Key Predictors of Mortality in Crimean-Congo Hemorrhagic Fever: A Retrospective Multicenter Cohort Study.

Objective: This study aimed to identify key predictors of mortality in patients with Crimean-Congo Hemorrhagic Fever (CCHF). Our specific goals included characterizing the demographic and clinical features of hospitalized CCHF patients in Türkiye, determining factors associated with mortality among these patients, and evaluating the impact of early ribavirin administration.

Methods: A retrospective study was conducted on 1103 CCHF patients across 18 hospitals in Türkiye from January 1, 2019, to November 20, 2024. All data were obtained via an online data collection system by the designated physician at each center. Patients with laboratory-confirmed CCHF infection who were hospitalized were included in the study. Univariate analyses and time-dependent Cox regression were conducted.

Results: Of the 1103 patients, 65.7% (725/1102) were male; 87.2% (962/1103) resided in rural areas; and the mean age was 53 years. Ticks were identified as the transmission route in 68.4% (755/1103) of cases. Comorbidities included diabetes mellitus, chronic heart disease, and hypertension. 4.6% (51/1103) of patients developed healthcare-related infections. ICU admission was required in 8.0% (88/1103) of patients and the overall mortality rate was 5.1% (56/1103). In univariate analyses, age ≥50 years (OR=3.1, 95% CI=1.58-6.08, p<0.001), and diabetes mellitus (OR = 4.49, 95% CI: 2.20-9.18, p<0.001), were associated with increased mortality. Both variables remained statistically significant predictors in the multivariate analysis. While early ribavirin administration, ≤96 hours from symptom onset, did not reach statistical significance in univariate analysis (OR=0.52, 95% CI=0.26-1.05, p=0.065), it was significantly associated with reduced mortality in time-dependent Cox regression (aHR = 0.21, 95% CI: 0.07-0.69, p=0.010).

Conclusion: Key factors such as age, and comorbidities can predict mortality in CCHF patients. Timely identification of these predictors, along with early administration of ribavirin, may contribute to improved survival and better clinical outcomes.