Influencing factors and trends in post-vaccination serologic testing completion rates among infants born to HBsAg-positive mothers in Guangdong Province, 2021-2023.

Objective: This study aims to assess the trends and influencing factors in post-vaccination serologic testing (PVST) completion rates among infants born to hepatitis B surface antigen (HBsAg)-positive mothers using real-world data, providing insights to guide future PVST strategy implementation.

Methods: Data were obtained from the case records of HBsAg-positive pregnant women and their newborns in Guangdong Province from January 1, 2021, to December 31, 2023. The Cochran-Armitage test was used to analyze trends in PVST completion rates and the age distribution of infants completing PVST, among HBV-exposed neonates, stratified by birth weight, from 2021 to 2023.

Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs.

Objective: The aim of this study is to assess the therapeutic effects of Wendan decoction on endolymphatic hydrops (EH), a condition characterized by excessive inner ear fluid accumulation that is associated with Meniere's disease, in guinea pigs, offering insights for clinical application.

Methods: The active components and action targets of compound Wendan decoction were identified using BATMAN-TCM in this study. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted on Metascape and bioinformatics.

Epidemiology of hand, foot, and mouth disease outbreaks before and during availability of EV-A71 vaccine in China's mainland: analysis of outbreak surveillance data from 2011 to 2023.

Background: Hand, foot, and mouth disease is a common contagious illness of childhood that causes a heavy disease burden in China's mainland. There are three enterovirus A71 (EV-A71) vaccines licensed and used in China since 2016. Our study describes changes in epidemiological characteristics of HFMD outbreaks following EV-A71 vaccine introduction.

[Exposure to Lead, Arsenic, Mercury, and Cadmium in Populations in Sichuan and Chongqing : A Comparative Study of Reference Intervals Derived From Direct and Indirect Sampling Methods].

Objective: To assess the exposure levels of heavy metals, including lead, arsenic, mercury, and cadmium, in the local population in Sichuan and Chongqing, China, to compare and analyze the differences in reference intervals (RIs) obtained from direct and indirect sampling methods, and to explore the interchangeability and limitations of these two sampling methods.

Methods: RIs were obtained by the direct sampling method and the indirect sampling method. In the direct sample method, the levels of blood arsenic, urinary cadmium, urinary mercury, and blood lead levels of 5562 healthy participants aged 22-50 years in Sichuan and Chongqing, China were measured by atomic absorption spectrometry and inductively coupled plasma-mass spectrometry.

Dietary baking soda (NaHCO) therapy recovered urolithiasis-induced kidney injury in mice by inhibition of oxidative stress, pyroptosis, and inflammation through gut-kidney axis.

Background: Urolithiasis is one of the most common urological diseases, and its incidence has increased globally in recent years. Multiple potential mechanisms are involved in urolithiasis, including renal oxidative stress, inflammatory response, fibrosis, pyroptosis, and gut microbiota disturbance. Sodium bicarbonate (NaHCO) is commonly used clinically to alkalize urine and slow the progression of chronic kidney disease, including urolithiasis.

Development and validation of a nomogram combining cytokines with traditional clinical parameters in predicting the risk of postoperative sepsis after ureteroscopic lithotripsy.

Background: Sepsis is one of the most severe complications of ureteroscopic lithotripsy (URSL) surgery and is the main cause of death in hospitalized patients. Traditional preoperative patient management and risk assessment systems need to be updated urgently to reduce the occurrence of postoperative sepsis. This study aimed to construct a novel nomogram to preoperatively predict the risk of septic complications after URSL.

Construction and evaluation of a minicell-based dendritic cell-targeted multi-epitope vaccine against .

Background: infection is a global health concern linked to various gastrointestinal diseases, highlighting the urgent need for effective vaccines.

Methods: In this study, we developed two multi-epitope vaccine candidates based on minicells: TA-2m and Apt-TA-2m. Apt-TA-2 is an advanced formulation of TA-2m, coated with dendritic cell-targeting RNA aptamer to enhance antigen delivery and immune activation.

Characterization of the gut microbiota in urinary calculi patients with preoperative urinary tract infection.

Background: Urinary tract infection is one of the most common comorbidities of urinary stones. Disorders of gut microbiota can affect various infectious diseases and the formation of the stones. Therefore, alterations in the gut bacteria profile may be a potential risk factor for the development of infections in patients with urinary tract stones.

Perillaldehyde ameliorates sepsis-associated acute kidney injury via inhibiting HSP90AA1-mediated ferroptosis and pyroptosis: Molecular structure and protein interaction of HSP90AA1.

Heat shock protein 90α (HSP90AA1) is a molecular chaperone involved in a variety of cellular processes. Special attention is paid to how perillaldehyde ameliorates kidney injury by inhibiting HSP90AA1-mediated iron and pyrotoxicity, and in-depth analysis of the molecular structure and protein interactions of HSP90AA-1. The interaction between perillaldehyde and HSP90AA1 and the effect of perillaldehyde on the molecular structure of HSP90AA1 were analyzed by molecular docking and surface plasmon resonance technique.

N,O Co-Doped Carbon Spheres Enable Stable Anode-Less Sodium Metal Batteries.

Anode-less sodium metal batteries (SMBs) suffer from the formation of Na dendrites and inactive Na on an anode substrate though showing advantages of high energy densities and low costs. Herein, N,O co-doped carbon spheres (NOCS), which are synthesized via a scalable polymerization and pyrolysis method, are employed as a thin and stable sodiophillic nucleation layer on the Cu foil. Combined with electrochemical measurements, Na deposition morphology observations and density functional theory calculations, it is revealed that the introduced N and O heteroatoms can greatly enhance the adsorption of Na on the carbon substrate and reduce the nucleation overpotential, thus forming sufficient seeding sites and guiding homogeneous Na deposition.

Deep Learning-Based Method for Detecting Traffic Flow Parameters Under Snowfall.

In recent years, advancements in computer vision have yielded new prospects for intelligent transportation applications, specifically in the realm of automated traffic flow data collection. Within this emerging trend, the ability to swiftly and accurately detect vehicles and extract traffic flow parameters from videos captured during snowfall conditions has become imperative for numerous future applications. This paper proposes a new analytical framework designed to extract traffic flow parameters from traffic flow videos recorded under snowfall conditions.

Retrospective analysis of reference intervals for dried blood spot based ms/ms newborn screening programs in Chinese preterm neonates: a nationwide study.

Objectives: Although recent discoveries regarding the biomarkers of newborn screening (NBS) programs by tandem mass spectrometry (MS/MS) highlight the critical need to establish reference intervals (RIs) specifically for preterm infants, no such RIs has been formally published yet. This study addressed the gap by offering a comprehensive set of reference intervals (RIs) for preterm neonates, and illustrating the dynamic changes of each biomarker with age.

Design And Methods: The NBS data of 199,693 preterm newborns (< 37 weeks of gestation) who met the inclusion and exclusion criteria from the NNSCP database were included in study analysis.

Advance in Iron Metabolism, Oxidative Stress and Cellular Dysfunction in Experimental and Human Kidney Diseases.

Kidney diseases pose a significant global health issue, frequently resulting in the gradual decline of renal function and eventually leading to end-stage renal failure. Abnormal iron metabolism and oxidative stress-mediated cellular dysfunction facilitates the advancement of kidney diseases. Iron homeostasis is strictly regulated in the body, and disturbance in this regulatory system results in abnormal iron accumulation or deficiency, both of which are associated with the pathogenesis of kidney diseases.

Biomimetic Hydrogel-Mediated Mechano-Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery.

The unique physical tumor microenvironment (TME) and aberrant immune metabolic status are two obstacles that must be overcome in cancer immunotherapy to improve clinical outcomes. Here, an in situ mechano-immunometabolic therapy involving the injection of a biomimetic hydrogel is presented with sequential release of the anti-fibrotic agent pirfenidone, which softens the stiff extracellular matrix, and small interfering RNA IDO1, which disrupts kynurenine-mediated immunosuppressive metabolic pathways, together with the multi-kinase inhibitor sorafenib, which induces immunogenic cell death. This combination synergistically augmented tumor immunogenicity and induced anti-tumor immunity.

Identification of biomarkers and potential therapeutic targets of kidney stone disease using bioinformatics.

Purpose: Kidney stone disease (KSD) is a common urological disease, but its pathogenesis remains unclear. In this study, we screened KSD-related hub genes using bioinformatic methods and predicted the related pathways and potential drug targets.

Methods: The GSE75542 and GSE18160 datasets in the Gene Expression Omnibus (GEO) were selected to identify common differentially expressed genes (DEGs).

The survival of murine hepatitis virus (a surrogate of SARS-CoV-2) on conventional packaging materials under cold chain conditions.

Introduction: The cold chain conditions have been suggested to facilitate long-distance transmission of SARS-CoV-2, but it is unclear how viable the virus is on cold chain packaging materials.

Methods: This study used the MHV-JHM strain of murine hepatitis virus as a model organism to investigate the viability of SARS-CoV-2 on foam, plastic, cardboard, and wood sheets at different temperatures (-40°C, -20°C, and 4°C). In addition, the ability of peracetic acid and sodium hypochlorite to eliminate the MHV-JHM on plastic and cardboard sheets were also evaluated.

Overexpression of efflux pump genes is one of the mechanisms causing drug resistance in .

Gene mutations cannot explain all drug resistance of , and the overexpression of efflux pump genes is considered another important cause of drug resistance. A total of 46 clinical isolates were included in this study to analyze the overexpression of efflux pump genes in different resistant types of strains. The results showed that overexpression of efflux pump genes did not occur in sensitive strains.

Administration of a glypican-3 peptide increases the infiltration and cytotoxicity of CD8 T cells against testicular yolk sac tumor, associated with enhancing the intratumoral cGAS/STING signaling.

Background: Glypican-3 (GPC3) is highly expressed in testicular yolk sac tumor (TYST). GPC3 has been evaluated as a cancer vaccine for some types of tumors, but little is known on the effects of GPC3 peptide-based therapy on TYST. Here, we evaluated the antitumor effect of GPC3 on TYST and its potential mechanisms.

Experimental Investigation on the Impact of Coal Fines Migration on Pores and Permeability of Cataclastic Coal.

During the production process of coalbed methane, the generation and migration of coal fines can obstruct fractures in coal reservoirs and reduce their permeability. In order to investigate the effects of coal fines migration on the porosity and permeability of coal reservoirs, we conducted core water flooding experiments, low-field nuclear magnetic resonance (NMR), and low-temperature N adsorption experiments to study the variations in porosity and permeability of cataclastic coal during coal fines migration and the impact of coal fines migration on porosity and permeability. The experimental results reveal that the initial porosity ratio of cataclastic coal exhibits the characteristics of micropore > macropore > transitional pore > mesopore, with the pore types being predominantly fissured.

The Relationship between Preoperative Urine Culture and Post-Percutaneous Nephrostolithotomy Systemic Inflammatory Response Syndrome: A Single-Center Retrospective Study.

Background: To predict the occurrence of systemic inflammatory response syndrome (SIRS) after percutaneous nephrostrolithotomy(PCNL), preoperative urine culture is a popular method, but the debate about its predictive value is ongoing. In order to better evaluate the value of urine culture before percutaneous nephrolithotomy, we conducted a single-center retrospective study.

Methods: A total of 273 patients who received PCNL in Shanghai Tenth People's Hospital from January 2018 to December 2020 were retrospectively evaluated.

The reference intervals for thyroid hormones: A four year investigation in Chinese population.

Introduction: The reference intervals (RIs) are of great importance for physicans to determine whether or not an individual is healthy. However, many clinical laboratories in China still adopted the default RI provided by the manufacturers; and these "uncalibrated" RIs might lead to the misdiagnosis of diseases. In the present study, we enroll reference people with the purpose of determining the RIs of serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in Chinese population, and explore the possible roles of age and sex on the levels of biomarkers.

A novel prognostic model based on six methylation-driven genes predicts overall survival for patients with clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a lethal urological malignancy. DNA methylation is involved in the regulation of ccRCC occurrence and progression. This study aimed to establish a prognostic model based on DNA methylation to predict the overall survival (OS) of patients with ccRCC.

Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Levels as Early Markers of the Renal Function in Patients With Urinary Stone-Induced Hydronephrosis.

Introduction: Urinary stones cause hydronephrosis, which leads to kidney function impairment. The serum creatinine level is frequently used as a marker of kidney function. However, in some patients with hydronephrosis, it does not reflect the kidney function changes in the early stages of kidney stone disease.