National Trends in Immediate and Early Delayed Postmastectomy Breast Reconstruction: An Updated Population-Based Study of 84,088 Reconstructed Patients.

Background: There remain ongoing concerns regarding the accessibility of breast reconstruction. We aimed to analyze recent data from the Surveillance, Epidemiology, and End Results (SEER) database to reveal trends in immediate and early delayed breast reconstruction across the United States.

Methods: Patients undergoing mastectomy from 2010 to 2020 were identified using the SEER database.

Immediate lymphatic reconstruction for prevention of secondary lymphedema in cancer patients: A meta-analysis of 42 studies.

Background: Secondary lymphedema, a common complication following lymph node dissection, affecting up to 53% of cancer survivors, imposes significant morbidity and reduced quality of life. Immediate lymphatic reconstruction (ILR) has emerged as a preventive strategy; however, its efficacy remains unclear.

Methods: We conducted a PRISMA/AMSTAR-compliant systematic review and meta-analysis.

Additive Manufactured FeCrNi Medium Entropy Alloy Lattice Structure with Excellent Dynamic Mechanical Properties.

Aerospace and marine engineering impose higher requirements on mechanical properties and lightweight design of materials. In this work, combining the high mechanical properties of FeCrNi medium entropy alloy (MEA) and the lightweight advantages of lattice structure, four types of high-performance FeCrNi MEA lattice structures (BCC, BCCZ, FCC, and FCCZ) were prepared by selective laser melting (SLM) technology, and their dynamic mechanical properties were systematically characterized via split Hopkinson pressure bar (SHPB) method. The results demonstrate that the FCCZ FeCrNi MEA lattice structure exhibits superior comprehensive performance among the four lattice structures, achieving the highest specific compressive strength of 59.

Greenhouse gas emission and denitrification kinetics of woodchip bioreactors treating onsite wastewater.

The accurate evaluation of denitrification rate and greenhouse gas (GHG) emission in field-scale woodchip bioreactors for onsite wastewater treatment are problematic due to inevitably varied environmental conditions and underestimated GHG production with limited analysis of dissolved gas in field samples. To address these problems, batch incubation experiments were conducted with controlled conditions to precisely evaluate the denitrification kinetics and NO and CH emission of both gaseous and dissolved phases in fresh (6 months) and aged (5 years) woodchip bioreactors treating onsite wastewater at high (1-3 mg L) and no (0 mg L) dissolved oxygen (DO) levels. NO removal rate decreased from 37.

Microstructure and Mechanical Properties of the Powder Metallurgy Nb-16Si-24Ti-2Al-2Cr Alloy.

The Nb-16Si-24Ti-2Al-2Cr alloy was prepared by plasma rotating electrode process (PREP) technology and the hot-pressing (HP) method, and the effects of sintering temperature on the microstructure, mechanical properties and fracture behavior were investigated. The HP alloys sintered at temperatures below 1400 °C are composed of Nbss (Nb solid solution), NbSi and NbSi phases. When the sintering temperature reaches 1450 °C, the NbSi phase is completely decomposed into Nbss and NbSi phases.

Hot Deformation Behavior and Microstructure Evolution of a Graphene/Copper Composite.

Graphene/copper composites are promising in electronic and energy fields due to their superior conductivity, but microstructure control during thermal mechanical processing (TMP) remains a crucial issue for the manufacturing of high-performance graphene/copper composites. In this study, the hot deformation behavior of graphene/copper composites was investigated by isothermal compression tests at deformation temperatures of 700~850 °C and strain rates of 0.01~10 s, and a constitutive equation based on the Arrhenius model and hot processing map was established.

Prediction of metastases in confusing mediastinal lymph nodes based on flourine-18 fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging using machine learning.

Background: For patient management and prognosis, accurate assessment of mediastinal lymph node (LN) status is essential. This study aimed to use machine learning approaches to assess the status of confusing LNs in the mediastinum using positron emission tomography/computed tomography (PET/CT) images; the results were then compared with the diagnostic conclusions of nuclear medicine physicians.

Methods: A total of 509 confusing mediastinal LNs that had undergone pathological assessment or follow-up from 320 patients from three centres were retrospectively included in the study.

Comparative analysis of asian carps parvalbumin reveals the divergence pattern of major fish allergen.

Background: Asian carps, a popular freshwater fish globally, are valued for their flavor and serve as a crucial protein source, especially for infants. However, grass carp parvalbumin is highly allergenic, surpassing the allergenicity of fish like salmon and cod. The allergenic potential of parvalbumin in other Asian carps remains unknown, underscoring the need for allergen identification to improve the precision of fish allergy diagnosis and treatment.

Exploring the NRF2-TP53 Signaling Network Through Machine Learning and Pan-Cancer Analysis: Identifying Potential targets for Cancer Prognosis Related to Oxidative Stress.

Oxidative stress (OXS) is closely related to tumor prognosis and immune response, while TP53 integrated with NRF2 is closely associated with the regulation of cancer-related OXS. Hence, constructing a TP53-NRF2 integrated OXS signature of pan-cancer is essential in predicting survival prognosis and facilitating cancer drug treatment. The pan-cancer analysis acquired the Cancer Genome Atlas (TCGA) transcriptome sequencing data from UCSC Xena, which consisted of 33 cancer types (n = 10 440).

Analysis of CD4 T-helper-associated hub gene signature and immune dysregulation via RNA-sequencing data in a mouse tail model of lymphedema.

Background: T-helper cells play an essential role in the progression of lymphedema. This study aimed to explore the biological significance of T-helper cell-associated genes (THAGs) in a mouse tail model of lymphedema by RNA-sequencing (RNA-seq) data.

Methods: The expression profiles of a murine model of secondary lymphedema were obtained from European Nucleotide Archive (ENA) database.

Efficacy and Safety of Surgical Procedures for Congenital Moderate and Severe Blepharoptosis: A Network Meta-analysis.

Background: There are various surgical approaches to treat congenital moderate and severe blepharoptosis (CMSBP), but their efficacy and safety remain unclear owing to a lack of high-level evidence. This network meta-analysis aimed to evaluate the efficacy and safety of 3 classical operations: and their modifications frontal muscle flap suspension (FMS), levator palpebrae muscle shortening (LMS), conjoint fascial sheath suspension (CFSS), and modified CFSS.

Methods: We searched the PubMed, MEDLINE, Cochrane Library, CNKI, and Wanfang databases until March 2022.

The Function of T Cell Immunity in Lymphedema: A Comprehensive Review.

Lymphedema is a debilitating disease characterized by extremity edema, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatics, often with lymphatic injury secondary to the treatment of malignancies. Emerging evidence has shown that immune dysfunction regulated by T cells plays a pivotal role in development of lymphedema. Specifically, Th1, Th2, Treg, and Th17 cells have been identified as critical regulators of pathological changes in lymphedema.

Effect of Si on Microstructure and Mechanical Properties of FeCrNi Medium Entropy Alloys.

FeCrNi medium entropy alloy (MEA) has been widely regarded for its excellent mechanical properties and corrosion resistance. However, insufficient strength limits its industrial application. Intermetallic particle dispersion strengthening is considered to be an effective method to improve strength, which is expected to solve this problem.

Preparation and Microstructure of High-Activity Spherical TaNbTiZr Refractory High-Entropy Alloy Powders.

High-activity spherical TaNbTiZr refractory high-entropy alloy (REHA) powders were successfully prepared by electrode induction melting gas atomization (EIGA) and plasma rotating electrode process (PREP) methods. Both the EIGAed and PREPed TaNbTiZr RHEA powders have a single-phase body-centered cubic (BCC) structure and low oxygen content. Compared with the EIGAed powders, the PREPed powders exhibit higher sphericity and smoother surface, but larger particle size.

Cu/Fe oxide integrated on graphite felt for degradation of sulfamethoxazole in the heterogeneous electro-Fenton process under near-neutral conditions.

In the heterogeneous electro-Fenton (EF) system, high-efficiency and durable materials have attracted widespread attention as cathodes for degradation of refractory organic pollutants. In this study, a stable Cu/Fe oxide modified graphite felt electrode (CuFeNBDC-300/GF) was fabricated via a one-step hydrothermal method and subsequent thermal treatment, which used a bimetallic metal-organic framework (MOF) with 2-aminoterephthalic acid (NHBDC) ligand as the precursor. The CuFeNBDC-300/GF electrode was used as the cathode for sulfamethoxazole (SMX) degradation in the heterogeneous EF process.

Microstructure and Mechanical Properties of Novel Lightweight TaNbVTi-Based Refractory High Entropy Alloys.

A series of novel lightweight TaNbVTi-based refractory high entropy alloys (RHEA) were fabricated through ball-milling and spark plasma sintering (SPS). The reinforced phase of TiO precipitates were in-situ formed due to the introduction of AlO ceramic particles. The RHEA with 15% AlO exhibits a high compressive yield strength (1837 MPa) and a low density (7.

Microstructure and Mechanical Properties of TaNbVTiAl Refractory High-Entropy Alloys.

A series of TaNbVTiAl (x = 0, 0.2, 0.4, 0.

Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.

Substantial evidence has revealed that abnormalities in synaptic plasticity play important roles during the process of depression. LASP1 (LIM and SH3 domain protein 1), a member of actin-binding proteins, has been shown to be associated with the regulation of synaptic plasticity. However, the role of LASP1 in the regulation of mood is still unclear.

The Retrotransposition of L1 is Involved in the Reconsolidation of Contextual Fear Memory in Mice.

Background: The long interspersed element-1 (L1) participates in memory formation, and DNA methylation patterns of L1 may suggest resilience or vulnerability factors for Post-Traumatic Stress Disorder (PTSD), of which the principal manifestation is a pathological exacerbation of fear memory. However, the unique roles of L1 in the reconsolidation of fear memory remain poorly understood.

Objective: The study aimed to investigate the role of L1 in the reconsolidation of context-dependent fear memory.