Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway.

Inflammatory bowel disease (IBD) is a type of chronic inflammatory disorders. The main pathological features of IBD include immune homeostasis disorder and intestinal epithelial barrier dysfunction, which jointly lead to the deterioration of IBD. Mechanosensation refers to the ability of an organism to sense mechanical stimuli (such as pressure, pulling and shearing forces) and make adaptive responses, which plays an important role in the peristalsis and dilation of the intestines.

A Novel Open-Loop Current Sensor Based on Multiple Spin Valve Sensors and Magnetic Shunt Effect with Position Deviation Calibration.

To address the demands for wide-range and high-precision current measurement, this paper proposes a novel current sensor design that integrates spin sensing technology, magnetic shunt effect, and a multi-sensor data fusion algorithm. The spin valve sensors accurately detect the magnetic field generated by the signal current, while the soft magnetic shunt structure attenuates the magnetic field to a level suitable for the spin valve sensors. Consequently, the detection current range can be extended by 6.

Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.

Eukaryotic cells direct toxic misfolded proteins to various quality control pathways based on their chemical properties and aggregation status. Aggregated proteins are targeted to selective autophagy or specifically sequestered into the "aggresome", a perinuclear inclusion at the microtubule-organizing center (MTOC). However, the mechanism for selective aggresome recruitment remains unclear.

Improved state refinement for LSTM determined 3D CAISR-LSTM model for automatic myocardial infarction detection.

Electrocardiograms (ECGs) contain valuable information in the clinical diagnosis of myocardial infarction (MI). However, its interpretation process is dependent on cardiologists with extensive clinical experience and expertise. The issue not only causes a paucity of medical resources, but also restricts patients from receiving timely diagnoses.

Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy.

Glioblastoma (GBM) poses significant therapeutic challenges due to its hypoxic and immunosuppressive tumour microenvironment (TME), low immunogenicity and physical barriers. While combining photodynamic therapy (PDT) with immunotherapy holds promise, its efficacy is hampered by insufficient immune activation. In this study, we develop a multifunctional photodynamic-enhanced biomimetic intelligent nanoplatform (FBFO@HM@aOPN) responsive to the TME.

Improving Phase Stability of α-CsPbI through Combined Strain-Doping Engineering: Insights from First-Principles Calculations and Machine Learning.

The all-inorganic perovskite of cubic CsPbI (α-CsPbI) exhibited high thermal stability, owing to the absence of volatile organic cations. However, the poor phase stability at room temperature limits its practical applications. In this work, the phase transition mechanism of CsPbI from the cubic phase (α) to the tetragonal phase (β) was studied by first-principles calculations.

De novo design of insulated cis-regulatory elements based on deep learning-predicted fitness landscape.

Precise control of gene activity within a host cell is crucial in bioengineering applications. Despite significant advancements in cis-regulatory sequence activity prediction and reverse engineering, the context-dependent effects of host cellular environment have long been neglected, leading to ongoing challenges in accurately modeling regulatory processes. Here, we introduce an insulated design strategy to purify and model host-independent transcriptional activity.

cfDNA methylation detection as potential liquid biopsy of multiple organ injury in myocarditis patients.

Myocarditis is inflammatory injury of the myocardium and causes approximately 30,000 deaths globally each year. Fulminant myocarditis is an extremely severe form of myocarditis. Currently, the clinical evaluation of myocarditis and fulminant myocarditis is primarily based on symptoms, ECG findings, and biochemical markers.

Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway.

Background: Breast cancer is the most common malignant tumor among women. Recent studies have found that gut probiotics and their metabolic products play a significant role in activating the immune system, reshaping the tumor microenvironment, and inhibiting cancer progression.

Methods: We established a 4T1 tumor-bearing mice model and analyzed the proportions of CD4 T and CD8 T cells in the spleen using flow cytometry and immunohistochemistry.

Preliminary study on mother-approved infant handling behavior of black-and-white snub-nosed monkeys (Rhinopithecus bieti).

Mother-Approved Infant Handling (MAIH), a behaviour characterized by non-maternal individuals carrying a mother's offspring with her consent following a process of behavioural negotiation, is a well-documented phenomenon in colobine species. This study systematically documented MAIH within a semi-provisioned breeding band of black-and-white snub-nosed monkeys (Rhinopithecus bieti) in Xiangguqing, Yunnan, P.R.

Bifunctional Passivation of Wide-Bandgap Perovskite Solar Cells via Long-Chain Organic Ammonium Salts.

Perovskite solar cells (PSCs) with wide bandgaps (WBG) have emerged as critical enablers as the top subcells in various series-connected configurations, enabling effective absorption of high-energy photons and yielding a high open-circuit voltage (). However, these cells face significant challenges, including substantial photovoltage losses and phase separation, which hinder their potential efficiency and stability. We develop a molecular additive strategy employing the bifunctional ODABr diammonium salt (octadecane-1,8-diammonium bromide) during perovskite processing, and a hierarchically structured two-dimensional/three-dimensional (2D/3D) perovskite film with preferred crystallographic alignment and enhanced phase homogeneity is successfully engineered.

Activity and Safety Optimization of Mesoricin: A Dual-Domain Antifungal Peptide from sp.

infections pose a significant global health threat. This study introduces mesoricin, a novel dual-domain antimicrobial peptide (AMP) scaffold derived from sp. identified using an quantitative antifungal activity index (AFI).

Engineering exosome membrane disguised thermal responsive system for targeted drug delivery and controlled release across the blood-brain barrier.

The blood-brain barrier (BBB) presents a significant challenge for the delivery of chemotherapy drugs to brain tumors, leading to ineffective drug concentrations at the tumor site and contributing to chemotherapy resistance. The hypoxic tumor microenvironment further complicates this process, ultimately resulting in poor patient prognosis. In this study, we developed a thermoresponsive nanocarrier system that incorporates (Ru)(Pt) bimetallic nanoparticles onto defective TiOx nanoparticles with abundant oxygen vacancies, generating composite Ru/Pt-TiOx nanoparticles with photothermal and photocatalytic properties.

Gaining insights into nutrient and metal element distributions in radix using mass spectrometry.

is a medicine food homology plant. Its dried root (radix , RAS) is rich in nutrients and bioactive ingredients. This study involved a quantitative analysis of 401 RAS material batches harvested from different geographical regions over a time span of four years.

Elucidation of the mechanism by which the foliar application of triacontanol enhances Cd enrichment in L. through morphological, metabolomic, and transcriptomic analyses.

Phytoremediation is an effective technology for removing heavy metal cadmium (Cd) from soil without harming the soil; however, it is limited by its long remediation time and low efficiency. In this study, a plant growth regulator (PGR), triacontanol, was sprayed on the leaves of the hyperaccumulator L. at different growth stages to enhance the accumulation of soil Cd, thereby ultimately enhancing the efficiency of phytoremediation.

Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages.

Background: Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti-PD-1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti-PD-1 therapy is necessary to design more effective immunotherapies for GBM. This study aimed to dissect the molecular mechanisms of specific immunosuppressive subpopulations to drive anti-PD-1 resistance in GBM.

Intelligent risk stratification of hypertension based on ambulatory blood pressure monitoring and machine learning algorithms.

. Risk stratification of hypertension plays a crucial role in the treatment decisions and medication guidance during clinical practices. Although fruitful achievements have been reported on risk stratification of hypertension, the potential use of ambulatory blood pressure monitoring data is not well investigated.

Engineering Multiresponsive Alginate/PNIPAM/Carbon Nanotube Nanocomposite Hydrogels as On-Demand Drug Delivery Platforms.

Second near-infrared (NIR-II) responsive hydrogels have shown significant potential in biomedical applications due to their excellent remote actuation property and the high tissue penetrations of the NIR-II light. Nevertheless, hydrogels with a single NIR-II light response may not meet the diverse requirements and complex conditions of clinical applications. Here, a novel multi-responsive nanocomposite hydrogel with enhanced suitability for controlled drug release is developed.

Continuous Provisioning Increases Breeding Success of Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti) in the Baima Snow Mountain Nature Reserve, Yunnan, China.

The high energy demands of primates during pregnancy and lactation often limit their breeding success due to the availability of food resources. Until now, few studies have focused on the effects of continuous provisioning on primate reproduction. To assess the impact of continuous provisioning on breeding success, we collected data on female reproductive status (primiparous or multiparous), maternal age of births, births, deaths, and sex of infants in a free-ranging semi-provisioned band (FSB) of Rhinopithecus bieti in China from 2010 to 2023.

Enhanced adsorption and regulation mechanism of ball milling-modified biochar on Cd and atrazine in soil.

In order to improve the adsorption and immobilization capacity of biochar for Cd and atrazine in soil, the biochar was prepared from corn straw and modified by dry ball milling under various conditions. Compared with the pristine biochar (PB), the ball-milled biochar (BB) had a larger specific surface area and more pores, the number of oxygen-containing functional groups increased significantly, and the adsorption capacity of Cd and atrazine increased by 9.0% and 139.

Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells.

Drugs that modulate microtubule (MT) dynamics are well-characterized at the molecular level, yet the mechanisms linking these molecular effects to their distinct clinical outcomes remain unclear. Several MT-destabilizing drugs, including vinblastine, combretastatin A4, and plinabulin, are widely used, or are under evaluation for cancer treatment. Although all three depolymerize MTs, they do so through distinct biochemical mechanisms.

The combination of and mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8 T cells in mice.

Unlabelled: The gut microbiota is closely associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC). Probiotics such as (CB) or (AKK) have the potential to treat inflammatory bowel disease (IBD) or colorectal cancer (CRC). However, research on the combined therapeutic effects and immunomodulatory mechanisms of CB and AKK in treating IBD or CRC has never been studied.

O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner.

Background: Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.

Accurate Coal Classification Using PAIPSO-ELM with Near-Infrared Reflectance Spectroscopy.

China has vast proven coal reserves, encompassing a wide variety of types. However, traditional coal classification methods have limitations, often leading to inaccurate classification and inefficient utilization of coal resources. To address this issue, this paper introduces the Extreme Learning Machine (ELM) as a novel coal classification method, based on the near-infrared reflectance spectroscopy (NIRS) of coal.