Data-Driven Model-Free Adaptive Dynamic Programming Resilient Control for Nonlinear Networked Control Systems Under DoS Attacks.

Enhancing system security under denial-of-service (DoS) attacks requires robust compensation mechanisms. However, existing model-free adaptive control-based compensation solutions are limited to constant reference signals and neglect control optimization, causing insufficient tracking performance in dynamic attacks. This study develops a data-driven adaptive dynamic programming (ADP) resilient control scheme for NCS under aperiodic DoS attacks.

Genotype-by-environment interaction influencing sensory attributes and biochemical components of peanuts from China.

Background: Peanuts are a vital global crop and healthy food, valued for their nutritional and physiological benefits. Their sensory attributes and biochemical composition, which determine taste and nutritional quality, are influenced by multiple factors. Thirteen peanut genotypes were cultivated across three locations using a randomized block design.

Changes in auditory cortex subregions and their prediction for sound therapy outcomes in patients with tinnitus.

Objective: To examine structural and functional changes in auditory cortex(AC) subregions of patients with tinnitus and identify potential predictive indicators for sound therapy.

Methods: 63 patients with tinnitus (29 in effective group[EG] and 34 in ineffective group[IG]) and 38 healthy controls(HCs) were included. High-resolution 3D T1-weighted images, diffusion tensor imaging, and resting-state functional magnetic resonance imaging were obtained before sound therapy.

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.

Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our research demonstrates that sepsis could induce the migration of IL-7R CD8 γδ T17 cells from the small intestine to the meninges, where they secrete IL-17A, impairing mitochondrial function in microglia and activating the cGAS-STING-C1q pathway in male mice.

Analysis of healing status and influencing factors of iatrogenic atrial septal defect in patients with atrial fibrillation after cryoballoon ablation.

Background: Iatrogenic atrial septal defect (IASD) may occur after cryoballoon ablation (CBA) for atrial fibrillation (AF) patients. This study aimed to investigate the incidence and healing status of IASD after CBA, and to analyze the risk factors and clinical significance associated with the occurrence of IASD.

Methods And Results: Patients with non-valvular AF who underwent CBA in Fujian Provincial Hospital from 2021 to 2023 were continuously enrolled.

Wheat Yield, N Use Efficiency, Soil Properties, and Soil Bacterial Community as Affected by Long-Term Straw Incorporation and Manure Under Wheat-Summer Maize Cropping System in Southern Shanxi Province, China.

Straw incorporation and manure are recognized as a sustainable farming practice to enhance soil fertility and improve crop yields. However, the effects of straw incorporation in combination with manure on productivity, soil nutrient status, N use efficiency (NUE), and the bacterial community are not well understood in wheat-summer maize rotation systems in the southern Shanxi Province. The five treatments were (1) CK, no fertilization; (2) NP, inorganic N and P fertilizers; (3) NPM, mineral N and P fertilizers plus chicken manure; (4) SNP, mineral N and P fertilizers plus maize straw; and (5) SNPM, mineral N and P fertilizers plus maize straw and chicken manure.

A machine learning-based prediction model for sepsis-associated delirium in intensive care unit patients with sepsis-associated acute kidney injury.

Sepsis-associated acute kidney injury (SA-AKI) patients in the ICU often suffer from sepsis-associated delirium (SAD), which is linked to unfavorable outcomes. This research aimed to develop a machine learning-based model for early SAD prediction in SA-AKI patients. Data was sourced from the Medical Information Mart for Intensive Care IV (MIMIC-IV) and eICU Collaborative Research Database (eICU-CRD).

Whole-genome identification of family genes in and expression analysis under high-temperature stress.

The heat shock factors () play important roles in activating heat stress responses in plants. () is a nutrient-rich fruit tree that can resist various abiotic and biotic stressors. However, the in have not yet been characterized and their roles remain unclear.

High-Purity Single-Photon Emission in Near-Infrared InAs Colloidal Quantum Dots with Strong Exciton Confinement.

Colloidal quantum dots (QDs) are promising solid-state single-photon emitters for quantum information processing due to their facile integration with nanophotonic components and cost-effective production. However, research on near-infrared QDs-based single-photon emitters for telecommunications remains limited. Here, we present bright near-infrared InAs/InP/ZnSe/ZnS QDs that achieve high-purity single-photon emission through strong exciton confinement within the core.

A prescribed-time functional observer for systems with unknown input.

This paper different from traditional approaches, proposes a novel method where the target vector z is treated as the state variable of an observer LTI system by system reformulations, which greatly facilitates the use of the classical Luenberger state observer to address the prescribed-time functional observer (PTFO) design issue. Subsequently, for the newly formulated LTI system with z as the state variable, a PTFO is developed for the single-output case that is capable of accurately estimating z within a user-defined time, and is subsequently extended to the multiple-output case. More importantly, it can avoid the jumps that usually occur in Engel's prescribed-time observers.

Inhibition of the Sp1/PI3K/AKT signaling pathway exacerbates doxorubicin-induced cardiomyopathy.

Objective: This study aimed to investigate the interaction and underlying mechanisms between specificity protein 1 (Sp1) and the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathway in the context of doxorubicin-induced cardiomyopathy (DIC).

Methods: A rat model of DIC was established by intraperitoneal injection of doxorubicin (1 mg/kg) twice a week for eight weeks. Cardiac function was evaluated using echocardiography, and myocardial histopathology was assessed by hematoxylin-eosin (HE) staining.

Integrated Transcriptomics and Metabolomics Reveal Key Genes and Metabolic Pathway in Flower and Fruit Color Formation of (Bge.) Sok.

Anthocyanins play a pivotal role in determining the color diversity in the flowers and fruits of (Bge.) Sok. This study performed a metabolomic analysis of the flowers and fruits of two varieties differing in pigmentation phenotypes ('Jinou 1' and 'Nongda 5'), and the results indicated that the cyanidin, pelargonidin, paeonidin, and delphinidin were the main substances serving as the primary pigments contributing to their striking chromatic divergence between two varieties.

Structural and functional alteration of the gut microbiomes in ICU staff: a cross-sectional analysis.

Background: 16S rRNA sequencing has revealed structural alterations in the gut microbiomes of medical workers, particularly those working in intensive care unit (ICU). This study aims to further compare the taxonomic and functional characteristics of gut microbiomes between ICU staff and non-medical individuals using metagenomic sequencing.

Methods: A prospective cross-sectional cohort study was conducted, fecal samples from 39 individuals in each group-ICU staff and non-medical subjects were analyzed using metagenomic sequencing.

Cardiac FGF23 Increases Intracellular Calcium in Atrial Myocytes and the Susceptibility to Atrial Fibrillation Decreased in FGF23 MyHC Mice.

Exogenous fibroblast growth factor (FGF) 23 is closely associated with atrial fibrillation (AF) and is able to alter the cardiac electrophysiological activity by increasing intracellular calcium. While its arrhythmogenic mechanism remains unclear, this study aims to investigate the electrophysiological effects of cardiac FGF23 on intracellular calcium in atrial cells and its underlying mechanism. The incidence of AF was significantly decreased in FGF23MyHC mice compared to Cre mice.

Efficient and stable near-infrared InAs quantum dot light-emitting diodes.

Visible quantum dot light-emitting diodes have satisfied commercial display requirements. However, near-infrared counterparts considerably lag behind due to the inferior quality of near-infrared quantum dots and limitations in device architecture suitable for near-infrared electroluminescence. Here, we present an efficient strategy using zinc fluoride to balance ZnSe shell growth across different core quantum dot facets, producing highly regular InAs/InP/ZnSe/ZnS quantum dots with near-unity quantum yield.

Impact of underweight status on mortality in sepsis patients: a meta-analysis.

Objective: The evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate the potential associations between underweight and the mortality rate among sepsis patients.

Methods: A comprehensive electronic search was performed in PubMed, Cochrane Library, Embase, and Web of Science databases.

Efficacy and safety of esketamine for emergency endotracheal intubation in ICU patients: a double-blind, randomized controlled clinical trial.

Emergency endotracheal intubation in critically ill patients are dangerous procedures with a greater risk of severe hypotension The efficacy and safety of esketamine with sympathoexcitatory effects for rapid sequence induction in critically ill patients remain unclear. In this prospective double-blinded randomized controlled trial, adult patients were randomly assigned to receive either esketamine or midazolam/sufentanil admixture for induction. The primary outcomes were the effects of induction with esketamine or midazolam/sufentanil admixture on hemodynamic responses (heart rate (HR) and mean arterial pressure (MAP) during and after induction).

Association between visceral fat area and metabolic syndrome in individuals with normal body weight: insights from a Chinese health screening dataset.

Background: Metabolic syndrome (MetS) is increasingly diagnosed in individuals with normal body weight, and visceral fat emerges as a significant risk factor. However, the relationship between visceral fat area (VFA) and MetS within this population remains inadequately explored, and the diagnostic threshold for MetS in normal-weight individuals is yet to be established.

Methods: This study used a cross-sectional design combined with longitudinal cohort analysis.

Low-density lipoprotein cholesterol predicts coronary artery calcification events in patients with type 2 diabetes: a longitudinal study.

Background: Coronary Artery Calcification (CAC) is a major risk factor for various cardiovascular diseases. Low-Density Lipoprotein Cholesterol (LDL-C) is a significant factor in atherosclerotic cardiovascular diseases and is usually elevated in patients with Type 2 Diabetes Mellitus (T2DM). However, the association between LDL-C levels and incident CAC in asymptomatic T2DM patients remains unclear.

Development and validation of a prediction model for coronary heart disease risk in depressed patients aged 20 years and older using machine learning algorithms.

Background: Depression is being increasingly acknowledged as an important risk factor contributing to coronary heart disease (CHD). Currently, there is no predictive model specifically designed to evaluate the risk of coronary heart disease among individuals with depression. We aim to develop a machine learning (ML) model that will analyze risk factors and forecast the probability of coronary heart disease in individuals suffering from depression.

Photodynamic bactericidal nanomaterials in food packaging: From principle to application.

Compared to traditional preservatives, photodynamic inactivation (PDI) offers a promising bactericidal approach due to its nontoxic nature and low propensity for microbial resistance. In this paper, we initially investigate the principles and antibacterial mechanisms underlying PDI. We then review factors influencing PDI's germicidal efficacy in food preservation.

Different Impacts of Long-Term Tillage and Manure on Yield and N Use Efficiency, Soil Fertility, and Fungal Community in Rainfed Wheat in Loess Plateau.

Conservation tillage and fertilization are widely adopted in agricultural systems to enhance soil fertility and influence fungal communities, thereby improving agroecosystems. However, the effects of no-tillage combined with manure on grain yield, nitrogen use efficiency (NUE), soil fertility, and rhizosphere fungal communities remain poorly understood, particularly in rainfed wheat fields on the Loess Plateau. A 15-year field experiment was conducted at the Niujiawa Experimental Farm of the Cotton Research Institute, Shanxi Agricultural University.

Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K+ currents.

Obesity is associated with abnormal repolarization manifested by QT interval prolongation, and oxidative stress is an important link between obesity and arrhythmias. However, the underlying electrophysiological and molecular mechanisms remain unclear. The aim of this study is to evaluate the role of obesity in potassium current in ventricular myocytes and the potential mechanism of NADPH oxidase 2 (Nox2).

Vascular Cell Adhesion Molecule 1 in atrial fibrillation.

Objective: Assessing whether serum Vascular Cell Adhesion Molecule 1(VCAM-1) concentration in the left atrial appendage(LAA) and the expression of VCAM-1 in LAA tissues are associated with the risk of atrial fibrillation-related stroke.

Method: Blood samples were collected from atrial fibrillation(AF) patients scheduled for catheter ablation of AF, both from within the LAA and peripheral veins(PV). The serum concentration of VCAM-1 was quantitatively analyzed using ELISA.

Concurrent assessment of time-to-isolation and temperature at 30 s as an innovative metric for predicting the persistence of pulmonary vein isolation using second-generation cryoballoons.

Background: We attempted to establish correlations between intraoperative variables such as time-to-isolation (TTI) and temperature (T) at the 30-second mark, and the sustained efficacy of pulmonary vein isolation.

Methods: One hundred patients underwent repeat procedures subsequent to their index ablation. Five time intervals were delineated based on TTI metrics of 30, 35, 40, 45, and 60 s during the initial procedure.