Endothelial Dysfunction and Therapeutic Advances in Chronic Kidney Disease.

Chronic kidney disease (CKD) substantially increases cardiovascular risk, with endothelial dysfunction as its central pathological mechanism. This review summarises the molecular regulatory mechanisms underlying endothelial dysfunction in CKD and highlights recent advances in treatment strategies. The pathophysiology of endothelial injuries involves a complex network of multiple factors and mechanisms, including oxidative stress, inflammation, glycocalyx damage, ischaemia, hypoxia, cellular senescence and endothelial-mesenchymal transition (EndMT).

Microstructure Design of Metal Selenides for Sodium-Ion Battery Anodes.

The advancement of sodium-ion batteries (SIBs) as next-generation energy storage systems is critically dependent on developing high-performance anode materials. Metal selenides have garnered significant attention as promising anode candidates due to their high theoretical capacities, yet their practical application is hampered by intrinsic issues such as large volume expansion, poor electrical conductivity, and structural pulverization during cycling. Engineering the microstructure of metal selenides offers a powerful avenue to overcome these limitations and unlock their full electrochemical potential.

Partial splenectomy and pericardial devascularization for symptomatic patients with portal hypertension: a single-center retrospective study.

Background: The dilemma of current treatments for symptomatic patients with portal hypertension is how to resolve the problems of the varices and hypersplenism simultaneously and meanwhile preserve the splenic function. Partial splenectomy and pericardial devascularization is a potential alternative to currently used approaches, but it is incompletely defined. This study aimed to evaluate the efficacy and safety of partial splenectomy and pericardial devascularization.

Long noncoding RNA MIR100HG regulates inflammatory response by interacting with RNA-binding protein Quaking in periodontitis.

Background: Long noncoding RNAs (lncRNAs) are emerging regulators of periodontal inflammation. This study investigates the role of lncRNA MIR100HG in periodontitis and its interaction with the RNA-binding protein Quaking (QKI).

Methods: In vitro, human gingival fibroblasts (HGFs) were stimulated with Porphyromonas gingivalis lipopolysaccharide (Pg.

Fracture Behaviour of Basalt Fibre-Reinforced Lightweight Geopolymer Concrete: A Multidimensional Analysis.

This study introduced basalt fibres as a reinforcing material and employed notched beam three-point bending tests combined with digital image correlation (DIC) technology to comprehensively evaluate key fracture parameters-namely, initial fracture toughness, unstable fracture toughness, fracture energy, and ductility index-of expanded polystyrene (EPS)-based geopolymer concrete with different mix proportions. The results demonstrate that the optimal fracture performance was achieved when the basalt fibre volume content was 0.4% and the EPS content was 20%, resulting in respective increases of 12.

NMDA receptor antagonist induced c-Fos expression in the medial entorhinal cortex during postnatal development.

-methyl-D-aspartate receptor (NMDAR) antagonists, including ketamine, phencyclidine (PCP), and dizocilpine (MK-801), are an important class of drugs that can produce antidepressant, hallucinogenic, dissociative, psychotomimetic, and anesthetic effects in humans and animal models. To understand the effects of NMDAR antagonists on the brain, it is essential to map their actions at cellular resolution. We quantified c-Fos expressing cells in the mouse telencephalon after systemic injection of the potent NMDAR antagonist MK-801 and found a 10-fold higher density of c-Fos in the medial entorhinal cortex (MEC) compared to other regions of the telencephalon.

Co-assembled polypeptides-adsorbing bridge molecules to enhance macrophage efferocytosis for the resolution of periodontitis inflammation.

Effective removal of apoptotic cells, namely efferocytosis, promotes inflammation resolution of periodontitis and tissue restoration. However, effective treatments to enhance macrophage efferocytosis in periodontitis are still lacking. Co-assembly of distinct building blocks is considered a versatile and effective method of modulating the structure and functionality of supramolecular materials.

Mechanistic Insight into Serine Flux Regulation through Nanoscale Organization of Glucose and Serine Transporters by Substrate Probe-Based Direct Stochastic Optical Reconstruction Microscopy Imaging.

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation. While serine transporters (SerTs) are known to be dysregulated in cancer, their functional nanoscale organization remains unresolved due to the limitation of resolution imaging and available probes. Here, we developed a substrate-based fluorescent probe (Ser-probe) enabling direct stochastic optical reconstruction microscopy of SerTs, revealing malignancy-associated clustering assembly of SerTs that correlates with transport capacity.

Frailty index is positively associated with stroke risk in nationally representative cohorts from the united States and China.

Frailty has been linked to adverse health outcomes, but its relationship with stroke remains insufficiently understood in general populations. In this study, we examined the association between frailty and stroke using two nationally representative cohorts: the U.S.

A multitask framework based on CA-EfficientNetV2 for the prediction of glioma molecular biomarkers.

Introduction: Glioma is the most common primary malignant tumor of the central nervous system. The mutation status of isocitrate dehydrogenase (IDH) and the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter are key biomarkers for glioma diagnosis and prognosis. Accurate, non-invasive prediction of these biomarkers using MRI is of significant clinical value.

Green solvent boosts fluorescence of copper nanoclusters: Achieving ultra-fast fabrication of a universal sensing platform for HO-related biomarkers detection.

Background: Copper nanoclusters (Cu NCs) exhibit considerable potential for biosensing applications. However, their practical application is hindered by low fluorescence emission intensity and inadequate stability. Conventional aqueous-based synthesis methods have shown limitations in addressing these issues effectively.

Decoding key aroma components of three cigar tobacco leaves based on molecular sensory science.

Cigar is a flavor-dependent cash crop. However, the key aroma compounds of tobacco leaves are less studied. In this study, we used molecular sensory science to explore the key aroma compounds of cigar tobacco leaves from three different origins in Yunnan, China.

Association Between Atherogenic Index of Plasma and Endometriosis: Evidence from NHANES 1999-2006.

Background And Aims: Due to its association with various diseases, atherogenic index of plasma (AIP) has garnered increasing attention. Exploration of the relationship between AIP and endometriosis risk has not been thorough. This nationwide study will attempt to explore this association.

Integrating methane conversion with multi-pathway nitrogen removal for wastewater in membrane-enabled stratified biofilm: System development and microbial dynamics.

Global demands for energy-neutral wastewater treatment drive innovation in sustainable nitrogen removal. A single-biofilm membrane biofilm reactor (MBfR) was constructed for efficient aerobic methane oxidation coupled with simultaneous ammonia oxidation and denitrification (AME-AOD). Through meticulous refinement in aspects such as membrane materials and gas-to-feed ratios, the best-performing biofilm achieved a high total nitrogen (TN) removal efficiency of 97 % ± 2 %.

Correction: A comprehensive review of rehabilitation approaches for traumatic brain injury: efficacy and outcomes.

[This corrects the article DOI: 10.3389/fneur.2025.

Accelerometer based independent and combined associations of physical activity and sedentary time on physical fitness in preschool children: a cross-sectional study.

To investigate the independent and combined associations between total physical activity (TPA) and sedentary time (ST) using accelerometer on physical fitness in preschool children. A cross-sectional study involving 375 participants (211 boys, and 164 girls) was conducted. Participants were classified as low- or high-active according to the PA guidelines of 180 min/day of TPA and low- or high-sedentary based on the median ST per day.

Egr1/Gc/vitamin transport axis mediates synergistic effect of macular thinning and underweight in age-related visual acuity decline.

To investigate the associated risk factors and potential molecular mechanisms affecting visual acuity (VA) in the elderly, this cross-sectional, population-based study collected the general information, past medical history and ophthalmologic data of 841 Shanghai elderly residents (mean age 69.61 ± 5.70 years, range 52-92 years).

Repurposing Antidiabetic Drugs for Gangrene: A Mendelian Randomization and Text Mining Study.

Gangrene has been a problem for many people with diabetes. Besides, the relationship and pathomechanism of diabetes-induced gangrene (DG) are still unclear. The aim of this study was to investigate the causal relationship between diabetes and gangrene through Mendelian randomization (MR) and to identify potential therapeutic agents using bioinformatics analysis.

Multiphysics Modeling of Photoelectrochemical Devices for Simultaneous Solar-Driven Biomass Reforming and Hydrogen Production.

Biomass reforming, including glycerol and 5-hydroxymethylfurfural oxidation, converts renewable biomass-derived molecules into value-added chemicals and fuels. This process is crucial for sustainable energy and chemical production, offering a carbon-neutral alternative to fossil-based feedstocks. Integrating biomass oxidation with photoelectrochemistry enables solar-driven reactions, reducing external electrical input and improving energy efficiency.

Low-strain spherical NaFe(SO) cathode enabled by morphology control for long-cycle sodium-ion batteries.

Alluaudite-type NaFe(SO), characterized by its cost-effectiveness and high operating voltage, has emerged as a prospective cathode material for sodium-ion batteries (SIBs). However, poor electronic conductivity and sluggish reaction kinetics hinder its practical application. In this study, we developed a low-strain spherical NaFe(SO)@C@KB (NFS@C@KB) cathode, enclosed within highly conductive Ketjen Black (KB) using a scalable spray-drying method.

The role of executive functions in young children's static and sustained inattentional blindness.

Inattentional blindness (IB), which refers to a failure to detect unexpected stimuli in the visual field, is associated with increased risk from undetected threats. While IB has been attributed to several individual factors, the role of cognitive control capacities, such as executive functions, remains unclear. To investigate this relationship, 154 Chinese children aged 3-6 (52.

Starlike Au nanoparticle unleashing siDDIT3 and photothermal power to combat ferroptosis - driven osteoarthritis.

Unlabelled: Osteoarthritis (OA), the most common degenerative joint disease globally, has garnered increasing attention, and emerging evidence implicated ferroptosis played an important role in both its onset and progression. In this study, we identify DDIT3, a ferroptosis-related gene, from the GEO public database of OA patient data. We demonstrate that DDIT3 accelerates articular cartilage degeneration by promoting ferroptosis, making it a viable target for therapeutic intervention.

Robust Multi-contrast MRI Medical Image Translation via Knowledge Distillation and Adversarial Attack.

Medical image translation is of great value but is very difficult due to the requirement with style change of noise pattern and anatomy invariance of image content. Various deep learning methods like the mainstream GAN, Transformer and Diffusion models have been developed to learn the multi-modal mapping to obtain the translated images, but the results from the generator are still far from being perfect for medical images. In this paper, we propose a robust multi-contrast translation framework for MRI medical images with knowledge distillation and adversarial attack, which can be integrated with any generator.

A comprehensive review of rehabilitation approaches for traumatic brain injury: efficacy and outcomes.

Traumatic Brain Injury (TBI), particularly in moderate-to-severe cases, remains a leading cause of long-term disability worldwide, affecting over 64 million individuals annually. Its complex and multifactorial nature demands an integrated, multidisciplinary rehabilitation approach to address the diverse physical, cognitive, behavioral, and psychosocial impairments that follow injury. We conducted a structured literature search using PubMed, Scopus, and Web of Science databases for suitable studies.