Using robotic single-port vNOTES for gynaecological oncology: omentectomy in a patient with an ovarian granulosa cell tumor-a case study.

Background: Robotic single-port transvaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) is an emerging minimally invasive approach that combines the advantages of robotic surgery with scarless transvaginal access. Its application in gynecologic oncology remains limited, particularly for omentectomy during ovarian cancer staging.

Methods: We present the case of a 45-year-old woman with an ovarian granulosa cell tumor (GCT) who underwent supplemental staging surgery following unilateral oophorectomy.

Developing Community-Informed Communication Resources to Improve Human Papillomavirus Vaccine Uptake in Tonga.

Introduction: Despite high coverage of routine childhood vaccines, uptake of the human papillomavirus (HPV) vaccine in the Pacific Island nation of Tonga has been slow. Culturally appropriate communication resources on the importance, safety, and effectiveness of the HPV vaccine are critical to support acceptance and uptake. To develop these resources, it is important to understand what people want to know.

PARP inhibitors-associated thrombosis in patients with ovarian cancer: a study of the Spanish Society of Medical Oncology (SEOM) thrombosis and cancer group.

Purpose: To determine the real-world incidence and predictive factors for venous and arterial thromboembolic events (VTE/AT) in ovarian cancer patients treated with poly-(ADP-ribose) polymerase inhibitors (iPARP).

Methods/patients: A multicenter retrospective study involving 329 ovarian cancer patients who initiated iPARP treatment between January 2015 and December 2022. The primary outcome was the incidence of VTE/AT.

SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies.

Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the anterior and posterior segments of the eye, significantly reducing the quality of life of patients, and even leading to irreversible blindness. Typical AREDs include age-related cataract (ARC), dry eye disease (DED), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR), the global prevalence of which continues to rise, becoming a serious public health concern. SIRT1 is an NAD + dependent deacetylase, which plays an important physiological regulatory role in ocular tissues, mainly affecting gene expression and various cellular processes by regulating the acetylation status of substrate proteins.

Development and validation of a machine learning model for predicting immune checkpoint inhibitor efficacy in advanced gastric cancer using dynamic changes in peripheral blood clinlabomics data: a retrospective multicenter cohort study.

Background: Immune checkpoint inhibitors (ICIs) play a pivotal role in the treatment of advanced gastric cancer (GC). However, the biomarkers used to predict ICI efficacy are limited due to their reliance on single or static tumor characteristics. This study aims to develop a machine learning (ML) model that incorporates dynamic changes in clinlabomics data to optimize the predictive accuracy of ICI efficacy.

Dynamic data balancing strategy-based Xception-dual-channel LSTM model for laparoscopic cholecystectomy phase recognition.

Purpose: To enhance the temporal feature learning capability of the laparoscopic cholecystectomy phase recognition model and address the class imbalance issue in the training data, this paper proposes an Xception-dual-channel LSTM fusion model based on a dynamic data balancing strategy.

Methods: The model dynamically adjusts the undersampling rate for each surgical phase, extracting short video clips from the original data as training samples to balance the data distribution and mitigate biased learning. The Xception model, utilizing depthwise separable convolutions, extracts fundamental visual features frame by frame, which are then passed to a dual-channel LSTM network.

Robotic upper urinary tract reconstruction for ureteral stricture: a single-center series.

The surgical approach of ureteral stricture has changed dramatically over the past 15 years with the rise of robotic upper urinary tract reconstruction. This study aimed to evaluate the outcomes of all robotic ureteral reconstructions performed at a single academic center for ureteral stricture and to assess the predictive factors of stricture recurrence. The charts of all patients who underwent robot-assisted ureteral reconstruction between 2013 and 2024 at a single academic center were retrospectively reviewed.

Clinical applied anatomical study between the uncinate process of the cervical spine and the vertebral artery.

Objective: Reveal the changing rule of the positional relationship between the uncinate process of cervical spine and vertebral artery by measuring the relevant parameters between the uncinate process of cervical spine and vertebral artery in different age groups.

Methods: A retrospective study was conducted on 1240 cases of cervical spine imaging data from 2018 to 2021 in the Radiology Department of the Affiliated Hospital of Inner Mongolia Medical University. The distance between the uncinate process superior ridge and vertebral artery and the maximum of pedicle transverse angle, the minimum of pedicle transverse angle, the range of pedicle transverse angle and the pedicle width were measured according to age groups.

The molecular mechanisms and therapeutic implications of PANoptosis in ischemic diseases.

The singular forms of programmed cell death (PCD), including pyroptosis, apoptosis, and necroptosis, are inadequate for comprehensively elucidating the complex pathological mechanisms underlying ischemic diseases. PANoptosis is a unique lytic, innate immune, and inflammatory cell death pathway, initiated by innate immune sensors and driven by caspases and RIPKs through PANoptosome complexes. In diseases like cerebral ischemia, retinal ischemia, myocardial ischemia, renal ischemia, and spinal cord ischemia, targeting key regulatory factors of PANoptosis can help mitigate tissue damage.

Plasma transfusion practice: A five-year audit of plasma transfusion at 23 hospitals.

Background: There is limited high-quality evidence to guide plasma transfusion, and plasma transfusion practices remain variable.

Study Design And Methods: This is a retrospective cohort study that included adult medical and intensive care unit (ICU) inpatients (age ≥ 18 years) admitted to 23 hospitals in Canada between January 1, 2017, and December 31, 2022, when both whole blood derived (~290 mL) and apheresis plasma (~250 mL) were available for transfusion. Nine additional hospital sites with missing plasma data or coagulation testing were excluded.

Correction of Tricuspid Regurgitation in Pulmonary Arterial Hypertension.

Background: Pulmonary hypertension is a contraindication to correction of tricuspid regurgitation.

Case Summary: A 75-year-old Italian woman with previous episodes of right heart failure was diagnosed with World Health Organization (WHO) functional class IV pulmonary arterial hypertension (PAH) complicated by torrential tricuspid regurgitation. After 6 months of treatment with diuretic agents, macitentan, and tadalafil, she improved to WHO functional class III, with a pulmonary vascular resistance (PVR) decreasing from 5.

Immunoglobulin free light chain-κ in association with NT-proBNP levels after smoking cessation.

Background: Smoking induces inflammation in the heart and intima layer of blood vessels by activating nuclear factor kappa B, which controls the transcription of immunoglobulin free light chain (FLC)-κ. FLC levels are indicative of higher mortality in the overall population and poorer prognoses in cardiovascular diseases. This study aimed to analyze the effect of smoking cessation (SC) on the levels of FLCs and markers of inflammation and heart failure.

Effect of Dietary Intervention With Berries on Anthropometric Indices: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Context: Cardiovascular protective properties of berries have been reported in numerous studies. Berries and their bioactive compounds may also be effective for improving body composition and anthropometric indices.

Objective: This systematic review and meta-analysis were aimed to investigate the effect of berries on anthropometric markers.

Enabling micro-assessments of skills in the simulated setting using temporal artificial intelligence-models.

Background: Assessing skills in simulated settings is resource-intensive and lacks validated metrics. Advances in AI offer the potential for automated competence assessment, addressing these limitations. This study aimed to develop and validate a machine learning AI model for automated evaluation during simulation-based thyroid ultrasound (US) training.

Multiview Deep Learning Framework for Precise Prediction of Transcription Factor Binding Sites.

Transcription factors (TFs) are essential proteins that regulate gene expression by specifically binding to transcription factor binding sites (TFBSs) within DNA sequences. Their ability to precisely control the transcription process is crucial for understanding gene regulatory networks, uncovering disease mechanisms, and designing synthetic biology tools. Accurate TFBS prediction, therefore, holds significant importance in advancing these areas of research.

When to Switch to Subcutaneous Infliximab? The RE-WATCH Multicenter Study.

Background: The infliximab (IFX) biosimilar, CT-P13, is available as an intravenous (IV) and subcutaneous (SC) formulation. Although current indications allow the transition from IV CT-P13 to SC CT-P13 after two IV administrations, some clinicians prefer to postpone switching until stable clinical remission has been achieved.

Methods: We evaluate the endoscopic response, treatment persistence, clinical remission, endoscopic remission, and safety profile after one year of treatment with IFX in patients switched from IV to SC after 6 weeks (early switch group) or after 6 months (late switch group).

Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.

Background: Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory bowel disease (IBD), most single nucleotide polymorphisms (SNPs) are in non-coding genomic regions containing TF binding sites.

Psychotropic pharmacogenetics in adult populations: From basic science to clinical trials and health economics - An evidence-based overview for decision makers.

Psychotropic pharmacogenetics (PGx) offers significant potential advancements in psychiatric care by optimising medication selection and dosing based on genetic factors. This perspective article highlights the clinical utility, health economic implications and implementation challenges of psychotropic PGx, proposing that its broader implementation could enhance patient outcomes and reduce healthcare costs. Landmark studies show that PGx-guided care results in fewer adverse drug reactions and improved medication efficacy, with substantial cost savings compared to traditional prescribing methods.