High-Pressure Synthesis and Characterization of the Novel Potassium Superhydride KH.

Through high-pressure diamond anvil cell experiments, we report the synthesis of two novel potassium superhydrides (KH-I and KH-II) and investigate their structural and vibrational properties via synchrotron X-ray powder diffraction and Raman spectroscopy, complemented by density functional theory (DFT) calculations. Above 17 GPa at room temperature, KH-II and H react to form KH-I; this reaction can be accelerated with temperature. KH-I possesses a face-centered-cubic () potassium sublattice with a slight rhombohedral distortion (space group 3̅).

The Italian validation of the Watson Caritas Co-Worker Score for nurses and health care professionals.

Purpose: To translate, adapt, and validate the Watson Caritas Co-Worker Score in Italian.

Design: A cross-sectional study was conducted with 182 nurses and healthcare professionals.

Methods: Content Validity and construct validity, with Cronbach's alpha (α) and test-retest Intraclass Correlation Coefficients (ICCs), were calculated to assess validity and reliability.

Isolation and characterization of β-sitosterol from Terminalia arjuna fruit and its growth-promoting effect on beneficial fungi.

Terminalia arjuna, an important medicinal plant in traditional Indian systems, has been extensively studied for its cardioprotective bark. However, limited attention has been given to its fruit, which contains several biologically active phytochemicals with potential antioxidant, anti-inflammatory, and immunomodulatory properties. This study aimed to isolate and partially purify phytoactive compounds from the fruit of T.

Evolutionary medicine of emunctory functions of the kidney: an empirical review.

Primitive emunctory functions to expel harmful substances from cells and the interstitial space of multicellular organisms evolved over the past billion and a half years into the complex physiology of the metanephric kidney. Integrative biology allows empirical testing of hypotheses of the origins of renal structures from homologous single-celled precursors. Emunctory cell complexes called nephridia evolved in metazoan (cnidarian) ancestors 750 million years ago (mya).

Central Neurophysiological Alterations in Dystrophic mdx Mice Correlate With Reduced Hippocampal Levels of the Endogenous NMDA Receptor Ligand D-Aspartate.

Patients with Duchenne muscular dystrophy (DMD) may experience neurobehavioral and cognitive concerns, including psychiatric symptoms, due to the absence of full-length dystrophin (Dp427), frequently accompanied by deficiencies in shorter isoforms. The lack of dystrophin affects neurophysiological processes from the uterine phase, impacting neural circuitry in brain regions such as the prefrontal cortex, hippocampus, and cerebellum. This leads to reduced inhibitory GABAergic transmission and altered hippocampal glutamatergic signaling.

Contrarian Design of Versatile MoS-Based Self-Lubrication Film.

Molybdenum disulfide (MoS) exhibits excellent lubrication capacity rooted in its layered structure, but it suffers significant structural and functional deterioration due to oxidation in ambient environments, limiting its applications. Concerted efforts are focused on enhancing the antioxidation ability of MoS, but challenges remain. This work conceptualizes and demonstrates a contrarian design of MoS-based film via metal incorporation and oxidation based on consideration of key fundamental principles of thermodynamics, chemistry, and physical mechanics.

Chemical characterization and antimicrobial activities of Citrus aurantifolia peel oils and Ocimum sanctum ethanolic extract.

Oral diseases affect more than 3.5 billion people globally, representing a major public health burden, particularly in low- and middle-income countries where access to dental care is often limited. Furthermore, the use of conventional antimicrobial agent may cause side effect.

A Simple and Highly Sensitive Liquid Chromatographic-Mass Spectrometric Method for the Determination of Itraconazole and Its Major Metabolite in Human Plasma and Its Application to a Bioequivalence Study.

Itraconazole is an oral triazole antimycotic drug. Bioequivalence studies are cornerstones for the approval of generic drug development globally. The present study describes a simple, sensitive and economical LC-MS/MS method for the determination of itraconazole and its metabolite in human plasma.

[Rapid determination of five antipyretic analgesics in surface water by online solid phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry].

Antipyretic analgesics are typical pharmaceutical and personal care products （PPCPs） that are widely used in our daily life because they relieve fever and pain， and have anti-inflammatory and anti-rheumatic properties. These drugs inhibit the synthesis and release of prostaglandins （PGs） in the neurons of the anterior hypothalamus and exert therapeutic effects as a consequence. However， these drugs are relatively commonly misused and abused， often owing to a lack of proper medication guidance.

[Determination of 26 perfluorinated and polyfluoroalkyl compounds in human serum by solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry].

Perfluorinated and polyfluoroalkyl compounds （PFASs） represent a category of synthetic chemicals renowned for their environmental persistence. Owing to their hydrophobic， oleophobic， and high-temperature-resistant properties， PFASs are extensively utilized in industrial， agricultural， and civilian sectors， including applications in leather， textiles， flame-retardant materials， lubricants， and coatings， among others. PFASs can accumulate within the human body， exhibiting multi-organ toxicity.

Chemical Profiling of Chixiaodou Danggui San Using Liquid Chromatography-Tandem Mass Spectrometry With Data Mining Strategy.

Rationale: Chixiaodou Danggui San (CDS), composed of Vignae semen (VS) and Angelicae sinensis radix (ASR), has been utilized for the treatment of hemorrhoids in China. However, the chemical profiling of CDS remains insufficiently explored. Therefore, it is necessary to establish an accurate and rapid method for the chemical profiling of CDS.

Rapid, low-temperature nanodiamond formation by electron-beam activation of adamantane C-H bonds.

Diamond and adamantane () share a -symmetric carbon skeleton, but converting to diamond has been challenging because it requires selective carbon-hydrogen (C-H) bond cleavage and monomer assembly into a diamond lattice. Our approach differs from the conventional high-temperature, high-pressure diamond syntheses. We electron-irradiated submicrocrystals at 80 to 200 kilo-electron volts and 100 to 296 kelvin in vacuum for tens of seconds.

Anisotropic Optoelectronic Synapses in 2D NbGeTe for Direction-Programmable Neuromorphic Perception and Decision-Making.

Neuromorphic computing presents a promising solution for the von Neumann bottleneck, enabling energy-efficient and intelligent sensing platforms. Although 2D materials are ideal for bioinspired neuromorphic devices, achieving multifunctional synaptic operations with simple configurations and linear weight updates remains challenging. Inspired by biological axons, the in-plane anisotropy of 2D NbGeTe is exploited to develop dual electronic-optical synaptic devices.

[Characterization of hippocampal components of Danzhi Xiaoyao Formula based on HPLC-Q-TOF-MS/MS and network pharmacology and assessment of its therapeutic potential for nervous system diseases].

In this study, the pharmacodynamic components and potential pharmacological functions of Danzhi Xiaoyao Formula in treating nervous system diseases were investigated by hippocampal component characterization and network pharmacology. After rats were administrated with Danzhi Xiaoyao Formula by gavage, high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(HPLC-Q-TOF-MS/MS) was employed to explore the components in the hippocampus of rats. Fifty-seven components were identified in the hippocampus of rats by comparing the extract of Danzhi Xiaoyao Formula, herbal components in the hippocampus after administration, and blank samples.

[Comparison on chemical components of Angelicae Sinensis Radix before and after wine processing by HS-GC-IMS, HS-SPME-GC-MS, and UPLC-Q-Orbitrap-MS combined with chemometrics].

The study investigated the intrinsic changes in material basis of Angelicae Sinensis Radix during wine processing by headspace-gas chromatography-ion mobility spectrometry(HS-GC-IMS), headspace-solid phase microextraction-gas chromatography-mass spectrometry(HS-SPME-GC-MS), and ultra-high performance liquid chromatography-quadrupole-orbitrap mass spectrometry(UPLC-Q-Orbitrap-MS) combined with chemometrics. HS-GC-IMS fingerprints of Angelicae Sinensis Radix before and after wine processing were established to analyze the variation trends of volatile components and characterize volatile small-molecule substances before and after processing. Principal component analysis(PCA) and orthogonal partial least squares-discriminant analysis(OPLS-DA) were employed for differentiation and difference analysis.

[Fast determination of maduramicin ammonium in serum by high performance liquid chromatography-tandem mass spectrometry].

To establish a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the fast determination of maduramicin ammonium (MAD) in rat serum. In February 2024, rat serum samples were selected and directly injected after extraction and purification with methanol: acetonitrile (1: 1), separated on a C18 chromatographic column, and gradient-eluted using 0.1% formic acid aqueous solution -0.

[Research progress on the relationship between periodontitis and anxiety disorders/depression disorders].

Periodontitis, a common chronic inflammatory disease, progressively damages the supporting tissues of teeth, ultimately resulting in tooth loss. The rising incidence of periodontitis in adults has prompted researchers to observe a frequent co-occurrence of mental health disorders (such as anxiety disorders, depression disorders) in patients undergoing periodontitis onset and treatment. The existence of severe periodontitis can even aggravate the mental and psychological disorders of patients.

Metabolomics Study on the Antitumor Effect of Osthole on HepG2 Cells Using UPLC-Q-TOF-MS/MS.

Hepatocellular carcinoma (HCC) stands as a globally common malignancy with persistently elevated incidence and mortality rates. It is known for being able to resist conventional chemotherapy. There is currently growing interest in natural products for the treatment of HCC, owing to their significant antitumor activity.

Relationship among Structure, Disorder, Magnetism, and Band Topology in the MnSbTe·(SbTe) Family.

The interplay between topology and magnetism induces various exotic quantum phenomena, with magnetic topological insulators (MTIs) serving as a prominent example due to their ability to host the quantum anomalous Hall effect (QAHE). However, the realization of the QAHE at a higher temperature approaching the magnetic transition temperature remains a significant challenge, primarily due to the scarcity of suitable material platforms and our limited understanding of the intricate relationships among band topology, magnetism, and defects. Here, we report a comprehensive investigation of MnSbTe·(SbTe) ( = 0-5) single crystals, including the discovery of the novel MnSbTe pure phase.

Development of an in vitro method to assess the immunogenicity of biologics in the prevention of infectious diseases.

We present a series of preclinical studies focused on developing in vitro 2D and 3D models for assessing immunogenic factors in preventing infectious diseases. Human peripheral blood mononuclear cells (PBMC) and Calu-3 cell lines (bronchial epithelial cells) were used to develop 2D and 3D models. Peptides: Spike-S1-His (S-His), nucleocapsid-His and adjuvants: human adenovirus five serotype-based viral vector (AdV-D24-ICOSL-CD40L), armed with inducible co-stimulator (ICOSL) and CD40 ligand (CD40L), and a vector lacking these transgenes (AdV5/3) were used due to their effective initial interaction with antigen-presenting cells (APC).

Metabolite Profiling of Guipi Pill Using UHPLC-Q-Orbitrap-HRMS and Determination of the Pharmacokinetics of its Major Prototype Components.

Guipi Pill (GPP), a classic traditional formula used to treat anxiety disorders, demonstrates significant pharmacological activity. However, research on its pharmacodynamic material basis remains limited. UHPLC-Q-Orbitrap-HRMS was used to systematically analyze the metabolites of GPP in the blood, urine, bile, and feces of rats after oral administration and elucidate its in vivo metabolic processes.

Resilience and nursing care quality in emergency departments: a 2024 study in Kermanshah, Iran hospitals.

Background: Emergency department (ED) nurses play a critical role in delivering urgent healthcare services and ensuring patient safety. The quality of nursing care in the ED significantly influences patient outcomes, satisfaction, and the overall performance of the healthcare system. Given the high-stress nature of the ED environment, nurses need to possess resilience—the capacity to adapt and cope effectively with challenging situations.

Unveiling how medical educators conceptualise resilience: a qualitative study.

Background: Medical educators operate in high-pressure environments where resilience is critical to their well-being and professional effectiveness. Studies exploring how medical educators conceptualise resilience is limited, particularly outside Western contexts. As such, research investigating culturally-sensitive conceptualisations of resilience in an Asian context is overdue.

Exploring the Emergent Concept of Patient Advocacy in Acute and Perioperative Settings: A Scoping Review.

Introduction: Staff shortages following the pandemic and the growing complexity of healthcare require continuous reflection on the part of professionals to improve patient protection efforts in high-pressure environments. This makes it essential to better understand and reinforce the role of patient advocacy in clinical practice. This study aims to map the concept of patient advocacy in nursing, identifying its key attributes, antecedents, and consequences in acute and perioperative settings, contributing to its update and integration into the current healthcare paradigm.

Earth's Hadean crust formed via operation of convergent tectonics.

Determining the composition, formation mechanisms and stability of the Hadean continental crust is essential for understanding the early geological history of Earth. Detrital zircons, largely from Jack Hills of Western Australia, provide the dominant direct records for the nature of continental crust during the Hadean eon and its formation processes. Although isotope and trace element compositions of these zircons are extensively determined, the major and trace element compositions of their host rocks and corresponding parental magmas remain largely debated, making the nature and evolution of the early Earth's crust ambiguous.