Nomograms Integrating Body Composition Metrics Predict Total Pathologic Complete Remission after Neoadjuvant Systemic Therapy for Breast Cancer.

Purpose: Neoadjuvant systemic therapy (NST) is a systemic treatment for locally advanced or initially unresectable breast cancer before surgery. Patients achieved total pathological complete response (tpCR) after NST exhibited significantly better overall prognosis than patients with non-pCR.

Materials And Methods: This study collected baseline indicators, body composition indicators and tpCR results of breast cancer patients at the First Affiliated Hospital of Nanjing Medical University.

Emerging cytokines contribute to the clinical manifestation of carotid artery plaque formation and stability in patients with diabetes.

Background: Type 2 diabetes mellitus (T2DM) promotes atherosclerosis and plaque instability through chronic inflammation and immune dysregulation. Emerging evidence implicates members of the interleukin-1 family-particularly IL-36, IL-37, and IL-38-in the modulation of inflammatory responses in diabetic and non-diabetic vascular disease. However, their roles in carotid atherosclerosis remain poorly defined.

Licochalcone D inhibits osteoclast differentiation and postmenopausal osteoporosis by inactivating the NF-κB signaling pathway.

Background: Osteoporosis is prevalent among postmenopausal women and is characterized by excessive bone resorption primarily mediated by osteoclasts. This study aimed to investigate the effects of the natural compound Licochalcone D (Lico D) on osteoclast differentiation and its therapeutic potential in ovariectomized (OVX) mouse models of osteoporosis.

Methods: The cytotoxicity of various doses of Lico D on mouse bone marrow-derived macrophages (BMMs) was evaluated using CCK-8 assays.

The mechanoresponsive chromosomal passenger complex sustains furrow ingression under confinement.

Cells sense and respond to forces from neighbouring cells and the extracellular matrix during growth and division. When cells undergo mitosis in a confined environment like in tumour environment, high compressive stress causes unstable cell cortex and prolonged mitosis. Confined mitotic cells frequently experience chromosome loss and multipolar division.

Role of various types of outdoor activities for school-aged children myopia in Fengyang County, Chuzhou City: a cross-sectional study.

Objectives: This study aimed to assess the association between various types of outdoor activities and myopia among school-aged children.

Design: A cross-sectional study.

Setting: Fengyang County, Chuzhou City, Anhui Province.

Therapeutic effect and mechanism of far-red/near-infrared light on lens-induced myopia Guinea pigs.

Purpose: In order to providing an experimental and theoretical bases for the clinical application of FR/NIR in myopia treatment, this work investigated the therapeutic efficacy and underlying mechanisms of far-red/near-infrared light (FR/NIR) intervention in lens-induced myopia (LIM) progression using a LIM guinea pig model.

Methods: In this study, 2-week-old healthy tricolor guinea pigs were randomly assigned to three groups: normal control (NC) group, LIM group and LIM treated with FR/NIR (LIM + FR/NIR) group. The guinea pigs in the LIM and LIM + FR/NIR groups wore a -6.

PPARα deficiency exacerbates retinal pathological changes and dysfunction in high-fat diet mice.

Aim: To examined the effects of a high-fat diet (HFD) on retinal pathological changes and dysfunction using peroxisome proliferator-activated receptor-alpha (PPARα) knockout mice.

Methods: For four months, C57BL/6J and knockout mice received either HFD or a standard diet (SD). A fluorometric method was used to determine the retinal triglycerides.

How microtopography affected waterbird habitat selection through bird-human visibility: Inspiration for habitat design.

Microtopography influenced the visibility of waterbirds to human activities, which effected the habitat selection of waterbirds. However, previous studies mainly used topographic data to explore the impact of hydrological conditions or vegetation factors on waterbird habitat selection, but largely ignored the discussion of human interference and were unable to fully explain the rules of waterbird habitat selection. This study focused on storks/cranes and shorebirds living in six waterbird habitats in Yancheng coastal area, China.

Professional identity among forensic medicine students: a cross-sectional study in Jiangsu Province, East China.

Background: Exploring the impact of professional identity on the academic performance of students is crucial for improving teaching effectiveness and educational outcomes in this field. Forensic medicine is a niche interdisciplinary discipline in the medical system. However, current educational literature on professional identity development does not adequately address forensic medicine students.

Objective biomarkers of cognitive performance in older adults with mild cognitive impairment: acoustic features of affective prosody.

Objectives: To explore negative affective prosody production patterns in older adults with mild cognitive impairment (MCI) and identify acoustic features as objective biomarkers for cognitive performances.

Methods: We recruited 42 older adults with MCI and 29 healthy controls (HC). The cognitive performances were assessed with the auditory verbal learning test-HuaShan version, the Trail Making Test A, the Digit Span-Forward, and the Digit Span-Backward.

Metabolomic profiling and biomarker identification for early detection and therapeutic targeting of doxorubicin-induced cardiotoxicity.

Background: Doxorubicin (DOX) is a widely used chemotherapeutic agent known for its efficacy against various cancers, but its clinical application is often limited by its cardiotoxic effects. The exact mechanisms of DOX-induced cardiotoxicity remain unclear, requiring further investigation. Early diagnosis is essential to enhance the quality of life and prognosis for patients with malignancies.

Efficacy and safety of anlotinib monotherapy or combination therapy in the treatment of patients with advanced non-small cell lung cancer: a retrospective real-world study conducted in East China.

Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality worldwide. Despite significant advancements in chemotherapy, targeted therapy, and immunotherapy, the prognosis for advanced NSCLC remains poor. The development of resistance to standard treatments and the lack of effective therapeutic options for heavily pretreated patients underscore the urgent need for novel treatment strategies.

Clinical prediction model of invalid recanalization after complete reperfusion after thrombectomy in acute ischemic stroke patients: a large retrospective study.

Background: Studies have been conducted to explore the potential predictive indicators of unfavorable outcomes in patients with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, few studies have proposed a comprehensive predictive model combined with clinical baseline data and ancillary examination before surgery.

Method: In a retrospective study, we collected data on 823 patients with AIS-LVO who had undergone endovascular therapy (EVT); 562 patients who achieved successful revascularization with complete clinical and prognostic information were incorporated into the study.

Omission of axillary lymph node dissection in patients with breast cancer with axillary pathological complete response confirmed by stained region lymph node biopsy after neoadjuvant systemic therapy (SrLNB study): study protocol for a single-arm, single-centre, phase-II trial.

Introduction: Given that axillary lymph node dissection (ALND) may not contribute to local control or survival and could lead to increased arm morbidity, axillary de-escalation procedures have replaced ALND in patients achieving axillary pathologic complete response (apCR) after neoadjuvant systemic therapy (NST). However, the application of targeted lymph node biopsy, one of the de-escalation procedures, remains limited due to a lack of long-term follow-up studies.

Methods And Analysis: This prospective, single-arm, open-label, non-inferiority, single-centre phase II trial targets breast cancer patients initially diagnosed with axillary metastasis who achieved apCR after NST.

A study on the practical logic and promotion path of agile governance of distorted health information on the internet: A review.

This paper aims to introduce the use of the agile governance theory in improving the identification and processing speed of distorted health information on the internet to ensure the security of public health information and maintain the authenticity of the network environment. Use literature research and content analysis to summarize the governance challenges of distorted health information and the shortcomings of governance responses. The governance of distorted health information encounters difficulties such as the rapid release of information, frequent updates, and the diversity and anonymity of information publishers.

Using waste CO to produce essential amino acids for humans: An efficient photoelectrochemical route.

l-phenylalanine (l-Phe), an essential amino acid for humans, is widely used as building blocks. Currently, l-Phe is obtained via biosynthetic methods including microbial and enzymatic processes, but their tightly complex feedback regulation and lengthy reaction steps lead to a low practical yield of l-Phe. Here, we have designed a hierarchical Si-based photocathode for l-Phe synthesis by photoelectrochemical coupling of waste CO and nitrophenyl ethane, achieving a high yield rate of 37.

[Acupuncture regulates dynamic flux of Ca, Na, and HO in skeletal muscle injury induced by eccentric exercise in rats].

This study aimed to investigate the effects of acupuncture on dynamic changes in Ca, Na, and HO flux following eccentric exercise-induced muscle injury. The total of 324 healthy male Wistar rats were randomly divided into 6 groups: control group (C), eccentric exercise group (E), eccentric exercise with acupuncture group (EA), EA with TRP channel blocker group (EAT), EA with NOX2 blocker group (EAN) and EA with placebo group (EAP). Gastrocnemius muscles were subject to lengthening contractions with percutaneous electrical stimulation, followed by immediate pretreatment with blocking agents.

Association between liver fibrosis's noninvasive scores and retinal imaging changes: insights from NHANES.

Background: There is a known association between liver disease and retinopathy. However, the relationship between non-invasive fibrosis scores and retinal image changes remains unknown. The research sought to explore the link between Fibrosis-4 score (FIB-4) and Fibrosis-8 score (FIB-8) and retinal image changes.

Red-crowned Cranes (Grus japonensis) habitat changes in China from 1980 to 2020: Spatio-temporal distribution.

The Red-crowned Crane (Grus japonensis) is a species unique to Asia, with a global population of about 3430. It was a Class I protected wild animal in China and was listed as vulnerable on the World Conservation Union (IUCN) Red List. The Red-crowned Crane was at the top of the food chain of wetland ecosystems and was one of the flagship species for wetland biodiversity conservation.

Overlooked importance: The supporting roles of satellite wetlands for waterbirds around the Yangtze-connected lakes, China.

Core-satellite wetland networks are widespread in large floodplains, but whether these satellite wetlands provide valuable alternatives for the core wetland remains often unknown in the context of global degradation and loss of natural wetlands. During the wintering season of 2022-2023, we conducted field surveys for waterbirds in two core wetlands (Shengjin Lake and Chao Lake located in the middle and lower reaches of the Yangtze River, China) and their surrounding satellite wetlands (aquaculture ponds, paddy fields, reservoirs and natural ponds). The supporting contribution of each satellite wetland was quantified using ratios in terms of individual numbers (SI), species richness (SI), Shannon-Wiener index (SI) and compositional similarity (SI) relative to the corresponding core wetland.

Design strategies for artificial intelligence based future learning centers in medical universities.

Background: This study explores the acceptance of artificial intelligence(AI) tools in medical students and its influencing factors, thus providing theoretical basis and practical guidance for the construction of future learning centers in medical universities.

Methods: This study comprehensively applied the unified theory of acceptance and use of technology(UTAUT), expectancy confirmation theory (ECT), and innovation diffusion theory (IDT) to analyze the data through structural equation modeling.

Results: Effort expectancy (EE), facilitating condition (FC), social influence (SI), and satisfaction (SA) significantly influence medical students' continuance intention (CI) to use artificial intelligence tools.

Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis, nomogram model for its prognosis and acute exacerbation was constructed.

Methods: Two hundred and sixty eight patients with IPF were grouped with different severity according to fibrosis area, serum Club cell secretory protein 16(CC16) was compared between these groups. All patients were randomly divided into training and testing sets.

Reconfigurations of dynamic functional network connectivity after 1HZ repetitive transcranial magnetic stimulation in insomnia disorder.

Aims: The objective of the current study was to investigate the dynamic functional connectivity among large-scale brain networks in patients with insomnia, and to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in these individuals.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data from 62 insomnia patients and 69 healthy controls were used to compare differences in dynamic functional connectivity between the two groups. A total of 26 insomnia patients underwent rTMS for four weeks.