Inflammatory mediation by neutrophil percentage to albumin ratio in the association between chronic kidney disease and presbycusis.

This study assessed the association between chronic kidney disease (CKD) and presbycusis and investigated whether inflammatory neutrophil percentage-to-albumin ratio (NPAR) indicators influence this relationship. This study used data from the National Health and Nutrition Examination Survey and employed methods such as restricted cubic spline analysis, multiple logistic regression analyses, and mediation analyses to explore these relationships. High-frequency hearing impairment (HI) was correlated with moderate CKD (OR = 3.

Refined analysis and representation of atomic polarization in NMOR atomic magnetometers.

The nonlinear magneto-optical rotation (NMOR) atomic magnetometer is a highly sensitive total-field device with significant applications in fundamental physics, geophysics, and biomedical monitoring. The atomic polarization, which is optically induced through resonant light pumping, plays a pivotal role in determining the sensitivity and stability of the magnetometer. In this paper, refined analysis and representation of atomic polarization in NMOR atomic magnetometers are presented through the establishment of a three-dimensional polarization distribution model based on the rate equation.

PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication.

Introduction: Autophagy is an important process in host cell responses to viral replication and spread, including those against infectious bursal disease virus (IBDV). Programmed death-1 (PD-1) is a known immunoinhibitory receptor, and its expression causes immune dysfunction in B lymphocytes, resulting in increased progression of immunosuppressive diseases. However, the role of PD-1 in autophagy during IBDV infection remains unclear.

A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls.

The ultimate potential of B cells imprinted by ancestral SARS-CoV-2 in developing neutralizing breadth and potency remains to be explored. Here, we longitudinally tracked B cells that recognize the wild-type spike in two individuals who were repeatedly infected by Omicron variants after receiving prototype mRNA vaccines. Functional and genetic analysis of 632 monoclonal antibodies (mAbs) from those B cells reveals that mAbs cloned after a second infection have dramatically enhanced neutralizing breadth and potency due to immune recalls.

Discovery of Synergistic Broadly Neutralizing Antibodies Targeting Non-Dominant Epitopes on SARS-CoV-2 RBD and NTD.

: Identification and characterization of broadly neutralizing monoclonal antibodies from individuals exposed to SARS-CoV-2, either by infection or vaccination, can inform the development of next-generation vaccines and antibody therapeutics with pan-SARS-CoV-2 protection. : Through single B cell sorting and RT-PCR, monoclonal antibodies (mAbs) were isolated from a donor who experienced a BA.5 or BF.

Self-assembling TLR2 agonists promote mucosal immune responses without pulmonary immunopathologic injuries in mice.

Nasal vaccines offer advantages in eliciting mucosal immunity, particularly through the induction of dimeric IgA. However, the complex mucosal environment poses challenges in achieving optimal immunogenicity and safety. This study introduced Diprovocim, a TLR2 agonist, as an effective and safe adjuvant for mucosal vaccines.

Signal enhancement in single-beam free-induction-decay magnetometers by manipulation of spin polarization.

The conventional single-beam free-induction-decay (FID) magnetometers based on an optical modulation scheme suffer from the reduction of signal in non-orthogonal magnetic field orientations, leading to worse magnetometer sensitivity. Here, we propose a scheme to enhance the signal in single-beam FID magnetometers by manipulation of spin polarization. The spin polarization built up by synchronous optical pumping is rotated to fully undergo free precession under the manipulation of the RF pulse field.

Screening of Adaptive Cultivars and Identification of QTNs Associated With Flowering Time and Related Traits of Diverse Soybean Cultivars Grown in Low-Latitude, High-Altitude Regions.

Soybean has been grown across diverse latitudes; however, its adaptation to low-latitude, high-altitude environments with short days and low temperature remains unclear. To understand the genetic basis of adaptation, we screened 200 diverse cultivars and conducted genome-wide association studies (GWAS) in Bamei and Xianshui, Daofu country, Sichuan Province, China, in 2019 and 2023, respectively. Six agronomic traits: flowering time (DTF), maturity time, node number on main stem (NNM), plant height (PH), effective number of pods per plant and 100-seed weight (HGW) were evaluated.

An Eco-Friendly Inorganic Phosphor for WLEDs of Yttrium-Doped Perovskite: A Sustainable Alternative to Toxic Lead Perovskites.

To circumvent the toxicity problem of lead, looking out for lead-free perovskites with a broadband emission and associated LEDs that cover the full region of white light is the key to research in sustainable chemistry and material community. In order to improve the luminescence properties of inorganic lead-free perovskites, chemical doping engineering is utilized. We have found that yttrium plays an important role as a dopant in broadening the emission of inorganic perovskites.

Sclerostin in ankylosing spondylitis: A meta-analysis.

Objective: This study aims to assess circulating sclerostin levels in patients with ankylosing spondylitis (AS).

Methods: The databases of PubMed, Embase, Medline, Web of Science, The Cochrane Library, China National Knowledge Infrastructure Database (CNKI), China Biomedical Literature Database (CBM), Wanfang Med Online Database (Wanfang), China Science and Technology Journal Database (VIP) were used to collect all relevant published articles (up to 26 August 2024). The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by the random-effect model.

PET/CT-guided Tumor Ablation: Technical Insights and Clinical Applications.

PET/CT-guided ablation is increasingly being used in interventional oncology, due to its unique ability for precise tumor targeting and real-time intraprocedural evaluation of treatment completeness. This modality is extremely useful for targeting hypermetabolic tumors that may not be conspicuous on anatomic imaging. Intraprocedural postablation PET/CT can detect residual unablated tumor and depict ablation margins, permitting repeat ablation within the same treatment session.

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections.

Whether Omicron exposures could overcome ancestral SARS-CoV-2 immune imprinting remains controversial. Here we analyzed B cell responses evoked by sequential Omicron infections in vaccinated and unvaccinated individuals. Plasma neutralizing antibody titers against ancestral SARS-CoV-2 and variants indicate that immune imprinting is not consistently induced by inactivated or recombinant protein vaccines.

Development of a nomogram to predict the probability of survival in hypopharyngeal squamous cell cancer based on systemic inflammation and nutritional indicators.

The prognostic significance of various systemic inflammatory and nutritional markers in hypopharyngeal squamous cell carcinoma (HPSCC) remains unclear. This study aimed to develop a nomogram to predict survival probabilities in patients undergoing HPSCC resection surgery based on these markers, which could help in the treatment of HPSCC. The study included data from 236 HPSCC patients.

[Simultaneous determination of 102 synthetic cannabinoids in electronic cigarette oil by liquid chromatography-tandem mass spectrometry].

Synthetic cannabinoids (SCs), which are among the most widely abused new psychoactive substances, are much more potent and have greater efficacy than natural cannabis. SCs can be disguised in various ways and are commonly sold in the form of electronic cigarette oil. SCs belong to a large family with structures consisting of a core with substituents, linker, ring with substituents, and tail.

AmTPS6 promotes trehalose biosynthesis to enhance the Cd tolerance in mangrove Avicennia marina.

Cadmium (Cd) pollution poses a significant ecological risk to mangrove ecosystems. Trehalose has excellent potential to mitigate the adverse effects of heavy metals. Unfortunately, the mechanisms related to trehalose-mediated heavy metal tolerance in plants remain elusive.

A patient treated with ofatumumab for myasthenia gravis in conjunction with systemic lupus erythematosus and thyroid carcinoma.

Myasthenia gravis (MG) is an autoimmune disease mediated by B cells and is associated with acetylcholine receptor (AChR) and muscle-specific receptor tyrosine kinase (MuSK) antibodies in the postsynaptic membrane at the neuromuscular junction. Anti-CD20 monoclonal antibodies, such as ofatumumab demonstrated promising disease control in MG patients. We presented the rare case of a 34-year-old female with acetylcholine receptor-positive myasthenia gravis (AChR-MG), concomitant with systemic lupus erythematosus (SLE) and metastatic thyroid carcinoma, who was treated with ofatumumab and exhibited improvements during follow-up.

Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.

Glucagon-like peptide 1 (GLP1), which is mainly processed and cleaved from proglucagon in enteroendocrine cells (EECs) of the intestinal tract, acts on the GLP1 receptor in pancreatic cells to stimulate insulin secretion and to inhibit glucagon secretion. However, GLP1 processing is not fully understood. Here, we show that reticulon 4B (Nogo-B), an endoplasmic reticulum (ER)-resident protein, interacts with the major proglucagon fragment of proglucagon to retain proglucagon on the ER, thereby inhibiting PCSK1-mediated cleavage of proglucagon in the Golgi.

Trehalose along with ABA promotes the salt tolerance of Avicennia marina by regulating Na transport.

Mangroves grow in tropical/subtropical intertidal habitats with extremely high salt tolerance. Trehalose and trehalose-6-phosphate (T6P) have an alleviating function against abiotic stress. However, the roles of trehalose in the salt tolerance of salt-secreting mangrove Avicennia marina is not documented.

ZNT1 Regulates the Proliferation, Migration and Invasion of HaCaT Cells Infected with HPV Through the PI3K/Akt Pathway.

Background: Condyloma acuminatum (CA), which is a highly contagious sexually transmitted illness generated by human papillomavirus (HPV) infection, is characterized by abnormal proliferation of keratinocytes resulting in verrucous lesions. Although solute carrier family 30 member 1 (ZNT1) is highly expressed in CA tissues, the function of ZNT1 in CA remains unclear.

Methods: HPV transfection was performed in HaCaT to simulate the CA pathological environment.

MigraineTracker: Examining Patient Experiences with Goal-Directed Self-Tracking for a Chronic Health Condition.

Self-tracking and personal informatics offer important potential in chronic condition management, but such potential is often undermined by difficulty in aligning self-tracking tools to an individual's goals. Informed by prior proposals of goal-directed tracking, we designed and developed MigraineTracker, a prototype app that emphasizes explicit expression of goals for migraine-related self-tracking. We then examined migraine patient experiences in a deployment study for an average of 12+ months, including a total of 50 interview sessions with 10 patients working with 3 different clinicians.

The nasal and systemic inflammatory responses in early phase of acute radiation rhinosinusitis: A pilot study.

Disease severity in acute radiation rhinosinusitis (ARRS) peaks after radiation therapy. ARRS is mainly local inflammation, manifested by increased pro-inflammatory cytokines. Intranasal corticosteroids are effective anti-inflammatory drugs in the treatment of ARRS.

Effect of different antibacterial agents doping in PET-based electrospun nanofibrous membranes on air filtration and antibacterial performance.

In order to reduce the particulate matter pollution to human health in producing environments, series of polyethylene terephthalate/polyvinyl alcohol (PET/PVA) based nanofibrous membranes were fabricated and investigated the dust collection and antibacterial activity. Silver nanoparticles (AgNPs), berberine (Ber) and titanium oxide nanoparticles (TiONPs) were selected as antibacterial agents. These novel membranes were well-characterized using SEM, FTIR, TG, etc.