Evaluation of risk factors for acute stroke using combined CTA and MR HR-VWI imaging.

Objective: To investigate the correlation between the changes of peripheral carotid fat density (PFD), the occurrence of acute cerebral ischemia events and the characteristics of different dangerous plaques.

Methods: A retrospective analysis was performed on patients diagnosed with carotid plaque by head and neck CTA in the Affiliated Hospital of Qinghai University from January 2021 to March 2023. All patients received head magnetic plain scan, DWI and high resolution vascular wall imaging (MR HR-VWI).

Association between impaired lung function and risk of spondyloarthritis: a cross-sectional study in the UK Biobank.

Background: Impaired lung function has been noted in individuals with spondyloarthritis (SpA). However, a comprehensive summary of the existing evidence related to these conditions is still lacking.

Objective: The aim of the study is to explore the association between impaired lung function and the prevalence and incidence of SpA, utilizing data from the UK Biobank.

[Two cases of X-linked adrenoleukodystrophy presenting with Addison's disease as the initial manifestation and analysis of novel ABCD1 variants].

Clinical data of two patients with X-linked adrenoleukodystrophy (X-ALD) initially presenting as Addison's disease were collected from the Department of Endocrinology, First Medical Center of Chinese PLA General Hospital. Relevant medical history, clinical features, laboratory tests, and genetic results were analyzed. The two male patients, aged 7 years (case 1) and 15 years (case 2), initially presented with generalized skin hyperpigmentation, without any family history of similar disorders.

[Multi-system involvement characteristics and influencing factors of disease progression in Kennedy's disease].

To investigate multi-system involvement in Kennedy's disease and its association with disease progression. We retrospectively reviewed the clinical, laboratory, and electrophysiological data from 48 genetically confirmed patients with Kennedy's disease at the Department of Neurology, First Medical Center of the Chinese PLA General Hospital, between February 2016 and February 2024. The disease progression rate was calculated based on the functional scores at baseline and follow-up.

[Study on strategies and methods for discovering risk of traditional Chinese medicine-related liver injury based on real-world data: an example of Corydalis Rhizoma].

In recent years, there have been frequent adverse reactions/events associated with traditional Chinese medicine(TCM), especially liver injury related to traditional non-toxic TCM, which requires adequate attention. Liver injury related to traditional non-toxic TCM is characterized by its sporadic and insidious nature and is influenced by various factors, making its detection and identification challenging. There is an urgent need to develop a strategy and method for early detection and recognition of traditional non-toxic TCM-related liver injury.

[Cross-organ effects of drug intervention: indirect pharmacology].

With the continuous advancement of medical research, it is increasingly recognized that the human body functions as a highly coordinated complex system, and the development of diseases often involves intricate interactions among multiple subsystems, including organs, tissues, and cells. Conventional pharmacological research, which primarily focuses on isolated subsystems, tends to emphasize direct interactions between drugs and the molecular targets in diseased organs. However, this approach often falls short in addressing the multifaceted challenges posed by complex diseases such as metabolic disorders, autoimmune diseases, cancers, and aging.

Comparative Analysis of MRI Features and Overall Survival: IDH-Wildtype Diffuse Lower-grade Glioma and Glioblastoma in Adults.

Rationale And Objectives: In depth comparison of imaging features and overall survival (OS) between IDH wild-type diffuse lower-grade glioma and glioblastoma (GB), providing precise guidance for early risk stratification and optimized clinical decision-making.

Materials And Methods: Retrospective inclusion of IDH wild-type glioma patients admitted between January 2017 and January 2024. Patients were classified into GB (histological and molecular) and lower-grade glioma not elsewhere classified (LGNEC) based on fifth edition of the Central Nervous System Tumor Classification Standards.

Explainable mortality prediction models incorporating social health determinants and physical frailty for heart failure patients.

There is limited evidence on how social determinants of health (SDOH) and physical frailty (PF) influence mortality prediction in heart failure (HF), particularly for in-hospital, 90-day, and 1-year outcomes. This study aims to develop explainable machine learning (ML) models to assess the prognostic value of SDOH and PF at multiple time points. We analyzed data from adult patients admitted to the intensive care unit (ICU) for the first time with a diagnosis of HF.

Dynamic nomogram predicts sepsis risk in patients with acute liver failure: Analysis of intensive care database with external validation.

Background: Acute liver failure (ALF) with sepsis is associated with rapid disease progression and high mortality. Therefore, early detection of high-risk sepsis subgroups in patients with ALF is crucial.

Aim: To develop and validate an accurate nomogram model for predicting the risk of sepsis in patients with ALF.

Hepatitis B virus rtCYE/rtCYEI mutations may contribute limited tenofovir resistance: Analysis of a large sample of Chinese patients.

Background: Whether rtS106C+H126Y+D134E/rtS106C+H126Y+D134E+L269I (rtCYE/rtCYEI) mutations in the hepatitis B virus (HBV) reverse-transcriptase (RT) region are associated with tenofovir disoproxil fumarate (TDF) resistance is controversial.

Aim: To evaluate the presence of the rtCYE/rtCYEI mutations in a large cohort of Chinese patients with chronic HBV infection.

Methods: A total of 28236 patients who underwent drug resistance testing at the Fifth Medical Center of Chinese PLA General Hospital from 2007 to 2019 were enrolled.

Rare complete replacement-type left hepatic artery originating from the left gastric artery: A case report.

Background: A complete replacement left hepatic artery (LHA) solely originating from the left gastric artery (LGA), with no supply from the hepatic artery proper, is exceptionally rare. This variant places entire left lobe perfusion on the LGA. Literature review confirms no prior reports of such an isolated LHA replacement pattern in surgical/radiological publications.

FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.

Introduction: Fatty acid synthase (FASN) is a key regulator of lipid metabolism, but its role in colorectal cancer (CRC) stemness and ferroptosis remains unclear.

Methods: FASN expression in CRC was analyzed using TCGA data and validated in CRC cell lines (CACO-2, HCT116, SW480) and normal HIEC-6 cells via qRT-PCR and Western blot. HCT116 cells (highest FASN expression) were used for experiments.

Ruxolitinib and decitabine plus a busulfan-cyclophosphamide conditioning regimen for relapse prophylaxis in patients with high-risk acute myeloid leukemia or myelodysplastic syndromes.

Purpose: Relapse remains the leading cause of treatment failure in high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome-IB (MDS-IB) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ruxolitinib has demonstrated antileukemic activity , and decitabine has been found to be tolerable when combined with modified busulfan-cyclophosphamide (mBu/Cy) conditioning regimen. Here, we investigated the efficacy of ruxolitinib and decitabine plus a mBu/Cy conditioning regimen (Rux-Dec-mBu/Cy) in reducing relapse in high-risk AML/MDS patients ().

Joint and Temporal Relationships of Systemic Inflammation and Atherogenic Dyslipidemia with Risk of Cardiometabolic Disease: A Longitudinal Cohort Study.

Purpose: We sought to investigate the joint association of systemic inflammation and atherogenic dyslipidemia with cardiometabolic disease (CMD) and whether the temporal relationship between them is associated with risk of CMD.

Patients And Methods: This prospective cohort study included 78,206 participants without history of cardiovascular disease and diabetes mellitus at study entry in 2006. Systemic inflammation and atherogenic dyslipidemia were evaluated by C-reactive protein (CRP) and atherogenic index of plasma (AIP), respectively.

Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock.

Background/objectives: Burns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the World Health Organization-recommended oral rehydration solution (WHO-ORS) lacks specific components to address the critical physiological changes in patients with burns.

Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects.

Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide. Despite significant efforts and recent advances in GC treatment, therapeutic efficacy remains suboptimal. In recent years, emerging nanomaterials have demonstrated considerable potential for cancer therapy, primarily due to their ability to function as drug carriers that enable targeted and precise delivery of therapeutic agents to tumour tissues.

Efficacy and Safety of a Probiotic Mixture Containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in Children With Attention-Deficit/Hyperactivity Disorder.

Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder. Emerging evidence suggests that gut microbiota may contribute to ADHD pathogenesis and that microbiota modulation could improve its symptoms. This study evaluated the safety and efficacy of a probiotic mixture containing Bifidobacterium animalis subsp.

The difference between cystatin C- and creatinine-based estimated glomerular filtration rate and survival in amyotrophic lateral sclerosis: a population-based cohort study.

Objectives: We investigated the relationship between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFRdiff) and amyotrophic lateral sclerosis (ALS) outcomes.

Methods: We enrolled ALS patients diagnosed between January 2014 and December 2019. Experienced neurologists followed up the participants until January 2022.

Risk factors for surgical site infection after open transforaminal lumbar interbody fusion in treating degenerative lumbar diseases.

Open transforaminal lumbar interbody fusion (O-TLIF) is an acknowledged surgical technique for addressing lumbar degenerative diseases. Postoperative surgical site infections (SSIs) can occur. This study aims to identify the independent risk factors for SSIs following O-TLIF in the treatment of lumbar spinal stenosis.

The performance evaluation of the AI-assisted diagnostic system in China.

Background: Artificial intelligence (AI) has been regarded as a major success in healthcare services. At present, few studies have successfully empirically analyzed this view through large-scale multi-center trails, especially in China as well as other less-developed regions. The research aim of this work is to empirically reveal how artificial intelligence benefits in less-developed regions and reallocates medical resources.

The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.

Background: Cardiometabolic multimorbidity (CMM) imposes a progressively severe health burden worldwide. Triglyceride-glucose (TyG) index and waist-to-height ratio (WHtR), as indicators of insulin resistance and central adiposity, respectively, have been shown to be strongly associated with CMM. However, there is currently a lack of research combining the two for CMM risk assessment.

Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats.

Objectives: Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury. This study aimed to evaluate the apoptosis following SM-induced acute pulmonary injury.

Materials And Methods: Acute pulmonary injury models were established using SM at an equivalent toxicity dose (1 LD50), administered via intraperitoneal injection or intratracheal instillation.

Multiple biomarkers risk score for accurately predicting the long-term prognosis of patients with acute coronary syndrome.

Background: Biomarkers-based prediction of long-term risk of acute coronary syndrome (ACS) is scarce. We aim to develop a risk score integrating clinical routine information (C) and plasma biomarkers (B) for predicting long-term risk of ACS patients.

Methods: We included 2729 ACS patients from the OCEA (Observation of cardiovascular events in ACS patients).

Development of cardiovascular clinical research data warehouse and real-world research.

Background: Medical informatics accumulated vast amounts of data for clinical diagnosis and treatment. However, limited access to follow-up data and the difficulty in integrating data across diverse platforms continue to pose significant barriers to clinical research progress. In response, our research team has embarked on the development of a specialized clinical research database for cardiology, thereby establishing a comprehensive digital platform that facilitates both clinical decision-making and research endeavors.

Development and validation of an interpretable multi-task model to predict outcomes in patients with rhabdomyolysis: a multicenter retrospective cohort study.

Background: Rhabdomyolysis (RM) is a complex clinical syndrome with heterogeneous progression patterns among patients of varying severity. Early and accurate prediction of acute kidney injury (AKI), disease severity, renal replacement therapy (RRT) requirements, and mortality risk is essential for timely identification of high-risk individuals, personalized treatment planning, and optimal allocation of healthcare resources. We aimed to develop and externally validate an interpretable multi-task machine learning (ML) model to predict four clinical outcomes in patients with rhabdomyolysis: AKI, disease severity, the need for RRT, and in-hospital mortality.