Circ_0049472 downregulation relieves Amyloid-β-induced neuronal injury by modulating PDE4A expression via targeting miR-22-3p in Alzheimer's disease.

Neuronal injury is a common event in the development of Alzheimer's disease (AD). Previous studies have suggested that circular RNAs (circRNAs) are involved in neuronal injury in the pathological progression of AD. However, the potential role of circ_0049472 in the AD process is still unclear.

Multi-parametric MRI diffusion models combined with clinical information for predicting Ki-67 expression in pancreatic ductal adenocarcinoma: a prospective cohort study.

Purpose: To evaluate the diagnostic value of intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) parameters combined with clinical information for predicting Ki-67 expression in pancreatic ductal adenocarcinoma (PDAC).

Methods: This prospective cohort study enrolled 65 patients with histopathologically confirmed PDAC between January 2024 and May 2025. All patients underwent 3.

Estimates of global, regional, and national incidence of Hodgkin lymphoma attributable to Human Immunodeficiency virus: A population attributable modeling study.

Hodgkin lymphoma (HL) is one of the prevalent non-acquired immunodeficiency syndrome (AIDS)-related tumors in people living with human immunodeficiency virus (PLWH). This study investigates the risk of HL among PLWH and the global incidence of HL associated with human immunodeficiency virus (HIV). A meta-analysis was conducted to examine the association between HIV infection and HL, utilizing HIV prevalence data from Joint United Nations Programme on HIV/AIDS and pooled relative risk (RR) to calculate the population attributable fraction.

Relationship between body mass index and quality of life among Malaysian young adults: Sequential mediated effects of perceived weight stigma and weight-related self-stigma.

The present cross-sectional study examined how perceived weight stigma (PWS) and weight-related self-stigma (WRSS) may sequentially mediate the relationship between body mass index (BMI) and quality of life (QoL) among Malaysian young adults. Malaysian university students ( = 1044; mean age = 21.3 years) self-reported their height/weight and completed the Weight Self-Stigma Questionnaire, Perceived Weight Stigma Scale, and World Health Organization Quality of Life-BREF.

Complete mitochondrial genome sequence of a potential novel entomopathogenic fungus, sp. GWSS32, isolated from the glassy-winged sharpshooter.

A putative entomopathogenic fungus, sp. GWSS32 was isolated from glassy-winged sharpshooter, an insect vector of the Pierce's disease bacterium . This genome resource describes the 33,494 bp mitochondrial genome of this fungus, which should allow improved overall characterization of entomopathogenic fungi for Pierce's disease management.

Antigen escape in CAR-T therapy: A tumor microenvironment perspective from hematological to solid tumors.

Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable efficacy in hematologic malignancies, but antigen escape remains a major challenge, especially in solid tumors, where the tumor microenvironment (TME) exacerbates the problem. Mechanisms of antigen escape include antigen loss, epitope masking, lineage switching, and trogocytosis-mediated CAR dysfunction. The TME promotes immune evasion through physical barriers, immunosuppressive cells, and metabolic competition.

Prediction of infusion capacity to deliver Alzheimer's disease treatments in the United States relative to expected demand.

BackgroundCapacity to deliver intravenous Alzheimer's disease (AD) treatments could constitute an obstacle to access in addition to AD specialist and PET scan capacity.ObjectiveWe aim to estimate the overall capacity for AD treatment infusions compared to expected demand in the United States.MethodsWe used published data and a survey of infusion sites to estimate the capacity to deliver AD treatments in physician offices, hospitals, standalone centers and at patients' homes from 2024 to 2033 relative to demand.

Selective Activation of Conditionally Replicating Influenza A Virus in Pulmonary Tumors for Enhanced Oncolytic Efficacy and Systemic Safety.

Influenza A virus demonstrates significant potential as an oncolytic agent. Nevertheless, being replication-competent pathogens, they may induce adverse effects in cancer patients who have compromised immune systems. Here, the results show that the 4-hydroxytamoxifen (4-HT)-dependent H1N1 influenza virus S218 can inhibit the proliferation and lung metastasis of melanoma in vivo, and 4-HT enhances the anti-tumor effect of S218 virus.

Dual-Targeting Peptide Assembly Probe for Precise Detection of Biomarkers of Circulating Tumor Cells in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) represents the predominant malignant hepatic neoplasm globally and constitutes a principal contributor to cancer-associated mortality. Contemporary diagnostic methodologies exhibit limited sensitivity for early-stage detection, while the disease's substantial metastatic propensity and recurrence rates significantly compromise survival outcomes. Circulating tumor cells (CTCs), detectable throughout disease progression and harboring crucial pathological signatures, present compelling potential as liquid biopsy biomarkers for early-stage detection and prognostic assessment.

Blood Pressure Response Index and Mortality in Patients With Cardiogenic Shock: A Multicenter Retrospective Cohort Study.

Background: The blood pressure response index (BPRI) is an easy, rapid, precise dose-effect index to reflect the cardiovascular response of patients with septic shock. However, the relationship between BPRI and clinical outcomes in patients with cardiogenic shock (CS) has not been elucidated.

Methods: We extracted the clinical data of patients with CS admitted to the ICU from the MIMIC-IV (v3.

Adsorption Mechanisms and AI-Driven Discovery of Biomass-Based CO Sorbents.

The pressing need to reduce carbon dioxide emissions has driven recent advances in carbon capture technologies. Among these, adsorption has emerged as one of the most efficient and promising methods for CO sequestration. This review provides a comprehensive analysis of recent progress in biomass-derived activated carbon (AC) as a sustainable solution for carbon capture.

Impact of Short-Term Exposure to Ozone on Hospital Admissions for Multiple Cardiovascular Diseases: A Systematic Review and Meta-Analysis.

Background: The associations between short-term exposure to ambient ozone (O) pollution and the risks of hospital admissions (an indicator for morbidity) for different subtypes of cardiovascular disease (CVD) remain unclear. Therefore, this study aimed to evaluate the associations between short-term exposure to O and the risks of hospital admissions for all-cause CVD, arrhythmia, atrial fibrillation, cardiac diseases, heart failure, ischemic heart disease, myocardial infarction (MI), and stroke.

Methods: Four electronic databases, including PubMed, Web of Science, Scopus, and Embase, were searched for articles published up to December 21, 2023.

Sensitive and Anti-Interference Al Sensing with a Luminescent Eu-MOF.

A luminescent lanthanide metal-organic framework, [(TD)Eu(HCO)(DMF)] (Eu-TD, TD/HBTDB = 4,4'-(benzo[][1,2,5] thiadiazole-4,7-diyl)dibenzoic acid), was synthesized via a solvothermal method by coordinating Eu ions with the strongly emissive ligand HBTDB. Single-crystal X-ray diffraction analysis reveals that the Eu-TD is in the hexagonal system with space group 622. Eu-TD demonstrated exceptional selectivity toward Al ions, exhibiting remarkable sensitivity with a low detection limit (limit of detection (LOD) = 0.

Serum from patients with oral squamous cell carcinoma remodels the tumor immune escape ecological niche by promoting regulatory T‑cell differentiation and T‑cell exhaustion.

Oral squamous cell carcinoma (OSCC) ranks as the sixth most prevalent malignancy worldwide, and is characterized by high morbidity and mortality rates. Elucidating the molecular and cellular mechanisms of tumor‑directed immune escape through ecological niche remodeling is crucial for advancing tumor biotherapy. The serum of patients with cancer contains not only tumor biomarkers but also immune regulators secreted by immune cells and/or cancer cells.

A Novel Self-Regulated, Non-Directional Magnetic Thermos-Brachytherapy I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape.

Integrating mild hyperthermia (MH) with I brachytherapy holds potential for overcoming treatment resistance and improving anticancer efficacy. Here, magnetic nanoparticles (MNPs) with a suitable Curie temperature are constructed and incorporated with silver rods coated with I to form composite seeds. In vitro simulations and in vivo validations demonstrated their effective performance in radiation dose and temperature control.

Superior neurometabolic protection by 8-hydroxy-dihydromyricetin over dihydromyricetin in diabetic zebrafish: insights from integrated metabolomics and transcriptomics.

Herein, the effects of C-8 hydroxylation on the protective properties of dihydromyricetin (DHM) in a zebrafish larval model of diabetes and neurometabolic dysfunction were investigated. Diabetes was induced using alloxan and glucose, followed by treatment with DHM and its hydroxylated form, 8-hydroxy-dihydromyricetin (H-DHM), obtained through fermentation. Biochemical, metabolomic, and transcriptomic analyses were conducted to evaluate their differences in efficacy.

To Share or Not to Share: Food Sharing in Wild Azure-Winged Magpie (Cyanopica cyanus).

Food sharing is very common in the animal kingdom. Despite extensive research, the mechanisms underlying food sharing remain debated. Moreover, the majority of studies on food sharing in non-human animals have been conducted under controlled environments.

Minimizing Photovoltage Loss for Efficient p-i-n Perovskite Solar Cells via a Dual-Site Anchoring Bridge.

Perovskite solar cells (PSCs) suffer from severe nonradiative recombination-induced photovoltage loss, limiting the device overall performance. To address this key issue, an efficient strategy via a dual-site anchoring bridge is developed to engineer the heterointerface between perovskite and PCBM electron transport layer. The resulting reinforced and homogeneous passivation by forming strong dual-site P─O─Pb covalent bonds, effectively decreases perovskite surface defect density.

Engineering Bacteria as Living Therapeutics in Cancer Therapy.

Cancer is the second-leading cause of death globally, yet traditional therapies like chemotherapy face significant limitations. Recent advances in synthetic biology enable the design of various genetic circuits and the reprogramming of biological systems. Collectively, these efforts have led to the repurposing of engineered bacteria as therapeutics to achieve tumor targeting, tumor microenvironment modulation, and anticancer drug release.

Cation Engineering Enhanced Moisture Resistance in Centimeter-Sized Lead-Free Halide Perovskite Crystal for Ultrastable X-Ray Detection.

Halide perovskites, particularly those that are lead-free, have garnered significant attention owing to their eco-friendly nature and exceptional performance in X-ray detection. Nevertheless, despite their promising potential, halide perovskites suffer from structural instability in moist environments, which reduces device reliability. Herein, a cation engineering strategy involving the substitution of N-acidic protons with methyl groups of aniline is employed to synthesize a moisture-resistant lead-free halide perovskite (NDMA)BiI (NDMA = N,N-dimethylanilinium).

When covalent organic frameworks meet supramolecular nanofibers: a recyclable composite membrane for efficient air filtration.

For the first time, covalent organic frameworks (COFs) are integrated into the supramolecular nanofibrous membranes thermally induced precursor crystallization (TIPC), preparing recyclable filters for air purification. Benefiting from their hierarchical porous structures and thermally reversible properties, the composite nanofibrous membranes exhibit high particulate matter (PM) filtration efficiency alongside excellent closed-loop recyclability.

A high-sensitivity and clogging-free microfluidic impedance flow cytometer based on three-dimensional hydrodynamic focusing.

Microfluidic impedance flow cytometry has functioned as an enabling instrument in single-cell analysis, which, however, suffers from the limiting tradeoff between high sensitivity and clogging-free operation. In order to address this issue, this study presented a microfluidic impedance flow cytometer based on three-dimensional (3D) hydrodynamic focusing, in which the crossflow of conductive sample fluids and insulating sheath fluids was leveraged to centralize and restrict electric field lines to the sample fluid, thereby achieving high impedance sensitivity of single cells without the concern of channel blockage. Different from conventional impedance flow cytometry, in this study, impedance amplitude dips (rather than pulse singles) generated by single microparticles traveling through the 3D hydrodynamic focusing region were experimentally validated using microbeads.

Superior NO sensing semiconductor-metal transition in undoped HfCO MXene: doping-mediated trade-offs between surface reactivity and electronic properties.

In this paper, we employ density functional theory (DFT) and non-equilibrium Green's function (NEGF) calculations to investigate the gas-sensing properties of monolayer HfCO MXene, focusing on intrinsic vacancy defects and carbon-site substitutional doping. Among tested gases, NO exhibits exceptional sensitivity due to strong adsorption energy and significant charge transfer. Boron doping at carbon sites enhances charge transfer and adsorption strength through d-band center upshift (-0.

Can Tuberculosis Infection After Liver Transplant Induce Lung Squamous Cell Carcinoma from Squamous Metaplasia of Alveolar Epithelium?

This case report describes a 65-year-old male patient with hepatocellular carcinoma who received an orthotopic liver transplant. One month after surgery, the patient was treated for tuberculosis due to the fever. At 16 months after the operation, a chest computed tomography scan revealed a mixed ground-glass nodule at the apex of the right upper lobe, which gradually grew from 5 mm to 10 mm and then was removed via thoracoscopy.

Exploring the Causal Association Between Erectile Dysfunction and Brain Cortical Structure: Insight from a Bidirectional Mendelian Randomization Study and Cross-Sectional Neuroimaging Study.

Purpose: This study aims to investigate the bidirectional causal relationship between erectile dysfunction (ED) and cerebral cortical structure.

Materials And Methods: This study employed bidirectional two-sample Mendelian randomization (MR) framework. Exposure and outcome data were derived from genome-wide association study (GWAS) datasets.