical immune regulatory cells with recognized immunosuppressive properties. Despite the immunosuppressive properties, researchers have acknowledged the significance of Tregs in maintaining tissue homeostasis and facilitating repair/regeneration.

The Influence of Heat and Cryogenic Treatment on Microstructure Evolution and Mechanical Properties of Laser-Welded AZ31B.

The pores and coarse lamellar MgAl that inevitably occur in the weld zone are the major challenge for laser-welded magnesium (Mg) alloys including AZ31B. In order to improve microstructure uniformity and eliminate welding defects, a new process assisted with combination of heat and cryogenic treatment was applied in this study. The results showed that after solution treatment, the number and size of precipitates decreased and the uniformity of the microstructure improved.

Effects of cavitation erosion-induced surface damage on the corrosion behaviour of TA31 Ti alloy.

This study used electrochemical noise technology to analyse the effects of surface damage induced by cavitation erosion (CE) on the pitting and passivation behaviours of TA31 Ti alloy. According to the results, TA31 Ti alloy exhibited high corrosion resistance in NaCl solutions. However, the residual tensile stress layer generated during grinding and polishing reduced its passivation ability.

Therapeutic assessment of crystalloid fluid resuscitation in experimental military injury.

Background: A significant part of blast injury is accompanied by hemorrhagic shock (BS), while research on its fluid resuscitation strategies have not been reported. Although blood products are usually recommended in most resuscitation cases, they are less available in certain conditions. To this end, here, we focused on a widely used and more accessible fluid type- crystalloid fluid, in BS treatment.

Cholesterol suppresses human iTreg differentiation and nTreg function through mitochondria-related mechanisms.

Background: Both the crystalline and soluble forms of cholesterol increase macrophage secretion of interleukin 1β (IL-1β), aggravating the inflammatory response in atherosclerosis (AS). However, the link between cholesterol and regulatory T cells (Tregs) remains unclear. This study aimed to investigate the effect of cholesterol treatment on Tregs.

Determination of Soil Cadmium Safety Thresholds for Food Production in a Rice-Crayfish Coculture System.

Previous studies have mainly focused on cadmium (Cd) contamination in conventional rice monocultures, and no research on rice-crayfish coculture has been reported. In this study, a Cd-contaminated (0−30 mg kg−1) rice-crayfish co-culture system was established by adding exogenous Cd. The results showed that the Cd concentration in each tissue of rice and each organ of crayfish increased with increasing soil Cd concentration.

Coupling life cycle assessment and global sensitivity analysis to evaluate the uncertainty and key processes associated with carbon footprint of rice production in Eastern China.

An accurate and objective evaluation of the carbon footprint of rice production is crucial for mitigating greenhouse gas (GHG) emissions from global food production. Sensitivity and uncertainty analysis of the carbon footprint evaluation model can help improve the efficiency and credibility of the evaluation. In this study, we combined a farm-scaled model consisting of widely used carbon footprint evaluation methods with a typical East Asian rice production system comprising two fertilization strategies.

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation.

Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in the colonic lamina propria (cLP) and protect against nonintestinal inflammatory diseases, such as atherosclerosis and post-infarction myocardial inflammation. However, whether and how SCFAs protect the inflamed aortas of subjects with abdominal aortic aneurysm (AAA) remains unclear. Here, the authors revealed the protective effect of SCFAs on AAA in mice and the expansion of Tregs in the cLP, and propionate exerted Treg-dependent protection against AAA by promoting the recirculation of cLP-Tregs through colonic draining lymph nodes (dLNs) to the inflamed aorta.

Diagnostic and Prognostic Nomograms for Lung Metastasis in Triple-Negative Breast Cancer.

Background: The lungs are one of the common sites of metastasis of triple-negative breast cancer (TNBC). Patients with lung metastases (LM) have a shorter duration of survival. This study is aimed at determining the prognostic factors of patients with TNBC with LM and constructing two nomograms to assess the risk of LM and the prognosis of patients with TNBC with LM.

Aorta Regulatory T Cells with a Tissue-Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms.

In addition to maintaining immune tolerance, Foxp3 regulatory T cells (Tregs) perform specialized functions in tissue homeostasis and remodeling. However, whether Tregs in aortic aneurysms have a tissue-specific phenotype and function is unclear. Here, a special group of Tregs that potentially inhibit abdominal aortic aneurysm (AAA) progression are identified and functionally characterized.

Pathogenic Tconvs promote inflammatory macrophage polarization through GM-CSF and exacerbate abdominal aortic aneurysm formation.

Abdominal aortic aneurysms (AAAs) elicit massive inflammatory leukocyte recruitment to the aorta. CD4 T cells, which include regulatory T cells (Tregs) and conventional T cells (Tconvs), are involved in the progression of AAA. Tregs have been reported to limit AAA formation.

Transcriptional and physiological data revealed cold tolerance in a photo-thermo sensitive genic male sterile line Yu17S.

Background: Rice is highly sensitive to chilling stress during the seedling stage. However, the adaptable photo-thermo sensitive genic male sterile (PTGMS) rice line, Yu17S, exhibits tolerance to low temperatures. Currently, the molecular characteristics of Yu17S are unclear.

Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration.

Overactivated inflammatory responses contribute to adverse ventricular remodeling after myocardial infarction (MI). Regulatory B cells (Bregs) are a newly discovered subset of B cells with immunomodulatory roles in many immune and inflammation-related diseases. Our study aims to determine whether the expansion of Bregs exerts a beneficial effect on ventricular remodeling and explore the mechanisms involved.

A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection From Myocardial Infarction.

Background: Regulatory T cells (Tregs), traditionally recognized as potent suppressors of immune response, are increasingly attracting attention because of a second major function: residing in parenchymal tissues and maintaining local homeostasis. However, the existence, unique phenotype, and function of so-called tissue Tregs in the heart remain unclear.

Methods: In mouse models of myocardial infarction (MI), myocardial ischemia/reperfusion injury, or cardiac cryoinjury, the dynamic accumulation of Tregs in the injured myocardium was monitored.