A Novel Classification and Surgical Treatment Strategies for Congenital Accessory Auricle With Tragus Malformation.

Background: Congenital accessory auricle is a common aurcile malformation, often associated with tragus malformation, impacting the appearance and psychology of patients. To optimize surgical treatments for congenital accessory auricle with tragus malformation, this article proposes a novel classification and explores surgical strategies.

Methods: This retrospective study included 120 patients with congenital accessory auricle and tragus malformation who underwent surgery between December 2019 and June 2024.

Construction of Zeolite Framework-Anchored Rh-(O-Zn) Sites for Ethylene Hydroformylation.

Zeolite-confined Rh-based catalysts have emerged as promising heterogeneous candidates for olefin hydroformylation. However, they face challenges of reactant- and product-induced Rh leaching and aggregation. Herein, zeolite framework-anchored Rh-(O-Zn) sites were designed and are shown to have remarkable activity and stability for gas-phase ethylene hydroformylation.

Salivary Duct Carcinoma Spread to the Internal Auditory Canal Along the Facial Nerve: A Case Report.

Salivary duct carcinoma (SDC) is a rare high-grade parotid malignancy prone to perineural spread. However, perineural spread of SDC has rarely been reported. The case of a 46-year-old male with SDC spread along the facial nerve (FN) is presented here.

Finite Element Analysis of Mandibular Distraction Osteogenesis With a New Partially Bioabsorbable Distractor.

Objective: We designed a new distractor pairing a bioabsorbable upper fixing plate fixed by bioabsorbable screws with a traditional titanium distractor to simplify the second surgery removing the distractor after mandibular distraction osteogenesis. The present study aims to evaluate its biomechanical properties using finite element method.

Materials And Methods: Ten computer-aided designed models simulating mandibles of 5 patients under 2 working conditions, the instance of distraction and mastication, were produced.

Rapid Growth of Scalp Masses During Pregnancy: A Case Report of Malignancy Diagnosis Post-Surgery.

Scalp masses are common scalp lesions, most of which are benign, with a small proportion being malignant. Scalp sarcomas constitute one category of malignant tumors, primarily including fibrosarcoma, liposarcoma, rhabdomyosarcoma, and leiomyosarcoma. Among these, scalp leiomyosarcoma is exceedingly rare.

Comparative effectiveness and safety of second-line therapies and dosing regimens for advanced hepatocellular carcinoma: a network meta-analysis.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated death globally. Second-line therapies are crucial for improving survival and quality of life among individuals suffering from advanced HCC who have not responded to first-line therapies. This study sought to evaluate the safety and efficacy of different second-line therapies for advanced HCC by network meta-analysis.

Exploring the molecular mechanism of Crohn's disease and rheumatoid arthritis: a bioinformatics and functional analysis approach.

Background: Crohn's disease (CD) and rheumatoid arthritis (RA) are autoimmune diseases. CD is known to be closely associated with RA. However, the mechanisms underlying these relationships remain unclear.

Multicriteria Assessment of Text Quality in Large Language Model-Generated Gynecomastia Materials: DeepSeek Versus OpenAI Versus Claude.

Background: With the development of artificial intelligence, obtaining patient-centered medical information through large language models (LLMs) is crucial for patient education. However, existing digital resources in online health care have heterogeneous quality, and the reliability and readability of content generated by various AI models need to be evaluated to meet the needs of patients with different levels of cultural literacy.

Objective: This study aims to compare the accuracy and readability of different LLMs in providing medical information related to gynecomastia, and explore the most promising science education tools in practical clinical applications.

Feasibility and Preliminary Efficacy of combined home-based fecal calprotectin self-testing and therapeutic drug monitoring-guided intervention in Patients with moderate-to-severe inflammatory bowel disease.

Background: Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, significantly impact patients' lives. Effective management often involves invasive and costly monitoring.

Objective: To evaluate the feasibility of integrating home-based fecal calprotectin testing with therapeutic drug monitoring (TDM) in managing moderate-to-severe IBD.

Association between diabetes duration and risk of pancreatic cancer: a meta-analysis of observational studies.

Background: Prior studies have implicated diabetes as a risk factor for pancreatic cancer, yet the impact of diabetes progression on pancreatic cancer incidence remains unclear. We aim to assess pancreatic cancer risk across different stages of diabetes.

Methods: Employing a predefined search strategy, we conducted a literature review of electronic databases up to 29 February 2024.

Direct measurement of the horizontal and vertical ciliary sulcus placements using ultrasound biomicroscopy in myopic eyes.

Purpos: To investigate the spatial placements of the horizontal and vertical ciliary sulcus through ultrasound biomicroscopy (UBM) analysis.

Setting: EYE & ENT Hospital of Fudan University, Shanghai, China.

Design: Prospective observational clinical study.

Multimodal Deep Learning for Predicting Postoperative Vault and Selecting ICL Sizes Using AS-OCT and UBM Images.

Purpose: To develop and validate a multimodal deep-learning model for predicting postoperative vault height and selecting implantable collamer lens (ICL) sizes using Anterior Segment Optical Coherence Tomography (AS-OCT) and Ultrasound Biomicroscope (UBM) images combined with clinical features.

Setting: West China Hospital of Sichuan University, China.

Design: Deep-learning study.

International students' experiences with U.S. healthcare providers and antibiotics: Quantitative and qualitative data.

The goal of this article was to examine international students' experiences with healthcare providers and antibiotic prescribing in their home countries versus in the United States. We collected survey and focus group data from international students from China, India, and South Korea. Both quantitative survey data and qualitative focus group data was collected.

Predicting Unplanned Readmission Risk in Patients With Cirrhosis: Complication-Aware Dynamic Classifier Selection Approach.

Background: Cirrhosis is a leading cause of noncancer deaths in gastrointestinal diseases, resulting in high hospitalization and readmission rates. Early identification of high-risk patients is vital for proactive interventions and improving health care outcomes. However, the quality and integrity of real-world electronic health records (EHRs) limit their utility in developing risk assessment tools.

Effect of Samarium Doping on the Energy Storage Properties of Bismuth Sodium Titanate-Based Lead-Free Ceramics.

Lead-free electroceramics have attracted significant research interest as alternatives to lead-containing systems due to concerns related to lead's toxicity to human health and the environment. Solid solutions based on bismuth sodium titanate (BNT) and barium titanate (BT), particularly those with compositions near the morphotropic phase boundary (MPB), such as 0.94 BiNaTiO-0.

Precise Modulation of Zeolite Acidity by Alkali Metal Ions for Enhancing Catalytic Performance in CO Cycloaddition Reactions.

The CO cycloaddition route is an effective way to achieve efficient conversion and utilization of CO. Zeolites with diverse topologies and tunable acidic sites can efficiently promote the cycloaddition reaction of CO with epoxides. The exchangeable cations in zeolites have a great influence on the performance of the CO cycloaddition, but there are few studies on it.

Protein Deamidation Reduced Digestive Resistance and Amyloid Antigenicity of Soy Proteins via Depolymerization.

Soy protein remains a key component of plant-based food development, but its application is challenged by inherent allergenicity. Previous work identified that native amyloid-like protein aggregates in soy 7S globulin that resist gastrointestinal digestion and exhibit pronounced antigenicity. Herein, we demonstrate that protein deamidation significantly enhances proteolysis under an infant gastrointestinal digestion model, leading to ∼80 and 50% reductions in IgG- and IgE-binding capacities, respectively.

Discovery of -(thiazol-2-yl) Furanamide Derivatives as Potent Orally Efficacious AR Antagonists with Low BBB Permeability.

Resistance-conferring mutations in the androgen receptor (AR) ligand-binding pocket (LBP) compromise the effectiveness of clinically approved orthosteric AR antagonists. Targeting the dimerization interface pocket (DIP) of AR presents a promising therapeutic approach. In this study, we report the design and optimization of -(thiazol-2-yl) furanamide derivatives as novel AR DIP antagonists, among which was the most promising candidate.

Recent Advances in the Isolation, Bioactivity, Biosynthesis, and Total Synthesis of Hamigerans.

Hamigerans, a class of diterpenoid natural products isolated from marine sponge , are characterized by distinctive 6-6-5 or 6-7-5 tricyclic skeletons. These compounds have been a focal point for synthetic chemists in recent years due to their remarkable biological activities. In this Review, we summarize the progress made in the isolation, biosynthesis, bioactivity, and total synthesis of hamigerans, with particular emphasis on synthetic studies published since 2013.

The Effect of the CBL-CIPK Signaling Pathway on Cucumber Plants Growth under High CO and Low Nitrogen Conditions.

Rising atmospheric CO exposes plants to high-CO environments, while excessive nitrogen fertilizer use degrades soil, highlighting the need to reduce nitrogen input and cultivate vigorous cucumber seedlings under HC-LN conditions. Calcineurin B-like proteins (CBLs) sense calcium signals and regulate carbon/nitrogen metabolism via CBL-interacting protein kinases (CIPKs), though their roles in cucumber under HC-LN conditions are unclear. Here, we identified seven and 19 genes.

Design, Synthesis, and Herbicidal Activity of Pyridinyl-benzothiazolone Heterocyclic Derivatives.

Protoporphyrinogen oxidase (PPO, EC 1.3.3.