SYSTEMATIC REVIEW ON THE USE OF COST-BENEFIT ANALYSIS TO EVALUATE FOOD ENVIRONMENT INTERVENTIONS.

Introduction: The global obesity epidemic is a complex issue influenced by various factors, including the food system and its environment. Increasingly, interventions targeting systemic changes in the food environment are being implemented to address obesity. Cost-benefit analysis (CBA) is gaining recognition as a valuable tool for evaluating these interventions, due to its ability to capture broader societal impacts beyond health outcomes.

Dynamic Changes in Microorganisms and Metabolites During Silage Fermentation of Whole Winter Wheat.

Winter wheat ( L.) silage has high feeding value and has become an important roughage resource in China. To recognize the optimal fermentation time of the silage product, this study systematically evaluated the temporal dynamics of microbial communities and metabolic profiles in whole winter wheat silage at days 7, 14, 30, 50, and 70.

Preparation and Applications of Silver Nanowire-Polyurethane Flexible Sensor.

To expand the application of silver nanowires (AgNWs) in the field of flexible sensors, this study developed a stretchable flexible sensor based on thermoplastic polyurethane (TPU). Initially, the TPU nanofiber membrane was prepared by electrospinning. Subsequently, high-aspect-ratio AgNWs were synthesized via a one-step polyol reduction method.

Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress.

Postoperative reduction in appetite perception, conceptualized as an interplay between emotion, perception, and cognition, may lead to adverse nutritional outcomes. However, an increasing body of research suggests that it may serve as an adaptive mechanism to inhibit inflammatory responses and regulate metabolic burden. This review comprehensively summarizes the multifaceted mechanisms underlying postoperative changes in appetite perception, particularly from the perspectives of immune regulation, inflammatory suppression, and metabolic reprogramming.

Two similar but distinct types of breast acinar cell carcinoma: evidence from histological, immunohistochemical and molecular features.

Aims: Breast acinar cell carcinoma (AciCC) is a rare breast cancer subtype that exhibits morphological similarities to salivary gland AciCC. However, the molecular profile of breast AciCC differs significantly from that of salivary gland AciCC, suggesting that they may not be related. Whether breast AciCC represents a distinct breast cancer subtype remains controversial.

Brinzolamide encapsulated β-cyclodextrin-chondroitin sulfate nanocomplexes anchored chitosan/polycaprolactone nanofibers as an ocular insert for glaucoma treatment.

Glaucoma ranked second among the causes of blindness globally, necessitates the development of novel and effective therapeutic strategy. Anti-glaucoma eye drops as a topical dosage form are still considered as a method of choice for glaucoma treatment. However, a short ocular drug residence time of eye drops leads to poor bioavailability of drug which requires repeated dosing.

Risk factors associated with high-dose methotrexate induced toxicities in primary central nervous system lymphoma.

High-dose methotrexate (HDMTX) is the cornerstone of the treatment for primary central nervous system lymphoma (PCNSL). The prevention of drug-induced toxicities is critical. This study aims to identify key factors associated with HDMTX-induced toxicities (hematotoxicity, hepatotoxicity and nephrotoxicit) in 713 Chinese PCNSL patients undergoing 3021 HDMTX treatment courses.

Physiological and Transcriptomic Mechanisms Underlying Vitamin C-Mediated Cold Stress Tolerance in Grafted Cucumber.

Cucumbers ( L.) are highly sensitive to cold, but grafting onto cold-tolerant rootstocks can enhance their low-temperature resilience. This study investigates the physiological and molecular mechanisms by which exogenous vitamin C (Vc) mitigates cold stress in grafted cucumber seedlings.

Recent advances in polysaccharide-protein complex coacervates for food applications.

Coacervates are typically formed through a combination of electrostatic interactions, hydrogen bonding, and hydrophobic forces between oppositely charged macromolecules. Polysaccharides and proteins are the most commonly used functional biopolymers, which play a crucial role in the food industry. Coacervates formed by the interaction of polysaccharides and proteins have been heavily researched and applied in food fields.

Serum Cytokeratin 18 and Fragment as Biomarkers for Severity and Prognosis in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Background: Cytokeratin (CK)18 is present in the bronchi and alveolar epithelium of the lung, and its cleavage product, CK-18M30, serves as a biological marker of apoptosis. However, the specific roles of CK-18 and CK-18M30 in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remain unclear.

Methods: This study enrolled 289 patients with AECOPD who met the inclusion criteria.

Cellular Senescence: A Pathogenic Driver for Pulmonary Fibrosis.

Pulmonary fibrosis is a life-threatening progressive lung disease characterized by increased fibrogenesis and decreased lung function. Pulmonary fibrosis has a poor prognosis and a low patient survival rate, with no effective treatments currently available. Cellular senescence is thought to contribute to the pathogenesis of this aging-related disease.

Hybrid advanced oxidation process for rapid ciprofloxacin removal: coupling hydrodynamic cavitation with UV/HO.

In this study, an innovative integration of hydrodynamic cavitation (HC), ultraviolet (UV) irradiation, and hydrogen peroxide (HO) was employed to effectively degrade ciprofloxacin (CIP), a representative antibiotic, in a 12-litre treatment system. The study systematically investigated the cavitation characteristics, synergistic interactions, and the influence of key operating parameters (inlet pressure, initial solution pH, HO concentration, and initial CIP concentration) on the performance of the HC/UV/HO system. Additionally, the potential degradation mechanism, practical applicability, and economic feasibility of the integrated process were thoroughly evaluated.

Advances and Mechanistic Studies of Cu-Based Heterostructures for Nitrate Reduction.

Ammonia is a carrier of high-energy density and a key component of agricultural fertilizers. Conventionally, the large-scale Haber-Bosch synthesis of ammonia necessitates harsh temperatures and pressures in excess of >500 °C and >200 atm, respectively, leading to considerable greenhouse gas emissions. Simultaneously, the intense use of nitrogen fertilizers and their discharge as agricultural waste have resulted in widespread nitrate accumulation in aquatic environments, posing serious risks to human health and ecological balance.

Construction of a sandwich-type DNA biosensor based on functionalized MOF@COF nanomaterials for the detection of NSCLC biomarker ctDNA.

As a key diagnostic biomarker for non-small cell lung cancer (NSCLC), the sensitive detection of circulating tumor DNA (ctDNA) is crucial for early-stage disease detection and monitoring. However, the existing detection methods still have limitations in terms of sensitivity, cost and operational simplicity. In this study, we successfully constructed a novel sandwich-structured electrochemical biosensor based on a methylene blue (MB)-based signal indication system, leveraging the synergistic effects of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), to realize the efficient quantitative analysis of ctDNA.

Tacrolimus eye drops treatment for recurrent exposure of the Ahmed glaucoma valve tube.

Purpose: To investigate the effectiveness and safety of 0.1% tacrolimus eye drops in treating recurrent exposure after initial repair of Ahmed glaucoma valve tubes.

Materials And Methods: After reviewing all patients who underwent AGV implantation at a single center from January 2016 to March 2022, 11 patients (11 eyes) were enrolled in this retrospective study and divided into two treatment groups: a study group and a control group.

Predictive value of a nomogram model for treatment response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

Background: Locally advanced rectal cancer (LARC) carries a substantial risk of recurrence, prompting the use of neoadjuvant chemoradiotherapy (nCRT) to improve tumor resectability and long-term outcomes. However, individual treatment responses vary considerably, highlighting the need for robust predictive tools to guide clinical decision-making.

Aim: To develop a nomogram model integrating clinical characteristics and biomarkers to predict the likelihood of poor response to nCRT in LARC.

Synthesis of a Wrinkled Hierarchically Porous Cerium-Based MOF for Thermal Decomposition Catalysis of Ammonium Perchlorate.

Since ammonium perchlorate (AP) thermal decomposition catalysis is a typical heterogeneous catalytic process, developing catalysts with optimized interfacial properties has become an urgent priority. Catalysts featuring hierarchically porous structures demonstrate significant advantages in heterogeneous catalysis due to their abundant accessible active sites. In this study, a wrinkled hierarchically porous structure cerium-based metal-organic framework material (WHP-UiO-66-Ce) was synthesized by the soft template method, and its interaction with AP enabled efficient catalysis of AP decomposition.

Recent advances in gelatin-cellulose composite films for food packaging applications.

Biopolymer films have attracted great attentions and been used as food packaging due to the severe environmental pollution caused by synthetic plastic-based packaging. Gelatin and cellulose are the most commonly used biopolymers, which play a crucial role in the field of bio-based films. Various emerging gelatin-cellulose composite films have been prepared to be used as food packaging for their excellent degradability, edibility, and film-forming properties.

Role of exosomal non‑coding RNAs in cancer‑associated fibroblast‑mediated therapy resistance (Review).

Cancer‑associated fibroblasts (CAFs) represent an important component of the stromal cell population within the tumor microenvironment (TME) and are intricately linked to tumor growth, metastasis and drug resistance. In the TME, non‑coding RNAs present in exosomes act as essential mediators of intercellular communication. Exosomal RNAs derived from cancer cells activate CAFs, which in turn regulate cancer cell proliferation, invasion and drug resistance.

Correlations of oral behaviors, pain, and psychological distress among patients with temporomandibular disorders: clinical investigation of axial II evaluation.

Purpose: This cross-sectional, observational study assessed physical, psychological and behavioral factors related to patients with temporomandibular disorder (TMD) using Axis II assessment instruments with diagnostic criteria for TMD (DC/TMD) and investigated the correlations among oral behavior, pain, and psychological distress in patients with temporomandibular disorders.

Methods: Participants were recruited from the Department of TMD at the authors' hospital. The TMD group comprised 96 patients (27 males and 69 females; mean age 39.

AhR-mediated histone lactylation drives cellular senescence during benzo[a]pyrene-evoked chronic obstructive pulmonary disease.

Benzo[a]pyrene (BaP) and the end-product BaP-7,8-diol-9,10-epoxide (BPDE) are representative environmental contaminants. In the present study, chronic BPDE exposure decreased pulmonary function and evoked chronic obstructive pulmonary disease (COPD)-like lung lesions. In addition, the expression of p53, p21, and p16, β-galactosidase-positive cells, and the mRNA levels of senescence-associated secretory phenotype (SASP) were all elevated in mouse lungs and mouse lung epithelial type II (MLE-12) cells after chronic BPDE.

Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study.

Introduction: Syndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However, there are few researches about the relation of serum syndecan-1 with corona virus disease 2019 (COVID-19).

Cathepsin S mediates the disruption of airway epithelial Pannexin 1 via an Akt-dependent pathway in an LPS-induced murine model of acute lung injury.

Airway epithelial dysfunction constitutes a pivotal contributor to the pathogenesis of acute lung injury (ALI). Pannexin 1 (Panx1), a plasma membrane channel activated during epithelial injury, not only helps dampen inflammation but also plays a key role in epithelial repair. Cathepsin S (CTSS) is implicated in ALI pathophysiology.