The Roles of myomiRs in the Pathogenesis of Sarcopenia: From Literature to In Silico Analysis.

Senile sarcopenia is a condition of age-associated muscular disorder and is a significant health issue around the world. In the current review, we curated the information from the NCBI, PubMed, and Google Scholar literature and explored the non-genetic and genetic causes of senile sarcopenia. Interestingly, the myomiRs such as miR-1, miR-206, miR-133a, miR-133b, miR-208b, and miR-499 are skeletal muscle's critical structural and functional regulators.

Revealing the key antioxidant compounds and potential action mechanisms of Bauhinina championii honey based on non-targeted metabolomics, mineralogical analysis and physicochemical characterization.

Bauhinia championii (BC) honey, highly regarded for its functional properties, is popular among consumers and holds significant economic potential, particularly in the food and health industries. However, limited knowledge of the bioactivities, especially its outstanding antioxidant activity, hampers the development of functional products. This study comprehensively compared BC honey's physicochemical properties, elemental composition, metabolic profile, and antioxidant properties with five other honeys.

Screening and Comparative Genomics of Probiotic Lactic Acid Bacteria from Bee Bread of : Influence of Stevia and Stevioside on Bacterial Cell Growth and the Potential of Fermented Stevia as an Antidiabetic, Antioxidant, and Antifungal Agent.

The purpose of this research is to identify and characterize lactic acid bacteria (LAB) species in bee bread produced by honey bees () in the east mountain area of Suzhou, China. We isolated three strains, (S1), (S2), and (S3), with S2 producing the highest amount of lactic acid. Phylogenetic analysis indicated that these isolates, along with the type strain, formed a distinct sub-cluster within the LAB group.

Effect of double-induced on whey protein isolate nanoparticle formation and stabilized food-grade Pickering emulsions: Stability and gastrointestinal digestion.

The effects of non-heat-induced and double-induced(heat-induced and Na-induced) whey protein isolate nanoparticles (WPINs) at concentrations of C = 1 %, 2 %, and 5 % as well as oil fractions (φ = 0.1, 0.4, and 0.

The role of anxiety factors in predicting smartphone addiction mediated by metacognition among university students: a two-stage SEM-ANN approach.

This study aims to investigate the associative factors related to smartphone addiction among university students and to further examine the mediating roles of positive and negative metacognition in the relationship between anxiety factors and smartphone addiction. The researchers randomly surveyed 760 university students from three universities in Henan province of China using a structured questionnaire to measure their self-reported responses on six constructs: academic anxiety, social anxiety, future anxiety, positive metacognition, negative metacognition, and smartphone addiction. By applying the Structural Equation Modeling-Artificial Neural Network (SEM-ANN) approach, the study interprets the non-compensatory and nonlinear relationships between predictor factors and smartphone addiction.

Effects of fermented wheat germ on the placenta of high-fat diet-induced obese maternal rats: morphology, metabolism, and nutrient transport.

Maternal obesity impairs placental function, affecting fetal growth and long-term health. Although fermented wheat germ (FWG) provides health benefits, its impact on maternal obesity-related metabolic disorders and placental function remains unclear. This study investigated FWG's effects on placental morphology, metabolism, and nutrient transport in high-fat diet (HFD)-induced obese maternal rats.

A comprehensive review of recombinant technology in the food industry: Exploring expression systems, application, and future challenges.

Biotechnology has significantly advanced the production of recombinant proteins (RPs). This review examines the latest advancements in protein production technologies, including CRISPR, genetic engineering, vector integration, and fermentation, and their implications for the food industry. This review delineates the merits and shortcomings of prevailing host systems for RP production, underscoring molecular and process strategies pivotal for amplifying yields and purity.

Capturing Copper Single Atom in Proton Donor Stimulated O-End Nitrate Reduction.

Ammonia (NH) is vital in global production and energy cycles. Electrocatalytic nitrate reduction (e-NORR) offers a promising route for nitrogen (N) conversion and NH synthesis, yet it faces challenges like competing reactions and low catalyst activity. This study proposes a synergistic mechanism incorporating a proton donor to mediate O-end e-NORR, addressing these limitations.

Molecular characterization and subtype analysis of Blastocystis sp. in captive wildlife in Henan, China.

Blastocystis sp. is a zoonotic intestinal protozoan that is ubiquitous globally, residing in the gastrointestinal tracts of both humans and various animals. In the present study, a PCR-sequencing tool based on the SSU rRNA gene was employed to investigate the prevalence and subtypes of Blastocystis spp.

Towards high-quality development: The complex role of environmental regulation.

High-quality development is a necessary condition for a healthy society, and environmental regulation is an important means to maintain high-quality development. Against this backdrop, this study takes the Yellow River Basin in China as an example to explore the complex impact of environmental regulation on high-quality economic development, with a particular focus on the indirect impact of regional pollution heterogeneity on the complex influence. Utilizing panel data from 2011 to 2022, this paper constructs an evaluation index system for the Yellow River Basin's high-quality development that encompasses 29 fundamental indicators and applies the Entropy-Weighted TOPSIS method for a comprehensive assessment.

Modulation of Molecular Quadrupole Moments by Phenyl Side-Chain Fluorination for High-Voltage and High-Performance Organic Solar Cells.

The ground-state charge generation (GSCG) in photoactive layers determines whether the photogenerated carriers occupy the deep trap energy levels, which, in turn, affects the device performance of organic solar cells (OSCs). In this work, charge-quadrupole electrostatic interactions are modulated to achieve GSCG through a molecular strategy of introducing different numbers of F atom substitutions on the BTA3 side chain. The results show that 8F substitution (BTA3-8F) and 16F substitution (BTA3-16F) lead to different patterns of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy level changes.

Insights into the regulation mechanisms of dual hydrothermal treatment on the structure and digestive characteristics of A- and B-type wheat starch granules.

Hydrothermal treatment is a physical modification technology to alter starch structures for the production of resistant starch (RS). However, the underlying regulation mechanism of the multiscale structure and digestive properties of starch by dual hydrothermal synergistic treatment remains unclear. To solve this problem, A- and B-type wheat starch granules (AWS and BWS) were separated and subjected to toughening and heat-moisture synergistic treatment (THT) with various moisture content (10 %, 15 %, 20 %, 25 %).

A Simple and Rapid "Turn-On" Fluorescent Probe Based on Binuclear Schiff Base for Zn and Its Application in Cell Imaging and Test Strips.

A series of colorful binuclear Schiff bases derived from the different diamine bridges including 1,2- ethylenediamine (bis-Et-SA, bis-Et-4-NEt, bis-Et-5-NO, bis-Et-Naph), 1,2-phenylenediamine (bis-Ph-SA, bis-Ph-4-NEt, bis-Ph-5-NO, bis-Ph-Naph), dicyano-1,2-ethenediamine (bis-CN-SA, bis-CN-4-NEt, bis-CN-5-NO, bis-CN-Naph) have been designed and prepared. The optical properties of these binuclear Schiff base ligands were fully determined by UV-Vis absorption spectroscopy, fluorescence emission spectroscopy, and time-dependent-density functional theory (TD-DFT) calculations. The inclusion of D-A systems and/or π-extended systems in these binuclear Schiff base ligands not only enables adjustable RGB light absorption and emission spectra (300~700 nm) but also yields high fluorescence quantum efficiencies of up to 0.

A perspective on field-effect in energy and environmental catalysis.

The development of catalytic technologies for sustainable energy conversion is a critical step toward addressing fossil fuel depletion and associated environmental challenges. High-efficiency catalysts are fundamental to advancing these technologies. Recently, field-effect facilitated catalytic processes have emerged as a promising approach in energy and environmental applications, including water splitting, CO reduction, nitrogen reduction, organic electrosynthesis, and biomass recycling.

Spin and valley dependent transport and tunneling magnetoresistance in irradiated ferromagnetic WSedouble barrier junctions.

Spin and valley polarizations (P and P) and tunneling magnetoresistance (TMR) are demonstrated in the ferromagnetic/barrier/normal/barrier/ferromagnetic WSe junction, with the gate voltage and off-resonant circularly polarized light (CPL) applied to the two barrier regions. The minimum incident energy of non-zero spin- and valley-resolved conductance has been derived, which is consistent with numerical calculations and depends on the electric potential U, CPL intensity ΔΩ, exchange field h, and magnetization configuration: parallel (P) or antiparallel (AP). For the P (AP) configuration, the energy region with P = -1 or P = 1 is wider (narrower) and increases with ΔΩ.

Computational design of CDK1 inhibitors with enhanced target affinity and drug-likeness using deep-learning framework.

Cyclin Dependent Kinase 1 (CDK1) plays a crucial role in cell cycle regulation, and dysregulation of its activity has been implicated in various cancers. Although several CDK1 inhibitors are currently in clinical trials, none have yet been approved for therapeutic use. This research utilized deep learning techniques, specifically Recurrent Neural Networks with Long Short-Term Memory (LSTM), to generate potential CDK1 inhibitors.

A label-free electrochemical biosensor for sensitive analysis of the PARP-1 activity.

Early diagnosis of tumors is becoming increasingly important in modern healthcare. As studies have demonstrated, Poly(ADP)ribose polymerase-1 (PARP-1) is overexpressed in more aggressive tumors. Consequently, sensitive detection of PARP-1 activity holds significant practical importance in clinical diagnostics and biomedical research.

Comparison of Plant Genomic DNA Extraction Kits Using the Proofman-LMTIA Amplification Assay.

Introduction: The extraction of DNA is the basis of molecular biology research. The quality of the extracted DNA is one of the key factors for the success of molecular biology experiments.

Objective: To select a suitable DNA extraction method for Chinese medicinal herbs and seeds.

Forecasting for electricity demand utilizing enhanced inception-V4 using improved Osprey optimization.

This research examines the impact of temperature, relative humidity, and wind speed on the electricity demand. It presents a unique method that combines an Enhanced Inception-V4 model with an Improved Osprey Optimizer to analyze weather-related factors. The combined model, which has been validated from 2003 to 2023, surpasses traditional forecasting techniques and significantly improves prediction accuracy.

Local anaesthesia with conscious sedation in parotid gland tumour resection: a retrospective review.

Objectives: This study explored the suitability of local anaesthesia with conscious sedation for parotid gland tumour surgery.

Methods: Three hundred sixty-four medical records were reviewed to gather data on several key aspects for retrospective analysis. These included age, incision length, operation time, tumour size, NNIS score, ASA score, and pathology.

Analysis of the influencing mechanism of low-frequency alternating magnetic field-assisted freezing on oxidative and structural attributes of pork myofibrillar proteins based on proteomic changes.

Using quantitative proteomics, the study investigated the effects of low-frequency alternating magnetic field-assisted freezing (LF-MFF) on the oxidative status and structural integrity of porcine myofibrillar proteins (MPs). LF-MFF, especially at 3 mT (LF-MFF-3) and 4 mT (LF-MFF-4), significantly reduced MPs' oxidation compared to refrigerator freezing (RF) (P < 0.05).

Wheat Embryo Albumin and Its Peptide Alleviate Acute Exercise Fatigue as Energy Supplement.

Wheat embryo albumin (WEA), rich in amino acids with a good balanced proportion, demonstrates plentiful biological activities. The effects of WEA and its peptide with the best antioxidant ability (F3) as a post-workout and pre-workout energy supplement on alleviating acute exercise fatigue were investigated. Under two experimental cases, the exhaustion-to-death swimming time and exhaustion swimming time were determined.

Combination of Deep and Statistical Features of the Tissue of Pathology Images to Classify and Diagnose the Degree of Malignancy of Prostate Cancer.

Prostate cancer is one of the most prevalent male-specific diseases, where early and accurate diagnosis is essential for effective treatment and preventing disease progression. Assessing disease severity involves analyzing histological tissue samples, which are graded from 1 (healthy) to 5 (severely malignant) based on pathological features. However, traditional manual grading is labor-intensive and prone to variability.

Upward social comparison on social networking sites (SNSs) and individual well-being: a moderated mediation model.

To explore the influence of upward social comparison on social networking sites on individual well-being, as well as the role of envy and nature connectedness, a questionnaire survey was conducted among 1078 college students. The results indicated: (1) upward social comparison on social networking sites had a significant negative effect on well-being; (2) envy played a mediating role in the relationship between upward social comparison on social networking sites and well-being; and (3) nature connectedness moderated the direct effect of upward social comparison on social networking sites on well-being and the mediating effect of envy. The present study revealed the relationship between upward social comparison on SNSs and well-being and its internal mechanism, providing concrete ways to intervene individual well-being in the Internet era.

Biocontrol of Salmonella Schwarzengrund and Escherichia coli O157:H7 planktonic and biofilm cells via combined treatment of polyvalent phage and sodium hexametaphosphate on foods and food contact surfaces.

Salmonella Schwarzengrund and Escherichia coli O157:H7 are ones of foodborne pathogens that can produce biofilms and cause serious food poisoning. Bacteriophages are an emerging antibacterial strategy used to prevent foodborne pathogen contamination in the food industry. In this study, the combined antibacterial effects of the polyvalent phage PS5 and sodium hexametaphosphate (SHMP) against both pathogens were investigated to evaluate their effectiveness in food applications.