Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aims: The objective of the current study was to investigate the dynamic functional connectivity among large-scale brain networks in patients with insomnia, and to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in these individuals.
Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data from 62 insomnia patients and 69 healthy controls were used to compare differences in dynamic functional connectivity between the two groups. A total of 26 insomnia patients underwent rTMS for four weeks. Changes in dynamic functional network connectivity was observed in insomnia patients following treatment. Additionally, the relationship between clinical symptoms and insomnia was analyzed using topological and correlation analyses.
Results: Our findings demonstrated that insomnia patients exhibited a significantly lower fraction rate of negative connectivity between the dorsal default mode network (dDMN) and the visual network (VN) compared to healthy controls, while showing strong positive connectivity within the VN and the auditory network (AUN). It may be attributed to the restoration of normal dynamic functional connectivity between the dDMN and VN in insomnia patients following rTMS. Furthermore, the dynamic functional connectivity between the dDMN and VN was found to predict sleep quality and treatment outcome in insomnia patients.
Conclusion: Abnormal dynamic functional network connectivity between the dDMN and VN is a hallmark of insomnia, and may serve as a biomarker to assess the effects of rTMS treatment in insomnia patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.sleep.2024.12.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Wave Speed Mapping as a Complementary Tool for Identifying Ventricular Tachycardia Substrate.
J Cardiovasc Electrophysiol
September 2025
Department of Cardiology, Stefan Cardinal Wyszynski Province Specialist Hospital, Lublin, Poland.
Introduction: Wave speed (WS) mapping, enabled by omnipolar technology, allows for real-time visualization of local conduction velocity (CV). Its utility in ventricular tachycardia (VT) ablation has not been fully characterized.
Methods And Results: We describe a case series of patients undergoing VT ablation in which WS mapping was applied alongside established techniques such as peak frequency (PF) mapping and isochronal late activation mapping (ILAM).
Development and validation of a gastric cancer prognostic model utilizing lymphatic endothelial cell-related genes.
Diagn Pathol
September 2025
Department of Gastrointestinal Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Background: Gastric cancer is one of the most common cancers worldwide, with its prognosis influenced by factors such as tumor clinical stage, histological type, and the patient's overall health. Recent studies highlight the critical role of lymphatic endothelial cells (LECs) in the tumor microenvironment. Perturbations in LEC function in gastric cancer, marked by aberrant activation or damage, disrupt lymphatic fluid dynamics and impede immune cell infiltration, thereby modulating tumor progression and patient prognosis.
View Article and Find Full Text PDFDistinct evolutionary trajectories of subgenomic centromeres in polyploid wheat.
Genome Biol
September 2025
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101, Beijing, China.
Background: Centromeres are crucial for precise chromosome segregation and maintaining genome stability during cell division. However, their evolutionary dynamics, particularly in polyploid organisms with complex genomic architectures, remain largely enigmatic. Allopolyploid wheat, with its well-defined hierarchical ploidy series and recent polyploidization history, serves as an excellent model to explore centromere evolution.
View Article and Find Full Text PDFBacillus drives functional states in synthetic plant root bacterial communities.
Genome Biol
September 2025
Department of Biology, Plant-Microbe Interactions, Science for Life, Utrecht University, Utrecht, 3584CH, The Netherlands.
Background: Plant roots release root exudates to attract microbes that form root communities, which in turn promote plant health and growth. Root community assembly arises from millions of interactions between microbes and the plant, leading to robust and stable microbial networks. To manage the complexity of natural root microbiomes for research purposes, scientists have developed reductionist approaches using synthetic microbial inocula (SynComs).
View Article and Find Full Text PDFConstruction of an Ag-functionalized structural color hydrogel sensor for colorimetric detection of glutathione.
Mikrochim Acta
September 2025
Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, China.
An Ag-functionalized structural color hydrogel (Ag-SCH) sensor is constructed for colorimetric detection of glutathione (GSH). The hydrogel is prepared by using the coordination of Ag and 1-vinylimidazole (1-VI) as cross-linking network. GSH acts as a competitive ligand to break the coordination between Ag and 1-VI, leading to the expansion and structural color change of the hydrogel.
View Article and Find Full Text PDF