Myokines and osteokines in aging-related degenerative diseases: Regulatory networks in the muscle-bone-brain axis.

This review summarizes the biological properties of key myokines (Irisin, Apelin, CLCF1, and Myostatin) and osteokines (Osteocalcin, Sclerostin, FGF23 and the RANKL/OPG system). This work provides an in-depth analysis of the age-related network imbalance mechanism characterized by "downregulation of protective factors (Irisin, CLCF1, and uncarboxylated Osteocalcin) - upregulation of pro-degenerative factors (Myostatin, Sclerostin, and FGF23) - inflammation-driven amplification", and reveals the mechanism by which this network imbalance contributes to the comorbidity of sarcopenia, osteoporosis, and neurodegenerative diseases. Furthermore, the review evaluates the intersecting regulatory networks and molecular pathways through which myo-osteogenic factors modulate neurotrophic factors (BDNF, NGF and GDNF), and proposes intervention strategies based on these intersecting regulatory networks.

Impact of orthokeratology lens decentration on axial length growth in Chinese myopic children: A meta-analysis.

Background: Orthokeratology (OK) lenses have become a prevalent intervention for myopia control. However, lens decentration, a frequent complication, may influence the efficacy of myopia control. The aim of this study was to systematically assess the impact of OK lens decentration on axial length growth (ALG) in Chinese myopic children through a meta-analysis.

A distributed time-varying neurodynamic algorithm for multi-UAV collaborative target tracking problem in maritime search and rescue.

This work investigates the problem of collaborative target tracking by multiple unmanned aerial vehicles (UAVs) in maritime search and rescue. A class of time-varying (TV) convex optimization problems with inequality constraints is presented. In contrast to existing studies that address UAV-based maritime search and rescue under fixed wind speed conditions, this study also explores collaborative target tracking by UAVs under varying wind speed conditions.

Cooperative active disturbance rejection motion control of multi-manipulator based on mechanical-electrical-hydraulic joint simulation.

Multi-arm rock drilling robots frequently encounter challenges in extreme environments, such as tunnels, where they are subjected to high-frequency impact loads, multi-degree-of-freedom motion coupling, and large-range motion control vibrations. First, we propose a collision-free path planning method that combines an improved genetic algorithm (IGA) and an improved artificial potential field method. This method is based on the kinematic model of the rock drilling robot.

Oxytocin-mediated empathy internally facilitates cooperative behaviors in rats.

Reciprocity is considered one of the vital mechanisms that sustain the evolution of cooperative behavior. However, free-riding, where assistance is received but not reciprocated, poses a serious threat to reciprocity behavior, which relies on future payback. Previous theories proposed that third-party punishment plays a vital role in preventing free-riding behavior.

Insufficient telomeric DNA damage response promotes chromosomal instability in aged oocytes.

Increased chromosomal instability impairs oocyte quality, contributing to female reproductive aging. The telomeric DNA damage response (DDR) is essential for genomic stability; however, how oocytes respond to telomeric damage remains elusive. Here, we observed that aged human germinal vesicle (GV) oocytes accumulated telomeric DNA damage.

Tracing the possible origins of the clade 2.3.4.4b highly pathogenic avian influenza H5Nx viruses from India.

Highly pathogenic avian influenza (HPAI) clade 2.3.4.

Ambient temperature and coronary plaque rupture risk in STEMI: Insights from OCT analysis.

Background And Aims: Cold weather is associated with an increased risk of cardiovascular events, but its impact on culprit plaque characteristics in ST-segment elevation myocardial infarction (STEMI) remains unclear.

Methods: This study included 647 STEMI patients who underwent optical coherence tomography (OCT) to assess untreated culprit lesions. Participants were grouped based on ambient temperature on the day of admission or mean ambient temperatures over the preceding 7-, 14-, 21-, and 28-day periods.

Ultrasound-Stimulated BMSCs Promote Regenerative Healing in Refractory Foot Ulcer by Paracrine Effect.

Objective: Diabetic foot ulcer (DFU) is a common and serious complication of diabetes, often leading to infection, amputation and poor quality of life. Bone marrow mesenchymal stem cells (BMSCs) have shown promise in treating chronic wounds, but their therapeutic efficacy is limited due to poor survival and low regenerative activity. Low-intensity pulsed ultrasound (LIUS), a non-invasive physical modality, has been shown to enhance the biological behavior of BMSCs.

Ketamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and Tolerability.

Ketamine has emerged as a promising treatment for major depression, though its efficacy and safety remain incompletely characterized in older adults. This systematic review synthesizes current evidence for ketamine in geriatric depression. A search of PubMed, EMBASE, and PsycINFO was conducted.

Proliferative verrucous leukoplakia and unifocal verrucous leukoplakia in China: a comparative retrospective cohort study.

Objective: There are limited data regarding the association and differentiation between proliferative verrucous leukoplakia (PVL) and unifocal verrucous leukoplakia (UVL).

Methods: We retrospectively recruited oral leukoplakia (OL) patients from 2010 to 2024, analyzing the demographic, clinical, histopathological features, and malignant transformation of PVL and UVL.

Results: Among 1756 OL subjects, PVL and UVL accounted for 1.

Combined Fascia Iliaca Compartment-Sciatic Nerve Blocks Reduce Early Cardiovascular Events in Chronic Limb-Threatening Ischemia: A Propensity Score-Matched Retrospective Study.

Objective: To compare postoperative outcomes between combined fascia iliaca compartment-sciatic nerve blockade (FICB-SNB) and monitored anesthesia care (MAC) in patients with chronic limb-threatening ischemia (CLTI) undergoing lower-extremity revascularization (LER).

Design: Retrospective matched cohort study (1:1 propensity score matching).

Setting: Single-center analysis of CLTI patients undergoing LER.

MAFLD: a ferroptotic disease.

Ferroptosis, a regulated cell death pathway driven by iron-catalyzed lipid peroxidation, has recently been implicated as a major cause of hepatic injury in metabolic dysfunction-associated fatty liver disease (MAFLD). This review highlights how the identification of hyperoxidized peroxiredoxin 3 (PRDX3) as a ferroptosis-specific marker has led to the discovery that ferroptosis contributes to liver injury in MAFLD, and summarizes other emerging evidence connecting ferroptosis to MAFLD pathogenesis. These new findings suggest that dietary fat composition and genetic variants such as PNPLA3(I148M) may affect the progression of MAFLD by regulating cellular sensitivity to ferroptosis.

Kaempferol Inhibits Ferroptosis in Lung Epithelial Cells in LPS-Induced Acute Lung Injury via m5C Methylation of TFRC.

Ferroptosis is involved in the progression of sepsis-induced acute lung injury (ALI). Kaempferol is a flavonoid compound that can protect against ALI. 5-Methylcytosine (m5C) is involved in the pathogenesis of sepsis.

Mental health status and its associations with psychosocial working conditions among platform delivery workers in China: comparative analyses of migrant status.

The rapid expansion of delivery labor platforms in China has driven many people to move from rural to urban areas. Previous studies indicated that platform-based delivery work can be demanding, subject to algorithmic control, and lacking employment protections. While migrant workers are more likely to be exposed to adverse psychosocial working conditions and more vulnerable due to limited social services, few studies have examined the role of migrant status in mental health and its associations with psychosocial working conditions among platform delivery workers.

Aging performance and bacteria adhesion of 3D-printed, CAD/CAM-milled, and conventional definitive denture resins.

Purpose: This study aimed to evaluate the performance of 3D-printed denture base resins (DBRs) compared with conventionally printed DBRs, examine their biofilm formation and physical properties, and determine the viability of 3D-printed DBRs as a superior alternative in removable prosthodontics.

Methods: The DBR samples were fabricated using traditional packing (TRA), milling (MIL), and 3D printing (3DP) methods. All samples were serially polished with an abrasive paper.

Revisiting the Relationship between Homocysteine, Vitamin B12, Folate, and Aortic Diseases.

Although several observational studies have suggested an association between plasma homocysteine (Hcy), vitamin B12, and folate levels and aortic diseases, including aortic dissection (AD), thoracic aortic aneurysm (TAA), and abdominal aortic aneurysm (AAA), the causality remains unclear. The aortic diameter was also included in the analysis. Therefore, this study employed Mendelian randomization (MR) analysis to investigate the effects of plasma Hcy, vitamin B12, and folate levels on aortic diseases.