Formation and in-situ identification of unique microplastic-rock blends under anthropogenic thermal conditions.

Microplastic (MP) pollution poses a significant challenge for municipal solid waste (MSW) management, while landfills have been recognized as a primary source of secondary MPs, waste incineration offers a potential solution for MP elimination. This study discovered a kind of specifically MP-rock blends, which are generated through the melt-recrystallization of different plastics during incineration. MP-rock blend of polypropylene (PP) and polyethylene (PE) was confirmed using in-situ FTIR microscopy (LUMOS II), and three distinct morphologies, i.

Multifunctional Polyrotaxane Hydrogel with Dynamic Molecular Anchors and Microenvironment-Activatable Cationization Properties for Healing Drug-Resistant Bacterial-Infected Chronic Skin Wounds.

The wound healing process in diabetic patients is often complex and prolonged, frequently complicated by persistent bacterial infections that can develop into multidrug-resistant infections, posing significant challenges for treatment. However, traditional hydrogel dressings often exhibit limited efficacy against complex wounds, primarily because therapeutic molecules are confined within the cross-linked matrix and exert nonselective antibacterial effects. This study developed a novel polyrotaxane-based hydrogel (FDS) against diabetic wounds complicated by drug-resistant bacterial infections.

ZIF-8-Based Composites for Enhanced Biofilm Penetration and Synergistic Antibacterial Therapy against Periodontal Pathogens.

Periodontitis is initiated by bacterial biofilms, and the removal of plaque is critical in preventing the onset and progression of periodontal diseases, including gingival inflammation, periodontitis, and even alveolar bone resorption. Clinically, mechanical methods are commonly used to remove plaque and calculus. However, conventional methods struggle to access certain regions, such as deep periodontal pockets, root furcations, and dentinal tubules.

A STAT1-GBP3-STING positive feedback loop governs inflammation, oxidative stress, and DNA damage to trigger acute aortic dissection.

Acute aortic dissection (AAD) is a degenerative aortic remodeling disease characterized by exceedingly high mortality without effective pharmacologic therapies. Although oxidative stress, DNA damage, and inflammation are associated with AAD, the precise interplay among these responses has remained unclear. In this study, aortas from mouse AD models were subjected to integrative ATAC-seq and RNA-seq analysis.

Optimizing efficacy: Hyaluronic acid liposomes encapsulating minoxidil for enhanced transdermal delivery and treatment of androgenetic alopecia.

Minoxidil (Mi) is currently one of the most commonly used drugs for the treatment of hair loss in clinical settings. It works by accelerating blood flow around the hair follicles, enhancing local oxygen and nutrient supply, thereby promoting hair growth. However, traditional formulations of Mi have a short residence time on the skin, are prone to causing allergic reactions, scaling, and may even induce systemic hypertrichosis as side effects.

Complete chloroplast genome of two Brachycorythis (Orchidaceae) species from China: comparative analysis and phylogenetic implications.

Background: Brachycorythis Lindl. (Orchidinae, Orchidaceae) was characterized by a large and densely leafy stem throughout its length, comprising about 35 species with African-Asian disjunct distribution. However, the intergeneric and infrageneric phylogeny of Brachycorythis has been debated based on morphological and molecular data.

Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis.

Objective: The present study aimed to investigate the potential role and molecular mechanism of procyanidin B2 (PCB2) in the treatment of multiple sclerosis (MS), with the hope of providing novel strategies for the precision treatment of MS.

Methods: The target genes of PCB2 and the disease-related target genes of MS were gathered from databases like GEO, GeneCards, OMIM, and DisGeNET. R language was employed for the identification of differentially expressed genes (DEGs), unsupervised clustering analysis, immune infiltration analysis, weighted gene co-expression network analysis (WGCNA), Gene Ontology (GO) analysis, and gene set enrichment analysis (GSEA).

Corrigendum to "Nitric oxide synergizes Minoxidil delivered by transdermal hyaluronic acid liposomes for multimodal androgenetic-alopecia therapy" [Bioact. Mater. 32 (2024) 190-205].

[This corrects the article DOI: 10.1016/j.bioactmat.

Biplane Chevron Osteotomy in Hallux Valgus: Biomechanical Effects of Lateral and Plantar Displacement Under Simulated Standing Load.

Background: Plantar displacement during chevron osteotomy may improve load distribution in hallux valgus, but biomechanical evidence is limited. This study evaluates how lateral and plantar displacement affect contact properties in the first metatarsophalangeal (MTP-1) and the first tarsometatarsal (TMT-1) joints under standing load.

Methods: Twelve cadaveric feet with hallux valgus and 4 normal specimens were tested under simulated standing load.

Enhancing energy efficiency in CO-rich amine solution regeneration using a Cu-modified attapulgite catalysts.

In recent years, significant attention has been drawn to the advancement of high-performance solid acid catalysts, which enhance the CO desorption efficiency and concurrently lower energy requirements. Although solid acid catalysts show promise in reducing regeneration energy for amine-based CO capture, achieving an optimal balance between activity, cost, and stability remains a major challenge. Herein a series of solid acid catalysts were prepared by modifying attapulgite (ATP) with various CuO loading, and the effect of Cu modification on CO desorption performance was compared systematically.

Deciphering the etiology of congenital scoliosis: A genetic and epigenetic perspective.

Congenital scoliosis (CS) is a prevalent spinal deformity with a multifaceted etiology that remains incompletely understood. Recent advances in genetic and epigenetic research have provided novel insights into CS pathogenesis. Herein, we review the current progress in genetics and epigenetics to examine genetic variants, susceptibility factors, and the epigenetic regulatory mechanisms implicated in CS.

Amorphous Ni-Fe-B bimetallic borides: boron-mediated synergy for ultrafast and stable 4-nitrophenol reduction.

The efficient reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) has garnered significant interest in the fields of environmental remediation and chemical manufacturing. However, conventional catalytic reduction methods encounter challenges such as insufficient catalyst activity, poor stability, and high costs. Nickel-iron bimetallic systems offer promise due to their synergistic effects, and recent studies have shown that boron incorporation (Ni-Fe-B) further enhances activity through electronic modulation and improved charge transfer.

A Weekly Session of Jumping Interval Training Effectively Enhances Aerobic, Anaerobic, and Jumping Performance in Aerobic Gymnastics.

This study aimed to compare the impact of varying weekly frequencies of jumping interval training (JIT) on aerobic and anaerobic fitness, as well as jumping abilities of youth female athletes specialized in aerobic gymnastics. A randomized controlled study design was conducted spanning 8-week duration, involving 69 youth female athletes (16.3 ± 1.

Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing.

Cyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. However, the effectiveness of CDK5 in macrophages on cutaneous wound healing remains inadequately characterized.

Analysis of the synchronous rise of water level in the Tangshan fault zone.

Since 2019, a synchronous and abnormal upward trend in water levels has been observed in the Tangshan and Majiagou observation wells, located within the Tangshan fault zone, coinciding with three earthquakes of magnitude 4.0 or higher in the Tangshan area. This study conducted a quantitative analysis of the influence of environmental factors on water level rises, based on data regarding groundwater exploitation, reservoir storage, and precipitation in the recharge areas surrounding the observation wells.

Experimental study on temperature and gas concentration evolution law during coal spontaneous combustion in the goaf.

Coal spontaneous combustion (CSC) constitutes a persistent threat to global mining safety, particularly through its impact on goaf environments. Understanding the evolutionary patterns of critical parameters (O, CH, CO, CH concentrations, and temperature) within goaf areas holds crucial importance for effective CSC prevention and control. Similarity simulation experiments were conducted using a scaled-down experimental platform to replicate CSC processes.

Leaf Morpho-Anatomy of Twelve (Orchidaceae) Species from China and Their Taxonomic Significance.

are endangered and ornamental orchids, and the taxonomy and species identification of this genus have been debated due to some overlapping morphological features between taxa and limited data being available. The leaf morpho-anatomy of 12 species from China was investigated using light microscopy and paraffin sectioning. Based on a comparative analysis, some leaf morphological features that varied between species were selected and used for taxonomic differentiation as follows: (1) The shape and structure of leaves were varied and could be used for species delimitation.

Cyclodextrin-based self-assembling hydrogel for Photothermal-controlled nitric oxide release in stage-specific treatment of MRSA-induced arthritis.

MRSA-induced arthritis is a prevalent and highly debilitating orthopedic condition. The inflammatory response induced by bacterial infection hinders tissue repair and exacerbates bone loss. Traditional antibiotic therapies are limited by low bioavailability, substantial side effects, and narrow efficacy, rendering them inadequate for comprehensive treatment of arthritis.

Hydroxysafflor yellow A inhibits neuronal ferroptosis and ferritinophagy in ischemic stroke.

Ischemic stroke is a significant cause of disability and mortality on a global scale, with neuronal dysfunction playing a critical role in its pathogenesis. Conventional treatment approaches for ischemic stroke involve surgical interventions and thrombolytic therapy, yet these methods frequently result in ischemia/reperfusion (I/R) injury. Recent studies have underscored the implication of diverse programmed cell death mechanisms, including ferroptosis, in the progression of ischemic stroke.

Recreational soccer and basketball improve anthropometric, body composition and health-related outcomes in overweight and obese young adults: A randomized multi-arm study.

This study aimed to investigate the effects of 8-week programmes based on recreational soccer (SCG) and basketball (BCG) conditioned games compared to self-exercise (SECG) and inactive (ICG) control groups on anthropometry, body composition, resting heart rate (RHR), and blood pressure among sedentary overweight and obese men and women. The study included 90 volunteers (aged 19.8 ± 1.

Hydroxysafflower yellow A alleviates the inflammatory response in astrocytes following cerebral ischemia by inhibiting the LCN2/STAT3 feedback loop.

Lipocalin-2 (LCN2), an acute phase protein mainly expressed in astrocytes (Ast), is closely related to the production of inflammatory cytokines following ischemic stroke. During the pathophysiological process of ischemic stroke, the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway is activated. Despite evidence suggesting some link between the two, the relationship between the JAK2/STAT3 signaling pathway and the LCN2 expression in Ast following brain ischemia is incompletely understood.

Hyaluronic acid-liposomes hybridized with HucMSC exosomes for enhanced exosomes transdermal delivery and acute skin photodamage repair.

Long-term exposure to ultraviolet (UV) radiation can damage human skin, resulting in photodamage. Repairing photodamaged skin has been a major focus of research in recent years. Extensive research has shown that human umbilical cord mesenchymal stem cell-derived exosomes (Exo) possess anti-inflammatory, pro-angiogenic, and wound healing properties, holding great potential for treating skin damage.