Optimizing multi-system coupling to mitigate carbon emissions in agrifood systems at county level in China.

The growing demand for food has led to overuse of land, exacerbating the environmental sustainability of agrifood systems. Insufficient coordination and coupling within agrifood systems (soil-crop-animal-food consumption) reduce material cycle efficiency and limit the system's carbon reduction potential. Given the lack of global research on the impact of system coupling on carbon reduction, the value of regional practice cases is particularly evident.

The value of intellectual structural imbalance in the differentiation of autism spectrum disorder and attention deficit hyperactivity disorder.

Background: The study delves into the intricate task of differentiating intellectual structures among children diagnosed with the high-functioning Autism Spectrum Disorder (HF-ASD), Attention Deficit Hyperactivity Disorder (ADHD), or comorbidity (ASD+ADHD), aiming to assist in their clinical differentiation, with the goal of refining clinical diagnoses and developing targeted therapeutic interventions.

Methods: The study included 200 outpatients aged 6.5-13.

P300 event-related potentials as diagnostic biomarkers for attention deficit hyperactivity disorder in children.

Objectives: This study aimed to evaluate the utility of P300 event-related potentials (ERPs) as neurophysiological biomarkers for diagnosing attention deficit hyperactivity disorder (ADHD) and to establish preliminary diagnostic thresholds for their use.

Methods: A total of 106 children diagnosed with ADHD and 66 healthy controls were enrolled. Using a visual Oddball paradigm, P300 parameters were recorded at Fz, Cz, and Pz zones.

Untangling transformation products in a semi-closed sea by nontarget and suspect screening analysis.

Although transformation products are important parts of chemical contaminants in the environment, their occurrence and risks remain largely unclear. In this study, MS-initiated nontarget analysis and MS-initiated suspect screening analysis strategy were performed to identify transformation products. The integration of these two approaches provided a complementary strategy to broaden transformation product identification, by covering diverse structural modifications during transformation processes and fragmentation behaviors in mass spectrometry.

Can different small-sided game formats impact physiological, physical, technical, and tactical demands in basketball players? A systematic review with meta-analysis.

This systematic review with meta-analysis aimed to compare the effects of different game formats (1 v 1, 2 v 2, 3 v 3, 4 v 4, 4 v 3, 3 v 3+1, and 5 v 5) on basketball players' physiological, physical, technical, and tactical responses during SSGs. The data sources utilized were PubMed, Scopus, SPORTDiscus, and Web of Science. Eligibility included basketball players of any age or sex, competing in tier 2 or higher, exposed to at least two different formats.

Advancements in SO tolerance for low-temperature NH-SCR through tailoring oxidation ability and pore size in MnCe-based catalysts.

The detrimental effects of SO poisoning pose a critical challenge for the practical implementation of Mn-based catalysts in low-temperature NH-SCR systems for NO abatement. The causes of NH-SCR catalyst deactivation are the deposition of ammonium sulfates on the active sites and the formation of metal sulfates due to reactions between SO and the active metal oxide. Herein, a HO-assisted redox precipitation method has been employed to tailor MnCe-based catalysts by enlarging their pore size and enhancing their oxidation ability, thereby respectively increasing sulfate decomposition rates and reducing metal sulfate formation.

Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.

Background: Parkinson's disease (PD) is a neurodegenerative disease whose cause and molecular mechanism remain unclear. Dingzhen pill (DZP), a water extract from crude herbs, is thought to possibly play a neuroprotective role in PD. However, the underlying pharmacological mechanisms of the DZP and its impact on the potential pathways against PD have not been elucidated.

Mendelian Randomization Uncovers Potential Repurposable Medications for Neuropsychiatric Disorders.

Background: The growing prevalence of neuropsychiatric disorders is becoming a major health challenge. Traditional pharmacotherapies face limitations, making drug repurposing a valuable strategy. However, high-throughput screening approaches for these conditions are scarce.

Increasing indoxyl sulfate induces iNOS expression via aryl hydrocarbon receptor leading to microglia hyperactivation in the prefrontal cortex of autism-like offspring rats.

The abnormal indole metabolism is associated with the progression of Autism Spectrum Disorder (ASD). Indoxyl sulfate (IS), one of the active products of indole metabolism, still has an unknown role in ASD progression. This study investigates the role of IS/Aryl hydrocarbon receptor (AhR)/iNOS pathway in microglial activation in the prefrontal cortex (PFC) of ASD-like rats.

Contemporary factors affecting serum 25-hydroxyvitamin D concentrations in Chinese children aged 2-6 years.

Objective: We investigated vitamin D (VitD) nutritional status in children aged 2-6 years to provide a basis for prevention and intervention strategies for VitD deficiency (VitDD) in Chinese children.

Design: From November 2018 to September 2019, a total of 2192 healthy children aged 2-6 years were enrolled. The serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography tandem MS.

Social jet lag is associated with core symptoms in 2-3-year-old children with autism spectrum disorders.

Background: Social jet lag (SJL) is a form of circadian rhythm misalignment caused by the mismatch between social schedules and biological clocks, which is associated with cognition, behavior, and emotion in children. However, social jet lag among children with autism spectrum disorders (ASD) and its impacts are unknown.

Methods: This cross-sectional study recruited 2-7-year-old children with ASD from special education institutions and outpatient clinics.

Prenatal Exposure To Valproic Acid Induces Increased Autism-Like Behaviors and Impairment of Learning and Memory Functions in Rat Offspring by Upregulating ADAM10 Expression.

Autism spectrum disorder (ASD) involves a complex neurodevelopmental pathogenesis. A disintegrin and metalloproteinase 10 (ADAM10) plays a crucial role in embryonic brain development and neural network stability. This study aimed to investigate the influence of ADAM10 on excitation/inhibition (E/I) balance, autism-like behaviors, and learning and memory dysfunction in rats prenatally exposed to valproic acid (VPA) and determine potential intervention strategies.

The role of HIF-1α silencing in late pregnancy hypoxia-induced autism-like behavior in rat offspring.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can be caused by a variety of factors. Our previous study indicated that hypoxia-inducible factor 1 alpha (HIF-1α) plays a role in hypoxia-caused autism-like behavior. In this study, we investigated the mechanism by which HIF-1α contributes to prenatal hypoxia-induced autism-like behavior in vivo to provide an experimental basis for the treatment of ASD.

Unravel the molecular basis underlying inflorescence color variation in based on widely targeted metabolomics.

, a perennial evergreen crop valued for its nutritious nuts, also exhibits a diverse range of inflorescence colors that possess both ornamental and biological significance. Despite the economic importance of macadamia, the molecular mechanisms regulating flower coloration remain understudied. This study employed a combination of metabolomic and biochemical approaches to analyze metabolites present in inflorescences from 11 Macadamia cultivars, representing distinct color phenotypes.

Interaction of PHGDH with IGF2BP1 facilitates m6A-dependent stabilization of TCF7L2 mRNA to confer multidrug resistance in gastric cancer.

Multidrug resistance (MDR) remains a significant barrier to effective chemotherapy and results in a poor prognosis for gastric cancer (GC). Exploring the mechanism of MDR is highly important for identifying biomarkers for MDR and developing new treatment strategies. In this study, integrative analyses of multiomics and bioinformatics data were combined with experimental validation to explore the mechanism of MDR in GC.

Recreational soccer and basketball improve anthropometric, body composition and health-related outcomes in overweight and obese young adults: A randomized multi-arm study.

This study aimed to investigate the effects of 8-week programmes based on recreational soccer (SCG) and basketball (BCG) conditioned games compared to self-exercise (SECG) and inactive (ICG) control groups on anthropometry, body composition, resting heart rate (RHR), and blood pressure among sedentary overweight and obese men and women. The study included 90 volunteers (aged 19.8 ± 1.

Gender specific influence of serotonin on core symptoms and neurodevelopment of autism spectrum disorders: A multicenter study in China.

Background: High serotonin (5-hydroxytryptamine [5-HT]) blood levels are the most reliable and frequently replicated biomarker for autism spectrum disorders (ASDs). However, their differential influence on core ASD symptoms in males and females remains unclear. This study aimed to investigate the changes in 5-HT levels in children with ASD to assess and compare its influence on the core symptoms and neurodevelopment of boys and girls.

Control of Fungal Spores on Surfaces with UV-C Exposure Necessitates Complete Inactivation to Prevent Mycorrhizal Network Establishment.

Mold infestations on surfaces present significant challenges to public health. Germicidal UV-C irradiation effectively inactivates spores suspended in water, yet information on surface spore mitigation is surprisingly absent. We show the effectiveness of 265-275 nm UV-C light to mitigateon nutrient-rich surfaces.

Influence of the ion-exchange functional groups on protein anion-exchange chromatography.

Several anion-exchange resins with different ion-exchange functional groups were prepared and evaluated with a protein mixture commercially available for evaluating anion-exchange resin (Myoglobin, Conalbumin, Ovalbumin, Soybean trypsin inhibitor). These functional groups include the commonly used diethyl amino group, two diamines, and the dibutyl amino group. The elution behaviors of the diamines are almost identical to that of the diethyl amino group, while dibutyl amino group provided significantly different elution behaviors.

The discriminate value of event-related potentials in executive function of ADHD and comorbidity of ADHD and ASD.

Purpose The study aimed to assess the value of event-related potentials (ERP) of executive functions in distinguishing between attention deficit hyperactivity disorder (ADHD) and ADHD combined with autism spectrum disorder (ADHD&ASD). Methods This retrospective analysis included 204 participants divided into three groups: ADHD&ASD (64/204), ADHD (70/204), and typical development (TD) (70/204). Neuropsychological tests, including the Digit Span Test, Behavior Rating Inventory of Executive Function (BRIEF), Trail Making Test at its Chinese equivalent version, the Shape Trail Test (STT), and the Stroop Color Word Interference Test, were compared across groups.

Synergistic effects of ginsenoside Rb1 and peroxiredoxin 6 in enhancing myocardial injury treatment through anti-inflammatory, anti-oxidative, and anti-apoptotic mechanisms.

Aim: Ginsenosides have notable bioactivity in treating cardiovascular diseases, but the mechanisms of their combined use with Peroxiredoxin 6 (PRDX6) in myocardial injury remain unclear. This study explores the synergistic effects of Ginsenoside Rb1 (Gs-Rb1) and PRDX6, aiming to provide a theoretical foundation for their therapeutic potential.

Methods: We established a rat model of isoproterenol (ISO)-induced myocardial injury and observed that combination therapy was more effective than single-drug treatments, as shown by ECG monitoring and Masson staining.

Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.

Background: Motor disturbance, as a related symptom of autism spectrum disorders (ASD), has not received the attention it deserves. We aimed to investigate the different degrees of motor developmental delay and influencing factors in Chinese preschool children with ASD, in order to enhance people's awareness of motor developmental delay in ASD children.

Methods: We recruited 1,256 ASD children aged 2-6 years from the China Multi-Center Preschool Autism Project (CMPAP).

Ntoco Promotes Ferroptosis via Hnrnpab-Mediated NF-κB/Lcn2 Axis Following Traumatic Brain Injury in Mice.

Objective: Emerging evidence highlights the involvement of long non-coding RNAs (lncRNAs) and ferroptosis in the pathogenesis of traumatic brain injury (TBI). However, the regulatory role of lncRNAs in TBI-induced ferroptosis remains poorly understood. This study aims to investigate the role of a specific lncRNA, noncoding transcript of chemokine (C-C motif) ligand 4 (Ccl4) overlapping (Ntoco), in the regulation of ferroptosis following TBI and explore its potential as a therapeutic target.