Metabolic Syndrome and Insulin Resistance Are Associated With Normal-Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome.

Aim: To determine whether metabolic syndrome (MS), insulin resistance (IR), myocardial enzymes, and kidney function are related to the normal-range of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and their ratio in Chinese women with polycystic ovary syndrome (PCOS).

Methods: The research, a secondary analysis of the Acupuncture and Clomiphene for Chinese Women with PCOS trial (PCOSAct), enrolled 922 participants with less than 40 U/L of AST and ALT. Linear regression and trend analyses were used to analyze the relationship between AST, ALT, AST/ALT ratio and anthropometric and metabolic characteristics.

Comparative toxicological impacts of tire wear and latex particle leachates on zebrafish embryos: Chemical characterization, oxidative stress, and transcriptomic disruption.

Rubber-derived pollutants, such as tire wear particles (TWP) and latex particles (LAP), pose increasing threats to aquatic ecosystems due to their complex chemical composition and potential toxicity. This study systematically evaluated the embryotoxicity of 30-day leachates from TWP and LAP (10 g/L) in zebrafish (Danio rerio) by integrating chemical characterization and toxicological assessment. ICP-MS and GC-MS analyses revealed elevated levels of toxic metals, notably zinc and aluminum that exceeded established ambient water quality criteria for aquatic life, along with numerous organic contaminants including antioxidants, plasticizers, and accelerators.

Environmental toxicity of tire wear and latex particle leachates in zebrafish embryos: Oxidative stress and ferroptosis as key mechanisms.

Microrubber, a subset of microplastics, has raised global concerns due to its persistence and ecological risks in aquatic systems. This study systematically compared the toxicity of leachates (0, 0.5, 2.

Exploring the molecular mechanism of Polygonum multiflorum in treating androgenic alopecia based on the methods of bioinformatics and molecular docking.

This study aims to research and discuss the molecular mechanism of Polygonum multiflorum (PM) to treat androgenic alopecia (APA). The target network and protein interaction network of APA of PM were established using traditional Chinese medicine molecular mechanism bioinformatics databases and disease gene databases. The core subnetworks were screened based on topological analysis, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed, molecular docking of the 10 genes with the highest connectivity.

Investigating the Effect of Different Riboflavin Concentrations on Corneal Biomechanical Properties in Cross-linking.

Purpose: To evaluate the corneal cross-linking (CXL) efficacy of riboflavin (RF) at 5 different concentrations (0.1%, 0.25%, 0.

Network meta-analysis of different modalities of intense pulsed light therapy in the treatment of dry eye disease induced by meibomian gland dysfunction.

Purpose: This network meta-analysis aimed to evaluate the comparative effect of five different protocols of IPL treatment in treating MGD-related DED, including optimal pulse technology [OPT]-based IPL, E > eye-based IPL, OPT-based IPL plus meibomian gland expression (MGX), E > eye-based IPL plus MGX, Eyesis-based IPL plus MGX.

Methods: PubMed, Embase, Cochrane Library, SCOPUS and China National Knowledge Infrastructure (CNKI) were searched for eligible studies published before November 10, 2022.

Results: Random network meta-analysis was conducted to estimate the differences between different protocols of IPL treatment in ocular surface disease index (OSDI), standard patient evaluation of eye dryness (SPEED), tear break-up time (TBUT), meibomian gland quality (MGQ), meibomian gland evaluation (MGE), and corneal fluorescein staining (CFS).

Vehicle-specific toxicological profiles of tire wear particles: Physiological, microbial, and transcriptomic disruptions in zebrafish induced by light and heavy-duty vehicle emissions.

Tire wear particles (TWPs) from vehicles have emerged as significant sources of environmental microplastics, releasing hazardous metals and organic contaminants into aquatic ecosystems. However, the differential toxicological effects of TWPs originating from heavy-duty vehicle tire wear particles (HTWPs) versus light-duty vehicle tire wear particles (LTWPs) remain inadequately characterized. Here, we comprehensively evaluated physiological responses, gut microbiota alterations, and liver transcriptomic changes in zebrafish exposed to HTWPs and LTWPs.

Oxygen-releasing microneedles enhance the therapeutic effect of corneal ectasia by increasing corneal oxygen content and riboflavin concentration during cross-linking.

Corneal ectasia, characterized by progressive corneal thinning and reduced biomechanical properties, significantly impairs patients' visual quality. The epithelium-off (epi-off) procedure, the gold standard for treating corneal ectasia, avoids corneal transplantation but can cause pain and delayed healing. In contrast, trans-epithelial therapy preserves the epithelium but suffers from limited riboflavin penetration, reducing its efficacy.

Gap solitons in moiré optical lattice with quartic dispersion.

This work investigates the theoretical properties and stability mechanisms of semi-infinite gap solitons in moiré optical lattices governed by quartic dispersion. Using the framework of Floquet-Bloch theory, we explore linear modes in commensurate and incommensurate lattice configurations, revealing distinct localization characteristics influenced by the lattice twist angle and dispersion coefficient. Numerical simulations confirm that gap solitons can emerge in a self-focusing Kerr medium, originating from nonlinear evolution of localized linear Bloch modes.

Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.

High myopia poses a significant public health challenge due to its rising prevalence and the associated risk of vision-threatening complications. Macrophages play a crucial role in myopic changes; however, the underlying mechanisms remain poorly understood. In the present work, we utilized a mouse lens-induced myopia (LIM) model to elucidate the role of macrophages in myopic scleral remodeling through the release of macrophage extracellular traps (METs).

Association between hemoglobin, albumin, lymphocyte, and platelet scores and all-cause and cardiovascular mortality among adults with atherosclerotic cardiovascular disease in the United States: An analysis of NHANES.

Atherosclerotic cardiovascular disease (ASCVD) remains the foremost cause of mortality in the United States. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a straightforward and economical indicator, combines inflammatory and nutritional status. However, its association with ASCVD incidence and long-term mortality is uncertain.

Elevated Triglyceride-Glucose Index Is Associated With Insulin Resistance, Metabolic Syndrome Components, Nonalcoholic Fatty Liver Disease, and Adverse Pregnancy Outcomes in Chinese Women With Polycystic Ovary Syndrome.

Aim: To investigate the associations of triglyceride-glucose index (TyG) with anthropometric characteristics, metabolic/endocrine profiles, and pregnancy outcomes in Chinese women with polycystic ovary syndrome (PCOS).

Methods: This secondary analysis of the Acupuncture and Clomiphene for Chinese Women with Polycystic Ovary Syndrome trial (PCOSAct) included 956 participants with prospectively collected data. TyG was calculated using fasting triglyceride and glucose levels (Ln [TG (mg/dL) × FPG (mg/dL)/2]).

Size- and duration-dependent toxicity of heavy vehicle tire wear particles in zebrafish.

Tire wear particles (TWPs), as a pervasive environmental pollutant, pose significant risks to aquatic ecosystems. This study investigates the effects of small (HS) and large (HL) TWPs produced by heavy vehicles on zebrafish, focusing on physiological, microbial, and transcriptomic levels, as well as their intergenerational consequences, under short-term (15 days) and long-term (90 days) exposure. Short-term exposure to small particles (HS15) significantly reduced body width and triggered widespread oxidative stress, while long-term exposure to large particles (HL90) increased gut weight and decreased gill weight, reflecting respiratory and digestive disruptions.

Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition.

The human cerebral cortex exhibits intricate interareal functional synchronization at the macroscale, with substantial individual variability in these functional connections. However, the spatial organization of functional connectivity (FC) variability across the human connectome edges and its significance in cognitive development remain unclear. Here, we identified a connectional axis in the edge-level FC variability.

Size-dependent ecotoxicological impacts of tire wear particles on zebrafish physiology and gut microbiota: Implications for aquatic ecosystem health.

The ecological impact of tire wear particles (TWP), a significant source of microplastics pollution, is increasingly concerning, especially given their potential effects on the health of aquatic ecosystems. This study investigates the size-dependent ecotoxicological responses of zebrafish (Danio rerio) to TWP exposure, focusing on physiological, metabolic, and microbial community impacts over a 15-day exposure period followed by a 15-day excretion period. Through integrated analysis of gut microbiome composition, liver transcriptomics, and host physiological markers, we found that smaller TWP particles (< 120 μm) induced oxidative stress, evidenced by increased SOD and MDA levels, and inhibited growth by reducing body mass and gut length.

Risk factors and prediction model for postpartum psychiatric disorders: a retrospective cohort study of 1418 Chinese women from 2020 to 2022.

Background: Postpartum psychiatric disorders (PPDs) have been deemed as a significant public health concern, affecting both maternal health and family dynamics. This study aimed to examine the current status of PPDs, identify the potential risk factors of PPDs, and further develop a clinical nomogram model for predicting PPDs in Chinese women.

Method: In this retrospective cohort study, 1418 postpartum women attending the routine postpartum examination at the 42nd day after delivery in Jiangsu Women and Children Health Hospital were recruited as participants from December 2020 to December 2022.

Transcranial low-level laser stimulation in the near-infrared-II region (1064 nm) for brain safety in healthy humans.

Background: The use of near-infrared lasers for transcranial photobiomodulation (tPBM) offers a non-invasive method for influencing brain activity and is beneficial for various neurological conditions. However, comprehensive quantitative studies on its safety are lacking.

Objective: This study aims to investigate the safety of 1064-nm laser-based tPBM across brain structure, brain function, neural damage, cognitive ability and tolerance.

Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children.

Background: The spatial layout of large-scale functional brain networks exhibits considerable inter-individual variability, especially in the association cortex. Research has demonstrated a link between early socioeconomic status (SES) and variations in both brain structure and function, which are further associated with cognitive and mental health outcomes. However, the extent to which SES is associated with individual differences in personalized functional network topography during childhood remains largely unexplored.

Development and Psychometric Assessment of a Chinese Version of the Ultra-Low Vision Visual Functioning Questionnaire-50.

Purpose: To develop a short form of Chinese ULV-VFQ-50 based on the ULV-VFQ-150 and compare the psychometrical properties of the two questionnaires.

Methods: We selected candidate items from the ULV-VFQ-150, considering the item response among ultra-low vision (ULV) participants, the even distribution of item measures, visual aspects, and visual domains, to construct a 50-item ULV-VFQ-50 questionnaire. Then, ULV participants were recruited to evaluate its psychometric characteristics by using Rasch analysis.

Microbial strategies for effective microplastics biodegradation: Insights and innovations in environmental remediation.

Microplastics (MPs), diminutive yet ubiquitous fragments arising from the degradation of plastic waste, pervade environmental matrices, posing substantial risks to ecological systems and trophic dynamics. This review meticulously examines the origins, distribution, and biological impacts of MPs, with an incisive focus on elucidating the molecular and cellular mechanisms underpinning their toxicity. We highlight the indispensable role of microbial consortia and enzymatic pathways in the oxidative degradation of MPs, offering insights into enhanced biodegradation processes facilitated by innovative pretreatment methodologies.

The discriminatory capability of anthropometric measures in predicting reproductive outcomes in Chinese women with PCOS.

Objective: Obesity is a common feature in women with polycystic ovary syndrome (PCOS) and potentially significantly influences reproductive function. However, opinions are divided as to which factor is a more appropriate obesity predictor of reproductive outcomes. The aim of this study was to investigate the discriminatory capability of anthropometric measures in predicting reproductive outcomes in Chinese women with PCOS.

NEDD1 Promotes the Development of Lung Adenocarcinoma and Can be Used as a Prognostic Marker.

To explore the roles of Neural precursor cell expressed developmentally down-regulated 1(NEDD1) in lung cancer tumorigenesis and the relationship between NEDD1 expression and clinicopathology of patients with lung adenocarcinoma (LUAD). : Expression of NEDD1 or other proteins in tissues and cell lines were determined with immunohistochemistry or western blot, the data of patients with LUAD in The Cancer Genome Atlas (TCGA) datasets and LUAD tissue array were collected and analyzed, the effects of NEDD1 on proliferation, migration, cell cycle progression and apoptosis of cancer cells were detected with colony formation assay, transwell assay and Flow cytometry (FCM) analysis respectively. the impact of NEDD1 knockdown on DNA damage was analyzed using Immunofluorescence staining of H2AX and comet assay.

Accumulation and depuration of tire wear particles in zebrafish (Danio rerio) and toxic effects on gill, liver, and gut.

The toxic effects of tire wear particles (TWPs) in the environment are a growing concern for a variety of aquatic organisms. However, studies about TWPs toxicity on aquatic organisms are limited. This study investigated the accumulation and depuration of TWPs in zebrafish at three different concentrations (5 mg/L, 10 mg/L, and 20 mg/L), as well as the toxic effects on the gill, liver, and gut.

Mechanism and treatment of intracerebral hemorrhage focus on mitochondrial permeability transition pore.

Intracerebral hemorrhage (ICH) is the second most common subtype of stroke, characterized by high mortality and a poor prognosis. Despite various treatment methods, there has been limited improvement in the prognosis of ICH over the past decades. Therefore, it is imperative to identify a feasible treatment strategy for ICH.