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Background: There is a substantial gap between the objective of hierarchical diagnosis and treatment (HDT) construction and its actual effectiveness in resolving the problems of difficult and expensive access to medical treatment. Consequently, it has become essential to address these issues through research.
Objectives: This study intends to examine the mismatch in China's HDT construction and identify its underlying causes.
Methods: Grounded theory was employed in this research. Open questions were designed through theoretical sampling and coding processes until theoretical saturation was achieved. A total of 52 participants, all doctors from different levels of medical institutions in ZX City, Hubei Province, China, with more than 3 years of experience, were recruited.
Results: This study uncovers significant mismatches between residents' "pursuit of high-quality medical care" and HDT's requirement of "initial diagnosis at the grassroots level," between the service supply capacity and the functional positioning of medical institutions in HDT, and between the policy environment and HDT's construction needs, respectively. The primary reasons for these discrepancies are residents' lack of confidence, improper allocation of health resources, and the absence of in-depth health policy reforms.
Conclusion: This study recommends restoring residents' confidence in the service provision of low-level medical institutions to achieve initial diagnosis at the grassroots level, establishing a positive health resource-allocation pyramid from lower to higher levels to enhance the service capacity of primary health care institutions, and adjusting the policy environment to address and reform deep-seated policy contradictions and rationalize the functional positioning and matching relationship of medical institutions at all levels in HDT.
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http://dx.doi.org/10.3389/fpubh.2025.1524732 | DOI Listing |
Spectrochim Acta A Mol Biomol Spectrosc
September 2025
College of Chemistry, Chemical Engineering and Material Science, Soochow University, No. 199 Ren'Ai Road, Suzhou 215123, China; Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China. Electronic address: g
The dynamic monitoring of cell death processes remains a significant challenge due to the scarcity of highly sensitive molecular tools. In this study, two hemicyanine-based probes (5a-5b) with D-π-A structures were developed for organelle-specific viscosity monitoring. Both probes exhibited correlation with the Förster-Hoffmann viscosity-dependent relationship (R > 0.
View Article and Find Full Text PDFThromb Res
September 2025
Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. Electronic address:
Warfarin is a widely used vitamin K antagonist (VKA) with known pleiotropic effects beyond anticoagulation. Preclinical and case-control evidence suggests that warfarin may affect hematopoiesis, but longitudinal human evidence is lacking. To explore this potential effect, we conducted a post-hoc analysis of participants in the Hokusai-VTE and ENGAGE AF-TIMI 48 trials, which randomized patients to warfarin or the direct oral anticoagulant edoxaban with routine laboratory testing at predefined follow-up visits.
View Article and Find Full Text PDFCurr Opin Microbiol
September 2025
Cryptosporidiosis Laboratory, The Francis Crick Institute, London, United Kingdom. Electronic address:
The movement of molecules across the membranous barriers of a cell is fundamental to cellular homeostasis in every living organism. This vital process is facilitated through a mechanistically diverse class of proteins, collectively known as membrane transporters. Among these are so-called carrier proteins that can function in passive and active transport mechanisms.
View Article and Find Full Text PDFPublic Health
September 2025
Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Objectives: Participation rates in fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening differ across socio-demographic subgroups. The largest health gains could be achieved in subgroups with low participation rates and high risk of CRC. We investigated the CRC risk within different socio-demographic subgroups with low participation in the Dutch CRC screening program.
View Article and Find Full Text PDFBrain Dev
September 2025
Institute of Medical Science, Gyeongsang National University College of Medicine, Jinju, Republic of Korea; Department of Neurology, Gyeongsang National University Hospital, Jinju, Republic of Korea.
Objective: To compare parenting stress between parents of children with autism spectrum disorder (ASD) and other developmental disabilities (DDs) and to examine ASD's influence on parenting stress through mediation analysis.
Methods: We retrospectively analyzed 48 children with ASD (ASD group) and 77 with non-ASD DDs (non-ASD group), along with one of their parents, at the Gyeongsang National University Hospital between May 2021 and August 2024. All underwent developmental assessments and completed the Korean version of the Parenting Stress Index-4 and the Child Interactive Behavior Test (CIBT).