Unveiling how medical educators conceptualise resilience: a qualitative study.

Background: Medical educators operate in high-pressure environments where resilience is critical to their well-being and professional effectiveness. Studies exploring how medical educators conceptualise resilience is limited, particularly outside Western contexts. As such, research investigating culturally-sensitive conceptualisations of resilience in an Asian context is overdue.

Exploring the Emergent Concept of Patient Advocacy in Acute and Perioperative Settings: A Scoping Review.

Introduction: Staff shortages following the pandemic and the growing complexity of healthcare require continuous reflection on the part of professionals to improve patient protection efforts in high-pressure environments. This makes it essential to better understand and reinforce the role of patient advocacy in clinical practice. This study aims to map the concept of patient advocacy in nursing, identifying its key attributes, antecedents, and consequences in acute and perioperative settings, contributing to its update and integration into the current healthcare paradigm.

Earth's Hadean crust formed via operation of convergent tectonics.

Determining the composition, formation mechanisms and stability of the Hadean continental crust is essential for understanding the early geological history of Earth. Detrital zircons, largely from Jack Hills of Western Australia, provide the dominant direct records for the nature of continental crust during the Hadean eon and its formation processes. Although isotope and trace element compositions of these zircons are extensively determined, the major and trace element compositions of their host rocks and corresponding parental magmas remain largely debated, making the nature and evolution of the early Earth's crust ambiguous.

Probing the Compositional and Structural Effects on the Electrochemical Performance of Na(Mn-Fe-Ni)O Cathodes in Sodium-Ion Batteries.

This study systematically investigates an Mn-Fe-Ni pseudo-ternary system for Na(Mn-Fe-Ni)O cathodes, focusing on the effects of varying transition metal fractions on structural and electrochemical properties. X-ray diffraction reveals that increasing Mn content induces biphasic behavior. A higher Ni content reduces the parameter, while higher Mn and Fe concentrations expand the lattice.

FtsZ as a novel target for antibiotics development: Promises and challenges.

Filamenting temperature-sensitive mutant Z (FtsZ), a protein essential for bacterial cell division, is highly conserved across bacterial species but absent in humans, positioning it as a strategic target for the development of antibiotics. Significant efforts to identify FtsZ inhibitors- biochemical assays (, GTPase activity) and cellular approaches (, immunofluorescence)-have yielded over 100 natural products and synthetic compounds, whose cheminformatics clustering underscores a limited chemical diversity among the current scaffolds. Structural studies, including X-ray crystallography and cryo-electron microscopy, have resolved 97 FtsZ structures revealing conserved polymerization mechanisms and conformational plasticity, as exemplified by extremophile adaptations (, from the high-pressure environment of the Mariana Trench's Challenger Deep).

High-Pressure MgCl Synthesized in a Diamond Anvil Cell as a Polar Metal with Second-Harmonic Generation.

Polar metals have attracted growing interest due to both their significance in fundamental science and their potential functionalities. Here, we report the discovery of a novel polar metal, magnesium chloride MgCl, in which the metallicity of the polar structure is uniquely driven by attractive halogen interactions. MgCl was synthesized in laser-heated diamond anvil cells and observed at pressures of 28(2)-93(3) GPa.

Integrative Analysis of Curcuma kwangsiensis Reveals Markers for Distinguishing Rhizome, Radix, and Non-Medicinal Parts via LDA-Based Classification.

Introduction: Curcumae Rhizoma (Ezhu) and Curcumae Radix (Yujin) are both derived from Curcuma kwangsiensis (CK), an important species in the Zingiberaceae family. They have different clinical applications in traditional Chinese medicine (TCM): The rhizome is mainly used for antitumor treatments, whereas the radix is known for antidepressant and cholagogic effects, both officially listed in the Chinese Pharmacopoeia. However, non-medicinal parts such as the aerial portions and fibrous roots are sometimes mixed in, leading to confusion in clinical formulation use.

Analysis of static electricity risks in nonmetallic pipelines for hydrogen transportation.

Nonmetallic pipelines are promising for medium-short distance hydrogen transport due to their lightweight, corrosion resistance, and durability. However, their low conductivity raises electrostatic safety concerns, given hydrogen's exceptionally low ignition energy (0.017 mJ).

Pharmacokinetic analysis of selective TRPV2 inhibitor SET2 in rats.

The TRPV2 channel, which regulates calcium transients, has emerged as a potential therapeutic target in various diseases, including cardiovascular injury, neurodegeneration, and cancer. However, the absence of selective inhibitors has limited functional studies. Here, we report the in vivo pharmacokinetic profile of SET2, a selective TRPV2 inhibitor.

Probing stress and magnetism at high pressures with two-dimensional quantum sensors.

Pressure serves as a fundamental tuning parameter capable of drastically modifying all properties of matter. The advent of diamond anvil cells (DACs) has enabled a compact and tabletop platform for generating extreme pressure conditions in laboratory settings. However, the limited spatial dimensions and ultrahigh pressures within these environments present significant challenges for conventional spectroscopy techniques.

Ultrahigh pressure compaction-resistant thin film crosslinked composite reverse osmosis membranes.

In this study, we present a class of thin-film crosslinked (TFX) composite reverse osmosis (RO) membranes that resist physical compaction at ultrahigh pressures (up to 200 bar). Since RO membranes experience compaction at virtually all pressure ranges, the ability to resist compaction has widespread implications for RO membrane technology. The process described herein involves crosslinking a phase inverted porous polyimide (PI) support membrane followed by interfacial polymerization of a polyamide layer, thereby forming a fully thermoset composite membrane structure.

Lipid metabolites as biomarkers and therapeutic targets in oral squamous cell carcinoma.

This study explores the association of lipid metabolism disruption and Oral Squamous Cell Carcinoma (OSCC). We aim to identify specific lipid biomarkers and therapeutic targets for OSCC. We included 78 OSCC patients and 80 healthy controls, and applied non-target lipidomics and transcriptomics for comprehensive analysis.

High-Pressure Synthesis of Metastable Superhydride PdH by Using Amorphous Pd as a Starting Material.

Pressure has been considered as a versatile and promising means in the discovery of metal superhydrides. However, although a series of metastable metal hydrides with excellent superconducting properties have been predicted through theoretical calculations, it is still challenging to obtain metal hydrides with metastable phases via a high-pressure synthetic route. Herein, we have successfully fabricated a metastable PdH superhydride using amorphous Pd nanoparticles (NPs) as a starting material at ∼32.

Quantification of Fatty Acids from Arctium lappa L. Leaves by C qNMR and HPLC-CAD.

Arctium lappa L. (burdock) leaves is effective in the traditional treatment of stroke. Fatty acids are abundant in burdock leaves, and may play an important role in the treatment of stroke.

Application of Isothermal Differential Scanning Calorimetry Equipped with a UV Probe for Photostability Assessment of Pharmaceutical Drugs in the Solid State.

Current methods for evaluating the photostability of pharmaceutical drugs typically separate the irradiation step from the analytical process, making it challenging to observe real-time photodegradation during irradiation. The use of HPLC equipped with UV and/or MS detectors, which are commonly used for quantitative analysis, requires considerable time to establish optimal conditions, and employs organic solvents, which are harmful to both the environment and the analyst. The aim of this study is to investigate the effectiveness of isothermal differential scanning calorimetry (DSC) equipped with a UV probe (photo-DSC) for evaluating the photostability of pharmaceutical drugs in the solid state.

Metagenomics and metabolomics to evaluate the potential role of gut microbiota and blood metabolites in patients with cerebral infarction.

Cerebral infarction, a cerebrovascular disorder, is characterized by the sudden onset of neurological deficits and clinical symptoms. It ranks among the leading causes of death and severe disability worldwide. The etiology of cerebral infarction is multifaceted, with common risk factors including dietary patterns, smoking, hypertension, and diabetes mellitus.

Effect of low-temperature sous vide under high-pressure on the moisture retention, tenderness, and color of pork loins.

This study investigated the effects of combining sous vide (SV) and high-pressure (HP, 0.1-200 MPa) on the structural changes of meat proteins and the eating quality of pork loin in comparison to commercial cooking (CC). Differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) spectroscopy showed that SV under HP stabilized the secondary structure of sarcoplasmic proteins.

GC-MS and HPLC chemical profile, antioxidant, anti-acetylcholinesterase, and anti-diabetic activities of Libyan Salvia lanigera herb extract and essential oil.

The current study explored the chemical composition and biological activities of the essential oil and ethanol extract of Salvia lanigera collected from Libya. The ethanol extract obtained from the wild growing S. lanigera was evaluated for the chemical composition via high-performance liquid chromatography with diode-array detection (HPLC-DAD), which demonstrated phenolic and flavonoid contents.

Plasma non-targeted metabolomics unravels the metabolic features of normal trans-right heart.

Introduction: Right heart (RH), as a junction between the venous system and pulmonary circulation, gains great emphasis on exploring the relevant pathological mechanism of many cardiopulmonary diseases. Although these pathogensis researches centering on RH-related diseases advance, the physiological mechanism research of the RH is scarce.

Objectives: This study aimed to accurately unravel the metabolic features of normal trans-RH through non-targeted metabolomics.

Enhanced mycoprotein extraction via cell wall disruption: A promising alternative protein with preferable digestibility and lubrication over soy protein.

Growing demand for alternative proteins has spurred research into microbial proteins, particularly Fusarium venenatum mycoprotein (MP). Naturally encapsulated within rigid fungal cell walls, MP requires efficient extraction to liberate intracellular protein for nutritional and functional applications. High-pressure homogenization (0-120 MPa) enhanced cell wall disruption and protein extraction, increasing protein content (47.

Effects of Pressure and Temperature on the Thermodynamics of α-Helices: Implications for Piezophilic Adaptation.

In light of the recent realization that a significant fraction of microbial biomass lives under high hydrostatic pressure, there is a renewed interest in understanding the molecular details by which proteins in these organisms modulate their functional native state. The effects of pressure on protein stability are defined by the volume changes between the native and denatured states. The conformational ensemble of the denatured state can depend on several extrinsic variables, such as pH and ionic strength of the solvent, temperature, and pressure.

Putting a lid on it: The N-terminal helix of Arf1 inhibits switching via uniform stabilization.

The Arf and Arf-like GTPases, unlike all other Ras family GTPase members, exhibit a repressed conformation in their inactive, GDP-bound form. An important component of this autoinhibition is their N-terminal helix, which is missing in the other Ras family members. This helix caps a switch element called the interswitch, confining it to this repressed state.

Development and Validation of a Stability-Indicating HPTLC-Based Assay for the Quantification of Nitrofurazone Ointment.

This paper reports on a validated, stability-indicating high-performance thin-layer chromatography (HPTLC)-based assay for the quantification of nitrofurazone in an ointment formulation. The simple and rapid HPTLC analysis was performed on silica gel 60 F254 HPTLC plates using toluene-acetonitrile-ethyl acetate-glacial acetic acid (6:2:2:0.1, /) as the mobile phase and chloroform-acetone (9:1, /) as the solvent.

Scandium(III) Solvation and Association and Water Structure in the Gigapascal Pressure Range Investigated by Neutron Scattering.

Scandium(III) (Sc(III)) is the smallest among the trivalent ions in Group 3, which includes yttrium(III) and lanthanides (III) with a hydration number of 8 and 8-9, respectively. The hydration number of Sc(III) in aqueous solutions reported so far varies from six to ten and remains an open question. In general, applying pressure and temperature to aqueous solutions perturbs the water structure and ion solvation, providing insight into the nature of ion solvation.

Plasma-Assisted Synthesis of TiO/ZnO Heterocomposite Microparticles: Phase Composition, Surface Chemistry, and Photocatalytic Performance.

The search for a simple, scalable, and eco-friendly method for synthesizing micro-sized photocatalysts is an urgent task. Plasma technologies are highly effective and have wide possibilities for targeted synthesis of novel materials. The mass-average temperature of plasma treatment is higher than the stability temperature of anatase and brookite, the most photoactive polymorphs of titanium dioxide.