Development of a lip colour chart across four ethnicities.

In the human face, the lips play a key role in social interactions and are a major element of makeup strategies. However, the amount of data available on lips, particularly relating to colour, is limited in comparison to that on skin. To gain a better understanding of lip colour, this study aimed to assess its diversity across four ethnicities (Asian Chinese, African American, Hispanic American and Caucasian American and French).

A Reaction-Diffusion-Coupled Strategy for Ampere-Level Electrocatalytic Nitrate Reduction to Ammonia.

Ampere-level electrocatalytic nitrate reduction to ammonia (eNRA) offers a carbon-neutral alternative to the Haber-Bosch process. However, its energy efficiency is critically hampered by the inherent conflict between the reaction and diffusion. Herein, we propose a reaction-diffusion-coupled strategy implemented on a well-tailored CuCoNiRuPt high-entropy alloy aerogel (HEAA) to simultaneously realize energy barrier homogenization and accelerate mass transport, endowing ampere-level eNRA with a high energy efficiency.

Loss of Skeletal Muscle Mass Is Associated With Reduced Cytotoxic T Cell Abundance and Poor Survival in Advanced Lung Cancer.

Background: Body composition alterations such as skeletal muscle (SM) loss in cancer patients are associated with poor survival. In turn, immune cell-driven pathways have been linked to muscle wasting. We aimed to investigate the relationship between body composition, tumour-infiltrating lymphocytes and survival in patients with advanced lung cancer.

Design, Synthesis, Insecticidal Activities, and Structure-Activity Relationship of Phenylpyrazole Derivatives Incorporating 1,2,4-Oxadiazole Moiety.

The ryanodine receptors (RyRs) represent an optimal target for insecticide development. To explore novel structures of RyRs agonists, a series of compounds containing 1,2,4-oxadiazole were designed and synthesized based on the RyRs structure. The compounds were confirmed by H and C nuclear magnetic resonance as well as high-resolution mass spectrometry.

Role of Inflammatory Cytokine Adsorption on VA-ECMO-Induced Acute Kidney Injury of Rats.

Extracorporeal membrane oxygenation (ECMO) is a high-risk, invasive therapy that sustains life through an external system. However, it often leads to complications such as bleeding, thrombosis, infection, and acute kidney injury (AKI). While up to 70% of ECMO patients develop AKI, the mechanisms driving this injury remain unclear, and effective treatments are limited.

A Uniquely Structured Heteronuclear Cluster Cage with Anion-Templated Pentagons and Hexagons.

Constructing structurally sophisticated molecules with interesting properties is the goal of supramolecular chemistry. Herein, two heterometallic clusters, formulated respectively as [GdNi(μ-CO)(μ-NO)(μ-OH)(μ-OH)(μ-CO)(HO)]Cl·49HO·90MeOH (, H = -methyliminodiacetic acid) and [TbNi(μ-CO)(μ-NO)(μ-OH)(μ-OH)(HO)]Cl·50HO·130MeOH (), were obtained by the cohydrolysis of Ln (Ln = Gd, Tb) and Ni in the presence of H and triethylamine. The essentially isostructural cationic cluster cages are constructed by coexisting pentagons and hexagons whose formation is respectively templated by nitrate and oxalate ions.

Semaglutide attenuates diabetic retinopathy progression via ameliorating retinal vasculopathy and oxidative stress in vivo and in vitro.

Background: Diabetic retinopathy (DR) is a major complication of diabetes mellitus, characterised by retinal vasculopathy and oxidative stress. Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has demonstrated cardiovascular benefits but has also been associated with mixed effects on DR progression. This study investigates the potential of semaglutide to attenuate DR progression by ameliorating retinal vasculopathy and oxidative stress in both in vivo and in vitro models.

Host Immune Response to Respiratory Syncytial Virus Infection in Children.

Respiratory syncytial virus (RSV) is one of the leading causes of severe respiratory diseases in children, especially in infants. The immune responses induced by RSV infection are a fairly complex process that can contribute significantly to disease severity. Despite decades of research on RSV, many immune mechanisms remain to be explored.

Highly Sensitive Determination of Bacillus subtilis by Microchip Electrophoresis Combining With A Dual Nucleic Acid Recycling Amplification.

In dairy products, Bacillus subtilis (B. subtilis) is considered a harmful spoilage bacterium. Consequently, it is imperative to establish highly sensitive and selective approaches for detecting B.

Identification of the In Vitro and In Vivo Metabolites of Chrysotoxine Using Liquid Chromatography Combined With Benchtop Orbitrap High-Resolution Mass Spectrometry.

Rationale: Chrysotoxine, a bibenzyl derivative from the stems of Dendrobium medicinal herbs, has recently emerged as a promising therapeutic candidate for cervical cancer. This study aimed to characterize chrysotoxine metabolites across multiple hepatocyte species and in rat urine.

Methods: Metabolites were identified and characterized using liquid chromatography coupled with benchtop Orbitrap high-resolution mass spectrometry (LC-Orbitrap-MS/MS) combined with Compound Discoverer software.

The Protective Effects of TLR2/NOD2 Combined Agonist CL429 on 14.1 MeV Neutron-Radiation Damage.

High-energy neutron radiation (HENR) induces severe cellular and tissue damage, yet effective prophylactic agents remain limited. In this study, the TLR2/NOD2 co-agonist CL429 was evaluated for its radioprotective potential against 14.1 MeV neutron exposure.

Early itch relief with ivarmacitinib improves quality of life, working productivity, and sleep quality in patients with moderate-to-severe atopic dermatitis: a post hoc analysis of a phase III trial.

Background: Ivarmacitinib (SHR0302), a selective Janus kinase-1 inhibitor, is a novel treatment for moderate-to-severe atopic dermatitis (AD).

Objectives: This post hoc analysis evaluated the impact of early itch relief with ivarmacitinib on quality of life (QoL), working productivity, and sleep quality in affected patients.

Methods: Data from ivarmacitinib treatment groups in a phase III trial (NCT04875169) were analyzed.

Adoptive transfer of third-party donor CMV-specific T cells for refractory cytomegalovirus infection following umbilical cord blood transplantation.

Refractory cytomegalovirus (CMV) infection is a severe complication following umbilical cord blood transplantation (UCBT). Antiviral agents, the standard first-line therapy, are limited by toxicity and resistance without robust T-cell immunity. We evaluated third-party donor (TPD)-derived CMV-specific T cells (CMVSTs) as a treatment option.

Dupilumab monotherapy in super-elderly patients with bullous pemphigoid: a retrospective study on long-term efficacy and safety in mild to moderate cases.

Background: Bullous pemphigoid (BP) is a common autoimmune subepidermal bullous disease. Dupilumab, an IL-4/IL-13 inhibitor, represents a novel therapeutic approach for BP, but real-world long-term data in super-elderly patients are limited.

Methods: This retrospective, single-center observational study included super-elderly BP patients (≥80 years) receiving dupilumab monotherapy from September 2022 to September 2024.

The cachexia index as a prognostic indicator in patients with cervical cancer treated with radiotherapy: A retrospective study.

Objective: The cachexia index (CXI) demonstrates potential as both a diagnostic tool for cachexia and a prognostic tool for survival in cancer. However, CXI's predictive value has not been verified in cervical cancer. The purpose of this study is to investigate the prognostic value of the CXI in patients with cervical cancer treated with radiotherapy.

Quantification of Trans- and Cis-Vitamin K1 Isomers in Human Plasma by a Rapid and Sensitive LC-MS/MS Method With Surrogate Matrix.

A rapid and specific liquid chromatography-tandem mass spectrometry method with a wide linear range was developed and validated for the simultaneous quantification of Vitamin K1 (VK1) trans- and cis- isomers in human plasma. Bovine serum albumin solution (15%) served as a surrogate matrix for preparing the calibrators to establish the quantitative curves. After liquid-liquid extraction, VK1 trans- and cis- isomers in plasma samples were separated on a ChromCore C30 column (15 cm × 4.

Dual function of itaconic acid from against .

Root-knot nematodes (Meloidogyne spp.) cause catastrophic yield losses in global agriculture. This study identified itaconic acid (IA), through comparative metabolomic analysis (the study of small molecules in biological systems), as a key virulence-related metabolite produced by the fungus Trichoderma citrinoviride Snef1910.

Metabolic Stability and Comprehensive Metabolite Profiling of Chrysotobibenzyl in Human Liver Microsomes and Hepatocytes Employing UPLC-MS/MS and UPLC-Orbitrap-HRMS Analysis.

Chrysotobibenzyl, a bioactive ingredient from Dendrobium chrysotoxum, exhibits potent anti-tumor activity. However, its metabolic profiles remain unelucidated. This study aimed to disclose the metabolic fates of chrysotobibenzyl using human liver fractions.

Kirschner wires combined with elastic tape for multilayer tension-reducing repair of a large stage 4 pressure injury of the greater trochanter: a case report.

Background: Pressure injuries are common, difficult to manage, and carry a high economic burden. They are challenging to physicians and a burden to society.

Case Report: An 89-year-old male, who had previously undergone internal fixation with screws and rods for a right intertrochanteric fracture, developed a deep circular open ulcer measuring 11 cm × 7.

Use of a novel zipper device for wound closure of cutaneous abscesses in pediatric outpatients: a case series.

Background: Current management of pediatric cutaneous abscesses involves either spontaneous healing by secondary intention or suturing through tertiary intention, which are often lengthy processes that cause discomfort and distress among children. As it is noninvasive and simple, a novel zipper device is widely used for the primary wound closure of surgical incisions.

Objective: To describe the effectiveness of novel zipper device use for pediatric cutaneous abscess wound closure in an outpatient context.

Single-cell atlas in the living fossil Yangtze sturgeon provides insight into the evolution of fish.

Background: Fish are the largest group of vertebrates. Studying the characteristics, functions, and interactions of different fish cells is important for understanding their roles in disease and evolution. However, most single cell RNA-seq studies in fish are restricted to a few specific organs, leaving a comprehensive cell landscape that aims to characterize the heterogeneity and connections among body-wide organs largely unexplored.

MAGdb: a comprehensive high quality MAGs repository for exploring microbial metagenome-assemble genomes.

Metagenomic analyses of microbial communities have unveiled a substantial level of interspecies and intraspecies genetic diversity by reconstructing metagenome-assembled genomes (MAGs). The MAG database (MAGdb) boasts an impressive collection of 74 representative research papers, spanning clinical, environmental, and animal categories and comprising 13,702 paired-end run accessions of metagenomic sequencing and 99,672 high quality MAGs with manually curated metadata. MAGdb provides a user-friendly interface that users can browse, search, and download MAGs and their corresponding metadata information.