Publications by authors named "Phuong Uyen Nguyen"
Plasma transfusion practice: A five-year audit of plasma transfusion at 23 hospitals.
Transfusion
September 2025
Background: There is limited high-quality evidence to guide plasma transfusion, and plasma transfusion practices remain variable.
Study Design And Methods: This is a retrospective cohort study that included adult medical and intensive care unit (ICU) inpatients (age ≥ 18 years) admitted to 23 hospitals in Canada between January 1, 2017, and December 31, 2022, when both whole blood derived (~290 mL) and apheresis plasma (~250 mL) were available for transfusion. Nine additional hospital sites with missing plasma data or coagulation testing were excluded.
The Healthcare Cost of Migraine: A Retrospective Cohort Study from Alberta, Canada.
Can J Neurol Sci
March 2025
Introduction: The economic burden of migraine is substantial; determining the cost that migraine imposes on the Canadian healthcare system is needed.
Methods: Administrative data were used to identify adults living with migraine, including chronic migraine (CM) and episodic migraine (EM), and matched controls in Alberta, Canada. One- and two-part generalized linear models with gamma distribution were used to estimate direct healthcare costs (hospitalization, emergency department, ambulatory care, physician visit, prescription medication; reported in 2022 Canadian dollars) of migraine during a 1-year observation period (2017/2018).
Post-Stroke Spasticity Treatment: A Retrospective Cohort Study From Alberta, Canada.
Can J Neurol Sci
November 2024
Article Synopsis
- A retrospective cohort study analyzed post-stroke spasticity (PSS) treatment data from Alberta, Canada, focusing on patients who started PSS treatment between 2012 and 2019.
- The most common treatment was oral baclofen, prescribed mainly by primary care physicians, with a median start time of 348 days after the stroke.
- The study highlighted issues such as over-reliance on oral baclofen (which has side effects) and underutilization of focal botulinum toxin injections, indicating a need for better alignment with treatment guidelines to improve patient outcomes.
Healthcare Cost of Multiple Sclerosis and in Relation to Disability Level in Alberta.
Can J Neurol Sci
October 2024
Article Synopsis
- The study estimates the direct healthcare costs for people living with multiple sclerosis (pwMS) in Alberta, Canada, compared to a control group, highlighting that pwMS incur significantly higher costs.
- The analysis shows that as disability levels increase among pwMS, their healthcare costs rise dramatically, with mild disabilities costing around $14,430 and severe disabilities costing up to $58,697 per person per year.
- The overall financial burden of MS in Alberta may exceed $218 million annually, stressing the importance of efforts to prevent disease progression and minimize functional impairment.
Poststroke Care Pathways and Spasticity Treatment: A Retrospective Study in Alberta.
Can J Neurol Sci
January 2025
Background: Limited evidence exists regarding care pathways for stroke survivors who do and do not receive poststroke spasticity (PSS) treatment.
Methods: Administrative data was used to identify adults who experienced a stroke and sought acute care between 2012 and 2017 in Alberta, Canada. Pathways of stroke care within the health care system were determined among those who initiated PSS treatment (PSS treatment group: outpatient pharmacy dispensation of an anti-spastic medication, focal chemo-denervation injection, or a spasticity tertiary clinic visit) and those who did not (non-PSS treatment group).
Objective: Understand health resource, medication use, and cost of adults with chronic migraine who received guideline-recommended onabotulinumtoxinA (botulinum toxin) treatment frequency and then continued or reduced/stopped.
Background: Botulinum toxin may be a beneficial treatment for chronic migraine; the trajectory of health resources utilization among those with continued or reduced/stopped use is unclear.
Methods: A retrospective population-based cohort study utilizing administrative data from Alberta, Canada (2012-2020), was performed.
Introduction: A better understanding of current acute pain-driven analgesic practices within the emergency department (ED) and upon discharge will provide foundational information in this area, as few studies have been conducted in Canada.
Methods: Administrative data were used to identify adults with a trauma-related ED visit in the Edmonton area in 2017/2018. Characteristics of the ED visit included time from initial contact to analgesic administration, type of analgesics dispensed during and upon being discharged home directly from the ED (≤ 7 days after), and patient characteristics.
Detection of maternal carriers of common α-thalassemia deletions from cell-free DNA.
Sci Rep
August 2022
Article Synopsis
- * A new method was developed to identify female carriers of α-thalassemia using non-invasive prenatal test samples, finding that 7.76% of 68,885 Vietnamese pregnant women carried deletions related to the disorder.
- * The approach showed high accuracy, with F1-scores between 94.74% and 99.55% for detecting various genotypes, and it suggests that using cfDNA from prenatal tests could be a cost-effective way to identify carriers of α-thalassemia.