Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.

Background: The introduction of novel therapeutics into clinical practice could impact equity in health outcomes.

Methods: This was a retrospective, observational cohort study based on the Get With The Guidelines-Stroke program of the American Heart Association. Two epochs were considered: January 2010 to December 2014 and January 2016 to December 2019.

Identification of two novel pathogenic mutations in the SKOR2 gene linked to cerebellar hypoplasia and a broad spectrum of neurodevelopmental delay in two Iranian families.

SKOR2 is a transcriptional repressor expressed in central nervous system tissues, mainly in the Purkinje cells (PCs). This is essential for the proper migration, development, and differentiation of PCs at embryonic stages, and its disruption can affect cerebellar function. SKOR2 protein has two DHD and SAND domains, which play an important role in the TGF-β signaling pathway by binding to Smad transcriptional regulators.

Kueselia aquadivae gen. nov., sp. nov., the first member of the family Isosphaeraceae isolated from subsurface percolates.

Subsurface habitats, found under various geological conditions, exhibit diverse microbial communities. The vadose zone, a previously unexplored subsurface compartment, connects the surface to phreatic groundwater. Drilling into the subsurface allows access to these habitats for microbial diversity study.

sp. nov., isolated from mouse faeces.

An extracellular polysaccharide-producing strain labelled GBG-M4 was isolated from the faeces of a C57BL/6 J mouse model with ulcerative colitis prognosis. Using a polyphasic approach, the taxonomy of this novel species was characterized. The strain was Gram-negative, non-motile, non-spore-forming, non-pigmented and rod-shaped.

Duganella hordei sp. nov., Duganella caerulea sp. nov., and Duganella rhizosphaerae sp. nov., isolated from barley rhizosphere.

Duganella sp. strains R1, R57, and R64, isolated from barley roots in Japan, are Gram-stain-negative, motile, rod-shaped bacteria. Duganella species abundantly colonized barley roots.

Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors: a win ratio analysis of the NOAH-AFNET 6 trial.

Aims: Patients with device-detected atrial fibrillation (DDAF) have a lower stroke risk than those with ECG-diagnosed AF, requiring careful evaluation of oral anticoagulation benefits vs. its inherent bleeding risk.

Methods And Results: An unmatched win ratio analysis was performed of the NOAH-AFNET 6 trial dataset, using components of the primary efficacy and safety outcomes of the trial.

Impacts of climate change and human activities on net primary productivity of vegetation in Ningxia, Northwest China.

This study aimed to quantitatively distinguish the contributions of climate change and human activities to net primary productivity (NPP). Based on meteorological observation data from 27 ground-based meteorological observation stations in Ningxia from 2000 to 2022 and Moderate Resolution Imaging Spectroradiometer (MODIS) data, we examined the spatiotemporal variations of potential net primary productivity (PNPP), actual net primary productivity (ANPP), and human-induced net primary productivity change (HNPP). The Thornthwaite Memorial model and the improved Carnegie-Ames-Stanford Approach (CASA) model, as well as Theil-Sen slope estimation, Mann-Kendall trend test, Hurst index, and partial correlation analysis were used.

Rational design of 2D-2D porphyrin metal-organic nanosheet/g-CN heterostructure for enhanced production of hydrogen under visible-light.

The development of heterojunction-based photocatalysts is a promising strategy to achieve enhanced green hydrogen (H) production by facilitating the competent separation of photo-induced charge carriers. In this context, two-dimensional (2D) metal-organic nanosheets (MONs) have garnered considerable attention owing to their unique properties of highly exposed active sites, ultrathin thickness, and large surface area. Especially, porphyrin-based 2D MONs have gained significant interest due to their optimum band structure and exceptional visible light harvesting properties.

Impact of timing of treatment for cardiac implantable electronic device infections on healthcare utilization and expenditures.

Aims: Early extraction for cardiovascular implantable electronic device (CIED) infections has been associated with longer survival, while the impact on healthcare utilization is unknown. The aim is to evaluate the impact of early extraction on healthcare expenditures and utilization.

Methods And Results: Using 100% Medicare fee-for-service data with Part D from 1/1/2006 through 12/31/2019, patients with a de novo CIED implant and CIED infection > 12 months after implant were identified to analyse healthcare utilization according to the occurrence and timing of extraction.

Synergistic ammonium and carbon removal in aquaculture effluent using red seaweed Agardhiella subulata.

The environmental challenges posed by nutrient-rich aquaculture wastewater emphasize the need for sustainable bioremediation strategies that integrate carbon capture and utilization (CCU) with effective nutrient removal. The bioextractive potential of Agardhiella subulata (AS) was investigated under fish wastewater (FW) and ammonium-supplemented fish wastewater (AFW) conditions. Over 14 days, AS cultivated in AFW exhibited a 67% higher growth rate, reaching a carbon capture efficiency of 10.

Immune correlates and mechanisms of TIL therapy efficacy: current insights and knowledge gaps.

Tumor-infiltrating lymphocyte (TIL) therapy has emerged as a transformative approach in cancer immunotherapy, particularly following the recent US Food and Drug Administration (FDA) approval of lifileucel for advanced melanoma. This review synthesizes current insights into the immune correlates and mechanisms underlying the efficacy of TIL therapy, highlighting the pivotal role of tumor immunogenicity, TIL functional states, and the tumor microenvironment (TME). Recent advances in single-cell profiling and biomarker discovery have enabled more precise patient selection and therapy optimization, while novel expansion protocols and engineered TILs are addressing resistance and broadening applicability to non-melanoma tumors.

Cancer Incidence and Mortality Risk: Associations with Diet Quality Scores in a Predominantly Low-Income and Black Cohort Study.

Background: Diet quality is a modifiable risk factor for cancer incidence and mortality. However, a substantial research gap exists regarding diet quality metrics' relationships with cancer risk among Black individuals or those with low socioeconomic status (SES).

Objective: This study aimed to investigate the associations of Dietary Approaches to Stop Hypertension (DASH), Empirical Dietary Inflammatory Pattern (EDIP), and Empirical Dietary Index for Hyperinsulinemia (EDIH) scores with total, colorectal, prostate, and breast cancer incidence and mortality within the prospective Southern Community Cohort Study (SCCS).

Computational screening of g-CN supported transition metals single-atom catalysts for electrocatalytic NO reduction reaction.

Electrocatalytic nitric oxide reduction reaction (NORR) offers a promising approach for the efficient synthesis of ammonia (NH). Density functional theory (DFT) study was conducted to investigate the activity and selectivity of NORR on transition metal (TM-Cv-CN) single-atom catalysts (SACs) supported on graphitic carbon nitride. Initially, 13 stable SACs were screened based on thermodynamic and electrochemical stability.

Regulatory limits of aluminium content of vaccines have not been set based on toxicological studies.

Aluminium-Based Adjuvants (ABAs) have been used in vaccines since the 1920s to boost immune responses. Despite their widespread use, their mechanisms of action remain only partially understood, and growing concerns exist about their long-term safety, particularly in vulnerable populations. This study examines the regulatory history of the aluminium content limit in vaccines and identifies major gaps in toxicological and epidemiological evaluation.

Precisely Bonded Fe─Cu Diatomic Sites with Nitrogen-Bridged Coordination on Hollow CN Spheres for Efficient C─N Coupling and Selective Photocatalytic Urea Synthesis.

The photocatalytic synthesis of urea from CO and N co-reduction presents a promising alternative to the conventional energy-intensive Haber-Bosch process. However, competitive adsorption on the catalyst surface often limits selectivity and yield. Here, we designed hollow graphitic carbon nitride (g-CN) spheres, which serve as a high surface area scaffold for precise anchoring of Fe─Cu diatomic sites.

Higher butanol titer and selectivity in electro-fermentation experiments with Clostridium acetobutylicum ATCC 824 are due mainly to methyl viologen rather than electrode polarization.

Butanol selectivity is crucial for the development of an industrial process targeting butanol as the main product of acetone-butanol-ethanol (ABE) fermentation by solventogenic Clostridia. This study evaluated electro-fermentation (EF), with an electron carrier, methyl viologen (MV), as a strategy to modify solvent production in Clostridium acetobutylicum ATCC 824 under optimized batch fermentation conditions. Cathodic EF was performed with or without 0.

Whole-Brain Analysis of Increased Brain Iron in Patients with β-Thalassemia.

Rationale And Objectives: β-thalassemia (β-TM) is an inherited hematological disorder characterized by impaired hemoglobin synthesis, leading to chronic anemia and systemic iron overload. While numerous studies have documented widespread iron deposition caused by repeated blood transfusions and disrupted iron metabolism, the impact of iron overload on the brain remains poorly understood. This study aimed to investigate whole-brain iron accumulation in patients with β-TM using quantitative susceptibility mapping (QSM).

Management of Chronic Myeloid Leukemia During Pregnancy: Review of Evidence and Treatment Algorithm.

Philadelphia chromosome-positive chronic myeloid leukemia (CML) during pregnancy is rare, with an annual incidence of 1 per 100,000 pregnancies. Managing CML in pregnancy is challenging due to concerns about the teratogenicity of the BCR::ABL1 tyrosine kinase inhibitors (TKIs). While some pregnant patients with chronic-phase CML may be managed with close monitoring and no therapy, others, particularly those diagnosed in the first trimester, may require treatment to prevent disease progression and maternal complications.

Transfer learning with graph neural networks for pressure estimation in monitoring-limited water distribution networks.

Water distribution networks (WDNs) constitute essential urban infrastructure, yet their monitoring is hindered by limited monitoring conditions. Soft sensing methods have been applied to estimate pressure at unmonitored nodes using the latest deep learning models, however, they rely on large datasets from the same WDNs for training. There is a critical gap in pressure estimation of WDNs under realistic monitoring limitations.

Complete genome sequence of the probiotic candidate strain Lacticaseibacillus rhamnosus B3421 isolated from Panax ginseng C. A. Meyer in South Korea.

Objectives: Lacticaseibacillus rhamnosus is a widely recognized probiotic bacteria with therapeutic applications in human and animal health. The L. rhamnosus B3421 strain, isolated from Panax ginseng, has been reported to be associated with antioxidant and anti-inflammatory properties, supporting its functional potential.

sp. nov., isolated from Niya Fish Salt Lake Sediment in Xinjiang, Northwest China.

A Gram-stain-negative, aerobic, rod-shaped, oxidase- and catalase-positive and non-motile bacterium, named MINF-07-Sa-05, was isolated from sediment samples collected from Niya Fish Salt Lake in Xinjiang, northwest China. Phylogenetic tree based on 16S rRNA gene sequences showed that strain MINF-07-Sa-05 consistently fell within the genus and formed a clade together with ZV-19 (98.97%) and 4CA (96.

Converging Patterns of Heterotrophic Respiration Between Growing and Non-Growing Seasons in Northern Temperate Grasslands.

Temperate grasslands are highly sensitive to climate change and play a crucial role in terrestrial carbon cycling. In the context of global warming, heterotrophic respiration (Rh) has intensified, contributing significantly to atmospheric CO emissions. However, seasonal patterns of Rh, particularly differences between the growing season (GS) and non-growing season (non-GS), remain poorly quantified.

Detection and Genomic Characteristics of NDM-19- and QnrS11-Producing O101:H5 Strain Phylogroup A: ST167 from a Poultry Farm in Egypt.

This study describes the first complete genomic sequence of an NDM-19 and QnrS11-producing multidrug-resistant (MDR) isolate collected from a fecal swab from a poultry farm in 2019 in Egypt. The was identified by PCR screening and DNA sequencing. The isolate was then subjected to antimicrobial susceptibility testing, conjugation and transformation experiments, and complete genome sequencing.

Functional and Safety Profile of and Development of Oral Fast-Disintegrating Tablets for Gut Microbiota Modulation.

: Early gut colonization by bifidobacteria, occurring more favorably in vaginally born infants than in those delivered via C-section, is crucial for maintaining overall health. The study investigated the health-promoting properties of BC17 both as viable cells and as postbiotics (i.e.

Genetic Variants and Their Potential Involvement in Migraine Pathogenesis.

Migraine is a prevalent neurological disorder that affects over 1 billion individuals worldwide. The pathogenesis of migraine remains incompletely understood, though evidence suggests a multifactorial etiology involving genetic factors. The gene has been implicated in rare forms of Familial Hemiplegic Migraine (FHM).