Dynamic changes of the S wave in lead V6: A novel visual indicator for left bundle branch capture.

Background: During the electrode screwing process in left bundle branch pacing (LBBP), the significance of the S wave in lead V6 remains elusive. Our study analyzes the change of the S wave in lead V6 under different patterns of capture and explores its mechanisms.

Methods: This study included 243 cases with criterion of selective LBBP (SLBBP), we performed continuous pacing technique and classified the electrophysiological characteristics observed during the screwing process into four patterns: left ventricular septal pacing (LVSP), non-selective LBBP (NSLBBP) in low output and in the lower output, selective LBBP.

3D-Printed Extracellular Matrix-Mimicking Hydrogels Derived from Multiple Tissues for Integrated Construction of Complex Organs.

Due to the lack of suitable donors and concerns about immune rejection after transplantation, the demand for artificial organs among patients is increasing. Extracellular matrix-mimicking hydrogels provide excellent prospects for overcoming the limitations of current artificial organ construction methods. Here, a set of extracellular matrix-mimicking hydrogels derived from multiple animal tissues is described, which meets the regeneration needs of multiple tissues after xenotransplantation.

Case Report: Dual immunomodulatory and hematologic benefits of rituximab in refractory anemia of ANCA-associated vasculitis.

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by necrotizing small-vessel inflammation, frequently complicated by severe anemia and progressive renal injury. Anemia, affecting 73-92% of AAV patients, arises from multifactorial mechanisms including renal dysfunction, chronic inflammation, and iron dysregulation. Despite conventional immunosuppressive therapies, refractory anemia remains a significant challenge, with limited strategies targeting inflammation-driven hepcidin dysregulation.

Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5-year update of the CinClare trial.

Background: The optimal regimen and chemotherapy intensity are still under investigation for neoadjuvant treatment of locally advanced rectal cancer (LARC). The CinClare trial has demonstrated improved pathologic complete response (pCR) with the addition of irinotecan to neoadjuvant chemoradiotherapy (CRT) guided by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype in LARC. Here, we report the 5-year follow-up outcomes of the CinClare study.

Applications of machine learning for computer-aided diagnosis of Parkinson's disease: progress and benchmark case study.

Machine learning (ML) has emerged as a vital tool for the diagnosis of Parkinson's Disease (PD). This study presents a comprehensive review on the applications of ML for computer-aided diagnosis (CAD) of PD. We conducted a comprehensive review by searching articles published from 2010 till 2024.

Improving CAR-T cell function through a targeted cytokine delivery system utilizing car target-modified extracellular vesicles.

Chimeric antigen receptor (CAR)-T-cell therapy has achieved remarkable clinical success in the treatment of B-cell malignancies; however, its efficacy can be limited by poor T-cell persistence and insufficient antitumor activity in certain cases. Moreover, interleukin-12 (IL-12) is a prominent agent in cancer immunotherapy, but its clinical application is constrained by severe toxicity associated with systemic exposure. In this study, we developed a novel cytokine delivery platform based on CAR target-modified cell-derived extracellular vesicles (EVs) that preferentially bind CAR-T cells to improve CAR-T-cell function.

Correction: Skin microbiota and diabetic foot ulcers.

[This corrects the article DOI: 10.3389/fmicb.2025.

Safety and Cost Evaluation of Modified Medium-Length Catheters in Patients With Advanced Cancer: A Randomized Controlled Trial.

Background: Deep vein catheterization is common in patients with advanced cancer, but safety and cost comparisons between catheter types are limited.

Purpose: To evaluate the safety and economic impact of a modified medium-length catheter versus a standard peripherally inserted central catheter (PICC) line in patients with advanced cancer.

Methods: A prospective cohort study was conducted involving 160 patients with advanced cancer receiving palliative care between January 2022 and April 2024.

Tanshinol: A Potential Antioxidant, Anti-Inflammatory Agent, and a Potent Apoptosis Inducer in Non-Small Cell Lung Cancer Cells.

Advances in therapy have yet to substantially improve the 5-year survival metrics for non-small cell lung cancer (NSCLC) patients, underscoring a significant gap that necessitates novel and efficacious treatment solutions. In this study, we demonstrated that tanshinol significantly diminished A549 cell viability and disrupted their proliferative and metastatic capabilities, while simultaneously promoting apoptosis. These cellular responses were linked to suppression of the PI3K/AKT signaling pathway.

AI-based diagnosis of acute aortic syndrome from noncontrast CT.

The accurate and timely diagnosis of acute aortic syndrome (AAS) in patients presenting with acute chest pain remains a clinical challenge. Aortic computed tomography (CT) angiography is the imaging protocol of choice in patients with suspected AAS. However, due to economic and workflow constraints in China, the majority of suspected patients initially undergo noncontrast CT as the initial imaging testing, and CT angiography is reserved for those at higher risk.

Computer aided diagnostic model for knee osteoarthritis: A multi-modal feature regression approach.

Background: X-ray imaging is crucial for diagnosing knee osteoarthritis (KOA) in clinical treatment. Computer-assisted diagnostic models reduce the impact of physicians' subjective factors on the accuracy of X-ray diagnoses. Therefore, continuous improvement of these models is necessary.

Comparison of the efficacy of soaking and drying methods for the disinfection of handwashing sinks in ICU.

Objective: This study aimed to investigate the effects of drying, soaking, and two combined disinfection methods on the disinfection efficiency of ICU handwashing sinks.

Methods: From January to June 2024, eight handwashing sinks in the ICU were randomly divided into control group ( = 2), soaking group ( = 2), drying group ( = 2), and combination group ( = 2). The control group wiped with quaternary ammonium wipes only; the soaking group used chlorine disinfectant for 30 min based on the control group; the drying group was dried in a dryer for 15 min based on the control group; and the combined group was a combination of soaking and drying.

Clinical Application of Contrast-Enhanced Ultrasound in Giant Cell Arteritis.

Objective: The application of contrast-enhanced ultrasound (CEUS) to evaluate temporal arterial wall enhancement in giant cell arteritis (GCA) provides valuable information for evaluating disease activity and predicting treatment response.

Methods: A total of 90 patients clinically diagnosed with GCA at our hospital between January 2020 and March 2024 were enrolled. Patients were divided into an active group and an inactive group based on the NIH criteria.

Hyaluronic acid-based composite hydrogels embedded with core-shell microgels with properties of mucosal adhesion and combined drug administration for chemoradiotherapy induced oral mucositis.

Chemoradiotherapy-induced oral mucositis (CIOM), characterized by high incidence and delayed healing, severely impairs patient recovery and quality of life. Current treatments face challenges due to poor wet adhesion, dynamic oral environments, and lack of multiple active substances for mucosal repair. This situation makes an urgent need for therapeutic platforms that combine robust mucosal adhesion with multifunctionality.

Anti-PD-1 therapy for preventing recurrence and improving survival in hepatocellular carcinoma patients after hepatectomy.

Background And Aim: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with a high recurrence rate after resection. This study investigates the efficacy of postoperative anti-PD-1 antibody therapy on overall survival (OS) and recurrence-free survival (RFS) in HCC patients, with a particular focus on those positive for vessels encapsulating tumor clusters (VETC), a marker of aggressive disease behavior and high recurrence risk.

Methods: This prospective observational study analyzed data from HCC patients who underwent curative liver resection between June 2015 and June 2022.

Impact of ventilation and ambient temperature on COVID-19 transmission in clinic waiting rooms: A computational fluid dynamics approach.

The ongoing COVID-19 pandemic underscores the necessity of understanding the transmission dynamics in enclosed, high-risk environments, such as clinic waiting rooms. This study used computational fluid dynamics (CFD) to investigate the behavior of virus-laden aerosols in clinic waiting rooms under six different scenarios with various temperatures and ventilation setups, offering insights into practical strategies for enhancing safety in healthcare environments. Key findings demonstrated that effective ventilation, through open windows and mechanical systems, can reduce virus-laden aerosol concentrations by up to 99.

Ultra-sensitive room temperature ammonia detection enabled by MEMS-based 0D/1D/2D PAMo nanocomposites.

A 0D/1D/2D Au/PANI/MoS hierarchical nanocomposite based on micro-electromechanical systems (MEMS) was successfully synthesized through in situ chemical oxidative polymerization. This composite overcomes the performance bottlenecks of single or dual-component combinations through a multi-dimensional synergy of "interface coordination-charge penetration-path optimization-stability enhancement." The built-in electric field generated by the p-n heterojunction formed between PANI and MoS₂ can drive the directional migration of carriers, thereby optimizing the carrier transport process.

Discovery of Potent Dual PROTAC Degraders Targeting BET-Kinase To Overcome FLT3 Inhibitor Resistance.

FMS-like tyrosine kinase 3 (FLT3) is a validated therapeutic target in acute myeloid leukemia (AML). However, numerous single-agent FLT3 or multitarget inhibitors fail to achieve complete and sustained suppression of FLT3 signaling due to the development of drug resistance. Herein, we report the design, synthesis, and evaluation of a novel series of dual BET-kinase degraders targeting FLT3, JAK2, and BRD4.

A new target for the treatment of oral squamous cell carcinoma: Circ_0046336.

BackgroundThis study was designed to investigate the mechanism of Circ_0046336 in oral squamous cell carcinoma (OSCC).MethodsThe expression pattern of Circ_0046336 and its distribution in OSCC cell lines (SCC-9 and CAL-27) were identified. Fluorescence hybridization was applied to determine the location of Circ_0046336.