Improvement in rheological and tribology properties of thickened liquids for dysphagia management through the mixing guar gum and xanthan gum at different addition ratios.

The synergistic effect of guar gum (GG) and xanthan gum (XG) can effectively improve food texture, alleviating difficulties faced by dysphagia patients. This study analyzed the thickening effects by preparing various blending ratios of GG and XG (ranging from 0:10 to 10:0). The results showed optimal thickening at GG:XG ratios of 8:2 or 9:1, with high zero shear viscosity (210.

Signal enhancement in single-beam free-induction-decay magnetometers by manipulation of spin polarization.

The conventional single-beam free-induction-decay (FID) magnetometers based on an optical modulation scheme suffer from the reduction of signal in non-orthogonal magnetic field orientations, leading to worse magnetometer sensitivity. Here, we propose a scheme to enhance the signal in single-beam FID magnetometers by manipulation of spin polarization. The spin polarization built up by synchronous optical pumping is rotated to fully undergo free precession under the manipulation of the RF pulse field.

Transfer learning of neural operators for partial differential equations based on sparse network λ-FNO.

When the solution domain, internal parameters, and initial and boundary conditions of partial differential equation (PDE) are changed, many potential characteristics of the equation's solutions are still similar. This provides the possibility to reduce the cost of PDE operator learning through transfer learning methods. Based on Fourier neural operator (FNO), we propose a novel sparse neural operator network named λ-FNO.

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts.

Fibrotic skin diseases are characterized by excessive fibroblast proliferation and pathological extracellular matrix deposition. As a pivotal coenzyme in cellular energetics, NAD homeostasis perturbation is implicated in fibrosis. Multiple studies have demonstrated the therapeutic potential of mesenchymal stem cells (MSCs) against cutaneous fibrosis, while the specific mechanism remains elusive.

Auditory cortex learns to discriminate audiovisual cues through selective multisensory enhancement.

Multisensory object discrimination is essential in everyday life, yet the neural mechanisms underlying this process remain unclear. In this study, we trained rats to perform a two-alternative forced-choice task using both auditory and visual cues. Our findings reveal that multisensory perceptual learning actively engages auditory cortex (AC) neurons in both visual and audiovisual processing.

Case Report: SMARCB1-deficient phenotype may be a new specialized type of pleomorphic xanthoastrocytoma associated with poor prognosis.

Pleomorphic xanthoastrocytoma (PXA) is a rare, localized glioma characterized by frequent V600E mutations and deletions. Compared to -wildtype glioblastoma, PXA has a better prognosis. Recently, rare cases of PXA with rhabdoid histological characteristics have been reported, which are titled atypical teratoid/rhabdoid tumor arising in a PXA.

Scalp rhythmic epileptiform discharges in focal cortical dysplasia: A clinicopathological study.

Objective: Rhythmic epileptiform discharges (REDs) are a prevalent interictal pattern on scalp electroencephalogram (EEG) in patients with focal cortical dysplasia (FCD). The study aims to assess the relationship between REDs and epileptogenicity by investigating their clinical and pathological correlations.

Methods: We retrospectively included patients who underwent resective surgeries with confirmed FCD.

Impact of sodium butyrate on stroke-related intestinal injury in diabetic mice: Interference with Caspase-1/GSDMD pyroptosis pathway and preservation of intestinal barrier.

Diabetic stroke-associated acute intestinal injury is characterized by high mortality, disability, and poor prognosis due to the lack of effective therapies. Our prior research demonstrated that administration of 300 mg/kg sodium butyrate (NaB) can improve neurological outcomes post-diabetic stroke. Nonetheless, whether the effect of NaB is related to intestinal regulation, along with its underlying mechanisms, remains uncertain.

A real-world study on the characteristics of autoimmune gastritis: A single-center retrospective cohort in China.

Background And Aim: Autoimmune gastritis (AIG) was previously considered a rare disease in China, and its clinical characteristics were not fully understood. This study aimed to demonstrate the characteristics of AIG in China and evaluate gastric oxyntic mucosal atrophy using a modified AIG-atrophic staging.

Methods: This was a single-center retrospective observational real-world study.

Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds.

Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for emergency treatment of trauma in maritime activities. The bioadhesives are fabricated from the aggregation of LA, MXene and Ag through their supramolecular interactions, which can be rapidly formed in mild environments, showing strong interface adhesion without adhesive failure caused by depolymerization, while exhibiting mechanical self-reinforcing.

Mapping the Landscape of Digital Health Intervention Strategies: 25-Year Synthesis.

Background: Digital health interventions have emerged as promising tools to promote health behavior change and improve health outcomes. However, a comprehensive synthesis of strategies contributing to these interventions is lacking.

Objective: This study aims to (1) identify and categorize the strategies used in digital health interventions over the past 25 years; (2) explore the differences and changes in these strategies across time periods, countries, populations, delivery methods, and senders; and (3) serve as a valuable reference for future researchers and practitioners to improve the effectiveness of digital health interventions.

Modified Infrabrow Blepharoplasty for Periorbital Rejuvenation in Asia Women.

Objective: The infrabrow blepharoplasty is a common surgical operation indicated in Asians for periorbital rejuvenation. This operation alone is difficult to achieve the correction of crow's feet. Therefore, the authors elucidate the authors' experiences of applying infrabrow blepharoplasty combined with the subcutaneous undermining of the lateral periorbital region to treat upper eyelid dermatochalasis with lateral hooding deformity and alleviate crow's feet, including its indications, operative procedures, and postoperative outcomes.

Can social media promote vaccination? Strategies and effectiveness of COVID-19 vaccine popularization on Chinese Weibo.

Background: The COVID-19 pandemic has shown a high severity in terms of mortality, and to mitigate the impact of the COVID-19 pandemic, a great deal of reliance has been placed on vaccines with defensive effects. In the context of the transmission of hazardous Omicron variant strains, vaccine popularization and acceptance are very important to ensure world health security. Social media can spread information and increase public confidence in and acceptance of vaccines.

Exploring the role of aging in the relationship between obstructive sleep apnea syndrome and osteoarthritis: Insights from NHANES data.

Background: Osteoarthritis (OA) is characterized by high morbidity and disability. While studies have demonstrated that OA is correlated with age-related diseases, few have shown the potential relationship between OA and obstructive sleep apnea syndrome (OSAS). OSAS is characterized by intermittent hypoxia and hypercapnia.

Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation.

Ischemia-free liver transplantation (IFLT) is developed as a novel clinical approach to avoid ischemia-reperfusion injury (IRI). This study aims to identify the most distinguished programmed cell death pathway in grafts undergoing IFLT versus conventional liver transplantation (CLT) and to explore the underlying mechanism. Ferroptosis is the most distinct programmed cell death form between IFLT and CLT grafts.

Promoting Resilience and Well-Being of Young Adults with Diabetes Through Digital Storytelling in Arts-Based Research.

This arts-based research explores the role and impact of digital storytelling in supporting young adults with diabetes in China to face diabetes-related stigma and promote resilience and well-being. Twenty participants with diabetes recounted their experiences across three workshops and shared their perspectives on digital storytelling through semi-structured interviews. The results indicate that digital storytelling, as a health intervention, facilitates a comfortable environment for participants to articulate the traumatic impact of diabetes stigma.

Evaluation of safety, efficacy, and risk factors of different breast reconstruction strategies following polyacrylamide hydrogel removal: A 20-year retrospective cohort study of 436 cases.

Background: Globally implemented for breast augmentation, polyacrylamide hydrogel (PAAG) always leads to breast deformity upon its removal. Despite a pressing need for breast reconstruction following PAAG removal to address aesthetic issues, the optimal timing remains controversial.

Methods: A retrospective cohort study analyzed patients who underwent PAAG removal between 2003 and 2023.

Endoscopic detection and diagnostic strategies for minute gastric cancer: A real-world observational study.

Background: Minute gastric cancers (MGCs) have a favorable prognosis, but they are too small to be detected by endoscopy, with a maximum diameter ≤ 5 mm.

Aim: To explore endoscopic detection and diagnostic strategies for MGCs.

Methods: This was a real-world observational study.

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy.

JOURNAL/nrgr/04.03/01300535-202506000-00027/figure1/v/2024-08-05T133530Z/r/image-tiff Degenerative cervical myelopathy is a common cause of spinal cord injury, with longer symptom duration and higher myelopathy severity indicating a worse prognosis. While numerous studies have investigated serological biomarkers for acute spinal cord injury, few studies have explored such biomarkers for diagnosing degenerative cervical myelopathy.

AURKA Activates to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.

Keloids are benign fibroproliferative disorders with invasive growth exceeding the wound boundary. Aurora kinase A (AURKA) is a serine/threonine kinase highly expressed in various tumors, facilitating tumor growth and invasion. Currently, the role of AURKA in keloid remains unclear.

Single-cell transcriptomics across 2,534 microbial species reveals functional heterogeneity in the rumen microbiome.

Deciphering the activity of individual microbes within complex communities and environments remains a challenge. Here we describe the development of microbiome single-cell transcriptomics using droplet-based single-cell RNA sequencing and pangenome-based computational analysis to characterize the functional heterogeneity of the rumen microbiome. We generated a microbial genome database (the Bovine Gastro Microbial Genome Map) as a functional reference map for the construction of a single-cell transcriptomic atlas of the rumen microbiome.

Exploring the optimal range of central venous pressure in sepsis and septic shock patients: A retrospective study in 208 hospitals.

Background: The aim of this study was to investigate the optimal CVP range in sepsis and septic shock patients admitted to intensive care unit.

Methods: We performed a retrospective study with adult sepsis patients with CVP records based on the eICU Collaborative Research Database. Multivariable logistic regression was performed to explore the associations between CVP level and hospital mortality.

A novel SpaSA based hyper-parameter optimized FCEDN with adaptive CNN classification for skin cancer detection.

Skin cancer is the most prevalent kind of cancer in people. It is estimated that more than 1 million people get skin cancer every year in the world. The effectiveness of the disease's therapy is significantly impacted by early identification of this illness.