Publications by authors named "Caizhi Ma"
This study aims to explore the effects of problem-based learning (PBL) and prescription-based preoperative talk (PPT) teaching methods in the teaching of tumors in cerebellopontine angle (CPA) of clinical neurosurgery residents.One hundred-thirty neurosurgery residents working in Qilu Hospital of Shandong University from September 2021 to June 2024 were randomly divided into two groups. The experimental group adopted the combination of PBL and PPT, referred to as PPP.
View Article and Find Full Text PDFBackground: Infection after craniocerebral operation has always been a very focused problem, and dural closure can reduce perioperative infection by reducing drainage volume and subcutaneous effusion, so how to effectively perform dural closure seems to be a small but not negligible problem.
Methods: We proposed a classification and grading system for dural incisions based on the type and degree of suture, and based on the system, a standardized operation process for ADS (absorbable dural sealant) was developed. Then, we conducted a retrospective study.
Background: Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.
View Article and Find Full Text PDFArticle Synopsis
- * The study focuses on the role of HDAC7 in regulating SOX8 expression, which influences the secretion of LGALS3, creating a feedback loop that promotes the aggressive mesenchymal phenotype of GBM and M2 polarization of macrophages.
- * Findings suggest that targeting LGALS3 can enhance the effectiveness of HDAC inhibitors, positioning HDAC7 and LGALS3 as potential new biomarkers and therapeutic targets for GBM treatment.
Article Synopsis
- Some lower-grade gliomas (LGG) can be hard to differentiate from other conditions during surgery, leading to potential misdiagnosis; these challenging cases are defined as "ultra early stage lower-grade gliomas (UES-LGG)."
- Researchers studied 11 cases diagnosed as "gliosis" or "inflammatory changes" that tested positive for a specific mutation (IDH), along with 35 LGG samples, to find ways to better identify UES-LGG during surgery.
- Results indicated that while the average DNA concentration was similar between the two groups, the mutation detection thresholds differed significantly, suggesting that monitoring IDH mutations could help distinguish UES-LGG from other conditions in surgical settings.
Intraoperative rapid molecular diagnosis aids glioma subtyping and guides precise surgical resection.
Ann Clin Transl Neurol
August 2024
Objective: The molecular era of glioma diagnosis and treatment has arrived, and a single rapid histopathology is no longer sufficient for surgery. This study sought to present an automatic integrated gene detection system (AIGS), which enables rapid intraoperative detection of IDH/TERTp mutations.
Methods: A total of 78 patients with gliomas were included in this study.