Application of metabolomics to acquired hearing loss: Advances and systematic review.

Hearing loss poses a significant global public health challenge, seriously jeopardizing both physical and mental health. As an emerging omics technique, metabolomics reflects the metabolic state influenced by both genetic and environmental factors and has been increasingly applied to hearing loss research. This review summarizes the latest advances in metabolomics applied to several types of acquired hearing loss, including age-related hearing loss, noise-induced hearing loss, and sudden sensorineural hearing loss.

Exploration of risk factors affecting hearing loss in patients with granulomatosis with polyangiitis: A single-center retrospective study.

Introduction: Granulomatosis with polyangiitis (GPA) commonly affects the ears, leading to irreversible hearing loss and impacting patients' quality of life. This study aims to explore and summarize the risk factors associated with hearing loss in GPA patients, providing value for early diagnosis and improved prognosis.

Materials And Methods: We collected information from patients during their hospitalization at this center from 2013 to 2023, including 19 patients with normal hearing and 89 patients with hearing impairment which is divided into four groups furtherly.

Impact of Cancer Type and Anatomical Radiation Exposure on the Incidence of Radiotherapy-Induced Otitis Media with Effusion in Head and Neck Cancer Patients.

Objective: This study aimed to investigate the influence of cancer type on radiotherapy-induced otitis media with effusion (RTOME) occurrence and to assess the impact of anatomical region-specific radiation exposure on both RTOME incidence rates and associated pathogenic processes.

Methods: A retrospective analysis was conducted on 1046 head and neck cancer (HNC) patients who underwent radiotherapy at Peking Union Medical College Hospital between 2016 and 2023. The incidence of RTOME was assessed across various cancer types, and the radiation exposure probabilities of different head and neck regions were compared between patients with and without RTOME using the chi-squared test (χ) test and the Mann-Whitney test.

Identification of miRNA expression profile in middle ear cholesteatoma using small RNA-sequencing.

Background: The present study aims to identify the differential miRNA expression profile in middle ear cholesteatoma and explore their potential roles in its pathogenesis.

Methods: Cholesteatoma and matched normal retroauricular skin tissue samples were collected from patients diagnosed with acquired middle ear cholesteatoma. The miRNA expression profiling was performed using small RNA sequencing, which further validated by quantitative real-time PCR (qRT-PCR).

Construction of a novel disulfidptosis-related lncRNAs signature for prognosis prediction and anti-tumor immunity in laryngeal squamous cell carcinoma.

Disulfidptosis, an innovative type of controlled cellular death linked to metabolic dysfunction, has garnered attention. However, there is limited knowledge regarding the involvement of disulfidptosisrelated lnRNAs (DRlncRNAs) in laryngeal squamous cell carcinoma (LSCC). The objective of our team in this study seeks to establish a DRlncRNAs signature, investigate their prognostic value in LSCC, and explore their associations with immune cell subpopulations, biological signaling pathways, and exploring implications for drug sensitivity.

Association between the atherogenic index of plasma and hearing loss based on a nationwide cross-sectional study.

Background: Hearing loss (HL) is a worldwide public health issue for which the role of dyslipidemia has not been fully elucidated. This study aimed to use the atherogenic index of plasma (AIP), a well-established serum lipid marker, to investigate the association of dyslipidemia with HL among the general population.

Methods: Participants (n = 3267) from the National Health and Nutrition Examination Survey database (2005-2012, 2015-2018) were included in the present study.

Prognostic Factors Affecting Hearing in Otitis Media With ANCA-Associated Vasculitis Patients: A Systematic Review and Meta-Analysis.

To conduct a systematic review and meta-analysis of clinical studies describing the possible prognostic factors affecting hearing outcomes in Otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) patients. To provide guidance for clinical work, avoiding profound irreversible hearing loss affecting patients' lives. A literature search was performed in PubMed, MEDLINE, EMBASE, Cochrane, Scopus, and Web of Science to identify English articles published before December 1, 2022.

Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway.

Facial nerve (FN) injury seriously affects human social viability and causes a heavy economic and social burden. Although mesenchymal stem cell-derived exosomes (MSC-Exos) promise therapeutic benefits for injury repair, there has been no evaluation of the impact of MSC-Exos administration on FN repair. Herein, we explore the function of MSC-Exos in the immunomodulation of macrophages and their effects in repairing FN injury.

Effects of rosmarinic acid on the inflammatory response in allergic rhinitis rat models after PM2.5 exposure.

Background: Studies have shown the promising prospects of rosmarinic acid (RosA) for the prevention and treatment of allergic diseases.

Objective: The aim of this study was to investigate the effects of RosA on inflammatory reaction in rat models of allergic rhinitis (AR) after PM2.5 exposure.

miR-338-3p inhibits autophagy in a rat model of allergic rhinitis after PM2.5 exposure through AKT/mTOR signaling by targeting UBE2Q1.

Exposure to fine particulate matter (PM2.5) increases the incidence of allergic rhinitis (AR). microRNA (miRNA) can regulate cell proliferation, invasion and apoptosis.

Ozone inhalation induces exacerbation of eosinophilic airway inflammation and Th2-skew immune response in a rat model of AR.

Background: Ozone (O) exposure elicits allergic rhinitis (AR) exacerbations by mechanisms that remain poorly understood. We used a rat model to investigate the effects of O on eosinophilic airway inflammation and Th2-related response.

Methods: Sprague-Dawley (SD) rats were sensitized and challenged with ovalbumin (OVA) to make AR models.

Effects of N-acetylcysteine on oxidative stress and inflammation reactions in a rat model of allergic rhinitis after PM exposure.

Particulate matter 2.5 (PM) exposure can increase the prevalence of allergic rhinitis (AR), the mechanism underlying which may include oxidative stress and inflammatory response. As a ROS quenching agent, N-acetylcysteine (NAC) can attenuate the accumulation of inflammatory cells and hyper-responsiveness in animal asthma models.

Ursolic Acid Alleviates Mucus Secretion and Tissue Remodeling in Rat Model of Allergic Rhinitis After PM2.5 Exposure.

Background: According to recent epidemiologic studies, exposure to fine particulate matter (particulate matter 2.5 ≤ µm [PM2.5]) in the air increases the incidence and severity of allergic rhinitis (AR).

Effects of Ursolic Acid on the Expression of Th1-Th2-related Cytokines in a Rat Model of Allergic Rhinitis After PM2.5 Exposure.

Background: Allergic rhinitis (AR) is a global health problem and closely related to environmental factors. Ursolic acid (UA) has potential in the treatment of allergic inflammation. The effects of UA intervention on PM2.

Effects of PM2.5 on mucus secretion and tissue remodeling in a rabbit model of chronic rhinosinusitis.

Background: According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS).