Designing a paradigm model of employees' voice in organizations providing medical services (a case study: Al-Zahraa Teaching Hospital in Iraq).

Background: Al-Zahraa Teaching Hospital, one of the most important hospitals in Iraq, is currently facing extensive organizational problems. One reason for these problems is the lack of attention to the voice of the employees, which can be due to a lack of designing an appropriate model for this phenomenon.

Materials And Methods: Accordingly, the present interpretive, qualitative, and exploratory research mainly aimed at designing a voice pattern for the employees in Al-Zahraa Teaching Hospital in Iraq.

Comparative efficacy and safety of therapeutic strategies for EGFRvIII positive recurrent glioblastoma.

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, and EGFRvIII mutation has been associated with treatment resistance and poor prognosis, highlighting the need for more effective therapeutic strategies. We conducted a random-effects Bayesian network meta-analysis to compare the efficacy and safety of treatments for EGFRvIII-positive recurrent GBM (rGBM), evaluating overall survival (OS), progression-free survival (PFS), and objective response rate (ORR). Seven clinical trials were included ( = 716).

Adding pegylated interferon-α to nucleos(t)ide analogs improves HBsAg clearance in chronic hepatitis B with low-level viremia.

Introduction: Low-level viremia (LLV) is associated with the progression of liver fibrosis and a high risk of hepatocellular carcinoma in patients with chronic hepatitis B (CHB). The present study aimed to compare the efficacy between nucleos(t)ide analogs (NAs) therapy and combination therapy of NAs and pegylated interferon-α (pegIFN-α) in entecavir (ETV)-treated CHB patients with LLV.

Methods: This was a retrospective cohort study.

Correction: Autosomal recessive woolly hair/hypotrichosis caused by LIPH mutations: a case report.

[This corrects the article DOI: 10.3389/fmed.2025.

An empirical comparative study on the diagnostic index system for techniques and tactics in men's table tennis during the ABS plastic ball Era.

In order to accurately identify the diagnostic index system that can best reflect the technical and tactical performance of table tennis after the implementation of the new ABS material ball, and then more accurately and efficiently diagnose and analyze the technical and tactical ability of players. This paper uses the methods of match observation, mathematical statistics, literature and other methods to carry out an empirical comparative study on the representative segmented diagnostic indicator system constructed by predecessors in the past 20 years. Research suggests that: 1) in the New Ball Era, each segmented diagnostic indicator system has a certain degree of rationality, but in comparison, the five-segment diagnostic indicator system is the most optimal and the most accurate to reveal the technical and tactical performance in the new era.

Interportal Capsulotomy Closure Does Not Improve the Results After Hip Arthroscopy at 1-Year Follow-up: A Prospective Randomized Controlled Study.

Background: Management of the capsulotomy at termination of hip arthroscopic procedures in the treatment of femoroacetabular impingement syndrome (FAIS) is debated. Clinical outcomes in favor of capsular closure were demonstrated in a retrospective study; nonetheless, this finding could not be confirmed in a recent randomized, controlled trial comparing capsular closure with unrepaired capsulotomy.

Purpose/hypothesis: This randomized, controlled multicenter trial aimed to evaluate the effect of capsular closure on subjective postoperative outcomes and revision rates in patients undergoing hip arthroscopy for FAIS.

Impact of Caregiver Status on Academic Achievements and Family-Work Conflict: A Cross-Sectional Analysis of US Neurology Faculty.

Background And Objectives: With more women entering the medical workforce, caregiving challenges and family-work conflicts are of growing importance to today's neurologists. The aim of this study was to assess the impact of caregiver (CG) status on academic achievements in neurology, analyze the division of labor and time devoted to domestic responsibilities, and measure family-work conflict in US academic neurology faculty.

Methods: A total of 19 US neurology departments completed a survey on baseline demographics, academic achievements, CG status, division of domestic time and labor, and responses on a FWC scale.

Analysis of factors influencing the burden on family caregivers of disabled older adults in Guangzhou.

Objective: This study aims to investigate the current status of disability among older adults and analyze factors influencing the burden on their family caregivers in southern China.

Methods: A cross-sectional survey was conducted among 334 pairs of disabled older adults (≥65 years) and their primary family caregivers across three districts in Guangzhou. Face-to-face interviews using standardized questionnaires assessed disability levels via the "Long-term Care Disability Level Assessment" scale and caregiver burden via the Zarit Burden Interview (ZBI) scale.

Cost-effective analysis of sugemalimab plus chemotherapy as first-line treatment for advanced gastric or gastroesophageal junction adenocarcinoma with PD-L1 CPS ≥5.

Background: Results from the GEMSTONE-303 trial indicate that compared with placebo plus capecitabine and oxaliplatin (PLA-CAP), sugemalimab plus capecitabine and oxaliplatin (SUG-CAP) as first-line therapy provides clinical benefits for patients with advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma with programmed cell death ligand 1 (PD-L1) combined positive score (CPS) ≥5. However, the addition of sugemalimab increases medical costs. This study aimed to assess the cost-effectiveness of SUG-CAP vs.

The mismatch in hierarchical diagnosis and treatment construction and related reasons: a qualitative analysis from ZX City, Hubei Province.

Background: There is a substantial gap between the objective of hierarchical diagnosis and treatment (HDT) construction and its actual effectiveness in resolving the problems of difficult and expensive access to medical treatment. Consequently, it has become essential to address these issues through research.

Objectives: This study intends to examine the mismatch in China's HDT construction and identify its underlying causes.

Sequential treatment for diabetic foot ulcers in aortic dissection patients: a case report.

Diabetic foot ulcers (DFUs) represent a prevalent complication of diabetes, with a lifetime risk ranging from 15% to 25% among diabetic patients. Research indicates that anticoagulation plays a crucial role in the management of newly diagnosed cases of diabetic lower extremity atherosclerotic obliterative disease. However, in the present case, the patient developed dry gangrene in both toes after receiving vasodilator drugs during an emergency intervention for sudden aortic dissection.

Gender differences in the prevalence and correlates of COVID-19 fear among mental health professionals: a network perspective based on a national survey in China.

Background: Gender differences in COVID-19-related fear among mental health professionals (MHPs) have been inadequately studied. This study compared the gender differences in prevalence, correlates and network structure of COVID-19 fear among MHPs in China in the post-pandemic era.

Methods: A nationwide cross-sectional study was conducted between January 22 and February 10, 2023.

The non-linear association of physical fatigue with depression and anxiety among mental health professionals who recovered from COVID-19 infection: a national survey in China.

Background: The COVID-19 pandemic took a toll on everyone's health and mental health professionals were no exception. This study examined the trajectory of the relationship between levels of physical fatigue and each of depression and anxiety in mental health professionals (MHPs) recovering from COVID-19.

Methods: A national survey of 9,858 MHPs who had recovered from COVID-19 was conducted between January and February 2023.

mRNAome Analysis of Whole Blood of Patients with Psoriatic Arthritis, Ankylosing Spondylitis, and Rheumatoid Arthritis.

Introduction: Psoriatic arthritis (PsA), ankylosing spondylitis (AS), and rheumatoid arthritis (RA) are common chronic inflammatory diseases, with some clinical similarities and differences. mRNAome analysis provides a valuable approach to understanding disease pathogenesis. To elucidate the underlying mechanisms of similarities and differences among these inflammatory diseases, we analyzed the commonly and specifically expressed mRNAs in the whole blood of patients with PsA, AS, and RA.

miRNA-494 in Lymphocytes: A Promising Biomarker for Acute Ischemic Stroke.

Background: microRNA-494 (miRNA-494) plays a key role in neuroinflammation following cerebral ischemia. We aimed to assess miRNA-494 levels as a biomarker for predicting acute ischemic stroke (AIS) severity and outcomes.

Methods: miRNA-494 levels in peripheral lymphocytes were measured using reverse transcription-quantitative polymerase chain reaction.

Development, Evaluation, and Implementation of Guideline Adaptation and Its Frameworks: A Meta-Epidemiological Study of English-Language Guidelines.

Background: Guideline adaptation refers to the process of modifying or tailoring existing clinical practice guidelines (CPGs) in addressing local health system needs, improving the relevance of recommendations, and overcoming barriers like resource constraints. However, limited information is known about the current development, evaluation, and implementation of guideline adaptation.

Aim: This study aims to evaluate the methodological quality, utilization, and implementation of English-language adapted CPGs and compare frameworks used for adaptation.

Standardising Traditional Chinese Medicine Decoction Rooms: Current Challenges and Proposed Solutions for Medical Institutions.

Objective: To analyse current supervision methods and problems in traditional Chinese medicine (TCM) decoction rooms in medical institutions and to propose feasible methods of quality control.

Methods: This study is a literature review. Literature related to TCM decoction was obtained from the PubMed, CNKI and Web of Science databases.

A Reflective Verbalization Strategy to Trigger Alternative Diagnostic Hypotheses.

Rationale: Physicians sometimes encounter various types of gut feelings (GFs) during clinical diagnosis. The type of GF addressed in this paper refers to the intuitive sense that the generated hypothesis might be incorrect. An appropriate diagnosis cannot be obtained unless these GFs are articulated and inventive solutions are devised.

Methods used in early value assessments for nice: a scoping review.

Objectives: The National Institute for Health and Care Excellence (NICE) in England introduced early value assessments (EVAs) as an evidence-based method of accelerating access to promising health technologies that could address unmet needs and contribute to the National Health Service's Long Term Plan. However, there are currently no published works considering differences and commonalities in methods used between Assessment Reports for EVAs.

Methods: This rapid scoping review included all completed EVAs published on the NICE website up to 23 July 2024.

The disease burden of β-thalassaemia revisited.

Objective: The complexity of β-thalassaemia with associated morbidity, lifelong daily expensive treatment, and multidisciplinary care results in a considerable disease burden. Our study aimed to revisit the β-thalassaemia burden using epidemiological, clinical, and financial indicators related to patients, families, and healthcare systems.

Methods: Patient density measures, transfusion indices, complication rates, universal health coverage, and other indicators were tabulated by country and region.

Molecular engineering based on four-arm perylene diimide chromophores toward hypoxia-induced specific photothermal therapy.

Perylene diimide (PDI) radical anions have attracted increasing attention as hypoxia-responsive photothermal agents due to their strong near-infrared (NIR) absorption and efficient photothermal conversion. However, their biomedical application is often limited by aggregation-induced quenching and poor structural tunability. In this work, we report a rationally engineered four-arm PDI derivative (PDI-4Alky·4Cl) bearing terminal alkyne groups, which not only suppresses π-π stacking steric and electrostatic repulsion, but also serves as a versatile molecular scaffold for further functionalization.

The impact of opioid use associated with curative-intent cancer surgery on safe opioid prescribing practice among veterans: An observational study.

Background: Opioid exposure during cancer therapy may increase long-term unsafe opioid prescribing. This study sought to determine the rates of coprescription of benzodiazepine and opioid medications and new persistent opioid use after surgical treatment of early-stage cancer.

Methods: A retrospective cohort study was conducted among a US veteran population via the Veterans Affairs Corporate Data Warehouse database.

Causal Effects of Inflammatory Cytokines on Bipolar Disorder: A Bidirectional Two-Sample Mendelian Randomization Study.

Introduction: Inflammatory cytokine disturbance is a prominent outcome of immune dysregulation, extensively documented in bipolar disorder (BD). However, observational studies have exhibited inconsistent findings, and the causal relationships between inflammatory factors and BD remain unclear. Hence, this study aimed to uncover the causality between circulating inflammatory cytokines and BD.

Challenges and facilitators of electronic health record implementation: a scoping review.

Background And Objective: The rapid advancement of technology has made eHealth a vital part of modern healthcare. Electronic Health Records (EHRs), as core tools of eHealth, enhance care quality, enable access to medical data, and improve coordination among healthcare providers. Implementing EHRs successfully requires understanding the challenges and facilitators involved to inform effective policymaking and management.