Effect of Acupuncture on Functional Connectivity of the Limbic Network in Patients with Knee Osteoarthritis: A Resting State Functional Magnetic Resonance Imaging Study.

Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder. Acupuncture therapy demonstrates significant efficacy in alleviating KOA symptoms. However, the central neuroimaging mechanisms underlying acupuncture's therapeutic effects remain incompletely elucidated.

High-altitude adaptation strategies: active integration of higher-order cognitive processes by indigenous residents to overcome altitude-induced constraints in visual cognition.

This study explores the influence of indigenous residents at high altitudes on visuospatial cognitive functions, particularly focusing on mental rotation abilities among different populations. The study adopts a comprehensive methodological framework that combines behavioral assessments with advanced neuroimaging techniques. Data collection involves administering mental rotation task to the participants, followed by analyzing their behavioral responses.

AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis.

Endometriosis is a common gynecological endocrine disease with unclear pathogenesis. Evidence suggests enhanced aerobic glycolysis in ectopic endometrium of endometriosis. The role of N6-methyladenosine (m6A) modification in female reproductive diseases has been revealed in recent years, and it is involved in the regulation of glycolysis in a variety of diseases.

Expanding the spectrum of genetic causes of DNA-specific exonuclease TREX1 variants in thrombotic microangiopathy.

Introduction: Thrombotic microangiopathy (TMA) is a complex condition involving endothelial damage and microvascular thrombi. The International Society of Nephrology's aHUS International Forum identified genetic variants as crucial for tailored therapies like plasma exchange and anti-complement therapy. Recent studies suggested that new pathogenic genes beyond complement and coagulation pathways contribute to TMA including TREX1 variants.

Polymicrobial detection and salivary metabolomics of children with early childhood caries.

Background: Early childhood caries (ECC) has been proposed to be associated with various microorganisms and metabolites. This study aims to compare the prevalence of specific microbial species and salivary metabolomics profile in children with and without ECC, and to explore the correlation between salivary metabolites and targeted microbes.

Method: Five ml of unstimulated saliva was collected from 32 ECC and 22 caries-free children.

De novo AML spontaneously achieved PR after COVID-19 infection, and CR after reduced dose of azacytidine combined with venetoclax: A case report and literature review.

Rationale: Coronavirus disease (COVID-19) infection increases the mortality of patients with hematological malignancies. The optimal treatment for de novo acute myeloid leukemia (AML) patients with severe pneumonia caused by COVID-19 is not clear.

Patient Concerns: A 59-year-old woman was admitted to our department with fever, cough dyspnea, and thrombocytopenia for 1 week.

Usefulness of intraoperative choledochoscopy in laparoscopic subtotal cholecystectomy for severe cholecystitis.

Laparoscopic subtotal cholecystectomy (LSC) has been a safe and viable alternative to conversion to laparotomy in cases of severe cholecystitis. The objective of this study is to determine the utility of intraoperative choledochoscopy in LSC for the exploration of the gallbladder, cyst duct, and subsequent stone clearance of the cystic duct in cases of severe cholecystitis. A total of 72 patients diagnosed with severe cholecystitis received choledochoscopy-assisted laparoscopic subtotal cholecystectomy (CALSC).

Ultra-sensitive, versatile and portable detection of hydrazine in eco-environmental systems using a smartphone-integrated ratiometric fluorescent sensor.

Hydrazine (NH), a highly reactive specie widely used in industrial processes, poses significant ecological risks. Accurate detection of NH is essential for safeguarding public health, yet developing a robust tool for its global detection remains a significant challenge. Herein, we developed a ratiometric fluorescent sensor, DIPOT, designed for ultra-sensitive and portable detection of NH in eco-environmental systems.

Dual-response fluorescent triphenylamine chemoprobe HN2 for the detection of Cu ions and HS: Applications in real samples and biological imaging.

The pervasive presence of the heavy metal ion Cu and the harmful gas HS in the environment and foodstuffs constitutes a significant health hazard. To address this issue, we developed a novel dual-response, multifunctional fluorescent chemoprobe, HN2, based on triphenylamine. This probe facilitates the continuous detection of Cu and HS through an "on-off-on" fluorescence response mechanism.

Systematic mining and quantification reveal the dominant contribution of non-HLA variations to acute graft-versus-host disease.

Human leukocyte antigen (HLA) disparity between donors and recipients is a key determinant triggering intense alloreactivity, leading to a lethal complication, namely, acute graft-versus-host disease (aGVHD), after allogeneic transplantation. Moreover, aGVHD remains a cause of mortality after HLA-matched allogeneic transplantation. Protocols for HLA-haploidentical hematopoietic cell transplantation (haploHCT) have been established successfully and widely applied, further highlighting the urgency of performing panoramic screening of non-HLA variations correlated with aGVHD.

Re-exploration of phenolic compounds from natural waste rice husks: Combined synthesis of novel herbicide and evaluation of herbicidal activity.

In a global context, weed management has emerged as a significant challenge in agricultural production, causing substantial economic losses annually. Consequently, the development of innovative and efficient herbicides is crucial. Natural products serve as important sources for discovering novel herbicides.

[Research progress on N6-methyladenosine and ferroptosis in childhood combined allergic rhinitis and asthma syndrome].

Combined allergic rhinitis and asthma syndrome (CARAS) is one of the common chronic airway inflammatory diseases in children. With the development of epigenetics, research on CARAS has gradually extended from protein levels to molecular levels, such as transcription and post-transcriptional regulation. N6-methyladenosine (m6A) methylation and ferroptosis have emerged as promising research hotspots in recent years, playing crucial roles in tumors, growth and development, and allergic diseases.

Proteome Profiling of Serum Reveals Pathological Mechanisms and Biomarker Candidates for Cerebral Small Vessel Disease.

Cerebral small vessel disease (CSVD) is a global brain disorder that is characterized by a series of clinical, neuroimaging, and neuropathological manifestations. However, the molecular pathophysiological mechanisms of CSVD have not been thoroughly investigated. Liquid chromatography-tandem mass spectrometry-based proteomics has broad application prospects in biomedicine.

A near-infrared multifunctional fluorescent bio-probe with large stokes shift and high quantum yield for effective determination of heavy metal lead and pesticide glyphosate in vitro and vivo.

Heavy metal contamination and pesticide residues pose significant threats to human health and ecosystems. Despite its broad applications, fluorescence imaging technology often struggles in complex ecological and biological environments due to disadvantages of background autofluorescence and low quantum yield. This study introduced a near-infrared (NIR) multifunctional "off-on-off" isophorone-based fluorescent bio-probe, DHB, characterized by a high fluorescence quantum yield (10.

Combination of DMDD with Nanoparticles Effective Against Diabetic Kidney Disease in vitro.

Purpose: 2-Dodecyl-6-methoxy-2,5-diene-1,4-cyclohexanedione (DMDD), isolated from . root, has demonstrated the potential to reduce blood sugar levels. However, DMDD has poor solubility and bioavailability.

Sensitive detection of Hg(II) on MoS/NiS based on interfacial engineering to accelerate the Ni/Ni cycle: Identification the role of atomic-level heterojunction-induced electron transfer in electroanalysis.

The valence change of transition metal ions in nanomaterials can highly enhance the electrochemical detection performance toward heavy metal ions (HMIs), and how to further promote the valence change calls enormous concerns in electroanalysis. In this work, an interfacial engineering that combing the MoS and NiS together to form the MoS/NiS complex is proposed. The density functional theory (DFT) results reveals that the novel atomic-level heterojunction between MoS and NiS will build an internal electric field (IEF), which leads to an enhanced conductivity and valence change behavior of Ni atoms in MoS/NiS complex, resulting in a superior detection performance.

Nigenolides A-H, 13 new microperfuranones with ferroptosis inhibitory activity from the deep-sea-derived Aspergillus niger.

Thirteen new microperfuranones, including five pairs of enantiomers, (±)-nigenolides A-E (1a/1b-5a/5b), and three racemate nigenolides F-H (6-8), together with four known analogues (9-12) were isolated from a deep-sea-derived Aspergillus niger 3A00562. The absolute configurations of the five pairs of enantiomers were determined by the comparison of the calculated and experimental ECD spectra. Compounds 3a, 4a, 4b, and 12 were able to inhibit RSL3-induced ferroptosis.

Economic evaluations of robot-assisted radical prostatectomy and the factors affecting its cost-effectiveness: a systematic review.

This systematic review aims to summarize the progress made in the study of the cost-effectiveness of robot-assisted radical prostatectomy (RARP) worldwide and to analyze the economic factors influencing this, in an attempt to provide methodological guidance for conducting economic evaluation studies in a domestic context, and to put forward suggestions for improving the cost-effectiveness of RARP in emerging markets. We conducted a systematic literature review and analysis of studies published worldwide from January 2000 to July 2024 concerning the economic evaluation of RARP compared with laparoscopic radical prostatectomy (LRP) or open radical prostatectomy (ORP). A total of 16 papers were included.

Efficient expression and purification of rat CRP in .

C-reactive protein (CRP) plays a crucial role in the diagnosis and monitoring of the non-specific acute phase response in humans. In contrast, rat CRP (rCRP) is an atypical acute-phase protein that possesses unique features, such as a possible incapacity to trigger the complement system and markedly elevated baseline plasma concentrations. To facilitate studies on these unique characteristics, obtaining high-quality pure rCRP is essential.

Mechanism and treatment of intracerebral hemorrhage focus on mitochondrial permeability transition pore.

Intracerebral hemorrhage (ICH) is the second most common subtype of stroke, characterized by high mortality and a poor prognosis. Despite various treatment methods, there has been limited improvement in the prognosis of ICH over the past decades. Therefore, it is imperative to identify a feasible treatment strategy for ICH.

[Clinical anatomy of the free latissimus dorsi myocutaneous flap and its application in the restoration of giant defects of the head and neck].

Purpose: To investigate the feasibility and effect of free latissimus dorsi myocutaneous flap in the reconstruction of giant head and neck defects.

Methods: Free latissimus dorsi myocutaneous flap on the cadaver was simulated dissected, and measured by Image-Pro Plus 6.0 to assess the feasibility of repairing giant head and neck defects.