Exploring the potential association and experimental validation of disrupted circadian rhythms with polycystic ovary syndrome via meta-analysis and bioinformatics: a possible pathogenic mechanism.

Background: Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of this connection remains unclear. The aim of this study was to explore further links between circadian rhythm and PCOS and to identify potential mediators of the pathogenesis of PCOS.

Assessing the transfer of Cd and As from co-contaminated soil to peanut (Arachis hypogaea L.): prediction models and soil thresholds.

In China, the co-contamination of soil with cadmium (Cd) and arsenic (As) is one of the most severe forms of combined pollution. Modeling the transfer of Cd and As from co-contaminated soil to crops has not been thoroughly studied. In this study, five soils with significant differences in physicochemical properties were selected to simulate the compound pollution conditions by exogenously adding Cd and As, and the bioaccumulation and translocation behaviors of these two elements were thoroughly investigated.

AI in fungal drug development: opportunities, challenges, and future outlook.

The application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal infections and the challenge of antifungal resistance. This review evaluates the current landscape of fungal infections, highlights the limitations of existing antifungal therapies, and examines the transformative potential of AI in drug discovery and development. We specifically focus on how AI can enhance the identification of new antifungal agents and improve therapeutic strategies.

Elucidating the mechanisms of environmental pollutant BPA inducing neurotoxicity through metabolomics and network toxicology strategy.

Bisphenol A (BPA), a ubiquitous chemical compound in plastics and resins, is a pervasive environmental pollutant posing significant health risks to humans and animals. Despite evidence linking BPA exposure to neuronal damage and cognitive impairments, its underlying mechanisms and core targets remain poorly understood. Therefore, this study employed an integrated metabolomics and network toxicology strategy to elucidate the neurotoxic mechanisms of BPA.

Bioceramics-enhanced patch activates epicardial epithelial-to-mesenchymal transition via Notch pathway for cardiac repair.

Engineered cardiac patches (ECPs) introduced functional factors that offer a promising strategy for the treatment of myocardial infarction (MI). Silicate bioceramics have received widespread attention because of their great potential in the tissue repair field. Inspired by the biological functions of inorganic ions on the cardiovascular system, we prepared an ECP containing lithium magnesium silicon bioceramics (LMS) particles.

RABEP1 amplifies front signaling in neutrophil migration.

Neutrophils are the first responders of our innate immune system, crucial for defense against various infections. The intricate regulation of neutrophil migration is essential for neutrophil function. However, a complete mechanistic understanding is missing.

Bu-zhong-yi-qi decoction regulates JNK/c-JUN signaling pathway to improve skeletal muscle atrophy caused by cancer cachexia.

Ethnopharmacological Relevance: With a prevalence reaching 80 % in terminal cancer patients, cancer cachexia (CC) manifests as irreversible skeletal muscle wasting. Presently, there exists no effective therapeutic strategy for managing cancer cachexia. Traditional Chinese medicine (TCM) contributes significantly to the management of CC, enhancing quality of life and potentially prolonging survival in affected patients.

Optimizing Ionic Transport through a Bilayer Nanoporous Graphene by Tuning the Direction of Electric Fields.

Nanoporous graphene (NPG) serves as an excellent platform for ionic transport, enabling wide applications, from desalination to energy harvesting. However, the misalignment of pores in multilayer graphene will obviously impede ionic transport, which is unconducive to practical applications. With the hope of improving ionic transport through misaligned NPGs, in this work, a series of molecular dynamics simulations are employed to investigate ion and water transport across a bilayer NPG with different pore offset distances and functionalization, particularly focusing on the electric field direction.

Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis: A Randomized Clinical Trial.

Importance: A recent study reported that methotrexate may reduce joint pain in patients with inflammatory hand osteoarthritis (OA). However, it remains unknown whether methotrexate has similar effects on inflammatory knee OA.

Objective: To examine whether methotrexate has symptom-relieving and disease-modifying effects for participants with knee OA and effusion-synovitis.

Antimicrobial Activity of Nitric Oxide Delivery Nanoparticles for Lipopolysaccharides-Deficient Gram-Negative Bacteria.

The rapid emergence of antimicrobial resistant Gram-negative bacteria compromises current antibiotic efficacy, including the last-resort antibiotic polymyxins, emphasizing the urgent need for novel therapeutic strategies. Nanoscale-based antimicrobials exhibit potential as an alternative treatment strategy. In this study, four furoxan-based nitric oxide (NO)-releasing nanoparticles (NPs) were prepared and their antimicrobial efficacy was tested against different Gram-negative bacteria, including: , , , and via minimum inhibitory testing, where NPs exhibited selective activity against lipopolysaccharide (LPS)-deficient strains and LPS-truncated strains tested.

Hypoxia-sensitive macrocycle inclusion complexes for targeted protein degradation.

PROteolysis TArgeting Chimeras (PROTACs) have gained significant attention for targeted protein degradation in cancer therapy. However, their clinical application is limited by low bioavailability, poor tumor distribution, and potential off-target effects. This study presents NaC4A-PROTACs, a hypoxia-responsive host-guest drug delivery system where azo-modified calixarene derivative (Naph-SAC4A) acts as the host molecule, encapsulating PROTAC molecules as the guest.

Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice.

Introduction: Maternal immune activation (MIA) impairs gut immune function in offspring, with maternal microbiota and their metabolites influencing intestinal development. Indole-3-propionic acid (IPA), a microbial metabolite derived from tryptophan, promotes gut health by enhancing epithelial proliferation. However, the impact of prenatal IPA supplementation on offspring gut outcomes remains unclear.

Exposure to benzotriazole UV stabilizer-329 at environmental concentrations induces neurotoxicity by affecting neurotransmission in Caenorhabditis elegans.

Benzotriazole UV stabilizer-329 (UV-329), a novel stabilizer used in polymers, has been detected in various environmental matrices and organisms, where it exerts toxic effects. However, the neurotoxic effects and underlying mechanisms of UV-329 remain largely unexplored. In this study, Caenorhabditis elegans was used as a model organism to investigate the neurotoxicity of UV-329 at environmental concentrations (0.

Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication.

Viral replication is an energy-intensive process that often induces energy stress in host cells, and efficient mobilization of host cell energy resources facilitates optimal viral replication. The mechanisms by which Newcastle disease virus (NDV) regulates the host energy metabolism to facilitate its replication remain incompletely understood. For this purpose, transcriptomic analysis was conducted to delineate the transcriptional changes during NDV infection.

Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment.

Infective endocarditis, a life-threatening condition, poses challenges for early diagnosis and personalized treatment due to insufficient biomarkers and limited understanding of its pathophysiology. Here, we performed proteomic profiling of plasma and vegetation samples from 238 patients with infective endocarditis and 100 controls, with validation in two external plasma cohorts (n = 328). We developed machine learning-based diagnostic and prognostic models for infective endocarditis, with area under the curve values of 0.

The Epigenetic Reader PHF23 Is Required for Embryonic Neurogenesis.

Epigenetic mechanisms are crucial in the tightly regulated process of neurogenesis from radial glial cells (RGCs) to intermediate progenitor cells (IPCs) to neurons during embryonic brain development. Plant homeodomain (PHD) finger proteins as important epigenetic readers are implicated in development and diseases, yet their roles in embryonic neurogenesis remain largely unexplored. In this study, we found different PHD finger proteins are differentially expressed along the neurogenesis trajectory.

Advances in improving the efficacy of anti-PD-1/PD-L1 therapy in intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer following hepatocellular carcinoma (HCC), characterized by high malignancy and limited therapeutic options. For the majority of patients with advanced or recurrent ICC who are not candidates for surgical resection, non-surgical treatments have become the primary intervention. In recent years, immunotherapy, particularly immune checkpoint inhibitors (ICIs) either alone or in combination, has emerged as a promising systemic treatment for ICC.

Self-assembly of DNA tetrahedral multifunctionalized nanomaterial and its application in N-glycoproteins ultra-fast analysis in human serum.

Abnormal proteins glycosylation is associated with kinds of diseases. A thorough investigation of protein glycosylation can provide valuable insights into the mechanisms underlying disease development. In this work, DNA tetrahedral (DNA TET) functionalized hydrophilic magnetic nanosphere (FeO@PDA@AuNPs@DNA TET-Trypsin) was proposed for in-deep glycoprotein analysis.

Assessing the impacts of inter-basin water transfer projects on ecosystem services in water source areas: Evidence from the Hanjiang River Basin.

Inter-basin water transfer projects (IBWT) are a key strategy for alleviating regional water shortages. However, studies on the long-term effects of such projects on ecosystem services (ESs) in water source areas, as well as their spatiotemporal evolution, remain insufficient. In particular, the specific impacts of the entire project lifecycle (project initiation, dam heightening, project operation, and ecological restoration) on ESs need further exploration.

Age-related disparities in treatment and outcomes for newly diagnosed multiple myeloma: a population-based study.

Not available.

Integrated clinical and proteomic-based model for diagnostic and prognostic prediction in pRCC.

Papillary renal cell carcinoma (pRCC), a main pathological subtype of non-clear cell RCC (nccRCC), has strong heterogeneity. Comparing to other nccRCC subtypes, advanced pRCC has the poorest prognosis. Due to its lower incidence compared to ccRCC, clinical research and exploration of non-invasive biomarkers for pRCC are limited, and it is often misclassified.

Elastic circular organic microcrystals prepared by photoinduced delamination.

Circular organic crystals are essential as optically transducive components in flexible organic optoelectronics, yet this crystal habit is not easily obtained through traditional crystallization approaches. Here, we present a photoresponsive organic crystalline material that when exposed to ultraviolet or visible light, initially undergoes photoinduced bending, followed by photosalient effect and accompanied by delamination to elastic quasicircular microcrystals. Curvature analysis under different conditions confirms the controllability of this process.

FOXM1 Promotes Non-Small Cell Lung Cancer Progression by Increasing CHEK1 Expression.

Objective: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-associated mortality. This study aimed to investigate the role of checkpoint kinase 1 (CHEK1) in NSCLC progression and its regulatory relationship with forkhead box protein M1 (FOXM1).

Methods: Transwell assays were used to evaluate the migration and invasion capabilities of NSCLC cells with either CHEK1 overexpression or knockdown.

Multitrophic and Multidimensional Insights into Biodiversity and Functional Trait Responses to Precipitation Changes in Alpine Grasslands.

Biodiversity and functional traits are increasingly recognized as pivotal factors in regulating ecosystem functioning and stability. However, the patterns and processes of multidimensional biodiversity and functional traits along environmental gradients remain insufficiently understood. In this study, we examined taxonomic, phylogenetic, and functional diversity across multiple trophic levels in 38 alpine grassland sites along a precipitation gradient on the Qinghai-Tibet Plateau.