Gas-Sensing Mechanisms and Detection Optimization of ZnO/TiO-MoTe Composites for CFSOF Decomposition Products.

This study focuses on the detection requirements for breakdown products (HF, SO, SOF, and CF) produced by the partial discharge of the innovative, environmentally friendly insulating gas CFSOF in high-voltage electrical apparatus. A doping modification technique utilizing a metal oxide (ZnO/TiO) based on two-dimensional MoTe is proposed. The method for enhancing gas sensing is being systematically investigated through multiscale theoretical computations.

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.

Obesity is a major and increasingly prevalent chronic metabolic disease with numerous comorbidities. While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional medicines with distinct modes of action as independent or complementary therapeutics. Among the most promising candidates, supported by phase 1 and 2 clinical trials, is cagrilintide, a long-acting amylin and calcitonin receptor agonist.

Characteristics of coal crack development and gas desorption in the stress affected zone of rock pillar.

Coal (Rock) pillar retaining in the mining of protective layer would cause gas dynamic disaster in the protected layer. Based on the gas geological conditions of the two-layer coal seam in Jinhe Coal Mine of Yaojie Mining District, the stress evolution law of coal seam in the rock pillar affected area was studied by theoretical analysis and numerical simulation, and the crack development law of coal seam in different loading stages under conventional triaxial loading was studied by CT scanning technology. With the analysis of the stress evolution and crack development of coal in rock pillar affected area, the gas extraction effect under different stress states and the gas desorption law after pressure relief antireflection were studied on site.

Color Generation and Polarization-Sensitive Encryption by Laser Writing on Plasmonic Reflector Arrays.

Plasmonic color printing presents a sustainable solution for vibrant and durable color reproduction by leveraging the light-manipulating properties of nanostructures. However, the fabrication of plasmonic nanostructures has posed challenges, hindering widespread adoption. In this paper, we introduce plasmonic reflector arrays (PRAs) composed of three layers─Ag nanoparticles (NPs), an AlO spacer, and an Ag reflector─deposited via physical vapor deposition (PVD).

Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.

Inhibition of calcitonin gene-related peptide (CGRP) or its cognate CGRP receptor (CGRPR) has arisen as a major breakthrough in the treatment of migraine. However, a second CGRP-responsive receptor exists, the amylin (Amy) 1 receptor (AMYR), yet its involvement in the pathology of migraine is poorly understood. AMYR and CGRPR are heterodimers consisting of receptor activity-modifying protein 1 (RAMP1) with the calcitonin receptor (CTR) and the calcitonin receptor-like receptor (CLR), respectively.

Highly Sensitive Gas Sensor for Detection of Air Decomposition Pollutant (CO, NO): Popular Metal Oxide (ZnO, TiO)-Doped MoS Surface.

When partial discharges occur in air-insulated equipment, the air decomposes to produce a variety of contamination products, resulting in a reduction in the insulation performance of the insulated equipment. By monitoring the concentration of typical decomposition products (CO, NO, and NO) within the insulated equipment, potential insulation faults can be diagnosed. MoS has shown promising applications as a gas-sensitive semiconductor material, and doping metal oxides can improve the gas-sensitive properties of the material.

Structural insight into selectivity of amylin and calcitonin receptor agonists.

Amylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor activity-modifying proteins, are promising obesity targets. A hallmark of AMYR activation by Amy is the formation of a 'bypass' secondary structural motif (residues S19-P25). This study explored potential tuning of peptide selectivity through modification to residues 19-22, resulting in a selective AMYR agonist, San385, as well as nonselective dual amylin and calcitonin receptor agonists (DACRAs), with San45 being an exemplar.

Grazing practices affect soil microbial networks but not diversity and composition in alpine meadows of northeastern Qinghai-Tibetan plateau.

Livestock grazing is the primary practice in alpine meadows and can alter soil microbiomes, which is critical for ecosystem functions and services. Seasonal grazing (SG) and continuous grazing (CG) are two kinds of different grazing practices that dominate alpine meadows on the Qinghai-Tibetan Plateau (QTP), and how they affect soil microbial communities remains in-depth exploration. The present study was conducted to investigate the effects of different grazing practices (i.

Quantifying changes in soil organic carbon density from 1982 to 2020 in Chinese grasslands using a random forest model.

China has the second-largest grassland area in the world. Soil organic carbon storage (SOCS) in grasslands plays a critical role in maintaining carbon balance and mitigating climate change, both nationally and globally. Soil organic carbon density (SOCD) is an important indicator of SOCS.

A small fishing vessel recognition method using transfer learning based on laser sensors.

The management of small vessels has always been key to maritime administration. This paper presents a novel method for recognizing small fishing vessels based on laser sensors. Using four types of small fishing vessels as targets, a recognition method for small fishing vessels based on Markov transition field (MTF) time-series images and VGG-16 transfer learning is proposed.

Wavefront shaping with nonlinear four-wave mixing.

Wavefront manipulations have enabled wide applications across many interdisciplinary fields ranging from optics and microwaves to acoustics. However, the realizations of such functional surfaces heavily rely on micro/nanofabrication to define the structured surfaces, which are fixed and only work within a limited spectrum. To address these issues, previous attempts combining tunable materials like liquid crystal or phase-change ones onto the metasurfaces have permitted extra tunability and working spectra, however, these additional layers bring in inevitable loss and complicate the fabrication.

New Insights into the Structure and Function of Class B1 GPCRs.

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors. Class B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large extracellular domains (ECDs) and respond to long polypeptide hormones. Class B1 GPCRs are critical regulators of homeostasis, and, as such, many are important drug targets.

Response of leaf stoichiometry of to elevation in China's Qilian Mountains.

Plants adapt to changes in elevation by regulating their leaf ecological stoichiometry. L. that grows rapidly under poor or even bare soil conditions has become an important ground cover plant for ecological restoration.

Formation of Cr-based layered double hydroxide: effect of the amendments.

Chromium is one of the eight most popular inorganic soil pollutants in China, and its bioavailability is determined by the chemical states. Amendments, which are able to change the chemical forms of chromium and decrease its bioavailability, have received considerable attention in recent years. In this work, the formation of Cr-based layered double hydroxides (LDHs) and the immobilization of Cr in solution and soil were systemically investigated.

The effects of grazer exclosure duration on soil microbial communities on the Qinghai-Tibetan Plateau.

While determining the response of soil microbes to grazer exclosure duration is critical to understanding ecosystem restoration processes, few studies have focused on this issue. With seasonal grazing as a control, microbes of alpine grassland soils under 5, 13, 22, and 39 years of grazer exclosure situated in the eastern part of the Qinghai-Tibetan Plateau, were examined. Microbial diversity was determined through Illumina high-throughput sequencing of the 16S rRNA gene and an internal transcription spacer (ITS).

Analyzing the Effect of Badminton on Physical Health and Emotion Recognition on the account of Smart Sensors.

Emotional ability is an important symbol of human intelligence. Human's understanding of emotions, from subjective consciousness to continuous or discrete emotional dimensions, and then to physiological separability, has shown a trend of gradually diverging from psychological research to the field of intelligent human-computer interaction. This article is aimed at studying the effects of smart sensor-based emotion recognition technology and badminton on physical health.

A structural basis for amylin receptor phenotype.

Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of three receptor activity-modifying proteins (RAMPs), AMYR, AMYR, and AMYR. Selective AMYR agonists and dual AMYR/CTR agonists are being developed as obesity treatments; however, the molecular basis for peptide binding and selectivity is unknown. We determined the structure and dynamics of active AMYRs with amylin, AMYR with salmon CT (sCT), AMYR with sCT or human CT (hCT), and CTR with amylin, sCT, or hCT.

Predictive value of neutrophil to lymphocyte ratio on acute kidney injury after on-pump coronary artery bypass: a retrospective, single-center study.

Objective: To investigate the predictive value of preoperative neutrophil to lymphocyte ratio (NLR) on acute kidney injury (AKI) after on-pump coronary artery bypass (ONCAB).

Methods: Patients who underwent elective ONCAB for coronary heart disease were included. NLR was calculated according to the results of preoperative routine blood test, patients were divided into non-AKI and AKI groups, and the differences in clinical baseline data between the two groups were compared.

Broadband achromatic metalens for linearly polarized light from 450 to 800 nm.

Metalens is a planar optical component that uses nanostructures with a thickness on the order of the wavelength to manipulate the wavefront of the incident light. A key problem, especially in color imaging and display applications, is the correction of chromatic aberration, which is an inherent effect caused by the dispersion of periodic lattices and resonance modes. However, the current achromatic metalenses either use the PB phase method that is only valid for circularly polarized light or nanostructures with complex cross sections that are difficult to manufacture.

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.

G protein-coupled receptors (GPCRs) are key regulators of information transmission between cells and organs. Despite this, we have only a limited understanding of the behavior of GPCRs in the apo state and the conformational changes upon agonist binding that lead to G protein recruitment and activation. We expressed and purified unmodified apo and peptide-bound calcitonin gene-related peptide (CGRP) receptors from insect cells to determine their cryo-electron microscopy (cryo-EM) structures, and we complemented these with analysis of protein conformational dynamics using hydrogen-deuterium exchange mass spectrometry and three-dimensional variance analysis of the cryo-EM data.

Characterization of chemical components in the Guanxinning injection by liquid chromatography-mass spectrometry.

Guanxinning injection (GXNI) is widely used in the treatments of cerebral thrombosis, cerebral hemorrhage, sequela, coronary disease, stenocardia, arrhythmia, and so on. For the herbal injections, more components should be characterized and quantified as much as possible to guarantee the drug safety. However, large numbers of the chemical constituents in the GXNI still remain unknown.

Seasonal Dynamics of Leaf Stoichiometry of : A Case Study From Yangguan Wetland, Dunhuang, China.

Leaf stoichiometry can enhance our understanding of leaf elements' (C, N and P) concentrations and their corresponding ratios in an ecosystem with seasonal environment changes. This study quantified the seasonal dynamics of leaf stoichiometry of from Yangguan wetland, Dunhuang, China as a case study example. The leaf C concentration (LC) of changed between seasons and was 392.

Rumor detection based on propagation graph neural network with attention mechanism.

Rumors on social media have always been an important issue that seriously endangers social security. Researches on timely and effective detection of rumors have aroused lots of interest in both academia and industry. At present, most existing methods identify rumors based solely on the linguistic information without considering the temporal dynamics and propagation patterns.

Driving Factors and Future Prediction of Land Use and Cover Change Based on Satellite Remote Sensing Data by the LCM Model: A Case Study from Gansu Province, China.

Land use and cover change (LUCC) is an important issue affecting the global environment, climate change, and sustainable development. Detecting and predicting LUCC, a dynamic process, and its driving factors will help in formulating effective land use and planning policy suitable for local conditions, thus supporting local socioeconomic development and global environmental protection. In this study, taking Gansu Province as a case study example, we explored the LUCC pattern and its driving mechanism from 1980 to 2018, and predicted land use and cover in 2030 using the integrated LCM (Logistic-Cellular Automata-Markov chain) model and data from satellite remote sensing.

Immunoassay-type biosensor based on magnetic nanoparticle capture and the fluorescence signal formed by horseradish peroxidase catalysis for tumor-related exosome determination.

A sandwich-type fluorescent biosensor for the determination of tumor-related exosome was designed. It is based on magnetic nanoparticle (MNP) capture and horseradish peroxidase (HRP) catalysis. MNPs were used as the substrate to capture exosomes by modifying the CD63 antibody on MNPs surface.