Association between Cognitive Function and Spatial-Temporal Measures of Gait and Balance when Navigating a Virtual Reality Floor Maze.

Spatial navigation has been used as a behavioral marker of cognitive impairments. Floor Maze Tests (FMT) are used to characterize navigation where subjects physically move through a two-dimensional maze drawn on the floor. A Virtual Reality version of FMT (VR-FMT) has been developed, which provides a 3-dimensional navigation environment where the height of the maze walls can be altered.

A highly efficient ultra-broadband and wide-angle plasmon absorber based on nanocavity arrays for solar harvesting.

As the demand for renewable energy continues to rise, developing efficient solar energy harvesting technologies has become increasingly important. In this paper, we propose a plasmon absorber utilizing nanocavity arrays to achieve ultra-broadband absorption of solar energy. The results show that the absorber achieves an average absorption rate of 95.

Epidermal Growth Factor Receptor Activation Stimulates SOX9 Expression in Injured Renal Proximal Tubule Epithelial Cells.

Background: In surviving renal proximal tubule cells (RPTCs) following acute kidney injury (AKI), the induction of SOX9 expression plays a crucial role in promoting kidney repair. However, persistent upregulation of SOX9 in RPTCs contributes to the development of chronic kidney disease (CKD). The molecular mechanisms underlying SOX9 induction in response to kidney injury are not completely understood.

Diversity-oriented optimization of 1,2,4-oxadiazole pharmacophore for the discovery of nematicides.

Plant-parasitic nematodes are primary pathogen that cause global crop yield losses, the economic cost to global agriculture is $157 billion a year. With the prohibition of highly toxic chemical nematicides, there are few nematicides available for prevention and control of nematodes. Tioxazafen (3-phenyl-5-thiophen-2-yl-1,2,4-oxadiazole) is a new broad-spectrum nematicide with good control effects against various nematodes.

Targeting the akt/mtor signaling pathway by maprotiline leads to tumor suppression in T-cell lymphoma.

T-cell lymphoma (TCL) is a prevalent malignancy characterized by the aberrant proliferation of T cells. The molecular mechanism underlying TCL remains poorly understood, and effective therapeutic strategies are still limited. Maprotiline, a highly selective norepinephrine reuptake blocker, is primarily used in the treatment of various types of depression.

Ocular surface homeostasis instability in acoustic neuroma: corneal nerve density reduction and blink reflex abnormalities.

Purpose: To assess the condition of the ocular surface and electrophysiology in patients diagnosed with acoustic neuroma.

Methods: For this prospective case-control observational study, twenty-nine patients diagnosed with acoustic neuroma and eleven healthy individuals were included. All participants underwent a comprehensive ophthalmic assessment, including assessment of corneal sensitivity, morphologic examination of cornea nerves using in vivo confocal microscopy (IVCM), and electrophysiology evaluation.

Penetrating Triple-Layer Involvement: Scalp, Skull, and Dura Mater By Follicular Lymphoma -An Unusual Presentation Mimicking Traumatic Meningioma.

The authors report an exceptionally rare case of follicular lymphoma (FL) with simultaneous penetration through the scalp, skull, and dura mater in a 31-year-old female presenting with a progressive scalp mass and a left frontal lesion. Initially misdiagnosed as a traumatic meningioma based on history and imaging (showing a dural-based mass with "dural tail sign" and subgaleal fluid), surgical resection revealed FL with atypical features: BCL2 negativity (suggesting potential aggressiveness), high Ki67 (50%), and diffuse growth invading the dura. This case underscores the importance of including lymphoma, even indolent FL, in the differential diagnosis of lesions spanning scalp, bone, and meninges, especially with atypical features or trauma history.

Machine Learning Guided Assembly of a Nested Gd@Gd @Ni Cluster via Urea Controlled Carbonate Release.

Lanthanide-based polyhedral clusters are of great interest due to their unique geometries and functional properties, but their controlled synthesis remains a major challenge. Here, we report a nested three-shell cluster, [GdNi(MeIDA)(OH)(CO) (HO)]·(ClO)·(HO) (GdNi, HMeIDA = N-Methyliminodiacetic acid), achieved by using urea as a slow-release carbonate source to direct the formation of a dodecahedral inner shell. Single-crystal X-ray diffraction reveals a unique Gd@Gd@Ni arrangement, with the innermost Gd forming a Platonic dodecahedron templated by carbonate.

Patients with small fiber neuropathy exhibit more pronounced non-motor symptoms in Parkinson's disease.

BackgroundPeripheral neuropathy in Parkinson's disease (PD) may not be an isolated pathological phenomenon but may interact with other non-motor symptoms.ObjectiveTo conduct a comprehensive investigation of the non-motor symptoms observed in PD patients, with a comparative analysis between patients with and without peripheral neuropathy, to explore the relationships between peripheral neuropathy and non-motor symptoms.Methods100 PD patients were recruited from the Neurology Department of Guangdong Provincial People's Hospital.

Integrated Photoelectrochemical-Fluorescence Dual-Mode Aptasensor for Sensitive Detection of Fumonisin B1.

Long-term intake of fumonisin B1 (FB1) can pose a threat to human health. It is essential to develop an accurate and sensitive method to detect FB1. In this work, a photoelectrochemical-fluorescence (PEC-FL) dual-mode aptamer sensing platform was proposed for FB1 analysis.

Predicting the Risk of Deep Venous Thrombosis in Elderly Patients: A Comparative Analysis of Seven Machine Learning Models.

Deep venous thrombosis (DVT) is a leading cause of cardiovascular-related mortality, with an increasing incidence in elderly patients. However, existing risk assessment tools remain limited for this population. This study aimed to develop and validate machine learning (ML)-based models for predicting DVT risk in elderly patients.

Stretchable Photonic Crystal-Enhanced ECL for Sweat Neurotransmitter Detection.

Depression is linked to dysregulated neurotransmitter levels, making efficient and facile monitoring crucial for early diagnosis and improved treatment outcomes. However, rigid electrodes or unstable luminescence on flexible substrates have limited the adoption of electrochemiluminescence (ECL) in flexible health-monitoring platforms. Herein, we introduce a stretchable conductive photonic-crystal hydrogel (PCH) as an ECL electrode for sweat-based neurotransmitter detection.

Visible-light photoredox catalysis for vinyl sulfone construction sulfoxonium ylide alkynylation.

Herein, a visible-light-driven synthesis of 1,4-dicarbonyl vinyl sulfones sulfoxonium ylide homocoupling forming CC bonds, followed by sulfonyl hydrazide alkenylation is disclosed. Mechanistic studies support a sequential single-electron transfer (SET) and radical addition pathway. The method offers a sustainable alternative to conventional alkyne functionalization strategies.

ABCC3 mediates insecticide metabolism and functions as a receptor for Bt toxins in Plutella xylostella.

Plutella xylostella is a major global pest with increasing resistance to insecticides. ATP-binding cassette (ABC) transporters are implicated in the metabolism of insecticides, but their molecular mechanisms remain poorly understood. Here, we identified and characterized the role of P.

Selective Toluene Separation via π-π Interactions in Cobalt sql Network Rubber Composites.

Selective removal of aromatic contaminants from water matrices poses substantial difficulties in environmental remediation processes, necessitating sophisticated materials with discriminatory molecular recognition properties. Herein, we report a framework-elastomer hybrid membrane containing [Co(4-pmntd)(NO)] (4-pmntd represents ,'-bis(4-pyridylmethyl)naphthalene diimide) designed for effective toluene recovery from trace aqueous environments. Systematic structural analysis employing crystallographic diffraction, gas adsorption measurements, surface electron spectroscopy, and proton nuclear magnetic resonance elucidates the material's architectural characteristics and surface phenomena.

MicroRNAs for Diabetes Management: From Natural Bioactive Compounds to Nucleotide Networks.

MicroRNAs (miRNAs) have emerged as critical regulators in the pathogenesis of diabetes mellitus (DM) and its associated complications via orchestrating key cellular processes. Natural bioactive components such as flavonoids, polysaccharides, saponins, alkaloids, terpenoids, as well as anthraquinones derived from berries, herbs, vegetables, and fishes have been extensively demonstrated to treat or prevent DM and related complications through targeting miRNAs-mediated signaling pathways. Mechanistically, these compounds treat/prevent DM and its complications principally by modulating processes including glucose homeostasis, inflammatory response, oxidative stress, apoptosis, and autophagy, neovascularization, and fibrosis.

A New Phase Indium Tin Oxide (ITO) Activated Selective CO Reduction into Formate for Underwater Antifouling Glass.

Designing unique electrocatalysts that utilizes carbon dioxide reduction reaction (CORR) for real applications is highly appreciated, yet still suffers from low selectivity, stability, and compatibility. Herein, we first report a new two-dimensional metastable-phase transparent conducting oxide: 1T phase indium tin oxide (m-ITOs) with the space group of P-3m1 (164), which is totally different from that of the stable cubic phase ITO (Ia-3 (206)). The internal indium tin catalytic pairs in m-ITOs trigger the strong electronic coupling, move up the p-band center, and stabilize the adsorption of HCOO* for increased formate production.

The Role of the Complement C3-Hippocampus Pathway in Relation With Mood Symptoms in Offspring of Parents With Bipolar Disorder.

Objective: Accumulative research indicates key roles of the peripheral inflammation system and hippocampal function in major mood disorders. The complement system modulates inflammatory function and is abnormal in mood disorders, but its precise neural pathway remains unclear. This study investigates the interrelations among complement component 3 (C3) levels, hippocampal function, and mood symptoms among offspring of bipolar disorder (BD) parents who carry familial risk of mood disorders.

Interpretable Machine Learning Models for Predicting Malignant Ventricular Arrhythmia in Patients with Acute ST-Segment Elevation Myocardial Infarction Based on Systemic Inflammation Index.

BackgroundPercutaneous coronary intervention (PCI) improves outcomes in ST-segment elevation myocardial infarction (STEMI) by restoring myocardial perfusion. However, post-procedural malignant ventricular arrhythmias (MVA), as a serious complication, can cause hemodynamics instability and lead to in-hospital sudden cardiac death. Systemic inflammation indices serve as reliable biomarkers of inflammatory status and may predict arrhythmia risk.

The impact of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) on the development of prediabetes in middle-aged and older Chinese adults: a national cohort study.

Background: Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has demonstrated significant clinical application potential in the evaluation of vascular-related diseases. Our objective was to explore the impact of NHHR on the progression from prediabetes to diabetes or the regression to normal fasting glucose (NFG).

Method: This study utilized data from the first and third waves of the China Health and Retirement Longitudinal Study, involving 2922 participants.

Encapsulating peritoneal sclerosis outcomes: a retrospective study on the significance of nutritional parameter variations.

Background: Encapsulating peritoneal sclerosis (EPS) can result in abdominal organ encasement, and bowel obstruction, and is associated with a high mortality rate. While various risk factors have been identified for the development of EPS, the factors influencing patient outcomes in EPS are less well-studied. This study aims to investigate the prognostic factors that affect the clinical course and survival of EPS patients.

Reading ability in children with intermittent exotropia and its association with binocular visual function and visual information processing capability.

Purpose: To evaluate children's reading performance with intermittent exotropia (IXT) and investigate possible associations among reading abnormalities, binocular visual function, and visual information processing.

Methods: This cross-sectional, case-control study involved 61 children with basic-type IXT and 40 healthy controls aged 7 to 13. Reading performance was assessed objectively using the Development Eye Movement (DEM) test and subjectively with the Dyslexia Checklist for Chinese Children (DCCC).

Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats.

Unlabelled: Doxorubicin (DOX)-induced cardiotoxicity is the most prevalent adverse reaction of DOX during chemotherapy and significantly impacts its clinical application. At present, clinical interventions for mitigating DOX-induced cardiotoxicity remain sub-optimal. Mitochondria are the primary target organ of DOX-induced cardiotoxicity, which can result in cardiac mitochondrial dynamic imbalance and impaired mitochondrial autophagy.

Comprehensive analysis of MAGE-A10 in pan-cancer and its validation in gastric cancer.

Previous studies found that melanoma antigen genes (MAGE) were antigens expressed in various tumor cells but hardly expressed in normal tissues, and their unique expression pattern made them highly promising for cancer immunotherapy. MAGE-A10 was a member of the MAGE family, and although it was expressed in various tumors, its specific function remained unclear. In this study, we conducted a comprehensive pan-cancer analysis of MAGE-A10 expression, prognostic value, DNA methylation, genetic variation, function, immune infiltration, and drug sensitivity using multiple public databases.

Bioinformatic analyses and validated experiments reveal an aging hallmark gene set and protective miR of coronary artery disease.

To investigate how aging hallmarks exert roles in the age-related disease of coronary artery disease (CAD). R software and the GEO2R online tool identified differentially expressed genes (DEGs) and differentially expressed microRNAs (DEMis) in CAD microarray datasets from the Gene Expression Omnibus. Genes common to target genes of DEMis, DEGs, and an aging gene list from Human Aging Genomic Resources were then identified and analyzed for protein-protein interactions and functional and pathway enrichment.