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Article Abstract
Due to the lack of suitable donors and concerns about immune rejection after transplantation, the demand for artificial organs among patients is increasing. Extracellular matrix-mimicking hydrogels provide excellent prospects for overcoming the limitations of current artificial organ construction methods. Here, a set of extracellular matrix-mimicking hydrogels derived from multiple animal tissues is described, which meets the regeneration needs of multiple tissues after xenotransplantation. Combined with 3D printing technology, multiple extracellular matrix-mimicking hydrogels are used to prepare 3D layered hybrid structures to simulate complex organs with heterogeneous composition. In this process, the corresponding extracellular matrix-mimicking hydrogels participate in organ regeneration via their unique tissue-specific components. This strategy can potentially be extended to any complex organs with heterogeneous composition, providing the possibility for the manufacture of artificial organs based on animal tissues.
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