Optimizing tDCS parameters for post-stroke upper limb recovery: a systematic review and meta-analysis protocol.

Background: Stroke is a leading cause of death and disability globally, with significant impairments in upper limb motor function affecting the quality of life of survivors. Despite the potential of transcranial direct current stimulation (tDCS) as a noninvasive neuromodulation technique for enhancing post-stroke recovery, current findings regarding its efficacy and optimal parameters remain heterogeneous and controversial. The purpose of this study is to systematically evaluate the effects of different tDCS parameters on upper limb motor impairments in stroke patients and provide guidance for selecting optimal stimulation parameters via a meta-analysis of available literature.

Global Pediatric Epilepsy Burden: Analysis of the Global Burden of Disease Database (1990-2021) With Projections to 2035.

Background: To examine the trends in epilepsy prevalence, incidence, mortality, and disability-adjusted life years (DALYs) among children aged 0-14 years from 1990 to 2021, and projected the epidemiological patterns for the next decade to 2035.

Methods: Employing standardized Global Burden of Disease approaches, our study evaluated the burden of pediatric epilepsy in 204 countries and regions from 1990 to 2021. Our objective was to provide a comprehensive assessment of the health impact of pediatric epilepsy by incorporating four critical epidemiological indicators-prevalence, incidence, mortality, and DALYs-including their trends and projecting them for the next decade.

METTL3 promotes peritoneal metastasis of colorectal cancer through regulating m6A modification of NRXN3 mRNA.

Colorectal cancer (CRC) is a prevalent digestive system malignancy accompanied by peritoneal metastasis occurring in 7% of cases. Methyltransferase-like 3 (METTL3) promoted the progression of CRC whereas its function in peritoneal metastasis was incompletely understood. Here, we found that METTL3 was upregulated in peritoneal metastasis tissues of CRC patients compared with CRC tissues.

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thrombotic complications, but it concurrently amplifies the risk of bleeding. Unfortunately, traditional platelet function measurement methods cannot directly evaluate its efficacy and safety.

A population-based analysis of the global burden of epilepsy across all age groups (1990-2021): utilizing the Global Burden of Disease 2021 data.

Objective: To investigate the trends in epilepsy prevalence, incidence, mortality, and disability-adjusted life-years (DALYs) in all ages, with risk factors for epilepsy - associated death, from 1990 to 2021.

Methods: Using the standardized Global Burden of Disease (GBD) methodologies, we evaluated the burden of epilepsy in 204 countries and regions from 1990 to 2021, aiming to derive a more precise representation of the health burden posed by epilepsy by considering four distinct types of epidemiological data, namely the prevalence, incidence, mortality, and DALYs. The presented data were meticulously estimated and displayed both as numerical counts and as age-standardized rates per 100,000 persons of the population.

Rehabilitation Applications Based on Behavioral Therapy for People With Knee Osteoarthritis: Systematic Review.

Background: The development of digital applications based on behavioral therapies to support patients with knee osteoarthritis (KOA) has attracted increasing attention in the field of rehabilitation. This paper presents a systematic review of research on digital applications based on behavioral therapies for people with KOA.

Objective: This review aims to describe the characteristics of relevant digital applications, with a special focus on the current state of behavioral therapies, digital interaction technologies, and user participation in design.

The Effect of a Reminiscence Therapy-Based Hybrid Board Game on Anxiety and Loneliness Levels in Older Adults: An Experimental Study.

Anxiety and loneliness are prevalent psychological issues faced by older adults. To tackle these concerns, group reminiscence therapy has been widely recognized as an effective non-pharmacological form of intervention. Despite its proven efficacy, the implementation of this therapy normally requires professional guidance, limiting its accessibility to specialized institutions such as hospitals.

Neuronal sensorimotor integration guiding salt concentration navigation in .

Animals navigate their environment by manipulating their movements and adjusting their trajectory which requires a sophisticated integration of sensory data with their current motor status. Here, we utilize the nematode to explore the neural mechanisms of processing the sensory and motor information for navigation. We developed a microfluidic device which allows animals to freely move their heads while receiving temporal NaCl stimuli.

Investigation on the Effectiveness of Augmented Reality Memory Training Game for Chinese Older Adults: A Randomized Controlled Trial.

To evaluate the effectiveness of augmented reality (AR) game based on -back training paradigm as a training tool for working memory (WM) of Chinese healthy older adults. One hundred eighteen older adults self-assessed as healthy were included in this study. Individuals were randomly divided into an intervention group ( = 57) and a control group ( = 61).

A colorimetric chemosensor for sensitive and selective detection of copper(II) ions based on catalytic oxidation of 1-naphthylamine.

Rapid on-site detection of copper(II) ions (Cu) with high sensitivity and selectivity is of great significance in the safety monitoring of drinking water and food. Colorimetric detection is a robust fast determination method with the main drawback of low sensitivity. Herein, we developed a colorimetric chemosensor based on a colored polymer product.

Modulation of plasmonic chiral shell growth on gold nanorods nonchiral surfactants.

Recently, in combination with seed-mediated growth, thiolated chiral molecule-guided growth has shown great promise in obtaining chiral plasmonic nanostructures. Previously, with the assistance of chiral cysteines (Cys), we realized helical growth of plasmonic shells on gold nanorod (AuNR) seeds dispersed in cetyltrimethylammonium bromide (CTAB) solution. Herein, we further studied the roles of non-chiral cationic surfactants in tuning the helical growth.

Effect of Exergame Intervention on Balance Ability of Adolescents: A Randomized Controlled Trial.

Balance is a strong indicator of physical development of adolescents, and there is a trend of employing exergame for balance training. However, the effectiveness of exergame specifically designed for balance training on adolescents' balance abilities in various postures remains unclear. In this study, an exergame for balance training was developed with Kinect and a randomized controlled trial was conducted to assess its effect on balance ability development.

Real-time intelligent classification of COVID-19 and thrombosis via massive image-based analysis of platelet aggregates.

Microvascular thrombosis is a typical symptom of COVID-19 and shows similarities to thrombosis. Using a microfluidic imaging flow cytometer, we measured the blood of 181 COVID-19 samples and 101 non-COVID-19 thrombosis samples, resulting in a total of 6.3 million bright-field images.

Gold-Nanoparticle-Based Chiral Plasmonic Nanostructures and Their Biomedical Applications.

As chiral antennas, plasmonic nanoparticles (NPs) can enhance chiral responses of chiral materials by forming hybrid structures and improving their own chirality preference as well. Chirality-dependent properties of plasmonic NPs broaden application potentials of chiral nanostructures in the biomedical field. Herein, we review the wet-chemical synthesis and self-assembly fabrication of gold-NP-based chiral nanostructures.

GRID2 aberration leads to disturbance in neuroactive ligand-receptor interactions via changes to the species richness and composition of gut microbes.

Objective: To explore the association between phenotype and the gut microbiome following damage to the GRID2 gene.

Methods: Ten wild-type (WT) mice and 11 GRID2 knockout heterozygous mice (GRID2(±)) of a similar age and weight were randomly selected. Fresh feces were collected from both groups of mice under specified pathogen-free (SPF) conditions.

Effects of magnesium valproate adjuvant therapy on patients with dementia: A systematic review and meta-analysis.

Background: Current research has found contradictory results on the treatment of magnesium valproate (VPM) in patients with dementia (PwD).

Objectives: Here, we conducted a meta-analysis to evaluate the efficacy and safety of VPM in the adjuvant treatment of PwD.

Purpose: Current research has found contradictory results on the treatment of VPM in PwD.

Transforming waste into value: pomelo-peel-based nitrogen-doped carbon dots for the highly selective detection of tetracycline.

Tetracycline (TC) is widely used as a veterinary drug, and its residue in livestock products could enter the human body and cause damage. In this study, we developed an eco-friendly approach that utilized pomelo peel as a carbon source to synthesize new water-soluble N-doped carbon dots (P-NCDs) with blue fluorescence, obtaining a high quantum yield of up to 76.47% and achieving the goal of turning waste into value.

Improving peroxidase activity of gold nanorod nanozymes by dragging substrates to the catalysis sites via cysteine modification.

Surface chemistry control is a key means to improve substrate selectivity and enhance catalytic activity of nanozymes, a kind of novel artificial enzymes. Herein, we demonstrated that apart from chemical properties of functional groups, their spatial distance to the catalytic sites is also very important to improve the catalytic performance of nanozymes. Using cetyltrimethylammonium bromide (CTAB) coated gold nanorods (AuNR) as the example, we showed that cysteine (Cys) surface modification can greatly enhance the peroxidase activity of AuNR for the oxidation of substrate 3,3',5,5'-tetramethylbenzidine (TMB).

Constructing chiral gold nanorod oligomers using a spatially separated sergeants-and-soldiers effect.

A sergeants-and-soldiers (S&S) effect is very useful to the fabrication of supramolecular chirality. This strategy has not yet been explored in the construction of chiral plasmonic superstructures. Herein, we demonstrate a spatially separated S&S effect in fabricating plasmonic superstructures and modulating their chiroptical responses.

Effect of intensive self-management education on seizure frequency and quality of life in epilepsy patients with prodromes or precipitating factors.

Purpose: To explore the impact of an intensive self-management education strategy on seizure frequency and quality of life in patients with epileptic seizures with prodromes or precipitating factors. The intensive self-management education included monthly education sessions on prodromes and precipitating factors aiming to help patients to adopt self-management strategies.

Methods: Adult patients with epilepsy (PWE) able to identify prodromes or precipitating factors of their seizures were randomly assigned to an intensive education group (IEG) (n = 45) or a regular education group(REG) (n = 47).

A phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in southern Chinese men.

Background: Phenomics provides new technologies and platforms as a systematic phenome-genome approach. However, few studies have reported on the systematic mining of shared genetics among clinical biochemical indices based on phenomics methods, especially in China. This study aimed to apply phenomics to systematically explore shared genetics among 29 biochemical indices based on the Fangchenggang Area Male Health and Examination Survey cohort.

Development and validation of the Chinese Version of the Adult Epilepsy Self-Management Scale (C-ESMS) in Western China.

Purpose: To develop and validate the Epilepsy Self-Management Scale (ESMS) for Chinese persons with epilepsy (PWE).

Methods: On the basis of ESMS, the standard translation procedure was used to set up the Chinese version of the ESMS (C-ESMS). A consecutive cohort of PWE admitted in Sichuan Provincial People's Hospital were recruited randomly from May 2017 to December 2017 and required to complete the C-ESMS.