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http://dx.doi.org/10.1111/gcb.70209 | DOI Listing |
Int Immunopharmacol
August 2025
Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China; Shanghai Engineering Research Center of Lung Transplantation, Shanghai, China. Electronic address:
Background: Protein lactylation has been implicated in stress-responsive cellular mechanisms, yet its role in lung transplantation-associated ischemia-reperfusion injury (IRI) remains undefined.
Methods: Transcriptomic profiles from GSE145989 were analyzed through differential expression analysis (limma) and weighted gene co-expression network analysis (WGCNA). Integrating the identified genes with lactylation-related signatures uncovered key lactylation-related genes (LRGs) as potential targets.
Diabetes Res Clin Pract
September 2025
Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Aims: The mixed-meal tolerance test (MMTT), though considered the gold standard for evaluating residual beta-cell function in type 1 diabetes mellitus (T1D), is impractical for routine use. We aimed to develop and validate a machine learning (ML) model to predict MMTT-stimulated C-peptide categories using routine clinical data.
Methods: Data from 319 individuals in the T1D Exchange Registry with complete MMTT and clinical information were analyzed.
Toxicon
September 2025
Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address:
Lithobates palmipes is a frog species whose skin secretions contain peptides belonging to the ranatuerin, brevinin, and temporin families. In this study, the peptide ranatuerin-2PMe was isolated and evaluated for its antimicrobial, hemolytic, antiproliferative, and chemotactic activities. Ranatuerin-2PMe (2933.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Transplantation Center, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China; Key Laboratory of Translational Research in Transplantation Medicine of National Health Commission, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China; Clinical Resea
Kidney transplantation (KT) is an effective treatment for end-stage renal disease, with over 90 % of recipients requiring lifelong tacrolimus (Tac). However, The Tac pharmacokinetics exhibit high intra-patient variability (IPV), posing significant challenges. This study included 102 KT recipients at our center from October 2022 to December 2023.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
National Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China; Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
Chestnut (Castanea mollissima Blume) is a nutritionally dense food, notably rich in starch, making it an important natural source of carbohydrates and energy for human diets. However, its high content of rapidly digestible starch (RDS) limits its use in low-glycemic-index (GI) food products. This study developed a synergistic bioprocess combining Lactobacillus plantarum fermentation and pullulanase-catalyzed debranching to enhance the nutritional and structural characteristics of chestnut powder.
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