Unveiling the Distinct Effects of a Two-Dimensional Copper/Sodium Complex: Oxidative Stress on Erythrocytes and Cytotoxicity, Apoptosis, Drug Resistance, and Inflammation in Lung Cancer Cells.

Introduction: Copper complexes, as endogenous metals, have potential in cancer therapy, addressing issues associated with cisplatin. Since cisplatin uses Copper Transporter 1 (CTR1) for cellular entry, copper complexes may utilize this pathway to enhance transport efficiency.

Methods: The Cu/Na dipicolinic acid complex was synthesized to assess its cytotoxicity, induction of apoptosis, drug resistance, and inflammation in cancerous and normal lung cells.

Inhibition of myocyte-specific enhancer factor 2A (MEF2A) attenuates cardiac fibrosis and improves heart function by regulating the Snail1/RhoA/α-SMA pathway.

Myocardial fibrosis (MF) is a key pathological process driving heart failure, characterized by excessive extracellular matrix (ECM) deposition and impaired cardiac function. Although myocyte-specific enhancer factor 2 A (MEF2A) is implicated in cardiac fibroblast activation, its role in MF remains unclear. We manipulated MEF2A expression in cardiac fibroblasts (CFs) through knockdown and overexpression, and assessed fibrosis markers, migration, and RhoA signaling.

Predictors of infarction and outcomes in capsular warning syndrome: a retrospective observational study.

Background: Capsular warning syndrome (CWS), a rare subtype of transient ischemic attack, is associated with a high risk of progression to acute cerebral infarction. However, predictive factors for infarction and determinants of functional outcome remain inadequately defined.

Methods: In this retrospective study, we analyzed 89 CWS patients admitted between January 2021 and December 2024.

[Holmium laser ω-shaped pre-transection of prostate apex with preservation of the bladder neck improves urinary continence and sexual function in BPH patients after HoLEP].

Objective: To investigate the effect of holmium laser ω-shaped pre-transection of the prostate apex (PTPA) with preservation of the bladder neck on the urinary continence and sexual function of the patients with BPH after transurethral holmium laser enucleation of the prostate (HoLEP).

Methods: This retrospective study included 165 cases of BPH undergoing holmium laser ω-shaped PTPA with preservation of the bladder neck following HoLEP from January 2018 to January 2023. We recorded and compared the baseline, perioperative and 12-month follow-up data on the patients, and evaluated their urination function using IPSS, maximum urinary flow rate (Qmax), postvoid residual urine volume (PVR), and quality of life (QOL) scores.

Advancements in the clinical management of adhesive small bowel obstruction: A perspective.

This study rigorously addresses adhesive small bowel obstruction (ASBO), a common yet severe complication following abdominal surgery, marked by fibrous adhesions that disrupt normal intestinal operations. These adhesions often result in profound symptoms including severe abdominal pain and vomiting, and may lead to critical outcomes such as intestinal ischemia and necrosis. It delineates the considerable strain ASBO places on healthcare systems globally, highlighting its frequent occurrence post-surgery and the associated high medical costs and negative impacts on patient quality of life.

Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model.

Pain, particularly chronic pain, is a major reason patients seek physical therapy. Inflammation plays a crucial role in both the development and persistence of chronic pain. Neuronal PAS domain protein 2 (NPAS2), a core circadian transcriptional regulator, has been implicated in modulating pain-related stress responses.

Bioinformatics prediction of function of T-cell exhaustion related genes in ischemic stroke.

Ischemic stroke (IS) is a multifactorial disease caused by the interaction of a variety of environmental and genetic factors, which can lead to severe disability and heavy social burden. This study aimed to find potential biomarkers related to T cell exhaustion (TEX) in IS. Based on the GSE16561 dataset, differentially expressed genes (DEGs) were screened from IS and control groups, and their enriched biological pathways were explored.

Combination of Quercetin and Curcumin modulates NF-κB inflammatory signaling pathway in murine model of esophageal erosive reflux disease erosive reflux disease.

Background: This study aimed to investigate whether quercetin, in combination with curcumin, modulates the nuclear factor-kappa B (NF-κB) inflammatory signaling pathway in a murine model of esophageal erosive reflux disease.

Materials And Methods: The expression levels of NF-κB and inflammatory factors such as interleukin-1beta (IL-1β), IL-8, and tumor necrosis factor-alpha (TNF-α) were analyzed using Real-Time PCR. Additionally, enzyme-linked immunosorbent assay (ELISA) was employed to validate the Real-Time PCR findings.

Deep learning-based key point detection algorithm assisting vessel centerline extraction.

Background: Vessel centerline extraction assists in the quantitative analysis of plaque. Current algorithms generate significant errors for tortuous vessels, leading to inaccurate centerline extraction. This study proposed a key point detection algorithm to assist in vessel centerline extraction for the further quantitative analysis of plaque.

Aberrant interhemispheric resting state functional connectivity and corpus callosum microstructure in acute carbon monoxide poisoning.

Acute carbon monoxide poisoning (ACOP) is a significant contributor to acute poisoning incidents worldwide, with numerous patients suffering from cognitive impairment. Growing evidence indicates that patients with ACOP exhibit both disrupted functional connectivity and corpus callosum (CC) degeneration. Nevertheless, how interhemispheric connectivity is altered in ACOP and how such alterations relate to cognitive deficits remain largely unexplored.

[Measurement of radial artery diameter by optical coherence tomography via distal radial access].

To measure the radial artery (RA) diameter and explore its related factors by using optical coherence tomography (OCT). This was a cross-sectional study conducted in Cardiac Care Unit of Beijing Luhe Hospital, Capital Medical University. Patients who underwent first-ever right forearm access and OCT guided coronary intervention via right distal RA, and measurement of the whole portion of RA diameter with OCT in our center between January 2021 to December 2021 were enrolled.

Chemical composition of the traditional Chinese medicine compound (ICAM), its antifungal effects against Candida albicans, and the underlying Mechanisms: Therapeutic potential and safety evaluation for vulvovaginal candidiasis.

Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) compound preparations play a significant role in the clinical treatment of vulvovaginal candidiasis (VVC).

Aim Of The Study: Candida albicans (CA) is an opportunistic fungal pathogen responsible for various human diseases, including vulvovaginal candidiasis (VVC). Hyphal growth and biofilm formation are critical virulence factors contributing to CA's pathogenicity and drug resistance.

The Associations of Tobacco, Alcohol, and Coffee Consumption with Upper and Lower Gastrointestinal Disease Risk: A Mendelian Randomization Study.

Background/aims: Gastrointestinal diseases present a significant global health challenge and greatly impact healthcare expenditures. Despite alcohol, tobacco, and coffee being universally recognized risk factors for various gastrointestinal disorders, the exact causal linkages have not been clarified because of the predominance of observational studies on this topic. Mendelian randomization (MR) was used to explore to what extent alcohol, tobacco, and coffee increase the risk of developing 13 upper and lower gastrointestinal diseases.

The predictive value of triglyceride-glucose index, lipid accumulation product and lipid ratio on metabolic syndrome in polycystic ovary syndrome patients.

Objectives: To identify reliable indicators to predict the occurrence of metabolic syndrome (MetS) and to provide an effective way to prevent it in polycystic ovary syndrome (PCOS), we explored the relationships between triglyceride-glucose index (Ty-G), lipid accumulation product (LAP), lipid accumulation product ratio, and MetS.

Methods: We detected the relationship between the Ty-G index, LAP, lipid ratio, and incidence of MetS. In addition, we classified the Ty-G index and LAP into tertiles to determine the efficacy of these indicators in predicting the risk of MetS.

Distal radial access to prevent radial artery occlusion for STEMI patients (RAPID III): a randomized controlled trial.

Background: Compared with conventional transradial access (TRA), distal radial access (DRA) is rarely used for percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) and may be beneficial to prevent radial artery occlusion (RAO). We aimed to evaluate the incidence of RAO between DRA and TRA 24 h after primary PCI in patients with STEMI.

Methods: This is a single-center, open-label, prospective, randomized controlled trial conducted at Beijing Luhe Hospital, China, between January 2022 and July 2023.

Betanin Mitigates Inflammation and Ankle Joint Damage by Subduing the MAPK/NF-κB Pathway in Arthritis Triggered by Type II Collagen in Rats.

Background: Rheumatoid Arthritis (RA), a chronic inflammatory autoimmune illness, is characterized by synovitis, progressive joint damage, and bone erosion. Even though the potent drugs available contain biologics, several patients fail to react to them or cause hostile effects.

Objectives: Betanin (BTN), the betacyanin present in the red beetroot, has antioxidant, antiinflammatory, and apoptotic properties.

Clinicopathological features of Lynch syndrome pedigrees with MSH2 c.351G>A gene variant.

Background: Lynch syndrome (LS) is an autosomal-dominant disorder that increases the risk of many cancers. To identify novel or rare pathogenic variants of MMR genes associated with LS, especially in Chinese pedigrees.

Methods: One four-generation Chinese Han family from northeast China with 29 members was enrolled.

Morin Ameliorates Myocardial Injury in Diabetic Rats via Modulation of Autophagy, Apoptosis, Inflammation, and Oxidative Stress.

Background: Morin is a flavonol with beneficial effects on diabetic-related injuries. However, the effect of morin on diabetic cardiomyopathy and its association with autophagy, apoptosis, inflammation, and oxidative stress remains unclear. The current study aimed to reveal the mechanisms underlying morin-mediated protection against cardiac failure in diabetic rats.

A case series of the efficacy and tolerability of ketogenic diet in children with drug-resistant epilepsy due to neonatal hypoglycemia.

Objective: The objective of this study was to investigate the effectiveness and tolerance of the ketogenic diet (KD) in children who have drug-resistant epilepsy (DRE) caused by neonatal hypoglycemia.

Methods: We conducted a retrospective analysis of the data from pediatric patients who were diagnosed with neonatal hypoglycemia-related DRE and initiated a KD at Xi'an Children's Hospital between May 2014 and March 2023.

Results: Nine patients were enrolled in this study.

[Observation of the effect of single dose intravenous infusion of tranexamic acid on white blood cell, erythrocyte sedimentation rate and C-reactive protein after double segmental posterior lumbar interbody fusion].

Objective: To observe the safety and effectiveness of single dose intravenous infusion of tranexamic acid (TXA) in dual level posterior lumbar interbody fusion (PLIF), and to explore the changes and trends in perioperative white blood cell (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).

Methods: Between October 2020 and September 2022, 46 patients with lumbar degenerative disease were treated with dual level PLIF, including 18 males and 28 females, with an average age of (60.24±10.

PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.

Background: Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and a significant cause of visual impairment and blindness in adults. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis, which might improve insulin signaling and insulin sensitivity. Furthermore, it has been reported that the m6A methylation in mRNA controls gene expression under many physiological and pathological conditions.

Perspectives of clinical research on Shen-Shuai-Ning in the treatment of diabetic nephropathy.

Diabetic nephropathy (DN) is one of the most common chronic complications in patients with diabetes and remains a leading cause of end-stage renal disease. Despite current treatment strategies focusing primarily on blood glucose control and antihypertensive medications, their efficacy is often limited, failing to halt disease progression effectively. However, Shen-Shuai-Ning (SSN), a traditional Chinese medicine compound, has demonstrated significant clinical efficacy in DN treatment in recent years.

Effect of flexible cystoscopy combined with flexible ureteroscopy on short-term outcomes in patients with complex renal stones.

Objective: To investigate the short-term efficacy of combining flexible cystoscopy with flexible ureteroscopy in the treatment of complex renal stones.

Methods: The medical records of 145 patients with complex renal stones admitted to Yan'an People's Hospital from February 2020 to February 2022 were retrospectively analyzed. Among these, 65 patients treated with flexible ureteroscopy alone constituted the control group.

Analysis of anterior segment in primary angle closure suspect with deep learning models.

Objective: To analyze primary angle closure suspect (PACS) patients' anatomical characteristics of anterior chamber configuration, and to establish artificial intelligence (AI)-aided diagnostic system for PACS screening.

Methods: A total of 1668 scans of 839 patients were included in this cross-sectional study. The subjects were divided into two groups: PACS group and normal group.