Pharmacokinetics and Safety of Polaprezinc Granules Oral Administration in Healthy Chinese Volunteers Under Fasting and Fed Conditions.

The study aimed to demonstrate bioequivalence between generic and original polaprezinc granules by comparing pharmacokinetic (PK) profiles in healthy Chinese subjects under fasting and fed conditions. This PK investigation was conducted with two independent, randomized, open-label, single-dose, two-period, cross-over studies. Healthy Chinese fasting (N = 24, 75 mg) or fed (N = 24, 300 mg) subjects randomly received a single oral dose of the test or reference polaprezinc granules at each period.

Morphology and multigene phylogeny reveals five new species of Hydnaceae (Cantharellales, Basidiomycota) from China.

Wood-inhabiting fungi play a fundamental role in ecosystem processes, particularly in wood degradation and the recycling of organic matter. In this study, a new genus, , and five new species, viz. , , , , and , are described from China and illustrated based on morphological characteristics and molecular phylogenetic analyses.

Dietary baking soda (NaHCO) therapy recovered urolithiasis-induced kidney injury in mice by inhibition of oxidative stress, pyroptosis, and inflammation through gut-kidney axis.

Background: Urolithiasis is one of the most common urological diseases, and its incidence has increased globally in recent years. Multiple potential mechanisms are involved in urolithiasis, including renal oxidative stress, inflammatory response, fibrosis, pyroptosis, and gut microbiota disturbance. Sodium bicarbonate (NaHCO) is commonly used clinically to alkalize urine and slow the progression of chronic kidney disease, including urolithiasis.

Development and validation of a nomogram combining cytokines with traditional clinical parameters in predicting the risk of postoperative sepsis after ureteroscopic lithotripsy.

Background: Sepsis is one of the most severe complications of ureteroscopic lithotripsy (URSL) surgery and is the main cause of death in hospitalized patients. Traditional preoperative patient management and risk assessment systems need to be updated urgently to reduce the occurrence of postoperative sepsis. This study aimed to construct a novel nomogram to preoperatively predict the risk of septic complications after URSL.

A new genus and three new species of Lycoperdaceae (Agaricales) from Southern China revealed by molecular phylogeny and taxonomy.

Lycoperdaceae (Agaricales, Agaricomycetes) is a taxonomically significant fungal family based on the globally distributed and morphologically defined puffball structures. In the present study, one new genus, , and three new species, viz. , , and , collected from southern China are proposed based on a combination of morphological characteristics and molecular evidence.

SEM characterization technique for air-sensitive all-solid-state lithium battery materials.

Scanning electron microscopy (SEM) is an important tool for investigating the surface morphologies, chemical compositions, and failure mechanisms of functional materials. However, the microstructures of some materials change during the transfer to SEM, resulting in the inability to characterize them accurately because of the air-sensitive nature of the materials (e.g.

Weakly space-confined all-inorganic perovskites for light-emitting diodes.

Metal halide perovskites are promising materials for light-emitting diodes (LEDs). Spatially confining charge carriers using nanocrystal/quantum dots, low-dimensional perovskites and ultrathin perovskite layers have all been used to improve the external quantum efficiency of perovskite LEDs (PeLEDs). However, most strongly space-confined perovskites suffer from severe Auger recombination, ion migration and thermal instability, resulting in limited brightness and operational lifetime.

Diversity, divergence time, and biogeography of the genus (Agaricomycetes, Russulales).

The genus is an important group of stipitate terrestrial fungi in the order Russulales. Some species in the genus form ectomycorrhizae, mostly with trees of Pinaceae; some are well-known edible mushrooms. However, its diversity and biogeography are unclear.

Molecular phylogeny and morphology reveal four new species in Hymenochaetales and one new species in Cantharellales from Southwestern China.

Wood-decaying fungi represent a vital group of higher fungi that drive the cycling of matter and energy in forest ecosystems, and they have been the focus of thorough investigation. In this study, five new species, , , , , and from China, are described and illustrated based on the morphological characteristics and molecular phylogenetic analyses, in which the sequences of ITS+nLSU genes were used for the phylogenetic analyses by maximum likelihood and Bayesian inference methods. The phylogeny revealed that the groups with three taxa, , , , and .

Characterization of the gut microbiota in urinary calculi patients with preoperative urinary tract infection.

Background: Urinary tract infection is one of the most common comorbidities of urinary stones. Disorders of gut microbiota can affect various infectious diseases and the formation of the stones. Therefore, alterations in the gut bacteria profile may be a potential risk factor for the development of infections in patients with urinary tract stones.

Morphological characteristics and phylogenetic analyses revealed four new species (Basidiomycota) in the Yunnan-Guizhou Plateau, China.

Four new fungi, (Clavariaceae, Agaricales), (Porotheleaceae, Agaricales), , and (Xenasmataceae, Russulales), from Yunnan Province in China, are proposed, based on a combination of morphological features and molecular evidence. Phylogenetic analyses were conducted using a combined dataset of internal transcribed space and nuclear ribosomal RNA large subunit sequences. The ITS+LSU analysis showed that groups with , forms a sister group with , is clustered with , and is clustered with The morphology and multi-gene phylogenetic analyses confirmed the placement of the four new taxa.

Perillaldehyde ameliorates sepsis-associated acute kidney injury via inhibiting HSP90AA1-mediated ferroptosis and pyroptosis: Molecular structure and protein interaction of HSP90AA1.

Heat shock protein 90α (HSP90AA1) is a molecular chaperone involved in a variety of cellular processes. Special attention is paid to how perillaldehyde ameliorates kidney injury by inhibiting HSP90AA1-mediated iron and pyrotoxicity, and in-depth analysis of the molecular structure and protein interactions of HSP90AA-1. The interaction between perillaldehyde and HSP90AA1 and the effect of perillaldehyde on the molecular structure of HSP90AA1 were analyzed by molecular docking and surface plasmon resonance technique.

A New Genus Gen. Nov and Description of Sp. Nov. (Phyllotopsidaceae, Agaricales) from Northwestern China Based on Phylogeny, Morphology, and Divergence Time.

While investigating macrofungi diversity in Gansu province, northwestern China, five fresh and fleshy specimens were collected, which are characterized by nearly white to buff hemispherical pileus with waved margins, a disc depressed with coral to brownish red fibrillose scales, adnate to sub-decurrent lamellae with four relatively regular rows of lamellulae, a stipe that is central, hollow, frequently straight to curved; basidiospores that are globose to subglobose, 5.0-6.0 × (3.

Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm.

Background: Abdominal aortic aneurysm (AAA) is a macrovascular disease with high morbidity and mortality in the elderly. The limitation of the current management is that most patients can only be followed up until the AAA diameter increases to a threshold, and surgical intervention is recommended. The development of preventive and curative drugs for AAA is urgently needed.

Sustaining 500,000 Folding Cycles Through Bioinspired Stress Dispersion Design in Sodium-Ion Batteries.

Developing super-foldable electronic materials and devices presents a significant challenge, as intrinsic conductive materials are unable to achieve numerous true-folding operations (super-foldable) due to limitations from short-range forces of chemical bonds. Consequently, super-foldable batteries remain unexplored. This work focused on sodium-ion batteries as a breakthrough point to advance super-foldable devices.

Four new species of Cortinariaceae (Agaricales) from Northwestern China.

Introduction: Cortinariaceae, which belongs to the Agaricales order, is a globally recognized family, known for its high species diversity.

Methods: Eight internal transcribed spacer (ITS) and nuclear large ribosomal subunit (LSU) sequences were newly generated, and phylogenetic analyses were performed by combining ITS and LSU datasets. Four species were identified as forming four independent lineages with robust support in phylogenies based on both datasets.

Molecular and morphological data reveal two new polypores (Polyporales, Basidiomycota) with reddish brown to orange basidiomata from China.

Two taxonomically controversial polypore genera with reddish brown to orange basidiomata that stain reddish with KOH solution, and , are revised based on additional sampling, morphological examination, and phylogenetic analysis of a combined dataset of ITS1-5.8S-ITS2-nLSU sequences. is a monophyletic genus belonging to Phanerochaetaceae, whereas is a polyphyletic genus belonging to Meruliaceae.

Morphological characteristics and phylogenetic analyses revealed four new wood inhabiting fungi (Agaricomycetes, Basidiomycota) in Xizang Autonomous Region, China.

Four new fungi from Xizang in southwest China, , , , and are described and illustrated based on the morphological and molecular evidence. is characterized by the ramal and bright orange basidiomata, a monomitic hyphal system with simple septa generative hyphae, usually 4-septate basidiospores; is characterized by the cream to yellowish basidiomata with rhizomorphs, cylindrical basidiospores; is characterized by white with pink basidiomata, cylindrical to oblong ellipsoid basidiospores; is characterized by flesh pink basidiomata, branched dichotomously in 4-5 ranks, a monomitic hyphal system with clamped generative hyphae, ellipsoid to cylindrical and densely warted basidiospores.

Biomimetic Hydrogel-Mediated Mechano-Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery.

The unique physical tumor microenvironment (TME) and aberrant immune metabolic status are two obstacles that must be overcome in cancer immunotherapy to improve clinical outcomes. Here, an in situ mechano-immunometabolic therapy involving the injection of a biomimetic hydrogel is presented with sequential release of the anti-fibrotic agent pirfenidone, which softens the stiff extracellular matrix, and small interfering RNA IDO1, which disrupts kynurenine-mediated immunosuppressive metabolic pathways, together with the multi-kinase inhibitor sorafenib, which induces immunogenic cell death. This combination synergistically augmented tumor immunogenicity and induced anti-tumor immunity.

MOF-derived xPd-NPs@ZnO porous nanocomposites for ultrasensitive ppb-level gas detection with photoexcitation: Design, diverse-scenario characterization, and mechanism.

Metal-organic frameworks (MOFs) have been regarded as a potential candidate with great application prospects in the field of gas sensing. Although plenty of previous efforts have been made to improve the sensitivity of MOF-based nanocomposites, it is still a great challenge to realize ultrafast and high selectivity to typical flammable gases in a wide range. Herein, porous xPd-NPs@ZnO were prepared by optimized heat treatment, which maintained the controllable morphology and high specific surface area of 471.

Phylogenetic and Taxonomic Analyses Reveal Three New Wood-Inhabiting Fungi (Polyporales, Basidiomycota) in China.

Three new wood-inhabiting fungal species, , and are proposed based on a combination of the morphological features and molecular evidence. is characterized by the pileate basidiomata having a fawn brown to black pileal surface, a dimitic hyphal system with clamped generative hyphae, and the presence of the fusoid cystidioles and cylindrical basidiospores (9-12.5 × 3.

Identification of biomarkers and potential therapeutic targets of kidney stone disease using bioinformatics.

Purpose: Kidney stone disease (KSD) is a common urological disease, but its pathogenesis remains unclear. In this study, we screened KSD-related hub genes using bioinformatic methods and predicted the related pathways and potential drug targets.

Methods: The GSE75542 and GSE18160 datasets in the Gene Expression Omnibus (GEO) were selected to identify common differentially expressed genes (DEGs).

Amorphous Chloride Solid Electrolytes with High Li-Ion Conductivity for Stable Cycling of All-Solid-State High-Nickel Cathodes.

Solid electrolytes (SEs) are central components that enable high-performance, all-solid-state lithium batteries (ASSLBs). Amorphous SEs hold great potential for ASSLBs because their grain-boundary-free characteristics facilitate intact solid-solid contact and uniform Li-ion conduction for high-performance cathodes. However, amorphous oxide SEs with limited ionic conductivities and glassy sulfide SEs with narrow electrochemical windows cannot sustain high-nickel cathodes.

Large-Area Flexible Perovskite Light-Emitting Diodes Enabled by Inkjet Printing.

Metal halide perovskite light-emitting diodes (PeLEDs) are attracting increasing attention due to their potential applications in flat panel lighting and displays. The solution process, large-area fabrication, and flexibility are attractive properties of PeLEDs over traditional inorganic LEDs. However, it is still very challenging to deposit uniform perovskite films on flexible substrates using a blade or slot-die coating, as the flexible substrate is not perfectly flat.