Predicting stimulated C-peptide in type 1 diabetes using machine learning: a web-based tool from the T1D exchange registry.

Aims: The mixed-meal tolerance test (MMTT), though considered the gold standard for evaluating residual beta-cell function in type 1 diabetes mellitus (T1D), is impractical for routine use. We aimed to develop and validate a machine learning (ML) model to predict MMTT-stimulated C-peptide categories using routine clinical data.

Methods: Data from 319 individuals in the T1D Exchange Registry with complete MMTT and clinical information were analyzed.

A systematic review of health promoting effects of consumption of whey-based fermented products on adults.

Introduction: Fermented whey-based products show significant potential as functional foods, owing to their rich nutritional profile and the generation of bioactive compounds during fermentation. This systematic narrative review evaluates the health effects of fermented-whey consumption based on evidence from human studies in adults.

Methods: A systematic literature search was conducted using electronic databases including, PubMed, Scopus, and Cochrane Library for studies published between 1.

Translation and linguistic validation study of Munich Parasomnia Screening tool for Turkish.

Background: Parasomnias are prevalent sleep disorders that frequently go unrecognized and can have a substantial impact on an individual's sleep quality and daily functioning. The objective of this study was to translate and culturally adapt the Munich Parasomnia Screening (MUPS) scale into Turkish and to evaluate the psychometric properties of the MUPS-TR.

Methods: The present study was conducted with a sample of 311 adult Turkish-speaking individuals.

Exploring the acute recovery effects of dry cupping therapy and electrical stimulation on anaerobic performance metrics in active individuals: A quasi-experimental crossover study.

Background: This quasi-experimental crossover study aimed to examine the acute effects of dry cupping therapy (DCT) and neuromuscular electrical stimulation (NMES) on fatigue and perceived exertion in anaerobic performance among physically active individuals.

Methods: Twelve male participants (mean age: 24.1 ± 2.

Effect of pasture and feeding systems on hematological traits of ewes and lambs.

Context: Sustainable livestock production depends on efficient pasture management and the continuous monitoring of the health of grazing animals.

Objectives: This study investigated the effects of pasture types and sheep production systems on the hematological traits of Karacabey Merino (German Mutton Merino × Kıvırcık) ewes and lambs grazing on different pasture types throughout the year and reared in a semi-intensive system (control group).

Methods: In this twenty-six-month study, the hematological characteristics of ewes and lambs grazing on natural pastures and in spring (triticale and oat grass pasture), summer (sorghum Sudangrass and wheat stubble pasture), and autumn (triticale and oat grass pasture) were compared with ewes and lambs reared in a semi-intensive system (no pasture for lambs).

Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis.

Objective: This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size.

Methods: In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols.

Exploring the Therapeutic Potential of Bovine Colostrum for Cancer Therapies.

Colostrum is a nutrient-rich fluid secreted by mammals shortly after birth, primarily to provide passive immunity and support early immune development in newborns. Among its various sources, bovine colostrum is the most widely used supplement due to its high bioavailability, safety profile, and clinically supported health benefits. Rich in immunoglobulins, lactoferrin, growth factors, and antimicrobial peptides, bovine colostrum exhibits diverse biological activities that extend beyond neonatal health.

Is the Whistleblowing Behaviour of Nurses and Midwives Working in Delivery Rooms Related to Their Ethical Sensitivity? A Mixed-Methods Study.

Aim: This study sought to explore the relationship between whistleblowing and ethical sensitivity among nurses and midwives working in delivery rooms.

Design: A sequential mixed-methods research design.

Method: Online data collection included 209 participants (quantitative/snowball sampling) via demographic forms and Ethical Sensitivity Questionnaire, and 9 interviews (qualitative) with semistructured questions.

Influence of the cut-out-rescan procedure and rubber dam color on the trueness of intraoral scanners: A laboratory evaluation.

Purpose: To evaluate the laboratory effect of the cut-out-rescan procedure and the rubber dam color on the trueness of two intraoral scanners (IOS).

Methods: An onlay preparation was performed on a typodont maxillary left 1st molar. The left hemi-arch of the maxilla was scanned using two IOS (Trios 3, 3Shape; n=20).

The impact of postoperative intracoronal bleaching on the microtensile bond strength at the composite-dentin interface.

The study evaluated the effects of postoperative bleaching with HP and CP on microtensile bond strength (μTBS) and nanoleakage of composite restorations using total-/self-etch protocols. Sixty incisors with Black V cavities were restored using a multimode adhesive in total-/self-etch mode and resin composite. Samples were divided into five groups: control, CP×2, CP×5, HP×2, HP×5.

Effects of 8-week Tabata training on cardiopulmonary and performance parameters in wheelchair basketball players: A controlled study.

Background: Wheelchair basketball (WB) is a physically demanding sport requiring the development of various physiological and performance-related parameters. High-intensity interval training methods, such as Tabata, are increasingly used to enhance athletic performance. However, their specific effects on WB players remain underexplored.

Idiopathic Granulomatous Mastitis: A Consensus Report on Treatment and Follow-Up Approaches Based on the Turkish Clinical Classification.

Objective: The second consensus study on idiopathic granulomatous mastitis (IGM) aimed to establish treatment options based on the clinical classification proposed in the first consensus, standardize criteria for treatment discontinuation, and develop follow-up protocols.

Method: A structured methodology, identical to the first consensus study, was employed. An 11-member working group of breast surgeons experienced in IGM from various clinics across the country was formed.

A rare manifestation of Henoch-Schoenlein purpura: haemoptysis secondary to pulmonary involvement - a case report.

Henoch-Schoenlein purpura (HSP) in children is the most prevalent form of vasculitis. While the lungs are recognised as potential target organs in several vasculitides during childhood, pulmonary involvement in HSP is exceptionally rare. A 5-year-old girl presented with haemoptysis during week 3 of HSP vasculitis.

Performance of Advanced Artificial Intelligence Models in Pulp Therapy for Immature Permanent Teeth: A Comparison of ChatGPT-4 Omni, DeepSeek, and Gemini Advanced in Accuracy, Completeness, Response Time, and Readability.

Introduction: This study aims to evaluate and compare the performance of three advanced chatbots-ChatGPT-4 Omni (ChatGPT-4o), DeepSeek, and Gemini Advanced-on answering questions related to pulp therapies for immature permanent teeth. The primary outcomes assessed were accuracy, completeness, and readability, while secondary outcomes focused on response time and potential correlations between these parameters.

Methods: A total of 21 questions were developed based on clinical resources provided by the American Association of Endodontists, including position statements, clinical considerations, and treatment options guides, and assessed by three experienced pediatric dentists and three endodontists.

Key Predictors of Mortality in Crimean-Congo Hemorrhagic Fever: A Retrospective Multicenter Cohort Study.

Objective: This study aimed to identify key predictors of mortality in patients with Crimean-Congo Hemorrhagic Fever (CCHF). Our specific goals included characterizing the demographic and clinical features of hospitalized CCHF patients in Türkiye, determining factors associated with mortality among these patients, and evaluating the impact of early ribavirin administration.

Methods: A retrospective study was conducted on 1103 CCHF patients across 18 hospitals in Türkiye from January 1, 2019, to November 20, 2024.

The Regulatory Effect of Physical Activity on Perceived Fatigue from Digital Technology Use in Schools.

The increased use of digital technologies in educational settings has raised concerns about their impact on students' physical and mental well-being, particularly regarding perceived fatigue. This study explores the extent to which physical activity can regulate perceived fatigue associated with digital technology use among middle school students. Using an explanatory mixed-methods design, the study was conducted with 108 sixth-grade students (ages 11-12) who were assigned to exercise, nonexercise, and control groups.

Association between polypharmacy and mortality in the community dwelling elderly: A retrospective cohort study.

In this study, we examined the association between the use of multiple medications (polypharmacy) and mortality in 116 community-dwelling elderly people. This retrospective cohort study included 116 participants randomly selected from a population of 1161 community-dwelling elderly individuals. Of the 116 participants, 60 (51.

Determination of urinary iodine excretion and iodine deficiency in school-age children aged 7-11 after mandatory iodization in Canakkale, Turkiye.

Objective: The aim of this study is to determine the iodine deficiency status of school-age children in Canakkale, whose data were not known before.

Methods: The population of the research was created from students in the 7-11 age group studying in primary schools. 316 students were selected for the study group by multi-stage stratified sampling method.

The Effect of Online Progressive Muscle Relaxation Exercises on Sexual Satisfaction and Function of Applied to Women with Low Sexual Satisfaction: A Randomized Controlled Study.

Background: Sexuality is influenced by a combination of psychological, emotional, and physiological factors, where sexual satisfaction is a key component. Progressive muscle relaxation exercises are commonly used to reduce anxiety and improve physical relaxation, but their impact on sexual satisfaction and function, particularly for individuals with low sexual satisfaction, has not been widely studied. This study aimed to investigate the effect of progressive muscle relaxation exercises applied to women with low sexual satisfaction on the sexual satisfaction and function of both the women and their partners.

The Effect of Oleuropein on the Treatment of Allergic Rhinitis.

Introduction: Allergic rhinitis is a disease that negatively affects social and work life and sometimes does not respond to many treatments. Therefore, new treatments are needed. For the prevention and treatment of allergies, oleuropein has been emphasized, and positive results have been shown in the literature.

3D-Printable, Self-Stiffening (4D) and Shape Morphing Hydrogel through Single-Step Orthogonal Crosslinking of Phenolic Biopolymers for Dynamic Tissue Engineering.

Particularly for dynamic, shape-changing, or fibrillar tissues such as muscles and blood vessels, the development of innovative biomaterials is crucial for advancing tissue engineering and regenerative medicine. This study introduces a novel multicomponent hydrogel created from silk fibroin (SF), tyramine-modified hyaluronic acid (HA_Tyr), and tyramine-modified gelatin (G_Tyr). Using an enzymatic orthogonal covalent bonding between phenolic groups, i.

Inspiratory muscle training in natural bodybuilders: adaptations in diaphragm muscle thickness and maximal strength.

Background: The effect of inspiratory muscle training on diaphragm muscle thickness (DT) and one repetition maximal (1RM) in professional natural bodybuilders is still unclear. The aim of the study was to investigate the effect of inspiratory muscle training on diaphragm muscle thickness and 1RM in professional natural bodybuilders.

Methods: The study comprised a total of 22 athletes who participated in bodybuilding competitions.

Relationships among social support, healthy lifestyle beliefs, physical literacy, and enjoyment of physical activity: a moderated mediation model.

Objective: This study aims to examine the relationships between social support, physical literacy, and healthy lifestyle beliefs in adolescents and to investigate the moderating effect of enjoyment of physical activities on these relationships.

Method: The study was conducted with the participation of 1,349 adolescents. The ages of the participants ranged between 10 and 14 years, and 49.

Enhancing nutritional value and flavor profiles of whey powder through fungal fermentation with and .

Investigation of the nutritional properties, biological activities, volatile compounds and sensory properties of fungal biomass and supernatants obtained from cheese whey powder fermented with and was aimed in this study. The biomass produced by exhibited higher total lipid (118.54 g/kg) and total essential amino acid (62.