Fabrication of MIL-100(Fe)-GO Filler-Infused Sulfonated Polyether Ether Ketone Membrane for Room-Temperature Direct Methanol Fuel Cell Applications with Enhanced Selectivity.

This study reports the preparation of MIL-100(Fe)-GO composites by a one-pot synthesis approach at room temperature, assisted by ultrasonication. The synthesized MIL-100(Fe)-GO composites were utilized as a filler for the preparation of a sulfonated polyether ether ketone (SPEEK)-based proton exchange membrane (PEM). The in situ development of MIL-100(Fe) on GO creates a strong interaction between GO and MIL-100(Fe), which enhances the surface roughness (confirmed from the AFM study) of the SPEEK membrane with its incorporation as a filler.

Hypokalemic Periodic Paralysis in a Patient With Primary Sjögren's Syndrome and Distal Renal Tubular Acidosis: A Case Report.

Introduction: Hypokalemic periodic paralysis (HPP) is a severe yet reversible neuromuscular condition precipitated by profound hypokalemia. Autoimmune disorders can exacerbate renal potassium loss resulting in abrupt muscle weakness. Primary Sjögren's syndrome (pSS), an autoimmune disease characterized by exocrine gland insufficiency, can lead to renal tubular dysfunction and episodes of HPP when distal acidification is compromised.

NMR-Based Serum Metabolomics and Correlation Analysis Unraveled Metabolic Alterations Underlying Pathophysiology of Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus (T2DM) is a growing global health concern, with a high prevalence among individuals aged 45-50 years and above. Chronic inflammation, oxidative stress, and mitochondrial dysfunction play pivotal roles in its progression. This clinical metabolomics study aimed to identify distinct metabolic alterations associated with insulin resistance and other clinical features of T2DM.

Rational design of 2D-2D porphyrin metal-organic nanosheet/g-CN heterostructure for enhanced production of hydrogen under visible-light.

The development of heterojunction-based photocatalysts is a promising strategy to achieve enhanced green hydrogen (H) production by facilitating the competent separation of photo-induced charge carriers. In this context, two-dimensional (2D) metal-organic nanosheets (MONs) have garnered considerable attention owing to their unique properties of highly exposed active sites, ultrathin thickness, and large surface area. Especially, porphyrin-based 2D MONs have gained significant interest due to their optimum band structure and exceptional visible light harvesting properties.

Long-Term Genomic Surveillance of SARS-CoV‑2 in Campus Wastewater Depicts Lineage Trends and Public Health Implications during and after Omicron Waves.

SARS-CoV-2 transmission and detection on academic campuses in low- to middle-income countries has not been explored. The present study explored wastewater surveillance of SARS-CoV-2 in a campus setting in Pune, Maharashtra, India, offering insights into variant-specific trends and their correlation with clinical cases over a 2.5 year period from November 2021 to April 2024.

Study of Electron Capture by 5-Halogenated Cytosine in Gas and Condensed Phases.

Halogenated pyrimidines have been a compound of interest for a long time due to their wide range of applications in biological science. In this study, we sought to evaluate the effectiveness of halogenated cytosine as a radiosensitizer by analyzing its interaction with low-energy electrons produced during radiotherapy. Our results revealed that halogenated cytosine forms a dipole-bound state in the gas phase after electron attachment in the Franck-Condon region.

Comment on "There is no correlation between differences in adverse events and differences in patient-reported outcome measures in orthopaedic trauma randomized controlled trials: A systematic review".

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Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.

The misuse and overprescription of antibiotics have accelerated the rise of antimicrobial resistance (AMR), rendering many antibiotics ineffective and leading to significant clinical challenges. The conventional treatment methods have become progressively challenging, posing a threat of evolving into an impending silent pandemic. The long track record of bacteriophages combating bacterial infections has renewed hope into the potential therapeutic benefits of bacteriophages.

Global teal carbon: Stocks, sequestration, and its potential role in climate change mitigation.

A colour-based nomenclature has developed in recent decades to characterise the distribution and distinct functions of organic carbon in natural ecosystems. 'Teal carbon', which is found in shallow inland freshwater wetlands, is the newest type of carbon added to the colour spectrum. Teal carbon ecosystems are more susceptible to anthropogenic activities and climate change than green and blue carbon ecosystems.

A Bisphosphate Ligand for Zn Ion Detection and Co-Crystallization with N-Rich Organic Molecules.

Herein, a bisphosphate ligand with extended aromatic rings having methyl substitutes at ortho-position named as 3,3',5,5'-tetramethyl-[1,1'-biphenyl]-4,4'-diyl bis(dihydrogen phosphate) (tmbiphH) was utilized in zinc ion detection and the preparation of its cocrystals. The fluorescence sensing capability of tmbiphH for Zn ions confirms its high selectivity and sensitivity. Moreover, the density functional theory (DFT) calculations support the strong coordination between Zn and the phosphate functionality of the ligand, consistent with the observed sensing behavior.

Evaluating the Effects of Yoga on the Body Mass Index and Heart Rate among Individuals with Substance Use Disorder: A Randomized Controlled Trial.

Drug addiction significantly impacts physical and psychological health, often resulting in challenges such as weight management issues and cardiovascular irregularities. Yoga, a holistic practice, may serve as an adjunctive therapy to address these concerns. To evaluate the effects of yoga on body mass index (BMI) and heart rate (HR) in individuals undergoing drug addiction rehabilitation.

Gouty Arthritis Treatment: Advancements in Topical Lipid-Based Nanocarrier Delivery Systems.

The formation of urate crystals in the joints causes severe, erratic flare-ups of joint pain, swelling, and erythema in gout, one kind of inflammatory arthritis. The standard treatment currently available involves the use of nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, allopurinol, febuxostat, and corticosteroids which require lifelong management via oral or parenteral route. The challenge is the therapy adherence as the symptoms become better, patients may quit taking them, which could result in more episodes.

Deciphering the comprehensive microbiome of glacier-fed Ganges and functional aspects: implications for one health.

Glacier-fed rivers are significant ecological components of the river catchments, yet their microbial diversity and the associated antimicrobial potential remain underexplored. The Ganges is a glacier-fed river of immense cultural, religious, and ecological significance that supports over 400 million people downstream, providing essential water for agriculture, industry, and daily use. Despite its importance, the microbial community composition and antimicrobial potential, across its relatively pristine origin, remain largely underexplored.

Zinner Syndrome Presenting With Chronic Pelvic Pain and Ejaculatory Dysfunction.

Introduction: Zinner Syndrome is a rare congenital anomaly involving unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ejaculatory duct obstruction. We report a symptomatic case managed conservatively.

Case Presentation: A 19-year-old male presented with 6 months of intermittent pelvic pain, dysuria, and ejaculatory discomfort.

Central optical power of the isolated human lens without zonular tension.

The ability to focus at near is achieved by dynamic changes in the shape of the lens of the eye. The Helmholtz hypothesis of accommodation proposes that, at distance gaze, all of the lenticular supporting zonules are at maximal tension. To bring a near object into focus, this tension is reduced by action of the ciliary muscle.

Artificial Intelligence (AI)-Based Protein Structure Prediction and Analysis.

One of the significant challenges in fields of drug discovery and bioinformatics is the prediction of protein's 3-D structure due to its computational complexity. The vast conformational space and intricate energy functions make it hard to accurately predict protein structures. Two main approaches exist: template-based protein structure prediction uses known protein structures, while template-free protein structure prediction tackles proteins without known structures.

Takayasu's Arteritis with Systemic Lupus Erythematosus: A Case Report.

Takayasu arteritis (TA) is a rare granulomatous vasculitis affecting the aorta and its major branches, while systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder known for vascular and serological involvement. Although both diseases share certain immunopathological pathways, their co-occurrence is exceedingly rare. We report a case of a 44-year-old Indian female with a prior diagnosis of SLE who presented with breathlessness, palpitations, and nodular episcleritis.