Long-term outcomes of corneal intrastromal lenticule transplantation for necrotic scleral melting and glaucoma: A case report.

Rationale: Necrotic scleral melting presents a significant therapeutic challenge, especially when complicated by concurrent conditions like refractory glaucoma. Conventional repair materials often have limitations. This case report aimed to evaluate the long-term efficacy and safety of a novel approach: utilizing an allogeneic corneal intrastromal lenticule (typically discarded after small incision refractive lenticule extraction surgery) combined with an autologous conjunctival graft for repairing necrotic scleral melting in a complex patient with glaucoma.

Development and validation of a multi-platform LAMP system for rapid HAdV-3 and HAdV-7 detection.

Purpose: We developed a loop-mediated isothermal amplification (LAMP) multi-platform detection system that overcomes the limitations of traditional polymerase chain reaction (PCR) in timeliness and equipment dependency, establishing a rapid, accurate diagnostic framework for Human adenovirus types 3 and 7 (HAdV-3 and HAdV-7) across resource-varied clinical settings.

Methods: LAMP primers were designed based on the conserved regions of the Hexon genes of HAdV-3 and HAdV-7. The calcein, immunochromatography (IC), and fluorescence probe methods were used.

RVG29 and platelet membrane-modified pseudo-mitochondria for cascade targeting of cyclosporin a in traumatic brain injury.

Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Cyclosporin A (CsA) is a promising drug for TBI, as it can protect neuronal mitochondria from dysfunction and apoptosis. However, CsA also has serious limitations, such as poor blood-brain barrier (BBB) penetration, non-selective distribution characteristic, and immunosuppressive effects.

Soil transplantation: complex interplay between soil microbes and the local environment.

Soil transplantation, the introduction of co-adapted soil microbes to maintain plant-microbe interactions in novel environments, is increasingly used to mitigate climate change effects on plants. However, it yields variable outcomes. We performed a reciprocal transplantation experiment at three elevations, plus a glasshouse experiment, where seedlings of three species were grown in rhizosphere soils from conspecific individuals collected from their original (home soil) or transplanted (away soil) sites.

Assessment of synthetic post-therapeutic OCT images using the generative adversarial network in patients with macular edema secondary to retinal vein occlusion.

Aims: The aim of this study is to generate post-therapeutic optical coherence tomography (OCT) images based on pre-therapeutic OCT by using generative adversarial networks (GANs). The synthetic images enable us to predict the short-term therapeutic efficacy of intravitreal injection of anti-vascular endothelial growth factor (VEGF) in retinal vein occlusion (RVO) patients.

Methods: The study involved patients with RVO who received intravitreal anti-VEGF injection from 1 November 2018 to 30 November 2019.

Lactylation's role in bone health and disease: mechanistic insights and therapeutic potential.

This article reviews the mechanisms and research progress of lactylation, an emerging post-translational modification (PTM) of proteins, in bone metabolism and related diseases. Lactate-derived lactylation modifies lysine residues on histones, affecting chromatin structure and gene expression. Studies indicate that lactylation plays a significant role in bone metabolism, with mechanisms including the regulation of osteoblast differentiation, potential influence on osteoclast activity, and indirect effects on bone homeostasis through the modulation of immune cell functions such as macrophages and T cells.

Diagnostic report generation for macular diseases by natural language processing algorithms.

Aims: To investigate rule-based and deep learning (DL)-based methods for the automatically generating natural language diagnostic reports for macular diseases.

Methods: This diagnostic study collected the ophthalmic images of 2261 eyes from 1303 patients. Colour fundus photographs and optical coherence tomography images were obtained.

Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China.

Background: Studies have shown that both inter-arm blood pressure difference (IABPD) and cognitive impairment are associated with vascular events. However, the relationship between IABPD and cognitive impairment among elderly individuals in rural China remains unclear. This study aims to investigate the association between IABPD and cognitive impairment in rural older adults in Guizhou, southwestern China.

Prenatal Exposure To Valproic Acid Induces Increased Autism-Like Behaviors and Impairment of Learning and Memory Functions in Rat Offspring by Upregulating ADAM10 Expression.

Autism spectrum disorder (ASD) involves a complex neurodevelopmental pathogenesis. A disintegrin and metalloproteinase 10 (ADAM10) plays a crucial role in embryonic brain development and neural network stability. This study aimed to investigate the influence of ADAM10 on excitation/inhibition (E/I) balance, autism-like behaviors, and learning and memory dysfunction in rats prenatally exposed to valproic acid (VPA) and determine potential intervention strategies.

Association of urinary misfolded protein quantification with preeclampsia and adverse pregnancy outcomes: a retrospective case study.

Objectives: This study aimed to explore the relationship between the detection of misfolded proteins in urine and preeclampsia (PE) as well as adverse pregnancy outcomes.

Methods: A retrospective analysis was conducted on 400 pregnant women who underwent prenatal care at our hospital from January 2022 to May 2023. Demographic and clinical data were collected.

Integrated review of : From phylogenetic research to wheat breeding application.

Enhancing wheat yield and stress tolerance is a critical long-term objective for global food security. Historically, breeders selected genetic traits from wild wheat relatives for domesticated targets, such as non-shattering and free threshing characteristics, and developed the cultivated wheat. However, the genetic diversity of the cultivated wheat has become narrow after long-term domestication and conscious selection, which seriously limited the yield potential and stress tolerance.

Decoupling Responses of Phyllosphere and Rhizosphere Bacterial Communities to Spatiotemporal Environmental Changes.

Understanding and predicting how plant-associated microbes respond to environmental changes is of key importance to understanding future plant performance. Yet, how aboveground and belowground plant-associated microbial communities, which may interactively affect plant performance, simultaneously respond to environmental changes, remains unknown. To fill this gap, we monitored temporal changes of phyllosphere and rhizosphere bacterial communities of three perennial species at 18 sites spanning a 1500 m elevational gradient.

Functional analyses of the salivary protein SaE23 in Sitobion avenae.

To counteract host plant defenses, aphids secrete salivary effectors during feeding. Exact functional roles of many salivary effectors in Sitobion avenae (Fabricius), are still elusive. Here, we cloned a salivary glutathione peroxidase (GPx) coding gene (i.

Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis.

Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting disease characterized by chronic inflammation in the gastrointestinal tract. The exact etiology and pathogenesis of IBD remain elusive. Although ELF-1 has been known to be highly expressed in epithelial cells for past twenty years, little is known about its function in epithelial cells and epithelial-related IBD.

Utilizing Hybrid Mask and Upsampling Attention Gate for Multiple Immunohistochemistry Image Cell Recognition.

Multi-immunohistochemistry (mIHC) is a crucial technique for simultaneous detection of multiple cellular phenotypes within a single tissue section. Its application in cancer diagnosis and treatment underscores the importance of developing reliable automated cell detection and classification methods for mIHC images. However, existing approaches face significant challenges due to high cell density, heterogeneity, and the laborious nature of annotation.

Extracts of and relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress.

Solar dermatitis, a condition triggered by excessive exposure to ultraviolet B (UVB) radiation, results in inflammatory skin damage marked by erythema, edema, and epidermal injury. Portulaca oleracea (PO) and Patrinia scabiosaefolia (PS) have been traditionally used in dermatological treatments, though their mechanistic pathways in UVB-induced skin injury are not fully understood. In this study, a mouse model of UVB-induced solar dermatitis was employed to evaluate the therapeutic potential of combined PO and PS (POPS) extracts.

Current Knowledge on Craniodental Anatomy and Dental Pathology in Golden Snub-Nosed Monkeys (Rhinopithecus roxellana): A Comparative Review.

The Sichuan golden snub-nosed monkey (Rhinopithecus roxellana) is a rare and endangered species endemic to China that occupies a particularly important position in the evolutionary history of Rhinopithecus species. Oral health is a crucial aspect of overall well-being in both humans and nonhuman primates. We review the current limited literature on the dental characteristics and dental pathologies related to the golden snub-nosed monkey, based on skeleton data and morphological evidence.

Boron-Doped Molecular Carbons Bearing a Formal Boron-Inserted Pentalene: Synthesis, Electronic Structures and Properties.

Two boron-doped molecular carbons (BMCs), featuring one formal boron-inserted pentalene (BP) embedded into the CB or CB polycyclic π-skeleton, were successfully synthesized. Despite their small-size conjugated structures, both of them exhibit unusual broad light absorption, narrow energy gaps, and electron-accepting ability, as well as local antiaromaticity with pseudo 4π electrons. As disclosed, these intriguing physical properties are significantly contributed by the boron atom and pentagonal ring in the BP substructure, thus demonstrating the importance of such BP incorporation into polycyclic π-systems.

Sources of perceived social support and cognitive function among older adults: a longitudinal study in rural China.

Background: Studies have shown the positive impact of perceived social support on cognitive function among older adults in rural areas. However, existing studies often overlook the impact of different support sources. This study aimed to explore the relationship between the diverse sources of perceived social support and cognitive function.

Distribution characteristics of stress on the vertebrae following different ranges of excision during Modified Anterior Cervical Discectomy and Fusion: A correlation study based on finite element analysis.

Background: Modified Anterior Cervical Discectomy and Fusion with specific resection ranges is an effective surgical method for the treatment of focal ossification of the posterior longitudinal ligament (OPLL). Herein, we compare and analyse the static stress area distribution by performing different cuts on an original ideal finite element model.

Method: A total of 96 groups of finite element models of the C4-C6 cervical spine with different vertebral segmentation ranges (width: 1-12 mm, height: 1-8 mm) were established.