The revised risk analysis index outperforms the 5-factor modified frailty index in predicting postoperative morbidity after pilon fracture fixation.

Background: Pilon fractures often result from high energy mechanisms resulting in long-term morbidity and postoperative complications. While there is extensive literature investigating frailty scales as tools for preoperative risk stratification in orthopedic surgery, there is no literature regarding their use in fixation of pilon fractures. The objective of this study was to compare the predictive ability and discriminative accuracy of the Revised Risk Analysis Index (RAI-rev) and the 5-Item Modified Frailty (mFI-5) in 30-day postoperative outcomes following surgical fixation of pilon fractures.

Blueberries for brainpower: A systematic review and meta-analysis with Bayesian post hoc analysis of RCTS exploring cognitive function in the elderly with prior cognitive decline.

Blueberries are anthocyanin-rich fruits widely consumed by the general population, with well-established health benefits on the endocrine and cardiovascular systems attributed to their potent anti-inflammatory properties. However, the potential impact of blueberry consumption on cognitive function in elderly individuals with prior cognitive decline, such as Alzheimer's disease and dementia, remains insufficiently explored in the literature. Therefore, we aimed to evaluate the potential effects of chronic blueberry consumption on cognitive performance in this population through various memory assessment tools.

Prediction of blown pack in vacuum-packaged beef based on microbiome profiles and supervised machine learning.

The preservation of vacuum-packaged beef products is essential for maintaining shelf life. However, the occurrence of blown pack phenomenon, characterized by the expansion of packaging due to gas production by spoilage microorganisms, is still a challenge. In the present work, we demonstrate that microbiome analysis using next generation sequencing (NGS) and machine learning might be useful in the analysis, modeling and prediction of spoilage and blown pack in vacuum-packaged beef.

EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation.

Lung cancer histological subtypes include lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC). While typically distinct, combined LUAD/SCLC histology tumors occur, and LUAD can transform into SCLC as a resistance mechanism to targeted therapies, especially in -Mutant LUADs with / -inactivation. Although PRC2 complex expression increases during this transformation, its functional role has remained unclear.

Iatrogenic Horner's syndrome in pediatric patients: a report of two cases and a literature review.

Horner's syndrome (HS) is a condition characterized by ptosis, miosis, and facial anhidrosis. The causes include trauma and surgical procedures in the cervical, thoracic, or cranial regions, which can impair sympathetic fibers. In the cases presented, both patients - a infant and an adolescent - developed HS after cervical manipulations.

Comparison and Standardisation of Various Open Preperitoneal Techniques in Inguinal Hernia Surgery-Results of a Review and Consensus.

Introduction: Both open and laparoendoscopic preperitoneal mesh techniques are good options for the treatment of inguinal hernias. The 2023 updated HerniaSurge Guidelines recommend open preperitoneal mesh techniques as an acceptable alternative to Lichtenstein repair if a competent and experienced surgeon is available. However, although numerous open preperitoneal surgical techniques have been developed, only a few comparative studies comparing them are available.

What is the best: Functional rehabilitation or traditional immobilization after double-row suture anchor repair for insertional Achilles tendinopathy?

This retrospective study compared two rehabilitation methods for patients who underwent a double-row surgical technique for Insertional Achilles Tendinopathy (IAT). Group 1 (G1) received traditional immobilization with casting and no weightbearing for six weeks, while Group 2 (G2) followed a modern functional rehabilitation program with early weightbearing in a walking boot. Data were analyzed from 63 patients (68 feet), with 48 patients (51 feet) in G1 and 17 patients (17 feet) in G2.

Integrating Transformers and AutoML for Protein Function Prediction.

The next-generation sequencing technology and the decreasing cost of experimental verification of proteins made the accumulation of sequenced proteins in recent years possible. However, determining protein function is still difficult due to the cost and time required for this analysis. For that reason, computational methods have been developed to automatically assign annotations to proteins.

Twelve weeks of exercise training improves cognitive status, physical performance and quality of life in Alzheimer's disease: A systematic review and meta-analysis.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which there is slow and gradual impairment of mental function. Considering the increase in cases due to population aging, the potential benefits of physical training in AD are of great importance and need further elucidation. This study aims to identify the impact of physical training on crucial aspects of AD such as cognitive status, physical performances, quality of life and activities of daily living.

SUPERMAGO: Protein Function Prediction Based on Transformer Embeddings.

Recent technological advancements have enabled the experimental determination of amino acid sequences for numerous proteins. However, analyzing protein functions, which is essential for understanding their roles within cells, remains a challenging task due to the associated costs and time constraints. To address this challenge, various computational approaches have been proposed to aid in the categorization of protein functions, mainly utilizing amino acid sequences.

Advances in Tumor-Infiltrating Lymphocyte (TIL) as a Prognostic Factor and for Treating Invasive Cutaneous Melanoma.

Invasive cutaneous melanoma is responsible for about 5% of skin tumors yet is liable for nearly 70% of skin cancer-related deaths. Despite notable advancements over the past decade, including immunotherapies and targeted treatments, more than half of invasive melanoma patients ultimately succumb to the disease due to therapeutic resistance. To overcome this obstacle, strategies such as combining immunotherapies with targeted drugs or adding epigenetic therapies have been investigated.

Zileuton, a 5-Lypoxigenase Inhibitor, is Antiparasitic and Prevents Inflammation in the Chronic Stage of Heart Chagas Disease.

Chronic Chagas cardiomyopathy is associated with an unbalanced immune response and impaired heart function, and available drugs do not prevent its development. Zileuton (Zi), a 5-lypoxigenase inhibitor, affects inflammatory/pro-resolution mediators. Herein, Zi treatment in the early phase of infection reduced parasitemia associated mainly with the direct effect of Zi on the parasite, and the enzyme epoxide hydrolase was the potential molecular target behind the trypanocidal effect.

EfficientUNetViT: Efficient Breast Tumor Segmentation Utilizing UNet Architecture and Pretrained Vision Transformer.

This study introduces a sophisticated neural network structure for segmenting breast tumors. It achieves this by combining a pretrained Vision Transformer (ViT) model with a UNet framework. The UNet architecture, commonly employed for biomedical image segmentation, is further enhanced with depthwise separable convolutional blocks to decrease computational complexity and parameter count, resulting in better efficiency and less overfitting.

SUPRACONDYLAR FRACTURES IN CHILDREN: A SYSTEMATIC REVIEW OF TREATMENT OPTIONS.

Objective: To compare the outcomes of surgical stabilization of pediatric supracondylar humeral fractures with the use of crossed Kirschner wires versus divergent lateral pinning wires.

Methods: This is a systematic review with meta-analysis carried out by searching the MEDLINE/PubMed, Science Direct and Scielo databases. In these, the search for journals was carried out between January and August 2023, where 695 studies were found.

Biochemical characterization of an esterase from Thermobifida fusca YX with acetyl xylan esterase activity.

Background: Esterases (EC 3.1.1.

Healthcare Students' Perceptions About Approaching Spirituality in Their Training and Patient Care: Online, Cross-Sectional Survey.

Objective: Recent scientific literature points out that religiosity and spirituality play a relevant role in many aspects of life, including health issues. We aimed to evaluate the healthcare students' perceptions about approaching spirituality in their training and patient care in Brazilian universities.

Methods: A cross-sectional observational study was conducted following the STROBE guidelines.

β-1,3-Glucan recognition by as a putative mechanism of amoeba-fungal interactions.

In this study, we conducted an in-depth analysis to characterize potential () proteins capable of recognizing fungal β-1,3-glucans. specifically anchors curdlan or laminarin, indicating the presence of surface β-1,3-glucan-binding molecules. Using optical tweezers, strong adhesion of laminarin- or curdlan-coated beads to was observed, highlighting their adhesive properties compared to controls (characteristic time τ of 46.

Comparison of analytical performance and economic value of two biosurveillance methods for tracking SARS-COV-2 variants of concern.

The development of biosurveillance programs with strong analytical performance and economically accessible protocols is essential for monitoring viral pathogens. Throughout the COVID-19 pandemic, whole-genome sequencing (WGS) has been the prevailing technology for SARS-CoV-2 variant of concern (VOC) detection. While WGS offers benefits, it is a lengthy process, financially and technically straining for scalable viral tracking.

Vascular Growth Factor Inhibition with Bevacizumab Improves Cardiac Electrical Alterations and Fibrosis in Experimental Acute Chagas Disease.

Chagas disease (CD) caused by is a neglected illness and a major reason for cardiomyopathy in endemic areas. The existing therapy generally involves trypanocidal agents and therapies that control cardiac alterations. However, there is no treatment for the progressive cardiac remodeling that is characterized by inflammation, microvasculopathy and extensive fibrosis.

Plant-based diets benefit aerobic performance and do not compromise strength/power performance: a systematic review and meta-analysis.

Plant-based diets have emerged as athletic performance enhancers for various types of exercise. Therefore, the present study evaluated the effectiveness of plant-based diets on aerobic and strength/power performances, as well as on BMI of physically active individuals. This systematic review and meta-analysis was conducted and reported according to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.