Label-Free Dynamic Single-Molecule Sensing of Alpha-2-Macroglobulin in Complex Matrices.

Alpha-2-macroglobulin (A2M) is a critical biomarker implicated in inflammation, immune regulation, coagulation, and various pathological conditions such as liver fibrosis, neurodegenerative diseases, and cancers. However, its precise quantification remains challenging due to complex conformational dynamics, subtle abundance fluctuations, and interference from plasma proteins. Here, we present a label-free dynamic single-molecule sensing (LFDSMS) strategy for the sensitive and specific detection of A2M.

On Refining Exciton Dissociation and Charge Transport of Nonfullerene Organic Photovoltaics: from Star-Shaped Acceptors to Molecular Doping.

Nonfullerene acceptor-based organic solar cells have recently taken a milestone leap with power conversion efficiencies approaching 20%. A key to further boost the efficiencies up to the Shockley-Queisser limit rests upon attaining a delicate balance between exciton dissociation and charge transport. This perspective presents two seminal and reciprocal strategies developed by our group and others to reconcile the intricacy of charge carrier dynamics, spanning from intrinsic molecular structure design to extrinsic dopant exploitation.

Cumulative burden of estimated glomerular filtration rate and the risk of intracranial atherosclerosis: a prospective cohort study.

Background: Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke. The longitudinal associations of estimated glomerular filtration rate (eGFR) with ICAS are unclear. This study aimed to investigate the association of cumulative eGFR burden with incident ICAS.

Tissue-specific distribution of microplastics in human blood and carotid plaques: A paired sample analysis.

Backgrounds: Microplastics (MPs) have been increasingly detected in human tissues, raising concerns about their role in cardiovascular disease. However, their distribution in matched blood and vascular tissues, such as atherosclerotic plaques, remains poorly understood.

Methods: Paired blood and carotid plaque samples were analyzed for 12 polymer types of MPs using pyrolysis-gas chromatography-mass spectrometry among twenty patients undergoing carotid endarterectomy.

Trends and disparities in health status and health care in the United States during COVID-19 pandemic.

Background: Concerns exist over a possible worsening of disparities in health status and health care access across racial/ethnic and income groups during the COVID-19 pandemic. We aimed to characterize trends in racial/ethnic and income differences in self-reported measures of health status and health care access among US adults.

Methods: This serial cross-sectional nationally representative study included adults (age ≥ 18 years) participating in the National Health Interview Survey (NHIS) from 2019 to 2022.

The Effect of Frailty on Prognosis of Patients Undergoing Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis.

Background: This study aimed to systematically review the impact of frailty on outcomes following abdominal aortic aneurysm (AAA) surgery.

Methods: MEDLINE, Embase, and Scopus were searched for studies of frailty on AAA surgery. A modified Newcastle-Ottawa scale was used to assess the quality of the included studies.

The Cumulative Atherogenic Index of Plasma Exposure in Carotid Plaque: A Cohort Study in China.

Background: Atherogenic index of plasma (AIP) is recognized as a marker for atherosclerosis, but the impact of long-term AIP exposure on carotid plaque remains unknown.

Objectives: The objective of the study is to assess the associations of cumulative AIP (cumAIP), incorporating the time course of cumAIP accumulation with the risk of carotid plaque.

Methods: A total of 9,202 participants from the Beijing Health Management Cohort were followed up until December 31, 2021.

Plasma Metabolome, Long-term Body Weight Change, and Type 2 Diabetes in U.S. Individuals.

Objective: Body weight influences the blood metabolome, but whether specific plasma metabolomic profiles predict long-term weight change remains unclear. We aimed to investigate associations among plasma metabolites, current weight, weight change trajectories, and incident type 2 diabetes (T2D) in adults.

Research Design And Methods: We profiled 260 plasma metabolites in 7,499 U.

Life Course Adversity, Premature Mortality, and Life Expectancy: Role of Life's Essential 8.

Aims: Life course adversity has been linked to various health outcomes, but the interrelationship between adversity, Life's Essential 8 (LE8), and premature mortality remains unclear. We aimed to examine the associations of childhood and adulthood adversity with premature mortality and life expectancy, and whether LE8 modifies these associations.

Methods: This study included 148,137 participants from the UK Biobank, with LE8 data available for 94,289 individuals.

A Sensitive Ratiometric Thermometer Constructed by AIEgen-Based Mixed Lanthanide MOF for Intracellular Temperature Mapping.

Accurate temperature sensing at the subcellular level is of great significance for gaining insights into a wide range of biological processes. Aggregation-induced emission (AIE) is a promising photophysical phenomenon in which the luminescence intensity is highly related to the degree of restriction of intramolecular motions. By combining AIE luminogen (AIEgen) ligands with mixed lanthanide ions, an AIEgen-based mixed lanthanide MOF (LnMOF) can be synthesized.

Bionic helical sensor array inspired by mammal olfactory recess.

The performance of sensor arrays in electronic noses (E-noses) is influenced by their spatial distribution. Inspired by the mammalian olfactory recess, this paper presents a flexible sensor array with a bionic helical structure. By integrating Metal-Organic Framework (MOF) materials and thermal modulation, the array's sensor units exhibit differentiated odor selectivity.

Association of Weekend Warrior and Other Physical Activity Patterns With Mortality Among Adults With Diabetes : A Cohort Study.

Background: "Weekend warrior" and regularly active physical activity patterns have been associated with reduced mortality risk in the general population. The association in patients with diabetes is unknown.

Objective: To examine the associations of different physical activity patterns, particularly weekend warrior and regularly active behavior, with all-cause, cardiovascular, and cancer mortality among adults with diabetes.

Crystal Facet-Dependent Photocatalytic Hydrogen Evolution From Ultra-Stable Cu-Zr/Hf Heterobimetallic Metal-Organic Frameworks.

Solar-driven water splitting for hydrogen production over metal-organic frameworks (MOFs) is particularly attractive yet remains a challenge. Here, we report a series of ultra-stable heterobimetallic MOFs (M-BCA-M', M = Cu, M' = Zr or Hf) for photocatalytic hydrogen production, in which, the Cu(I) species act as the active center, whereas Zr(IV)/Hf(IV) plays an essential role in stabilizing the framework. Uniform MOF crystals with distinct morphologies were obtained, showing a rare crystal facet-dependent photocatalytic behavior.

Discordance of Small Dense LDL Cholesterol Beyond LDL Cholesterol or Non-HDL Cholesterol and Carotid Plaque.

Background: Different low-density lipoprotein (LDL) particles exhibit distinct proatherogenic properties.

Objectives: This study sought to evaluate associations of small dense low-density lipoprotein cholesterol (sdLDL-C), large buoyant low-density lipoprotein cholesterol (lbLDL-C), sdLDL-C/LDL-C ratio, and sdLDL-C/lbLDL-C ratio with carotid plaque (CP) risk in the general population, and to perform discordance analyses to determine which biomarker better reflects CP risk beyond low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C).

Methods: This study enrolled 20,369 participants from Beijing Health Management Cohort.

Global Prevalence of Deep Vein Thrombosis in Patients with Spinal Cord Injury: A Systematic Review and Meta-Analysis.

A meta-analysis of deep vein thrombosis (DVT) in patients with spinal cord injury (SCI) was performed using five databases (PubMed, Embase, the Cochrane Library, Web of Science, and Scopus) from 2000 to March 2023. Observational descriptive studies investigating the prevalence of DVT among patients with SCI were included. Data were retrieved by author, country, continent, gender, age, sample source, and additional variables.

CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration.

Background: Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease mainly affecting the colon. The exact etiology of UC remains elusive. CD131 is a receptor subunit mediating the effects of hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and Interleukin-3 (IL-3), which regulate various inflammatory responses.

Application of metabolomics to acquired hearing loss: Advances and systematic review.

Hearing loss poses a significant global public health challenge, seriously jeopardizing both physical and mental health. As an emerging omics technique, metabolomics reflects the metabolic state influenced by both genetic and environmental factors and has been increasingly applied to hearing loss research. This review summarizes the latest advances in metabolomics applied to several types of acquired hearing loss, including age-related hearing loss, noise-induced hearing loss, and sudden sensorineural hearing loss.

Biological Age Acceleration Associated with the Progression Trajectory of Cardio-Renal-Metabolic Multimorbidity: A Prospective Cohort Study.

Objectives: Previous studies have confirmed that biological age (BA) acceleration is associated with single cardio-renal-metabolic diseases (CRMDs), typically including type 2 diabetes mellitus, cardiovascular disease, and chronic kidney disease. However, its association with progression to cardio-renal-metabolic multimorbidity (CRMM, coexistence of ≥2 CRMDs) and subsequent mortality remains unexplored.

Methods: Using the multi-state model, we analyzed 278,927 UK Biobank participants free of CRMDs at baseline to investigate the association between BA acceleration-measured by phenotypic age (PhenoAge) and Klemera-Doubal method age (KDMAge)-and CRMM progression trajectory, from health to the first CRMD and then to CRMM and death.

Shizhifang alleviates hyperuricemia -induced renal injury by inhibiting Drp1 and maintaining mitochondrial homeostasis in renal tubular epithelial cells.

Ethnopharmacological Relevance: Shizhifang (SZF), a traditional Chinese herbal formula used at Shanghai Shuguang Hospital for over 20 years, has shown clinical efficacy in lowering serum uric acid (SUA) and protecting renal function.

Aim Of The Study: To explore the mechanism by which SZF protects against hyperuricemia (HUA)-induced renal tubular epithelial cell injury, focusing on mitochondrial dysfunction mediated by Drp1.

Materials And Methods: RNA-seq was performed on HK2 cells to identify affected pathways.

The Associations of Joint Exposure to Various Living Environmental Factors With the Risk of Frailty and All-cause Mortality: A Nationally Representative Cohort Study.

Background: The relationships of joint exposure to various outdoor and indoor environmental factors with the risk of frailty and mortality remain unclear.

Methods: Based on the China Health and Retirement Longitudinal Study, we enrolled 13 745 participants in the final analysis. The living environmental score incorporated 7 factors: ambient fine particulate matter, residential greenness, household fuel use, indoor temperature, water sources, building types, and household cleanliness (ranged from 0 to 8).

Exploration of risk factors affecting hearing loss in patients with granulomatosis with polyangiitis: A single-center retrospective study.

Introduction: Granulomatosis with polyangiitis (GPA) commonly affects the ears, leading to irreversible hearing loss and impacting patients' quality of life. This study aims to explore and summarize the risk factors associated with hearing loss in GPA patients, providing value for early diagnosis and improved prognosis.

Materials And Methods: We collected information from patients during their hospitalization at this center from 2013 to 2023, including 19 patients with normal hearing and 89 patients with hearing impairment which is divided into four groups furtherly.

Association of Differences in Cystatin C- and Creatinine-Based Estimated Glomerular Filtration Rate With Prevalence and Incidence of Stroke.

Background: The intraindividual difference between the estimated glomerular filtration rates by cystatin C and creatinine (ie, eGFRdiff) is of clinical importance. This study aimed to investigate the cross-sectional and longitudinal associations of eGFRdiff with stroke using nationally representative data from the CHARLS (China Health and Retirement Longitudinal Study).

Methods: This study included 11 869 participants (aged ≥45 years) from the CHARLS 2015 for the cross-sectional analysis.

Childhood Exposure to Multiple Types of Violence and Adult Cardiovascular Disease.

Aims: To explore the associations between childhood experience of violence from parents, siblings, and peers and the subsequent risk of cardiovascular disease (CVD) and to examine whether adult depressive symptoms modify these associations.

Methods And Results: This population-based cohort study used data from the China Health and Retirement Longitudinal Study (CHARLS). Childhood exposures to violence from parents, siblings, and peers were assessed through a life history questionnaire.

Trajectory of cognitive decline before and after incident arrhythmias in older adults: A 16-year population-based longitudinal cohort study.

Introduction: The temporal pattern of cognitive decline before and after incident arrhythmias remains largely unknown.

Methods: This population-based cohort study included 6,494 participants (mean age: 62.9 ± 9.