Preliminary study on mother-approved infant handling behavior of black-and-white snub-nosed monkeys (Rhinopithecus bieti).

Mother-Approved Infant Handling (MAIH), a behaviour characterized by non-maternal individuals carrying a mother's offspring with her consent following a process of behavioural negotiation, is a well-documented phenomenon in colobine species. This study systematically documented MAIH within a semi-provisioned breeding band of black-and-white snub-nosed monkeys (Rhinopithecus bieti) in Xiangguqing, Yunnan, P.R.

Engineering Multiresponsive Alginate/PNIPAM/Carbon Nanotube Nanocomposite Hydrogels as On-Demand Drug Delivery Platforms.

Second near-infrared (NIR-II) responsive hydrogels have shown significant potential in biomedical applications due to their excellent remote actuation property and the high tissue penetrations of the NIR-II light. Nevertheless, hydrogels with a single NIR-II light response may not meet the diverse requirements and complex conditions of clinical applications. Here, a novel multi-responsive nanocomposite hydrogel with enhanced suitability for controlled drug release is developed.

Continuous Provisioning Increases Breeding Success of Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti) in the Baima Snow Mountain Nature Reserve, Yunnan, China.

The high energy demands of primates during pregnancy and lactation often limit their breeding success due to the availability of food resources. Until now, few studies have focused on the effects of continuous provisioning on primate reproduction. To assess the impact of continuous provisioning on breeding success, we collected data on female reproductive status (primiparous or multiparous), maternal age of births, births, deaths, and sex of infants in a free-ranging semi-provisioned band (FSB) of Rhinopithecus bieti in China from 2010 to 2023.

Cholesterol paradox in the community-living old adults: is higher better?

Objective: To evaluate the associations of lipid indicators and mortality in Beijing Elderly Comprehensive Health Cohort Study.

Methods: A prospective cohort was conducted based on Beijing Elderly Comprehensive Health Cohort Study with 4499 community older adults. After the baseline survey, the last follow-up was March 31, 2021 with an average 8.

Effects of provisioning on the activity budget and foraging strategies of black-and-white snub-nosed monkeys (Rhinopithecus bieti) in the Baima Snow Mountain Nature Reserve, Yunnan, China.

Provisioning can significantly affect the ranging patterns, foraging strategies, and time budget of wild primates. In this study, we document for the first time, the effects of provisioning on the activity budget and foraging effort in an Asian colobine. Over 3-years, we used an instantaneous scanning method at 10-min intervals to collect data on the activity budget of a semiprovisioned breeding band (SPB) of black-and-white snub-nosed monkeys (Rhinopithecus bieti) (42-70 individuals) at Xiangguqing (Tacheng), Yunnan, China.

Analysis of influencing factors for prognosis of patients with ventricular septal perforation: A single-center retrospective study.

Background: Ventricular septal rupture (VSR) is a type of cardiac rupture, usually complicated by acute myocardial infarction (AMI), with a high mortality rate and often poor prognosis. The aim of our study was to investigate the factors influencing the long-term prognosis of patients with VSR from different aspects, comparing the evaluation performance of the Gensini score, Sequential Organ Failure Assessment (SOFA) score and European Heart Surgery Risk Assessment System II (EuroSCORE II) score systems.

Methods: This study retrospectively enrolled 188 patients with VSR between Dec 9, 2011 and Nov 21, 2021at the First Affiliated Hospital of Zhengzhou University.

Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics.

Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control.

Type-1 Na/H exchanger is a prognostic factor and associate with immune infiltration in liver hepatocellular carcinoma.

Aims: SLC9A1 plays an important role in the growth, differentiation and glycolysis of tumor cells. The present study aimed to elucidate the correlation between SLC9A1 and tumor immune infiltration.

Main Methods: Expression level of SLC9A1 gene in tumors was identified in GEPIA.

Description a new species of the genus Orphnebius Motschulsky, 1858 (Coleoptera: Staphylinidae: Aleocharinae) from Xizang, China.

A new species of the genus Orphnebius Motschulsky: Orphnebius lilizheni sp. nov. is described from Xizang, China.

1,25(OH)D mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis.

Cancer-related fatigue (CRF) is one of the most common and serious complications in cancer patients, which greatly reduces the quality of life. The mechanism induced fatigue may be diverse. In this study, we tried to investigate the effect of 1,25(OH)D, the active metabolite of vitamin D on CRF in Lewis lung cancer-bearing mice.

A new species of the genus Morimotanthribus Senoh & Trýzna (Coleoptera: Anthribidae) from South China.

A new species, Morimotanthribus leigongshani sp. nov. (Anthribidae: Anthribinae: Phloeophilini), from Guizhou and Guangxi provinces, South China, is described.

Antifungal Activity and Physicochemical Properties of a Novel Antimicrobial Protein AMP-17 from .

Antimicrobial peptides (AMPs) are cationic small peptide chains that have good antimicrobial activity against a variety of bacteria, fungi, and viruses. AMP-17 is a recombinant insect AMP obtained by a prokaryotic expression system. However, the full antifungal activity, physicochemical characteristics, and cytotoxicity of AMP-17 were previously unknown.

Discovery of the genus Micropeneta Pic in China, with description of a new species (Coleoptera: Tenebrionidae: Gnathidiini).

The tenebrionid genus Micropeneta, Pic 1921 is recorded from China for the first time. A new species, Micropeneta qilin Li Jiang sp. n.

A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.

In current work, a class of novel 4,5-dihydro-1H-pyrazole-1-carboxylate derivatives (E01-E28) were designed, synthesized and evaluated. Among them, the most potent compound E24 exhibited comparable activity against a panel of cancer cells (GI ranging 0.05-0.

Monomeric and dimeric ent-kauranoid-type diterpenoids from rabdosia japonica and their cytotoxicity and anti-HBV activities.

Two new ent-kauranoid-type diterpenoids (1 and 2) and one new rare dimer of ent-kauranoids (3) with a cyclobutane ring by a [2+2] cycloaddition, together with nine known diterpenoids (4-12) were obtained from the aerial parts of Rabdosia japonica. Their chemical structures were established by 1D and 2D NMR techniques and mass spectrometry and by comparison with spectroscopic data reported. All ent-kauranoids were test for their cytotoxic effects against A549, HCT116, CCRF-CEM and HL-60 tumor cell lines.

The clinicopathological significance of RUNX3 hypermethylation and mRNA expression in human breast cancer, a meta-analysis.

Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research publications.

Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhibitors.

A series of 1-methyl-1H-indole-pyrazoline hybrids were designed, synthesized, and biologically evaluated as potential tubulin polymerization inhibitors. Among them, compound e19 [5-(5-bromo-1-methyl-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide] showed the most potent inhibitory effect on tubulin assembly (IC50 =2.12 μm) and in vitro growth inhibitory activity against a panel of four human cancer cell lines (IC50 values of 0.

Evaluation of gas chromatography-mass spectrometry in conjunction with chemometric resolution for identification of nitrogen compounds in crude oil.

A chemometric resolution method is described for the identification of nitrogen compounds in crude oil. Prefractionation of crude oil into discrete chemical classes was performed by adsorption column chromatography using small quantities of neutral aluminum oxide and silicic acid. Subsequent high-resolution separation of individual components was achieved by using capillary column gas chromatography, and compound types were detected by mass spectrometer.

Comparison of performance of partial least squares regression, secured principal component regression, and modified secured principal component regression for determination of human serum albumin, gamma-globulin and glucose in buffer solutions and in vivo blood glucose quantification by near-infrared spectroscopy.

The performances of three multivariate analysis methods--partial least squares (PLS) regression, secured principal component regression (sPCR) and modified secured principal component regression (msPCR)--are compared and tested for the determination of human serum albumin (HSA), gamma-globulin, and glucose in phosphate buffer solutions and blood glucose quantification by near-infrared (NIR) spectroscopy. Results from the application of PLS, sPCR and msPCR are presented, showing that the three methods can determine the concentrations of HSA, gamma-globulin and glucose in phosphate buffer solutions almost equally well provided that the prediction samples contain the same spectral information as the calibration samples. On the other hand, when some potential spectral features appear in new measurements, sPCR and msPCR outperform PLS significantly.

Modified secured principal component regression for detection of unexpected chromatographic features in herbal fingerprints.

Secured principal component regression is modified for the qualitative analysis of chromatographic fingerprint data sets of herbal samples with residual concentrations. After chromatographic shift-correction and autoscaling are performed on the data, this modified secured principal component regression (msPCR) can detect unexpected chromatographic features in various herbal fingerprints. The successful application of msPCR to two real herbal medicines of Erigeron breviscapus from different geographical origins and Ginkgo biloba from various sources or vendors demonstrates that the proposed method can detect reasonably unexpected features differing from the regulars or not being modeled.

Moving window cross validation: a new cross validation method for the selection of a rational number of components in a partial least squares calibration model.

A new cross validation method called moving window cross validation (MWCV) is proposed in this study, as a novel method for selecting the rational number of components for building an efficient calibration model in analytical chemistry. This method works with an innovative pattern to split a validation set by a number of given windows that move synchronously along proper subsets of all the samples. Calculations for the mean value of all mean squares error in cross validations (MSECVs) for all splitting forms are made for different numbers of components, and then the optimal number of components for the model can be selected.

Alternative moving window factor analysis for comparison analysis between complex chromatographic data.

In this investigation, a novel chemometric method is developed for the analysis of five possible relationships of components or spectral features between two correlative but different hyphenated chromatographic systems. It is very helpful for comparison study of components present in different complex systems in both chemistry and systems biology. The proposed method, named alternative moving window factor analysis (AMWFA), could be utilized to determine the number of common components between different samples and then to identify their corresponding spectra half-automatically.

LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.

A valid chromatographic fingerprint method using liquid chromatography-diode array detection-atmospheric pressure chemical ionization mass spectrometry in negative mode (LC-DAD-APCI-MS) is proposed for studying the absorption and metabolites of a traditional Chinese medicine (TCM) Angelica sinensis (danggui) in rabbit plasma, after the rabbit is administered with danggui oral solution (DOS). More than thirty-two common components were detected in both DOS and rabbit plasma, which shows that the components in the DOS were absorbed into the body of the rabbit. Of these, senkyunolide I, senkyunolide H, Z-6,7-epoxyligustilide, 3-butylidene-7-hydroxyphthalide, Z-ligustilide, Z-butylidenephthalide, Diels-Alder dimers of ligustilide, linolenic acid, linoleic acid and falcarindiol were tentatively identified from their MS, UV spectra and retention behavior by comparing the results with the published literature.

Multicomponent spectral correlative chromatography applied to complex herbal medicines.

In this study, a novel chemometric algorithm is presented to facilitate the comparison of relevant chemical components from different herbal samples. This so-called multicomponent spectral correlative chromatography (MSCC) is developed to detect and decide whether two chromatographic clusters are correlated spectrally with each other. The target chromatographic cluster is first partitioned from one herbal spectrochromatogram obtained by hyphenated chromatography.